PO.EN01.01 · 内分泌肿瘤
Hormone Receptor Signaling and Therapeutic Targeting
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- 2281 2281 AZD4241：一种口服生物利用度良好的ERalpha PROTAC，可降解野生型和突变型ERalpha并在临床前乳腺癌模型中发挥抗肿瘤活性 AZD4241, an orally bioavailable ERalpha PROTAC, degrades wild-type and mutant ERalpha and delivers anti-tumour activity in preclinical breast cancer models Mandy Lawson, Natalie Cureton, Lynet Nyoni, Sophie D’Arcy, Lydia Parkinson, Ana Quiroga, Pablo Morentin Gutierrez, Ji Li, Hana Baakza, Thomas Hayhow, Claire Crafter, Lucy Ireland, Gemma Hardman Fowler, Georgia M. Simmons, Lakjaya Buluwela, Simak Ali, Neil Gibson
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- 2284 2284 孕激素受体调节抗原加工和呈递机制：降低肿瘤上的MHC I类表达 Progesterone receptor modulates the antigen processing and presentation machinery: Decreasing MHC class I expression on tumor Julio Tinoco, Eilidh Chowanec, Amanda Glen Heard, Christy R. Hagan
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- 2286 2286 通过循环肿瘤DNA分析监测ER+晚期乳腺癌患者来源异种移植物对新一代口服SERD camizestrant的反应 Monitoring response to camizestrant next-generation oral SERD in ER+ advanced breast cancer patient-derived xenografts via circulating tumor DNA profiling Susana Ros*, Paul Labrousse*, Hugh Russell, Fryer Henderson, Sara Talbot, Benjamin Phillips, Teresa Klinowska, Christopher Morrow, Claire Crafter, Daniel Stetson, Darren Hodgson, James Hadfield
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- 2289 2289 新设计的选择性雌激素受体下调剂及其在乳腺恶性肿瘤微环境和造血中的作用 Newly-designed selective estrogen receptor downregulators and their role in the tumor microenvironment and hematopoiesis in breast malignancies Mario Morales Martinez, Javier Mansilla, Eduardo Mauricio Gonzalez, Begoña Comin-Anduix, Marisol Chavez, Brian Aguirre, Julia Aguade Gorgorio, Gang Deng, Nalo M. Hamilton, Hannah Mikkola, Madhuri Wadehra, Michael E. Jung, Richard J. Pietras, Diana C. Marquez Garban
- 2290 2290 内分泌耐药性乳腺癌中ATAD2的治疗性靶向 Therapeutic targeting of ATAD2 in endocrine-resistant breast cancer Anil Kumar Devakrishnan, Murugesan Palaniappan
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- 2296 2296 新型他莫昔芬-褪黑素药物偶联物对雌激素耐药肿瘤的抗肿瘤作用及其对SCID_BEIGE小鼠肿瘤和子宫表达的ESR1的作用 Anti-tumor actions of novel tamoxifen-melatonin drug conjugates on estrogen-resistant tumors and actions on tumor-and uterine-expressed ESR1 in SCID_BEIGE mice Asef Faruk, Sophie Dietrich, Yong Myoung, Afsana Jahan, Mohamed Marzouk, Jane E. Cavanaugh, Simak Ali, Matthew Burow, Darius Zlotos, Paula Witt-Enderby
- 2297 2297 AVA-291（d3-睾酮）与睾酮对MCF-7雌激素受体阳性乳腺癌细胞的影响——缺乏芳香化为雌二醇导致高度分化的细胞增殖特征 Effects of AVA-291 (d3-testosterone) versus testosterone on MCF-7 estrogen receptor positive breast cancer cells - lack of aromatization to estradiol leads to a highly differentiated cellular proliferation profile Paul M. Tarantino, Judith A. Boice, Pamela A. Trail, Bradford C. Sippy
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- LB112 LB112 一种口服生物利用的AR-NTD降解剂，可绕过LBD依赖性耐药并防止晚期前列腺癌中AR-V7介导的反馈 An orally bioavailable AR-NTD degrader that bypasses LBD-dependent resistance and prevents AR-V7-mediated feedback in advanced prostate cancer Ling-Yu Wang, Chiu-Lien Hung, Wen-Ning Hsu, Tsan-Chun Wang
