DNA Damage and Repair 2

• 1735 · PDF 拓展TXNRD抑制剂治疗三阴性乳腺癌的治疗潜力 Expanding the therapeutic potential of TXNRD inhibitors for triple-negative breast cancer Brenna Flowers, Abigail Rullo, An Zhang, Iria Lloshi, Keacha Chang, Valentina Petukhova, Pavel A. Petukhov, Irida Kastrati
• 1736 · PDF 环吡酮胺与prexasertib在非小细胞肺癌细胞中的协同抗癌活性 Synergistic anticancer activity of ciclopirox and prexasertib in non-small cell lung cancer cells Zhu Huang, Bing Cheng, Shile Huang
• 1737 1737 使用sSTRIDE-NER直接测量NER活性 Direct measurement of NER activity using sSTRIDE-NER Olga Wójcikowska, Julita Imioło, Magdalena Bartyńska, Zsombor Prucsi, Magdalena Kordon-Kiszala, Kamil Solarczyk
• 1738 · PDF Alnodesertib（ART0380）联合伊立替康在ATM缺失胰腺癌临床前模型中高度有效 Alnodesertib (ART0380) in combination with irinotecan is highly efficacious in preclinical models of ATM null pancreatic cancer Helen M. R. Robinson, Elias Elinati, Eeson Rajendra, Paula Costales, Aurora Cerutti, Lerin Geo, Emily Graham, Kirsty Lawrence, Joana F. B. P. Neves, Marina Roy-Luzarraga, Ozgun Ozer, Vera Grinkevich, Jayesh B. Majithiya, Ian Smith, Graeme C. Smith
• 1739 · PDF 解析癌症中DNA损伤反应与自噬之间的分子联系：对化疗耐药的意义 Deciphering the molecular links between DNA damage response and autophagy in cancer: Implications for chemotherapy resistance Kavya Ajit Pandya, Neeru Singh
• 1740 · PDF 定量解旋酶和聚合酶实验以加速DNA损伤修复靶向药物开发 Quantitative helicase and polymerase assays to accelerate DNA damage repair targeted drug development Oganinma Okakpu, Kasia Zientara-Rytter, Veronique Baron, Michelle Kinbara, Guillermo Cardenas, Jonathan Mikolosko, Henry Zhu, Pavel Shashkin
• 1741 · PDF 纳米颗粒共递送微管抑制剂与顺铂克服头颈癌中DNA修复介导的耐药 Nanoparticle co-delivery of microtubule inhibitors and cisplatin overcomes DNA repair-mediated resistance in head and neck cancer Xin Li, Liubov Palchak, Ling Wang, Marina Sokolsky, Alexander Kabanov, Aimin Peng
• 1743 · PDF 一种用于PTEN缺陷型癌症的新型脑穿透性ATR-mTOR双重抑制剂 A novel brain-penetrant dual ATR-mTOR inhibitor for PTEN-deficient cancers Sarah Truong, Beibei Zhai, Louise Ramos, Mona Marzban, Fariba Ghaidi, Marshall Drew-Brook, Peter Guzzo, Ahmad Issa, Mehran Khodabandeh, Sara Omar, Jason Rolfe, Seyed A. Saberali, Kally Singh, John Langlands, Dennis Brown, Jeffrey Bacha, Mads Daugaard
• 1744 1744 CRISPR筛选鉴定SMARCAL1和MRN为MSI-H结直肠癌中WRN依赖性的调节因子 CRISPR screening identifies SMARCAL1 and MRN as modulators of WRN dependency in MSI-H colorectal cancer Tiantian Ma, Jibo Wu, Siting Li, Junjie Chen
• 1746 · PDF TREX1与聚合酶theta的双重抑制揭示BRCA缺陷型肿瘤中一种协同性DNA修复脆弱性 Dual inhibition of TREX1 and polymerase theta uncovers a synergistic DNA repair vulnerability in BRCA-deficient tumors Roger Shen, Daniel S Higginson
• 1747 1747 PG3与PARP抑制剂的组合在BRCA1突变型和BRCA1野生型TNBC中均表现出抗肿瘤作用 A combination of PG3 and PARP inhibitors exhibits antitumor effects in both BRCA1-mutated and BRCA1-wild-type TNBC Xiaobing Tian, Wafik S. El-Deiry
• 1748 · PDF FORX-428：利用PARG抑制靶向癌细胞中的复制应激 FORX-428: Exploiting PARG inhibition to target replication stress in cancer cells Frank Tadashi Zenke, Ulrich Lücking, Olivier Querolle, Luca Iacovino, Marta Malattia, Alessandro Potenza, Nicolas Bocquet, Serena Bologna, Hanna Kok, Anika Kuster, Roxanne Lourman, Jason Clochard, Irena Konstantinova, Thanos D. Halazonetis, Jens Wuerthner, Tarig Bashir
• 1749 · PDF 在MGMT过表达且MMR缺陷的胶质瘤同基因模型中模拟对烷化剂化疗的反应 Modeling response to alkylating chemotherapy in a syngeneic model of MGMT overexpression and MMR-deficient glioma Ranjini K. Sundaram, Deepti Bhatt, Ranjit S. Bindra, Juan Vasquez
• 1750 · PDF 构建用于DNA损伤反应领域药物发现的整合平台 Building an integrated platform for drug discovery in DNA damage response Bruno Vaz, Julien Brustel, Marie Cargnello, Marie Lafitte, Frédérique Dol-Gleizes, Rahul Valiya Veettil, Andrei Zinovyev, Anne-Sophie Casagrande, Francisco H. Cruzalegui, Stephen Durant
• 1751 · PDF DACH1基因肿瘤抑制因子的缺失增加前列腺癌中的复制叉应激、上皮间质转化及对WEE1激酶抑制剂的敏感性 Deletion of the DACH1 gene tumor suppressor increases replication fork stress, epithelial mesenchymal transition and sensitivity to WEE1 kinase inhibitors in prostate cancer Danni Li, Arijit Ghosh, Zhiping Li, Kenneth Iczkowski, Hidetoshi Mori, Samiha Nasser, Csaba Kerepesi, Andras Benczur, Hallgeir Rui, Ritika Harish, Li Lan, Xuanmao Jiao, Fred Saad, Janne Purhonen, Anthony W. Ashton, Richard G. Pestell
• 1752 · PDF APOBEC3B通过抑制卵巢癌干细胞增强PARP抑制剂反应 APOBEC3B enhances PARP inhibitor response by suppressing ovarian cancer stem cells Maria Rivera, Lucy Liu, Chae-Eun Lim, Sabina Enlund, Haoran Zhang, Kaifu Yang, Roman Sasik, Kathleen Fisch, Frida Holm, Leslie A. Crews, Qingfei Jiang

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