Alternative Cell Type and in Situ Cell Therapies

• 127 · PDF 核黄素生物合成副产物增加癌症对过继性MAIT TCR工程化T细胞转移的易感性 Riboflavin biosynthesis byproducts increase the vulnerability of cancer to adoptive MAIT TCR-engineered T-cell transfer Ying Zheng, Pakhi Birla, Wanting Shan, Samuel Huang, Franck Housseau, Drew Pardoll
• 128 · PDF 用LTBR基因对gammadelta CAR T细胞进行合成重编程，优化其在TME中的功能并克服效应器局限 Synthetic reprogramming of gammadelta CAR T cells with the LTBR gene optimizes function in the TME and overcomes effector limitations Mitchell S. Wang, Ivan Reyes-Torres, Kristen C. Vogt, Caroline K. Hanlon, Ashley N. Thornal, Maria Guarino, Eric M. Johnson, Mark P. Roberto, Navamallika G. Reddy, Miao Chen, Theodore Giavridis, Mateusz Legut
• 130 · PDF 拓展ACT范式：通过球形核酸对B细胞进行工程化以用于癌症免疫治疗 Expanding the ACT paradigm: B cell engineering via spherical nucleic acids for cancer immunotherapy Maryam Balibegloo, Yingying Li, Abu Baker, Jie Fan, Ping Xie, Mi Ran Choi, Catalina Lee Chang, Vinzenz Mayer, Michael Evangelopoulos, Chad A. Mirkin, Bin Zhang
• 131 · PDF 利用人血小板裂解物增强用于CAR-NK疗法的NK细胞的无饲养层扩增、存活、效力及生产后稳定性 Enhanced feeder-free expansion, survival, potency and post manufacture stability of NK cells for CAR-NK therapies using human platelet lysate Vanesa Alonso-Camino, Andrew Sullivan
• 132 · PDF 改进用于CAR-NK免疫治疗结直肠癌的效应细胞 Improving effector cells for CAR-NK immunotherapy against colorectal cancer Marco Cortese, Alice D'Andrea, Alfonso Navarro Zapata, Sahar Taebi, Consalvo Petti, Enzo Medico
• 133 · PDF NEO-201识别的截短Core 1 O-聚糖代表AML中CAR-NK治疗的一个新靶点 NEO-201-recognized truncated Core 1 O-glycans represent a new target for CAR-NK therapy in AML Joseph A. Clara, Nile Liu, Mala Chakraborty, Kwong Y. Tsang, Massimo Fanitni, Philip M. Arlen, Richard W. Childs
• 134 · PDF 工程化iPSC来源NK细胞对转移性葡萄膜黑色素瘤细胞的抗肿瘤活性 Anti-tumor activity of engineered iPSC-derived NK cells against metastatic uveal melanoma cells Nadia Anikeeva, Tong Zhang, Sota Deguchi, Sergei Koshkin, Masashi Yamada, Kouichi Tamura, Hironobu Kimura, Vitali Alexeev, Yuri Sykulev, Takami Sato, Mizue Terai
• 135 · PDF 靶向CD123和CD33的记忆样NK细胞可增强对急性髓系白血病的杀伤 Memory-like NK cell targeting to CD123 and CD33 improves killing of acute myeloid leukemia Emily Phillips, Lyra Morina, Lynne Marsala, Wilbur Song, Michelle Becker-Hapak, Yoojin Ahn, Sushanth Pureti, Elizabeth Juarez Diaz, Sadia Afrin, Pamela Wong, Jennifer Tran, Joseph Rueve, Allison Burdi, Nancy Marin, Melissa Marie Berrien-Elliott, Martin Felices, Jeffrey S. Miller, Todd A. Fehniger
• 136 · PDF 表面工程化NK/曲妥珠单抗细胞作为HER2低表达乳腺癌的新型免疫疗法 Surface engineered-NK/trastuzumab cells as a novel immunotherapy for HER2-low breast cancer Maria Jose Godoy Calderon, Manali Patwardhan, Shruti Rodrigues, Saanvi Sethi, Eric Gauchat, Vk Gadi
• 137 137 利用同种异体CAR-iNKT细胞用于肿瘤学和自身免疫领域的下一代治疗 Harnessing allogeneic CAR‑iNKT cells for next‑generation treatments in oncology and autoimmunity Yuhua Wan, Dexian Quan, Feng Xu, Yuzhu Cui, Jian Hua, Jingyu Li, Hua Zhang
• 138 · PDF 生成可规模化的现货型iNKT疗法 Generation of scalable off-the-shelf iNKT therapies John J. Swain, Eoin C. Whelan, Chiquita Hanindya, Peter Keller, Antonia Rotolo
• 139 · PDF 在NSCLC患者来源类器官型肿瘤球体中对同种异体NK细胞治疗产品进行功能分析 Functional profiling of an allogeneic NK cell therapy product in NSCLC patient-derived organotypic tumor spheroids Chunxiao Cui, Anthony Attardo, Mei Rosa Ng, Yana Wang, Michael A. Perricone
• 140 · PDF 靶向CLDN18.2阳性胃癌和胰腺癌的同种异体CAR-iNKT细胞疗法 Allogeneic CAR-iNKT cell therapy targeting CLDN18.2-positive gastric and pancreatic cancers Clinton M. Heinze, Elisa Landoni, Michelle Ferguson, Nicole van der Weerden, Robson Dossa, Simon Poon, Kelvin Yip, Jacqui Cumming, Alfie Baker, Sandford Sarah, Michael J. Baker, Barbara Savoldo, Gianpietro Dotti
• 141 · PDF 筛选富含成熟亚群的脐带血来源NK细胞可优化基于CAR-NK细胞的抗肿瘤治疗 Selecting cord blood-derived NK cells enriched in mature subsets optimizes CAR-NK cell-based anti-tumor therapy Ye Ethan Li, Huihui Fan, Rafet Basar, Wilson Jeffrey, Patrick Zhang, Katayoun Rezvani
• 142 · PDF 一种为与抗体和T细胞衔接器疗法协同联合而工程化设计的通用多受体NK细胞平台 A universal multi-receptor NK cell platform engineered for synergistic combination with antibody and T-cell engager therapies Rafet Basar, Bin Liu, Nadima Uprety, Francia Reyes Silva, Rejeena Shrestha, Sunil Acharya, May Daher, Ana K. Nunez Cortes, Deqiang Zhang, Bingqian  Hu, Silvia Tiberti, Madison Moore, Ye Ethan Li, Pinghua Liu, Hila Shaim, Jeong-Min Park, Mecit  Kaplan, Xingliang  Guo, Mayra Shanley, Ping Li, Paul Lin, Pinaki Banerjee, Huihui Fan, Patrick Zhang, Enli Liu, Seema Rawal, Elizabeth Joan Shpall, Katayoun Rezvani
• 143 · PDF 通过替代性CD3胞质结构域增强gammadelta CAR-T细胞功能 Enhancing gammadelta CAR T cell function through alternative CD3 cytoplasmic domains Philipp Metzger, Marina Zintchenko, Susana Minguet, Cynthia Obodozie, Holger Weber
• 144 · PDF 对适应性细胞和髓系细胞进行体内CAR mRNA工程改造可实现对实体瘤的强效抗肿瘤控制 In vivo CAR mRNA engineering of both adaptive and myeloid cells enables potent anti-tumor control of solid cancers Junming Tong, Moore Chen, Kevin Sek, Meghan Harris, Jerome Chal, Colin Pouton, Angus Johnston, Daniel Getts, Robert Hofmeister, Phil Darcy, Jian Ding
• 145 · PDF CD8纳米抗体靶向的脂质纳米颗粒包裹CD13 nanoCAR环状RNA用于原位CAR-T细胞根除急性髓系白血病 CD8 nanobody-targeted lipid nanoparticles encapsulating CD13 nanoCAR circular RNAs for in situ CAR-T cell eradication of acute myeloid leukemia Wilson Huang, Diva Chen, Yun-Chin Chou, Tsung-Chih Chen, Chia-Jen Wu
• 146 · PDF 体内慢病毒CAR-T基因递送在人源化B细胞淋巴瘤模型中显示出高特异性和强效抗肿瘤活性 In vivo lentiviral CAR-T gene delivery demonstrates high specificity and potent anti-tumor activity in a humanized B cell lymphoma model Ilian Radichev, Devin Stranford, Hailey Edelstein, Oanh Pham, Destanie Rose, Jiwon Yang, Mahdy Yassine, Henry Schirmer, Teresa Nikolich, Joshua Leonard, James Keck, Matteo Stoppato
• 147 · PDF 利用CD3和CD7再靶向LVV提高体内CAR-T基因递送效率的多管齐下方法 A multipronged approach to improve gene delivery efficiency for in vivo CAR-T using CD3 and CD7 retargeted LVVs Longshan Liu, Cheng Luo, Yangyang Tang, Lianqu Li, Hai Huang, Mangmang Li, Yu Liang
• 148 · PDF 体内CAR-T T-LNP系统（GT801）在血液和自身免疫疾病中驱动强效B细胞清除并具有临床可行性 In vivo CAR-T T-LNP system (GT801) drives potent B cell depletion and clinical feasibility in hematologic and autoimmune conditions Jingwei Sun, Xi Zhu, Jiahui Jin, Yiyang Tan, Liang Lin, Zhao Xu, Jingman Wang, Dalang Li, Hong Chen, Jiaming Ren, Jun Cui, Jing Yu, Pin Wang, Yarong Liu
• 149 · PDF 红细胞介导的mRNA递送实现体内生成CAR-髓系细胞用于癌症免疫治疗 Erythrocyte-mediated mRNA delivery enables in vivo generation of CAR-myeloid cells for cancer immunotherapy Xiaoqian Nie, Yuehua Liu, Xiaofei Gao
• 150 · PDF T细胞特异性转录调控消除CD3再靶向慢病毒载体的CAR介导脱靶转导，实现安全的体内生成强效alphaBCMA-CAR T细胞 T-cell specific transcriptional control eliminates CAR-mediated off-target transduction by CD3-retargeted lentiviral vectors, enabling safe in vivo generation of potent alphaBCMA-CAR T cells Karina Krotova, Nandakumar Packiriswamy, MD Yeashin Gazi, Collin Gwilt, Chia-Hsuan Chin, Ajay Kumar, Aaron Hawkes, Gopal Naik Nenavath, Thipparat Suwanmanee, Darren Phung, Luke W. Breigenzer, Timothy Carey, Christian Kinney, Hamid Salimi, Patrycja Lech, Kah-Whye Peng, Stephen Russell
• 151 · PDF 细胞因子、PM21颗粒刺激与TGF-beta预处理的联合应用可产生细胞毒性增强并能浸润实体瘤的自然杀伤细胞 Combination of cytokines, PM21-particle stimulation, and TGF-beta conditioning results in Natural Killer cells with enhanced cytotoxicity and infiltration of solid tumors Jeremiah L. Oyer, Tayler J. Croom-Perez, Javier A. Rivera-Huertas, Brian P. Tullius, Alicja J. Copik
• 152 · PDF 迈向体内抗BCMA/CD19 CAR-T细胞治疗B细胞介导的自身免疫性疾病 Toward an in vivo anti-BCMA/CD19 CAR-T cell treatment of B cell-mediated autoimmune diseases Alexander J. Najibi, Denise Wong, Jeff Wood, Tharani Sivanandam, Han K. Lee, Josue Figueroa, Kelly Nichols, Yao Wei, Emily T. Beura, Shannon Grande Contrastano
• 153 153 通过工程化干细胞来源的CD16增强型通用NKT细胞改善抗癌单克隆抗体疗法 Improvement of monoclonal antibody therapy against cancer through engineering stem cell-derived CD16-enhanced universal NKT cells Yan-Ruide Li, Yichen Zhu, Yanqi Yu, Lili Yang
• 154 · PDF 人gammadelta T细胞在人源化NSG™-SGM3-IL-15×MHC I/II双敲除小鼠中的稳健植入,用于评估基于gammadelta T细胞的治疗手段 Robust engraftment of human gammadelta T cells in humanized NSG TM -SGM3-IL-15 × MHC I/II double knockout mice for the evaluation of gammadelta T cell-based therapeutics Kevin Tsai, Beau Parry, Destanie Rose, James G. Keck, Li-Chin Yao

在会议检索中浏览本分会场