CAR T Cell Targets and TME Reprogramming

• 1519 · PDF AI设计的免疫传感器增强型CAR-T细胞用于强效实体瘤免疫治疗 AI-designed immune sensor-enhanced CAR-T cells for potent solid tumor immunotherapy Zoya Alteber, Jitka Sagiv, Reut Nave, Gil Friedman, Dor Shimon, Maayan Shamsian, Megi Cemel David, Dina Listov, Sharon Avkin Nachum, Ofer Levy, Michal Golan Mashiach
• 1520 · PDF 利用TGF-beta抵抗性和IL-18诱导性产生改善靶向BCMA的CAR-T细胞治疗骨髓瘤 Improving BCMA-targeted CAR-T cell therapy of myeloma using TGF-beta resistance and inducible production of IL-18 Sandhya Rai, Shijing Wang, Bin Sun, Tyce Kearl, Peiman Hematti, Joseph Zenga, Heather Himburg, Musaddiq Awan, Deepak Parashar, Binod Dhakal, Siegfried Janz, Fumou Sun
• 1521 · PDF 利用靶向成纤维细胞活化蛋白alpha的CAR-T细胞同时靶向肿瘤及其微环境 Concurrent targeting of tumors and their microenvironment using CAR-T cells specific for fibroblast activation protein alpha Larina Tzu-Wei Shen, Afsana Islam, Daiki Fujita, Kenji Nakamaru, Dan Macleod
• 1522 · PDF FMNL1过表达增强肿瘤特异性TIL和CAR-T细胞在实体瘤中的蓄积及治疗疗效 FMNL1 overexpression enhances tumor-specific TIL and CAR-T cell accumulation and therapeutic efficacy in solid tumors Jeffrey W. Chung, Jessica Olivas-Corral, Ashley M. Wood, Ashton L. Sigler, Edward Ning, Michelle E. Allen, Kayla Fairweather, Jordan Jacobelli
• 1523 · PDF Galectin-3阻断重编程肿瘤微环境并改善儿童肿瘤的CAR-T细胞疗法 Galectin-3 blockade reprograms the tumor microenvironment and improves CAR T-cell therapy in pediatric cancers Enrique Conde-Gallastegi, Karin Straathof, Sergio Quezada
• 1524 · PDF 用于晚期前列腺癌的胶原结合型IL-12武装STEAP1 CAR-T细胞 Collagen-binding IL-12-armored STEAP1 CAR-T cells for advanced prostate cancer Koichi Sasaki, Vipul Bhatia, Yuta Asano, Jakob Bakhtiari, Pooja Kaur, Chuyi Wang, Takumi Matsuo, Olivier Dubois, Po-Chuan Chiu, Donny Gun, Charanjit Singh, Ioanna Panagi, Laurine Noblecourt, Maria Nikolaidi, Truman Chong, Gerardo Javier, Saul J. Priceman, Aude G. Chapuis, John K. Lee, Jun Ishihara
• 1525 · PDF 优化的CAR-T细胞疗法用于重塑肿瘤微环境并消除消化道恶性肿瘤 Optimized CART cell therapy to remodel the tumor microenvironment and eliminate GI malignancies Omar L. Gutierrez Ruiz, Jennifer Feigin, Brooke Kimball, R. Leo Sakemura, Elizabeth L. Siegler, Dominic A. Skeele, Ateka Saleh, Claudia Manriquez Roman, Ismail Can, Olivia Sirpilla, Kun Yun, Carli M. Stewart, Mehrdad Hefazi, Yoh Yamaguchi, Lionel Aurelien Kankeu Fonkoua, Long K. Mai, Truc Huynh, Sophia Y. Goldberg, Grace E. DeFranco, Sara Foote, Ekene Johnkennedy Newton Ogbodo, Hong Xia, Michael Redig, Matthew L. Matthew, Tamiel Nichole Turley, Skyeler Klinge, John Alton Copland, Saad J. Kenderian
• 1526 · PDF 基于纳米抗体的DLL3靶向FAST-CAR T细胞疗法用于小细胞肺癌（SCLC） Nanobody-based, DLL3-directed FAST-CAR T-cell therapy for small cell lung cancer (SCLC) Qi Dong, Wenjie Yin, Xiangling Dai, Tao Wang, Guangyao Zhu, Manli Yin, Yu Zou, Yu Yang, Di Wu, Mark Cobbold, Lianjun Shen
• 1527 · PDF 适形外照射放疗在胰腺癌肝转移小鼠模型中增加B7-H3表达并促进CAR-T细胞功能 Conformal external beam radiation increases B7-H3 expression in a murine model of pancreatic cancer liver metastases and promotes CAR T cell function Megan C. Purl, Alexandria Shick, Annaiz Grimm, Hind Abdallat, Cyrus J. Sholevar, Makan Karimzadeh, Natalie M. Liu, Jinhwan Kim, Cameron E. Gaskill, Edward J. Kim, Arta M. Monjazeb, William J. Murphy, Robert J. Canter, Sean J. Judge
• 1528 · PDF AZD5851，一种TGF-beta抵抗性GPC3 CAR-T细胞产品，在髓母细胞瘤和非典型畸胎样横纹肌样瘤患者来源原位异种移植模型中延长动物生存期 AZD5851, a TGF-beta-resistant GPC3 CAR-T cell product, prolongs animal survival times in patient derived orthotopic xenograft models of medulloblastoma and atypical teratoid rhabdoid tumor Milagros Suarez, Aalaa Abdallah, Xin Zhai, Zilu Huang, Yuchen Du, Nitin Wadhwani, Alicia Lenzen, Jee Young Kwon, Steven B. Neuhauser, Timothy Stearns, Jeffrey H. Chuang, Emily L. Jocoy, Carol J. Bult, Beverly Teicher, Malcolm A. Smith, Xiao Nan Li
• 1529 · PDF ST6GAL1增强的CAR-T细胞改善在DLBCL中的持久性和抗肿瘤疗效 ST6GAL1 enhanced CAR-T cells improve persistence and antitumor efficacy in DLBCL Lee Seng Mari Lau, Maria Suarez, Brandon Fernandez, Aiza Berdalinova, Joseph Souchack, Aristotelis Antonopoulos, Anne Dell, Stuart Haslam, Avery D. Posey, Charles J. Dimitroff
• 1530 · PDF CAR-T细胞疗法在类器官-成纤维细胞共培养模型中的综合临床前评估 Comprehensive preclinical evaluation of CAR-T cell therapeutics in organoid-fibroblast co-cultures Yijie Ren, Tomas Veenendaal, Puxin Wang, Jiawen Gao, Jiawei Meng, Danting Yan, Yingying Li, Meng Zhang, Michelle Kop, Ashgard Weterings, Marten Hornsveld, Gera Goverse, Ludovic Bourre, Peng Wang, Jun Zhou
• 1531 · PDF 在临床前模型中，肥胖会加剧与嵌合抗原受体（CAR）T细胞疗法相关的细胞因子释放综合征（CRS）毒性 Obesity exacerbates cytokine release syndrome (CRS) toxicity associated with chimeric antigen receptor (CAR) T cell therapy in preclinical models Wahed A. Firoz, Craig P. Collins, Logan V. Vick, Michael K. Sheng, Ryan N. Nielsen, Spencer Rosario, Robert J. Canter, Arta M. Monjazeb, Sean J. Judge, Anthony E. Zamora, Shuchi Gulati, William J. Murphy
• 1532 · PDF 在人类T细胞中进行体内全基因组CRISPR筛选以增强针对实体瘤的T细胞疗法 In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors Qi Liu, Peixin(Amy) Chen, Esha Urs, Shimin Zhang, Maya M. Arce, Charlotte H. Wang, Zhongmei Li, Jin Seo, Nupura Kale, Taylor N. LaFlam, Fanglue Peng, Eric Shifrut, Greg Allen, Justin Eyquem, Katherine C. Fuh, Stacie E. Dodgson, Jason Cyster, Alexander Marson, Julia Carnevale
• 1533 · PDF 一种靶向肿瘤抗原和免疫抑制微环境的通用可开关CAR-T细胞疗法平台（zCART） A universal and switchable CAR T cell therapy platform (zCART) targeting tumor antigens and the immunosuppressive microenvironment Ki Hyun Kim, Soohwan Kim, Eun-Hoe Lee, Soo-Youn Lim, Tack-Jin Yoo, Sung Min Kim, E-Young Kim, Ji-Hun Park, Hyun-Jong Lee, Seong Yeol Kim, Min Yoon, Youngha Lee, In-Sik Hwang, Yoon Lee, Jong-Hoon Kim, Jong-Seo Lee, Junho Chung
• 1534 · PDF OriC613：一种利用靶向MSLN和CLDN18.2的双靶向CAR-T细胞治疗胃癌和胰腺癌的新型治疗策略，具有良好的安全性和强效疗效 OriC613: A novel therapeutic strategy for gastric and pancreatic cancers utilizing dual-targeting CAR-T cells against MSLN and CLDN18.2 with a favorable safety profile and potent efficacy Xiaowen He, Shasha Yang, Hao Guo, Huajing Wang, Xuefeng Kong, Zhongjun Shi
• 1535 · PDF 用于高危多发性骨髓瘤的异体BCMA/CD70双CAR-T细胞的临床前评估 Preclinical evaluation of allogeneic BCMA/CD70 Dual CAR T cells for high-risk multiple myeloma Mark K. O'Dair, David Qu, Duy Nguyen, Kristen Zhang, Zachary Roberts, Elvin Lauron, Cesar Sommer
• 1536 · PDF 靶向小细胞肺癌神经内分泌亚型的CADM1-CAR T细胞 CADM1-CAR T cells targeting neuroendocrine subtypes of small cell lung cancer Shiva Krishna Katkam, Sergei Chuikov, Zhefan Wang, Venkateshwar Keshamouni
• 1537 · PDF 抗GPC3 CAR-T淋巴细胞有效靶向NSCLC，包括化疗耐药的干细胞样细胞 Anti GPC3 CAR T lymphocytes effectively target NSCLC, including chemoresistant stem like cells Lucilla Minori, Alessia Proment, Francesca Napoli, Luisella Righi, Gabriella Doronzo, Elisa Vigna, Katherine Chaney, Woo Jin Shim, John Stone, Paolo Bironzo, Ashley Hamilton, Silvia Novello, Dario Sangiolo
• 1538 · PDF 基于Oncostatin-M配体的CAR T细胞疗法靶向并清除肺腺癌 Oncostatin-M ligand-based CAR T-cell therapy targets and eliminates lung adenocarcinoma Kayla Klatt, Daniel Feinberg, Reshmi Parameswaran
• 1539 1539 驾驭NOPE：一种通过肽段抗原受体巨噬细胞驱动肝细胞癌中beta-catenin信号的关键癌胚蛋白 Harnessing NOPE: A key oncofetal protein driving beta-catenin signaling through peptidic antigen receptor macrophages in hepatocellular carcinoma Carmen Oi Ning Leung, Rainbow Wing Hei Leung, Terence Kin-Wah Lee
• 1540 · PDF 针对实体瘤的EPHA2 CAR T细胞疗法的开发 Development of EPHA2 car t cell therapy for solid tumors Ali Cihan, Daoqi You, Armaan Siddiquee, Kristina Guillan, Tamar Feinberg, Erin Burns, Jasmine Um, Samantha Brosius, Joan Rou-En Choo, Andrew L. Kung, Anthony F. Daniyan, Filemon S. Dela Cruz
• 1541 · PDF 针对化疗耐药性结直肠癌的MUC4导向CAR-T细胞的开发 Development of MUC4-directed CAR-T cells against chemoresistant colorectal carcinoma Avik Chattopadhyay, Erin O’Connor, Anna Tingler, Kristi L. Helke, Melinda A. Engevik, Leonardo M. R. Ferreira
• 1542 · PDF ALK表达可识别出一类可治疗性靶向的Merkel细胞癌亚群，其对单用ALK.CAR-T细胞疗法或联合ALK抑制剂有反应 ALK expression identifies a therapeutically targetable subset of Merkel cell carcinomas responsive to ALK.CAR-T cell therapy alone or in combination with ALK inhibitors Alessandro Gasparetto, Jasna Metovic, Elisa Landoni, Carmen Mecca, Gabriele Saccu, Simone Piane, Nirmala Tilija Pun, Umberto Mortara, Chiara Anselmo, Marco Campisi, Haley Ohlson, Maria Vittoria Di Marco, Giulia Mura, Mauro Papotti, Rebecca Senetta, Claudia Voena, Gianpietro Dotti, Elisa Bergaggio, Roberto Chiarle
• 1543 · PDF B细胞激活因子在CAR-T细胞相关细胞因子释放综合征中发挥关键作用 B-cell activating factor plays a critical role in CAR-T cell-associated cytokine release syndrome Claire Fritz, Leland Metheny, David N. Wald, Paolo Caimi, Reshmi Parameswaran

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