PO.TB10.06 · 肿瘤生物学
Spatial Protein Profiling and Multi-Modal Mapping of Tumor and Circulating Ecosystems
- 789 789 PaintScape TM enables in situ, single cell spatial multiomic visualization of 3D genome organization in fresh frozen colorectal carcinoma tissue in spatially resolved tissue microenvironments Shyamtanu Chattoraj, Pamela Flatley, Stacy Elliott, David Castillo, Kenny Chung, Doug Werner, Jude Dunne, Huy Nguyen
- 790 790 Cellular decomposition and metabolic profiling of the tumor microenvironment tumor-stroma interface using high-dimensional spatial proteomics and image analytics Arutha Kulasinghe, Felicia Roland, Michelle Poulin, Ritu Mihani, Katherine Hales, Daniel Winkowski
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- 792 792 A standardized pan-cancer framework for spatial profiling of the tumor microenvironment using multiplex immunofluorescence Sidney van der Zande, Outi H. J. Hasu, Zhiying He, Katja E. Välimäki, Tuomas Mirtti, Antti S. Rannikko, Heini J. Lassus, Ari P. Ristimaki, Pia Osterlund, Tero A. Aittokallio, Lassi Paavolainen, Mikko J. Loukovaara, Olli P. Kallioniemi, Ralf C. Bützow, Teijo S. Pellinen
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- 794 794 Spatial analysis of the DLBCL tumor microenvironment via the novel SignalStar® multiplex immunohistochemistry assay Jennifer Ziello, Jason Weirather, Derek Papalegis, Lily Vu, Gabriella Spang, Sizun Jiang, Giorgio Ga. Inghirami
- 795 795 Integrating spatial transcriptomics and Imaging Mass Cytometry™ for multi-omic mapping of hepatocellular carcinoma Atefeh Khakpoor, Qanber Raza, Merrin Mary Eapen, Dina Kazemi, Erin Coll, Liang Lim, Christina Loh, Nick Zabinyakov, Ling Qiao, Anna Di Bartolomeo, Helen McGuire, Jacob George, Ankur Sharma
- 796 796 Digital spatial profiling reveals immune heterogeneity across tumor and stromal compartments in hepatocellular carcinoma Min Qing, Qibiao Wu, Xuesong Lyu, Tao Chen, Mingxuan Xia, Joshua J. Rusbuldt, Denis Smirnov, Flora Berisha, Longen Zhou, Chia-Jui Yen
- 797 797 Integrating hematoxylin & eosin histology with multiplexed imaging mass cytometry for spatial proteomic profiling of antibody-drug conjugate targeted biomarkers Nick Zabinyakov, Qanber Raza, Liang Lim, James Mansfield, Christina Loh
- 798 798 Tumor-associated neutrophil density and cancer cell interaction in microsatellite stable and unstable gastric cancer using multiplex immunofluorescence Soo Kyung Nam, Seo Hwan Yu, Sun Young Ahn, Yujun Park, Yoonjin Kwak, Sujin Oh, Kyoung Un Park, Hye Seung Lee
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- 801 801 Genomic and spatial single-cell profiling reveals BRCA-linked tumor microenvironment signatures in high-grade serous ovarian carcinoma Jue young Kim, Hayeon Shin, Yoon Joo Kim, Yookyung Lee, Jae-Hoon Kim
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- 803 803 A spatial profiling approach to evaluating the prognostic impact of heterogeneity in the triple-negative breast cancer immune microenvironment Prerana Sensharma, Huidan Zuo, Melanie Dawe, Megan Hopkins, Zeynep Baskurt, Osvaldo Espin-Garcia, Philippe L. Bedard, Melanie Spears, Susan J. Done
- 804 804 Distinct cellular phenotypes and spatial neighborhoods constitute the heterogeneous microenvironment of desmoplastic small round cell tumor Kevin A. Murgas, Jiaqian Fan, Diana Shamsutdinova, Khalida Wani, Davis R. Ingram, Alexander J. Lazar, Danh D. Truong, Joseph A. Ludwig
- 805 805 Fluorescence-guided multi-sampling and spatial multi-omics reveal functional lipid vulnerabilities in glioblastoma Adele-Asia Ponzoni, Evangelos Liapis, Lea Anne T. Maristela, Elizabeth E. Ginalis, Linda Szymanski, Kar Fai Chow, Kangmin Lee, George J. Kaptain, Claire L. Carter
- 806 806 Tumor microenvironment of ampulla of Vater cancer reveals distinct spatial niche of CAF, TIL, and TAM and their correlation with clinicopathologic features Yesul Jeong, Se Jun Park, Sung Hak Lee*, Younghoon Kim*
- 807 807 Integrated transcriptomic and proteomic characterization of the lung tumor microenvironment using BD®OMICS-One-Protein-Panels for CITE-seq Samuel X. Shi, Cynthia Sakofsky, Hye-won Song, Manish Thakran, Tamiyo Kobayashi, Aruna Ayer
- 808 808 Single cell spatial multiomics of TCR and BCR repertoires using CosMx® SMI to characterize immune cell dynamics in PBMCs and tumors Margaret L. Hoang, Rachel Liu, Dan McGuire, Ashley Heck, Kimberly Young, Megan Vandenberg, Claire Williams, Martin Shelton, Prajan Divakar, Patrick Danaher, Erin Piazza, Joseph M. Beechem
- 809 809 Spatially resolved multiomics profiling of glioblastoma reveals molecular signatures of neuropathology and immuno-oncology architecture using CosMx SMI Yi Cui, Claire Williams, Chia-Ying Lee, Chi Phan, Sierra Mckinzie, Shanshan He, Ashley Heck, Kimberley Young, Lidan Wu, John Lyssand, PRAJAN DIVAKAR, Joseph M. Beechem
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- 813 813 Linking tumor-infiltrating immune cells from tissue and peritoneal cytology to molecular markers in endometrial cancer Seungmee Lee, Jin-Young Kim, Shin-Wha Lee, Eun Ji Nam, Ji Hae Seo, Sojin Shin
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- 817 817 Spatial characterization, of T-cell receptors at subcellular resolution using in situ sequencing-by-synthesis and spatial protein detection on the same tissue section Hansueli Meyer, Robert Pinard, Ryan Hindman, Emily Neil, Chris Nehme, Sameh Soliman, Dongju Park, Rebecca C. Hennessey, Jinling Wang, Alex Makrigiorgos, John Lee, Seiyu Hosono, Matthias Wahl, Dominic Mangiardi, Mong Marma, Hsu-yi Lee, Andreas Bosio
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