Late-Breaking Research: Immunology 1

• LB075 · PDF 抑制PAK4通过诱导病毒模拟增强肿瘤免疫 PAK4 inhibition enhances tumor immunity by inducing viral mimicry Libin Gao
• LB076 · PDF 靶向SUV39H1表观遗传沉默以诱导病毒模拟并抑制胶质母细胞瘤生长 Targeting suv39h1 epigenetic silencing to induce viral mimicry and suppress glioblastoma growth Yi Sak Kim, Charles Spruck
• LB077 · PDF 用于乳腺癌脑转移的自然杀伤（NK）细胞疗法 Natural killer (NK) cell therapies for breast cancer brain metastasis Timothy M. McMullen, Pascal Naef, Erika Zagni, Aaron J. Longworth, Isam Adam, Noah Wechter, Jacob Insua-Rodriguez, Lincy Antony, Dennis Ma, Eva Zhao, Sharmila Mallya, Tatyana Lev, Hannah Savage, Lei Tian, Delia F. Tifrea, Robert Edwards, Miguel A. Villalona-Calero, Ahmed Mohyeldin, Timothy E. O’Sullivan, Jianhua Yu, Kai Kessenbrock, Devon A. Lawson
• LB078 · PDF 高度可塑的巨噬细胞龛协调乳腺癌骨转移中获得性静息与再激活 Highly plastic macrophage niches orchestrate acquired quiescence and reactivation in breast-cancer bone metastasis Noriko Gotoh
• LB079 · PDF 增殖性炎症性萎缩中的前列腺腔上皮细胞表现出促炎的先天免疫信号激活，而这在前列腺腺癌中不存在 Prostatic luminal epithelial cells in proliferative inflammatory atrophy display proinflammatory innate immune signaling activation that is absent in prostatic adenocarcinoma Thomas M. Steele, Jessica Hicks, Qizhi Zheng, Alan K. Meeker, Mindy K. Graham, Abhishek Shetty, Rulin Wang, Carolina Gomes-Alexandre, Fernanda Caramella Pereira, William G. Nelson, Sushant Kachhap, Srinivasan Yegnasubramanian, Angelo M. De Marzo
• LB080 · PDF 肥胖导致非共价KRAS G12D抑制剂在胰腺导管腺癌小鼠模型中疗效各异 Obesity contributes to varied efficacy of non-covalent KRAS G12D inhibitor in murine models of pancreatic ductal adenocarcinoma Sujith Sarvesh, Holly R. Stephens, Pia Muri, Henry Nnaemeka Ogbonna, Karen Aikhionbare, Jianqing Zhang, Dhana Sekar Reddy Bandi, Cherlene Hardy, Purnachandra Nagaraju Ganji, Bassel F. El-Rayes, Lyse A. Norian, Jeremy Foote
• LB082 · PDF 破坏错配修复使错配修复功能正常的肿瘤具有免疫原性，并在小鼠中诱导CD8 T细胞依赖但T细胞受体非依赖的、对异源肿瘤的免疫控制 Disrupting mismatch repair makes mismatch repair-proficient tumors immunogenic and induces CD8 T cell-dependent, but T cell receptor-independent, immune control of heterologous tumors in mice Haiwei Zhang, Ayijiang Yisimayi, Bowen Gu, Yuting Wang, Wayne M. Yokoyama, Sytse J. Piersma, Eduard Batlle, Daniele V. F. Tauriello, Judy Lieberman
• LB083 · PDF 晚期甲状腺癌中生存期与免疫治疗反应的肠道微生物组特征 Gut microbiome signatures of survival and immunotherapy response in advanced thyroid cancer Ahmad Abubaker, Ashish V. Damania, Zoey R. Neale, Sabitha Prabhakaran, Yasmine M. Hoballah, Patient Mosaic Team, Naifa  Busaidy, Sarah Hamidi, FAST Consortium, Jennifer A. Wargo, Andrew  Futreal, Stephen Y. Lai, Nadim  J. Ajami, Anastasios Maniakas
• LB084 · PDF 致癌性KRAS通过CD9重塑膜张力以清除细胞外肿瘤DNA从而抑制DNA感知 Oncogenic KRAS suppresses DNA sensing via CD9 by remodeling membrane tension to clear extracellular tumor DNA Di Cao, Weiyi Zhou, Zhixiong Li, Shixun Lu, Zhenlin Hou, Long Yu, Yuanjun Guan, Guoqiang Wang, Yifan Liu, Zhijie Huang, Hao Wang, Jingyi Dai, Cong Li, Jing Wang, Gong Chen
• LB085 · PDF Claudin-1调节黑色素瘤免疫微环境以促进肿瘤生长，是晚期黑色素瘤的候选治疗靶点 Claudin-1 modulates the melanoma immune microenvironment to promote tumor growth and is a candidate therapeutic target for advanced melanoma Antonin Lallement, Frank Jühling, Zeina Nehme, Bujamin Vokshi, Guillaume Davidson, Emilie Crouchet, Thomas F. Baumert, Irwin Davidson
• LB086 · PDF 巨噬细胞-树突状细胞-T细胞四联体协调抗肿瘤免疫和对检查点阻断的反应 Macrophage-dendritic cell-T-cell tetrads orchestrate antitumor immunity and response to checkpoint blockade Mehdi Chaib, Muhammad Aminu, Shelley Herbrich, Mahshid Arabi, Yue Xuan, Akshay Basi, Anna Casasent, Marc Macaluso, Kenneth Hu, Matthew Gubin, Xi Chen, James Mancuso, Sreyashi Basu, Sonali Jindal, Jared Burks, Stephanie Watowich, Jia Wu, James Allison, Padmanee Sharma
• LB087 · PDF 调节性T细胞在乳腺癌脑转移中控制抗肿瘤小胶质细胞功能 Regulatory T cells control anti-tumor microglia function in breast cancer brain metastasis Isam Adam, Pascal Naef, Erika Zagni, Aaron Longworth, Hannah Savage, Jacob Insua-Rodriguez, Noah Wechter, Lincy Antony, Timothy McMullen, Eva Zhao, Francesco Marangoni, Devon Lawson
• LB088 · PDF 鉴定NSCLC中KRAS抑制剂耐药的免疫抑制机制 Identifying mechanisms of immune suppression in KRAS-inhibitor resistance in NSCLC Samrat Kundu, Amrita Barua, Sofia Garza, David Peng, Jared Fradette, Don Gibbons

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