LBPO.IM02 · 免疫学 · Late-Breaking
Late-Breaking Research: Immunology 2
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LB136 · PDF Flotillin-2通过限制T细胞受体纳米簇形成和活化来抑制CD8⁺T细胞的抗肿瘤功能 Flotillin-2 suppresses CD8⁺T cell anti-tumor function by restricting T cell receptor nanoclustering and activation Sookjin Moon, Fei Zhao, Peer Karmaus, Michael Fessler
- LB137 LB137 E-选择素配体工程化克服转运障碍以增强过继性T细胞和BiTE治疗 E-selectin ligand engineering overcomes trafficking barriers to potentiate adoptive T-cell and BiTE therapies Yingqin Hou, Peng Wu
- LB138 LB138 EGFR靶向KIR-CAR T中基于自然杀伤细胞的信号传导克服了基于CD3的CAR T功能缺陷,在体内清除耐药性胶质母细胞瘤 Natural killer cell-based signaling in EGFR-targeted KIR-CAR T overcomes CD3-based CAR T functional deficits to eliminate resistant glioblastomas in vivo Jun Xu, Radhika Thokala, Yibo Yin, Chong Xu, Alina C. Boesteanu, Alexandria P. Cogdill, Zev A. Binder, Logan Zhang, Jiasi Vicky Zhang, Enxiu Wang, Carl H. June, Donald M. O'Rourke, Michael C. Milone, Laura A. Johnson
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LB139 · PDF 纳米抗体适配子导向的CAR T细胞实现对实体瘤精准而安全的靶向 Nanobody adaptor-directed CAR T cells enable precise and safe targeting of solid tumors Yoo-Shin Kim, Yogindra Vedvyas, Aroshi Mitra, Nathaniel Fredette, Irene Min, Yanping Yang, Moonsoo Jin
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LB140 · PDF B7H3 CAR T细胞疗法在多种免疫健全卵巢癌模型中的应用及可转移抗肿瘤免疫的证据 B7H3 CAR T cell therapy across immunocompetent ovarian cancer models with evidence of transferable anti-tumor immunity Thu Huyen Pham, Elizabeth Allen, Supreeti Tallapragada, Justine Chan, Naiara Martinez Velez, Elena Sotillo, Crystal L. Mackall, Oliver Dorigo
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LB141 · PDF 用于改善CAR T细胞功能的嵌合RNA结合蛋白高通量筛选 High-throughput screening of chimeric RNA-binding proteins for improved CAR T cell function Courtney Kernick, Oliver Takacsi-Nagy, Austin Hartman, Lujing Wu, Christie Chang, Ansuman Satpathy, Theodore Roth
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LB142 · PDF 抑制性VISTA LRIG1轴损害CAR T细胞的持久性和功能 The inhibitory VISTA LRIG1 axis impairs the persistence and function of CAR T cells Dia Roy, Keman Zhang, Amin Zakeria, Elizabeth Delaney, Hieu Minh Ta, Paolo Elguera Grandez, Lily Wang
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LB143 · PDF G3BP1的调控影响CAR T细胞对抗胶质母细胞瘤的功能疗效 Modulation of G3BP1 influences the functional efficacy of CAR T cells against glioblastoma Donghyun Lee, Yoo-Shin Kim, Yogindra Vedvyas, Nathaniel Fredette, Moonsoo Jin, Irene Min
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LB144 · PDF OBX-115膜结合IL15(mbIL15)表达型工程化肿瘤浸润淋巴细胞(TIL)在患者来源的自体非小细胞肺癌(NSCLC)模型中,通过直接杀伤和NK细胞的反式激活,克服与主要组织相容性复合体(MHC)沉默相关的靶细胞免疫逃逸 OBX-115 membrane-bound IL15 (mbIL15)-expressing engineered tumor-infiltrating lymphocytes (TIL) overcome target cell immune evasion related to major histocompatibility complex (MHC) silencing through both direct killing and transactivation of NK cells in patient-derived autologous non-small cell lung cancer (NSCLC) models Adam J. Schoenfeld, Alonso Villasmil Ocando, Zheng Ao, Rachel Burga, Alicia Adamovich, Hansini Wadan, Sarah Cascarino, Dhruv K. Sethi, Giridharan Ramsingh, Matthew Bott
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LB145 · PDF 用于胶质瘤免疫治疗中巨噬细胞特异性表达的基于慢病毒的造血干细胞平台 Lentiviral-based hematopoietic stem cell platform for macrophage-specific expression in glioma immunotherapy Jianzhong Zhang, Edward J. Allen, Víctor A. Arrieta, Heba Ali, Ningjia Zhou, Venkatanagasai Raju Alluri, Michael D. McRaven, Sergio Barajas, Adam M. Sonabend, Amy B. Heimberger, Yan Liu, Ajit Chande, Atique U. Ahmed, Jason M. Miska, Catalina Lee-Chang, Peng Zhang, Thomas J. Hope, Crismita Dmello
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LB146 · PDF 整合模拟禁食饮食以增强乳腺癌过继细胞转移后的抗肿瘤免疫 Integrating a fasting mimicking diet to augment antitumor immunity following adoptive cell transfer in breast cancer Evangelia Pavlou, Olga Blazevits, Giulia Salvadori, Sara Martone, Valter Longo
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LB148 · PDF 冷冻免疫疫苗接种(CIV):一种无毒的局部区域性多组分免疫治疗方法,可系统性根除播散性转移性癌症 Cryo-immune vaccination (CIV):A nontoxic locoregional multicomponent immunotherapeutic approach that can systemically eradicate disseminated metastatic cancers James B. DuHadaway, Alexander J. Muller, Lisa D. Laury-Kleintop, U. Margaretha Wallon, Marie Webster, Jason R. Williams, Gabriela R. Rossi, Mario R. Mautino, Charles J. Link, George C. Prendergast
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LB149 · PDF 在抗PD-1治疗期间,HPK1抑制可增强耗竭CD8+T细胞从祖细胞向中间态的分化 Progenitor-to-intermediate differentiation of exhausted CD8+T cells is enhanced by HPK1 inhibition during anti-PD-1 therapy Yong Joon Lee, Seung Hyuck Jeon, Seungmook Lim, Minwoo Jeon, Heejin Nam, A Yeong Park, Boeun Gu, Jee Ye Kim, Seung Il Kim, Jeon Yeob Jang, Chul-Ho Kim, Shin Hwang, Gi-Won Song, Jae-Ho Cheong, Byung Soh Min, Su-Hyung Park, Seong Il Seo, Jinhwa Lee, Minyong Kang, Jae Eun Kim, Eui-Cheol Shin
- LB150 LB150 衰老作为免疫耐受打破者:有丝分裂激酶TTK(Mps1)和AURKA的抑制剂通过cGAS-STING信号诱导促免疫原性衰老,为肿瘤微环境接受免疫治疗做准备 Senescence as an immune tolerance breaker: Inhibitors of mitotic kinases TTK (Mps1) and AURKA induce pro-immunogenic senescence that primes the tumor microenvironment for immunotherapy via cGAS-STING signaling Marina Capece, Evdokiya Reshetnikova, Yinchong Wang, Arjun Mittra, Anna E. Vilgelm
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LB151 · PDF 脂质体阿霉素增强口腔鳞状细胞癌的抗肿瘤免疫应答 Liposomal doxorubicin potentiates anti-tumor immune response in oral cavity squamous cell carcinoma Jennifer L. Anderson, Fabio H. Brasil Da Costa, Allison Nipper, Nicolas Oltean, Laxman Devkota, Rohan Bhavane, Ratna Veeramachaneni, Sofia Cortes, Neeraja Dharmaraj, Sarah L. Latka, Andrew Badachhape, Renuka T. R. Menon, Prajwal Bhandari, Sujuan Yang, Ansam Sinjab, Humam Kadara, Roberto Rangel, Faye M. Johnson, Jeffrey N. Myers, Ketankumar B. Ghaghada, Simon Young, Ananth V. Annapragada, Andrew G. Sikora
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LB152 · PDF ACR-368通过协调激活适应性和先天性免疫通路与PD-L1阻断产生协同作用,实现强效抗肿瘤疗效 ACR-368 synergizes with PD-L1 blockade by coordinated activation of adaptive and innate immunity pathways to achieve robust anti-tumor efficacy Amira Elbakry, Taronish Dubash, Joelle Baddour-Sousounis, Jessica Hopkins, Subodh Kumar, Ahmed Youssef, Yingchun Spring Liu, Kate Rappard, Calvin Yang, Ignacio Arribas Diez, Marc Isaksson, Luka Romero, Zachary Best, Nina Lipjankic, Sofija Skoric, Courtney Cooper, Emma Ahrman, Valentina Siino, Portia Lombardo, Corey Xu, Magnus E. Jakobsson, Helen Nilsson, Lei Shi, Ayesha Murshid, Michail Shipitsin, Joon Jung, David Proia, Erick Gamelin, Kristina Masson, Peter Blume-Jensen
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LB153 · PDF 用于免疫肿瘤学候选药物评估的肿瘤类器官-基质微环境中的定量MDSC浸润测定法 A quantitative MDSC infiltration assay in a tumor organoid-stromal microenvironment for immuno-oncology candidate evaluation Bo Eun Lee, Wookyeom Yang, Yoon-Ha Go, Phuong Lan Nguyen, Dong-Uk Lim
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LB154 · PDF 抗GARP在对抗PDL1+抗VEGFA治疗耐药的MASH-HCC小鼠模型中逆转免疫抑制并延长总生存 Anti-GARP reverts immune suppression and extends overall survival in a MASH-HCC murine model resistant to anti-PDL1+anti-VEGFA therapy Julia Huguet-Pradell, David Camell-Raventos, Elisa Fernández-Martínez, Anthony Lozano, Tiago de Castro, Marcus Zeitlhoefler, Ugne Balaseviciute, Albert Gris-Oliver, Daniela Sia, Roser Pinyol, Josep M Llovet
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LB155 · PDF 通过RetroT全RNA基因组整合平台进行体内CAR T细胞工程改造以实现持久的抗肿瘤免疫 Durable anti-tumor immunity through in vivo CAR T cell engineering using the RetroT all-RNA genome integration platform Jian Ding, Meghan Harris, Edward Cochran, Thach Ty, Glen Leary, Jason Rodriguez, Jerome Chal, Yuxiao Wang, Daniel Getts, Robert Hofmeister, Philippe Kieffer-Kwon