PO.TB10.06 · 肿瘤生物学
Spatial Protein Profiling and Multi-Modal Mapping of Tumor and Circulating Ecosystems
- 789 789 PaintScape™ 实现新鲜冷冻结直肠癌组织中三维基因组组织在空间解析的组织微环境内的原位、单细胞空间多组学可视化 PaintScape TM enables in situ, single cell spatial multiomic visualization of 3D genome organization in fresh frozen colorectal carcinoma tissue in spatially resolved tissue microenvironments Shyamtanu Chattoraj, Pamela Flatley, Stacy Elliott, David Castillo, Kenny Chung, Doug Werner, Jude Dunne, Huy Nguyen
- 790 790 利用高维空间蛋白质组学和图像分析对肿瘤微环境肿瘤-基质界面进行细胞分解和代谢分析 Cellular decomposition and metabolic profiling of the tumor microenvironment tumor-stroma interface using high-dimensional spatial proteomics and image analytics Arutha Kulasinghe, Felicia Roland, Michelle Poulin, Ritu Mihani, Katherine Hales, Daniel Winkowski
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- 792 792 利用多重免疫荧光对肿瘤微环境进行空间分析的标准化泛癌框架 A standardized pan-cancer framework for spatial profiling of the tumor microenvironment using multiplex immunofluorescence Sidney van der Zande, Outi H. J. Hasu, Zhiying He, Katja E. Välimäki, Tuomas Mirtti, Antti S. Rannikko, Heini J. Lassus, Ari P. Ristimaki, Pia Osterlund, Tero A. Aittokallio, Lassi Paavolainen, Mikko J. Loukovaara, Olli P. Kallioniemi, Ralf C. Bützow, Teijo S. Pellinen
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- 794 794 通过新型 SignalStar® 多重免疫组织化学检测法对 DLBCL 肿瘤微环境进行空间分析 Spatial analysis of the DLBCL tumor microenvironment via the novel SignalStar® multiplex immunohistochemistry assay Jennifer Ziello, Jason Weirather, Derek Papalegis, Lily Vu, Gabriella Spang, Sizun Jiang, Giorgio Ga. Inghirami
- 795 795 整合空间转录组学与成像质谱流式技术™以对肝细胞癌进行多组学图谱绘制 Integrating spatial transcriptomics and Imaging Mass Cytometry™ for multi-omic mapping of hepatocellular carcinoma Atefeh Khakpoor, Qanber Raza, Merrin Mary Eapen, Dina Kazemi, Erin Coll, Liang Lim, Christina Loh, Nick Zabinyakov, Ling Qiao, Anna Di Bartolomeo, Helen McGuire, Jacob George, Ankur Sharma
- 796 796 数字空间分析揭示肝细胞癌肿瘤与基质区室间的免疫异质性 Digital spatial profiling reveals immune heterogeneity across tumor and stromal compartments in hepatocellular carcinoma Min Qing, Qibiao Wu, Xuesong Lyu, Tao Chen, Mingxuan Xia, Joshua J. Rusbuldt, Denis Smirnov, Flora Berisha, Longen Zhou, Chia-Jui Yen
- 797 797 整合苏木精-伊红组织学与多重成像质谱流式技术以对抗体-药物偶联物靶向生物标志物进行空间蛋白质组学分析 Integrating hematoxylin & eosin histology with multiplexed imaging mass cytometry for spatial proteomic profiling of antibody-drug conjugate targeted biomarkers Nick Zabinyakov, Qanber Raza, Liang Lim, James Mansfield, Christina Loh
- 798 798 使用多重免疫荧光技术研究微卫星稳定与不稳定胃癌中肿瘤相关中性粒细胞密度及癌细胞相互作用 Tumor-associated neutrophil density and cancer cell interaction in microsatellite stable and unstable gastric cancer using multiplex immunofluorescence Soo Kyung Nam, Seo Hwan Yu, Sun Young Ahn, Yujun Park, Yoonjin Kwak, Sujin Oh, Kyoung Un Park, Hye Seung Lee
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- 801 801 基因组和空间单细胞分析揭示高级别浆液性卵巢癌中 BRCA 相关的肿瘤微环境特征 Genomic and spatial single-cell profiling reveals BRCA-linked tumor microenvironment signatures in high-grade serous ovarian carcinoma Jue young Kim, Hayeon Shin, Yoon Joo Kim, Yookyung Lee, Jae-Hoon Kim
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- 803 803 一种评估三阴性乳腺癌免疫微环境异质性预后影响的空间图谱分析方法 A spatial profiling approach to evaluating the prognostic impact of heterogeneity in the triple-negative breast cancer immune microenvironment Prerana Sensharma, Huidan Zuo, Melanie Dawe, Megan Hopkins, Zeynep Baskurt, Osvaldo Espin-Garcia, Philippe L. Bedard, Melanie Spears, Susan J. Done
- 804 804 独特的细胞表型和空间邻域构成促结缔组织增生性小圆细胞肿瘤的异质性微环境 Distinct cellular phenotypes and spatial neighborhoods constitute the heterogeneous microenvironment of desmoplastic small round cell tumor Kevin A. Murgas, Jiaqian Fan, Diana Shamsutdinova, Khalida Wani, Davis R. Ingram, Alexander J. Lazar, Danh D. Truong, Joseph A. Ludwig
- 805 805 荧光引导的多点取样与空间多组学揭示胶质母细胞瘤中功能性脂质的可干预弱点 Fluorescence-guided multi-sampling and spatial multi-omics reveal functional lipid vulnerabilities in glioblastoma Adele-Asia Ponzoni, Evangelos Liapis, Lea Anne T. Maristela, Elizabeth E. Ginalis, Linda Szymanski, Kar Fai Chow, Kangmin Lee, George J. Kaptain, Claire L. Carter
- 806 806 Vater壶腹癌的肿瘤微环境揭示CAF、TIL和TAM的独特空间微环境及其与临床病理特征的相关性 Tumor microenvironment of ampulla of Vater cancer reveals distinct spatial niche of CAF, TIL, and TAM and their correlation with clinicopathologic features Yesul Jeong, Se Jun Park, Sung Hak Lee*, Younghoon Kim*
- 807 807 使用BD®OMICS-One-Protein-Panels进行CITE-seq对肺肿瘤微环境的整合转录组学和蛋白质组学表征 Integrated transcriptomic and proteomic characterization of the lung tumor microenvironment using BD®OMICS-One-Protein-Panels for CITE-seq Samuel X. Shi, Cynthia Sakofsky, Hye-won Song, Manish Thakran, Tamiyo Kobayashi, Aruna Ayer
- 808 808 使用CosMx® SMI对TCR和BCR库进行单细胞空间多组学分析，以表征PBMC和肿瘤中的免疫细胞动态 Single cell spatial multiomics of TCR and BCR repertoires using CosMx® SMI to characterize immune cell dynamics in PBMCs and tumors Margaret L. Hoang, Rachel Liu, Dan McGuire, Ashley Heck, Kimberly Young, Megan Vandenberg, Claire Williams, Martin Shelton, Prajan Divakar, Patrick Danaher, Erin Piazza, Joseph M. Beechem
- 809 809 使用CosMx SMI对胶质母细胞瘤进行空间解析的多组学分析，揭示神经病理学和免疫肿瘤学结构的分子特征 Spatially resolved multiomics profiling of glioblastoma reveals molecular signatures of neuropathology and immuno-oncology architecture using CosMx SMI Yi Cui, Claire Williams, Chia-Ying Lee, Chi Phan, Sierra Mckinzie, Shanshan He, Ashley Heck, Kimberley Young, Lidan Wu, John Lyssand, PRAJAN DIVAKAR, Joseph M. Beechem
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- 813 813 将组织和腹腔细胞学中的肿瘤浸润免疫细胞与子宫内膜癌的分子标志物相关联 Linking tumor-infiltrating immune cells from tissue and peritoneal cytology to molecular markers in endometrial cancer Seungmee Lee, Jin-Young Kim, Shin-Wha Lee, Eun Ji Nam, Ji Hae Seo, Sojin Shin
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- 817 817 在同一组织切片上使用原位合成测序和空间蛋白检测对T细胞受体进行亚细胞分辨率的空间表征 Spatial characterization, of T-cell receptors at subcellular resolution using in situ sequencing-by-synthesis and spatial protein detection on the same tissue section Hansueli Meyer, Robert Pinard, Ryan Hindman, Emily Neil, Chris Nehme, Sameh Soliman, Dongju Park, Rebecca C. Hennessey, Jinling Wang, Alex Makrigiorgos, John Lee, Seiyu Hosono, Matthias Wahl, Dominic Mangiardi, Mong Marma, Hsu-yi Lee, Andreas Bosio
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