PO.CL05.05 · 临床研究
Immunomodulatory Effects of Targeted Therapies
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2557 · PDF 糖皮质激素抑制GARP/TGF-beta轴从而启动免疫依赖性黑色素瘤控制 Glucocorticoids inhibit the GARP/TGF-betaaxis initiating immune-dependent melanoma control Charles H. Earnshaw, Poppy Dunn, Shih-Chieh Chiang, Agrin Moeini, Maria A. Koufaki, Eduardo Bonavita, Massimo Russo, Laetita Nebot-Bral, Kimberley Hockenhull, Erin Richardson, Anna Pidoux, Charlotte R. Bell, Alexander R. Baker, Richard Reeves, Robert Sellers, Sudhakar Sahoo, Victoria Fife, Matthew G. Roberts, Theophile Bigirumurame, Caroline Dive, Julia A. Newton-Bishop, Jeremie Nsengimana, Christopher E. M. Griffiths, Santiago Zelenay
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2558 · PDF 接受177Lu-PSMA-617和pembrolizumab治疗的去势抵抗性前列腺癌患者的多组学单细胞评估显示放射性配体治疗的时机会改变免疫反应 Multi-omic single-cell assessment of castration-resistant prostate cancer patients receiving 177 Lu-PSMA-617 and pembrolizumab shows timing of radioligand therapy alters immune response Anusha Muralidhar, Karen Law, Zenghua Fan, Shloka Shukla, Aram Lyu, Serena Kwek, David Y. Oh, Michael Evans, Rahul R. Aggarwal, Lawrence Fong
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2559 · PDF 鉴定放射诱导干扰素信号传导的癌细胞内在调控因子 Identifying cancer cell intrinsic regulators of radiation-induced interferon signaling Olivia Kaneko, Bon Ham Yip, Arnav Mehta, Nir Hacohen, Ryan J. Park
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2560 · PDF 放疗塑造胶质母细胞瘤微环境中的记忆T细胞动态和区域特异性PD-1表达 Radiotherapy shapes memory T cell dynamics and region-specific PD-1 expression in the glioblastoma microenvironment Hsin-Yu Sherry Liu, Sanghee Lee, Itzel Gutierrez, Jasmine Borroel, Paris Offor, Emily Eastwood, Javier Rodriguez, Kristen Buck, Derrick Gorospe, Elizabeth Valencia, Catherine Elix, Bridget Corcoran, Manuel Reyes, Samantha Lin, Raffaella Pippa
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2562 · PDF 一种纳米药物在乳腺癌模型中诱导的定量和功能性免疫重编程 Quantitative and functional immune reprogramming induced by a nanomedicine in breast cancer model Mathilde Dacos, Léa Plantureux, Sarah Giacometti, Joseph Ciccolini, Raphaelle Fanciullino
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2563 · PDF mTOR抑制通过重编程TP53突变型免疫冷HNSCC肿瘤微环境增强抗肿瘤免疫反应 mTOR inhibition augments antitumor immune response by reprogramming the TP53 -mutant, immune-cold HNSCC tumor microenvironment Priyatosh Nath, Alok Khandelwal, Tara Moore-Medlin, Chun Li, Cherie-Ann Nathan
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2564 · PDF 探索自然杀伤细胞免疫疗法联合放射治疗用于肌层浸润性膀胱癌 Investigating the combination of natural killer immunotherapy with radiation therapy for muscle invasive bladder cancer Fatima Inigo, Jose Mansure, Eva Michaud, Brian Meehan, Tanner Connell, Ciriaco Piccirillo, Wassim Kassouf
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2565 · PDF mTOR作为FLASH放疗的机制性生物标志物:对免疫调节性黑色素瘤治疗的意义 mTOR as a mechanistic biomarker of FLASH radiotherapy: Implications for immune-modulated melanoma treatment Madison Hawkins, Joshua Knight, Camden VanTassell, Landen Barnett, Gennie Lynne Parkman, Dani Johnson-Erickson, Ramesh Rengan
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2566 · PDF 抑制KRAS G12D通过STING激活增强巨噬细胞介导的抗肿瘤免疫 KRAS G12D inhibition enhances macrophage-mediated anti-tumor immunity via STING activation Xiaoe He, Xiangyan Jiang, Wengui Shi, Long Qin, Tao Wang, Zuoyi Jiao
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2567 · PDF Axl是cDC1中I型IFN的负性调控因子,阻碍抗肿瘤免疫 Axl is a negative regulator of type I IFN in cDC1s hindering anti-tumor immunity Isaac Gonzalez, Eslam A. Elghonaimy, Qiongwen Zhang, Isaac Montgomery, Peter Q. Leung, Arely P. Rodriguez, Rolf A. Brekken, Todd A. Aguilera
- 2569 2569 粒子治疗、ATM和PD-1抑制用于pMMR直肠癌 Particle therapy, ATM and PD-1 inhibition for pMMR rectal cancer Cameron M. Callaghan
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2570 · PDF 重编程T细胞网络以克服卵巢癌复发中的免疫逃逸 Reprogramming T-cell networks to overcome immune evasion in ovarian cancer relapse Denarda Dangaj Laniti
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2572 · PDF 药理学靶向CTPS1可引发巨噬细胞介导的抗白血病免疫 Pharmacological targeting of CTPS1 elicits macrophage-mediated anti-leukemia immunity Meng Liu, Lei Zhang, Xin He, Haojie Dong, Yang Li, Shuaishuai Ge, Guohua Wu, Yadav P. Umesh, Wei Chen, Pinghui Feng, Guido Marcucci, Ling Li
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2573 · PDF 三阴性乳腺癌中铂类药物诱导的化疗免疫调节的鉴定与表征 Identification and characterization of platinum agent-induced chemoimmunomodulation in triple-negative breast cancer Mariana Makarem, Kathleen Streeks, Claudia Perez Perez, Iasmim Lopes de Lima, Mohammed Gbadamosi
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2574 · PDF 通过对治疗前后标本进行无监督转录组分析,鉴定并表征乳腺癌中化疗免疫调节的诱导轨迹 Identification and characterization of chemoimmunomodulatory induction trajectories in breast cancer via unsupervised transcriptomic analyses of pre- and post-treatment specimens Iasmim L. de Lima, Kathleen H. Streeks, Elizabeth Molchan, Mariana S. Makarem, Kennedy L. Coleman, Mohammed O. Gbadamosi
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2575 · PDF 三阴性乳腺癌中蒽环类药物诱导的化疗免疫调节的鉴定与表征 Identification and characterization of anthracycline-induced chemoimmunomodulation in triple-negative breast cancer Kennedy L. Coleman, Kathleen Streeks, Mariana Makarem, Iasmim Lopes de Lima, Mohammed Gbadamosi
- 2576 2576 靶向肠道的抗生素调节增强NSCLC的放疗反应,并揭示驱动活体生物治疗药物设计的表观遗传及微生物组驱动的免疫程序 Gut-targeted antibiotic modulation enhances radiotherapy response in NSCLC and uncovers epigenetic and microbiome-driven immune programs enabling live biotherapeutic design Steven J. Feigenberg, Francesca Costabile, Ceylan Tanses, Kyle Bittinger, Divyansh Agarwal, Roddy O'Connor, Jeffrey Bradley, Amit Maity, Benjamin A. Garcia, Andrea Facciabene
- 2577 2577 游离型和包裹型衣霉素通过阻断K-Ras G12D表达,显著增强吉西他滨对胰腺导管腺癌细胞中PD-L1的抑制 Free and encapsulated tunicamycin significantly enhances the suppression of PD-L1 by gemcitabine through blocking K-Ras G12D expression in pancreatic ductal adenocarcinoma cells Axel Hugo Breier, Sunil P. Upadhyay, Ojaswitha Ommi, Stefan Bossmann, Sushanta K. Banerjee, Snigdha Banerjee
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2578 · PDF Optim.AI 2.0的临床可行性研究——一个用于预测联合免疫治疗反应的共培养高内涵功能精准平台 Clinical feasibility study of Optim.AI 2.0, a co-culture high-content functional precision platform for predicting combinatorial immunotherapy response Sharon Pei Yi Chan, Masturah Rashid, Jhin Jieh Lim, Weng Tong Ho, Edward Kai-Hua Chow
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3806 · PDF 靶向胸腺癌的新型CAR T细胞疗法的开发 Development of a novel CAR T-cell therapy targeting thymic carcinoma Layla Ahmadi, Malak Khalifeh, Dimitar Donovski, DuyKhanh Pham Ceppa, Patrick Loehrer, Rohan Maniar, Huda Salman