PO.TB05.01 · 肿瘤生物学
Developmental Origins, Drivers, and Heterogeneity in Pediatric Cancer
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622 · PDF 婴儿KMT2A::AFF1急性淋巴细胞白血病干细胞模型揭示对蛋白质组的早期影响 Infant KMT2A::AFF1 acute lymphoblastic leukemia stem cell model reveals early impact on the proteome Alexandra Prosser-Dombrowski, Irina Pushel, Priyanka Prem Kumar, Thomas Gremminger, Michaella Rekowski, Midhat S. Farooqi, Michael Washburn, Jay L. Vivian, John M. Perry
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623 · PDF 通过无序区模拟肽靶向融合阳性腺泡状横纹肌肉瘤中的PAX3::FOXO1凝聚体 Targeting PAX3::FOXO1 condensates in fusion-positive alveolar rhabdomyosarcoma via disordered-region mimetic peptides Michael Di Martino, Yanghao Zhong, Shasha Chong
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625 · PDF 利用横纹肌肉瘤模型研究Li-Fraumeni综合征肌肉中的早期肿瘤启动 Early tumor priming in Li-Fraumeni Syndrome muscle using a rhabdomyosarcoma model Ashby Kissoondoyal, Paula Rosanna Quaglietta, Brianne Laverty, David Malkin
- 626 626 TLX3抑制IKZF2以激活PI3K/AKT信号通路:一条驱动白血病起始的新型转录轴 TLX3 represses IKZF2 to activate PI3K/AKT signaling: A novel transcriptional axis driving leukemia initiation Gisele Rodrigues, Julie Hixon, Hila Winer, Timothy Gower, Francisco Lobo, Nathan Wong, Erica Matich, Steven Hsu, Emma Wachter, Elijah Edmondson, Maggie Cam, Caroline Andrews, Sarah Cramer, Wenqing Li, Scott Durum
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627 · PDF 通过hiPSC来源模型研究ATRT的起源细胞和肿瘤异质性 Investigating ATRT cell of origin and tumor heterogeneity via hiPSC-derived models Clark G. Wang, Qi Wang, Nidhi Nathwani, Bryan K. Li, Takayuki Morimoto, Alison D. Parisian, G. Praveen Raju, Frank B. Furnari
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628 · PDF 探究BRCA2在儿童横纹肌肉瘤发生中的作用 Investigating the role of BRCA2 in the development of pediatric rhabdomyosarcoma Phillip Adam Weinstein, Elif Asik, Pagna Sok, Cem Ozdemir, Wei-Che Tseng, Ryan Zabriskie, Aniko Sabo, Philip J. Lupo, Alison A. Bertuch, Kyle Miller, Sharon E. Plon
- 629 629 SMARCD3调控的浦肯野细胞迁移是小脑发育和3组髓母细胞瘤转移的基础 SMARCD3-regulated Purkinje cell migration underlies cerebellar development and group 3 medulloblastoma metastasis Yash Patel, Han Zou, Allen Zheng, Anjali Talluru, Nirja Divekar, Chaim Sneiderman, Meghana Dodda, Katie Dietrich, Siheng Chao, Sameer Agnihotri, Gary Kohanbash, Antony Michealraj, Ian Pollack, Baoli Hu
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630 · PDF 在人诱导多能干细胞模型中阐明PAX3::FOXO1肿瘤起始机制 Elucidation of PAX3::FOXO1 tumor initiation mechanisms in human induced pluripotent stem cell models Bradley T. Stevens, Yang Zhang, Brian J. Abraham, Mark E. Hatley
- 631 631 中枢神经系统发育特异性复制修复缺陷的跨物种分析揭示胶质瘤发生和免疫治疗反应的差异模式 Trans-species analysis of central nervous system developmental-specific replication repair deficiency reveals differential patterns of gliomagenesis and response to immunotherapy Zoya Aamir, Melissa A. Galati, Emma Gattoni, Owen Crump, Nemanja Ilic, Anirban Das, Nicholas R. Fernandez, Angel K. Q. Wong, Lucie Stengs, Jose R. Dimayacyac, Yuan Chang, Vanessa Bianchi, Melissa Edwards, David Malkin, Cynthia Hawkins, Nuno M. Nunes, Uri Tabori
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632 · PDF 驱动儿童低级别胶质瘤的肿瘤微环境因素的动态表征 Dynamic characterization of tumor-microenvironment factors that drive pediatric low-grade gliomas Jenna Robinson, Joohee Lee, Sarah Reel, Shriya Rangaswamy, Michelle Boisvert, John Doench, David TW Jones, Timothy Phoenix, Pratiti Bandopadhayay
- 633 633 AVIL对YAP的依赖作为其致癌活性的关键介导者,为横纹肌肉瘤提供了治疗机会 AVIL's dependency on YAP as a key mediator of oncogenic activity offers a therapeutic opportunity in rhabdomyosarcoma Martyna Glowczyk-Gluc, Robert Cornelison, Zhongqiu Xie, Julie Fanburg-Smith, Robin D. LeGallo, Eyas Alzayadneh, Hui Li
- 634 634 CAF亚群通过不同的MYCN依赖性和非依赖性机制促成肿瘤对化疗的耐药 Subpopulations of CAF contribute to chemotherapy resistance in tumors through different MYCN-dependent and independent mechanisms Kevin Louault, Laurence Sarte, Liron D. Grossmann, Bruce Pawel, John M. Maris, Shahab Asgharzadeh, Yves Albert DeClerck
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635 · PDF 界定尤因肉瘤中EWS::FLI1的肿瘤间和肿瘤内转录异质性 Defining the intertumoral and intratumoral transcriptional heterogeneity of EWS::FLI1 in Ewing sarcoma Rachael Hinshaw, Zachary P. Tolstyka, Susan M. Kitchen-Goosen, Seneca Kinn-Gurzo, Rebecca Kaufman, Maggie Chasse, Elizabeth Wilson, Gretchen Lam, Stephanie The, Elissa Boguslawski, Patrick J. Grohar
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636 · PDF 通过空间RNA与蛋白分析解析颅内生殖细胞肿瘤的复杂生态系统 Dissecting the complex ecosystem of intracranial germ cell tumors by spatial RNA and protein analysis Torsten Pietsch, Verena Dreschmann, Pia Zapka, Evelyn Dörner, Christian Vokuhl
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637 · PDF CyTOF分析尤因肉瘤细胞系在体外和体内的异质性 CyTOF analysis of heterogeneity between Ewing sarcoma cell lines in vitro and in vivo Piper Harrell, Lily Golzar, Kenzie Wells, Poornima Gourabathini, Kimberly Q. McKinney, Erin M. Trovillion, Javier Oesterheld, Kaitlyn H. Smith
- 638 638 促结缔组织增生性小圆细胞肿瘤中上皮样和神经样肿瘤表型及其细胞邻域的空间组织 Spatial organization of epithelial- and neural-like tumor phenotypes and their cellular neighborhoods in desmoplastic small round cell tumors Jiaqian Fan, Kevin Murgas, Diana Shamsutdinova, Davis Ingram, Alexander Lazar, Danh Truong, Joseph A. Ludwig
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639 · PDF 不同的微环境定义了神经母细胞瘤的亚型 Distinct microenvironments define subtypes of neuroblastoma Joseph Seamus Toker, Katherine Elizabeth Masih, Noemi Kedei, Zahin Islam, Ben J. Somerville, Amir Jassim, Michail Mamalakis, Aysen Yuksel, Daniel R. Catchpoole, Li Zhou, Paul Aiyetan, Yong Yean Kim, David Milewski, Shaoli Das, Xinyu Wen, Yong Song, Jun Wei, Richard J. Gilbertson, Javed Khan
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640 · PDF 多组学分析揭示转移性骨肉瘤中的内皮细胞可塑性 Multiomic profiling reveals endothelial cell plasticity in metastatic osteosarcoma Ying Wu, Julian Burks, Demond Williams, Carly Sayers, Vidhur Daulatabad, Neeraja Syed, John F. Shern, Troy A. McEachron
- 641 641 通过阐明驱动骨肉瘤肺定植的肿瘤-宿主相互作用来识别脆弱性 Identifying vulnerabilities through an elucidation of the tumor-host interplay that drives osteosarcoma lung colonization Fatemeh Yazarlou, Matthew Cannon, Yogesh Budhathoki, Amy C. Gross, Leyre Jimenez Garcia, James Reinecke, Ryan D. Roberts
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642 · PDF 细胞外黏度调控SMARCB1缺陷型脑肿瘤细胞的球体形成 Extracellular viscosity modulates spheroid formation in SMARCB1-deficient brain tumor cells Yihsuan Chen, Long-Sheng Lu, Yu-Chun Lin
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643 · PDF Sean Karl队列:一项针对配对患者尤因肉瘤标本的国际单细胞RNAseq研究 The Sean Karl Cohort: An international single-cell RNAseq study of paired patient Ewing sarcoma specimens Abbe Pannucci, Elina Mukherjee, Jessica D. Daley, Shireen Sita Ganapathi, Elissa Boguslawski, Lea Surrey, Lauren Gutstein, Patrick Azar, Emily Stockfisch, Azfar Neyaz, Ivy John, Jennifer Picarsic, Yutaro Tanaka, Byron Butaney, Riaz Gillani, Brian D. Crompton, Katherine A. Janeway, Jaclyln Taroni, Jessica Davis, Damon Reed, Adam Shlien, Theodore W. Laetsch, Rajen Mody, Clémence Henon, Thomas G. Grünewald, Elizabeth R. Lawlor, Filemon Dela Cruz, Patrick J. Grohar, Jovana Pavisic, Ally Hawkins, Anthony R. Cillo, Kelly M. Bailey
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644 · PDF 利用人源类器官临床前平台评估靶向GD2的抗体偶联药物治疗DIPG Evaluating GD2-targeting antibody-drug conjugates for DIPG using human organoid-based preclinical platforms Zhikun Wang, Emily Miller, Wei Huang, Satoru Kawakita, Lauren Vanderpool, Francisco Bustamante, Uijin Kim, Zhaohui Wang
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645 · PDF 增强抗原呈递可恢复横纹肌肉瘤中的免疫识别 Enhancement of antigen presentation restores immune recognition in rhabdomyosarcoma Maya Groff, David Milewski, Hsien-Chao Chou, Vineela Gangalapudi, Alexandra Urbanek, Young Song, Meijie Tian, Yong Yean Kim, Jun Wei, Javed Khan
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646 · PDF 探索与上皮样肉瘤中SMARCB1缺陷相关的可靶向治疗靶点 Exploring actionable therapeutic targets associated with SMARCB1 deficiency in Epithelioid sarcoma Jiyeon Park, Ryo Miyamoto, David G. Kirsch
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647 · PDF EWSR1::FLI1抑制核糖体生物合成并在尤因肉瘤中创造可靶向的弱点 EWSR1::FLI1 suppresses ribosome biogenesis and creates a targetable vulnerability in Ewing sarcoma Matteo Colombo, Jason Sims, Christoph Dotter, Hana Bernhardova, Sanskriti Balaji, Jonathan Levi, Aleksandra S. Anisimova, Anja Wagner-Schrittwieser, Tamina Stelzer, Aikaterini M. Formouzi, Bernadette Liegl-Atzwanger, Marita Koelz, Anke Scharrer, Markus Schosserer, Peter Schlögelhofer, Thomas G. P. Grunewald, G. Elif Karagöz, Alice Soragni, Eleni M. Tomazou
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648 · PDF PP2A再激活上调神经母细胞瘤中的FGA基因 PP2A reactivation upregulates FGA gene in neuroblastoma Nazia Nazam, Shamza Manzoor, Maryam Ghufran, Morgan L. Brown, Ali M. Eakes, Pranava Nande, Joel C. Opara, Abdulraheem Kaimari, Michael Ohlmeyer, Elizabeth A. Beierle
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649 · PDF PML的位点特异性磷酸化调控崩溃控制高危儿童恶性肿瘤中的RTK过度激活 Site-specific phospho-regulatory collapse of PML governs RTK hyperactivation in high-risk pediatric malignancy. Sreenidhi Mohanvelu, Poorvi Subramanian, Natarajan Aravindan