PO.IM02.02 · 免疫学
Innate Immunity in Cancer
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1580 · PDF 病毒样颗粒实现原代人髓系细胞中的靶向基因工程和混合CRISPR筛选 Virus like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells Hyuncheol Jung, Pascal Devant, Carter Ching, Minetoa Ota, Jennifer Hamilton, Zachary Steinhart, Wayne Ngo, Luis Sandoval, Jae Hyung Jung, Da Xu, Merui An, Esha Urs, Peixin Amy Chen, Vincent Allain, Takuya Tada, James K. Nuñez, Nathaniel R. Landau, David R. Liu, Justin Eyquem, Jennifer A. Doudna, Alexander Marson, Julia Carnevale
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1581 · PDF 婴儿致命性发育性肿瘤中T细胞功能障碍与免疫冷微环境的驱动因素及机制 Driver and mechanism of t-cell dysfunction and immune cold microenvironment in deadly developmental tumor in infants Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Sabir Salim, Sivasubramani Narayanan, Natarajan Aravindan
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1582 · PDF 整合功能学与多组学分析揭示乳腺癌和卵巢癌中自然杀伤细胞反应的差异及肿瘤细胞可塑性 Integrative functional and multi-omics profiling reveals divergent natural killer cell responses and tumor cell plasticity in breast and ovarian cancer Jennifer C. Wischhusen, Rebecca Weber, Syed A. Ali, Brenda Besemer, David Palmero-Canton, Viktoria Sokolova, Christina Köhler, Elisa Donato, Andreas Trumpp
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1583 · PDF 以Galectin9为靶点的治疗策略旨在治愈致癌驱动改变阳性的非小细胞肺癌 Galectin9 targeted therapy for aiming cure in oncogenic driver alterations-positive non-small cell lung cancer Takanori Kondo, Toshiyuki Minami, Hidemi Kitai, Yoko Higashiguchi, Takashi Kandori, Naoki Kawamura, Misa Murakami, Jotaro Kiyota, Mayuko Tokuda, Tomoki Higashiyama, Akio Tada, Yoshiki Negi, Kazue Yoneda, Daichi Fujimoto, Taiichiro Otsuki, Koji Mikami, Ryo Takahashi, Kozo Kuribayashi, Takashi Kijima
- 1584 1584 转移相关巨噬细胞驱动胃癌腹膜癌病中的免疫抑制和纤维化 Metastasis associated macrophages drive immunosuppression and fibrosis in gastric peritoneal carcinomatosis Lilia Turcios, Neelima Hosamani, Ellen Beswick, Maria Carey, Joseph Kim, Mautin Barry-Hundeyin
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1585 · PDF 早期肝细胞癌发生过程中ILC和ILTC反应的动力学分析揭示IL-15-ILC1轴 Kinetic profiling of ILC and ILTC responses during early hepatocellular carcinoma development reveals IL-15-ILC1 axis Patrick Huang, Rajiv Trehan, Benjamin Ruf, Chi Ma, Dana Soika, Lorenz Kocheise, Gabriel B. Prata, Tim F. Greten, Firouzeh Korangy
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1586 · PDF 手术诱导的长期固有免疫变化促进肿瘤进展 Surgery-induced long term innate immune changes facilitate tumor progression Zhengyi He, Hamza O. Yazdani, Tony Haykal, Ruiqi Yang, Celine Tohme, Rihito Kanamaru, Krish Wasson, Anthony Gebran, Silvia Liu, David A. Geller, Jian-Hua Luo, Samer Tohme
- 1587 1587 树突状细胞的体内CRISPR筛选发现Traf2为通过调节非经典NF-kB通路调控抗肿瘤免疫的关键调节因子 In Vivo CRISPR screen of dendritic cells identifies Traf2 as a critical regulator of anti-tumor immunity via modulation of non-canonical NF-kB pathway Chang Yoon Moon, Meriem Belabed, Steven Chen, Jessica Le Berichel, Alexander Tepper, Camillia Azimi, Natalie Vaninov, Prerna Suri, Adam Marks, Alessandra Gurtner, Matthew D. Park, Alessia Baccarini, Brian Brown, Miriam Merad
- 1588 1588 TOX在人NK细胞中作为细胞毒性检查点发挥功能并受SLAMF7受体可逆调控 TOX functions as a cytotoxicity checkpoint in human NK cells and is reversibly regulated by SLAMF7 receptor Yasser Ali Aldhamen, Rana K. Alrabiah, Maram Alshuwaymi, Rita Alonaizan
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1589 · PDF 胰腺导管腺癌中多核巨噬细胞的空间与分子图谱分析 Spatial and molecular profiling of multinucleated giant macrophages in pancreatic ductal adenocarcinoma Marika Viatore, Rebecca Polidori, Anna Rita Putignano, Arturo Bonometti, Silvia Uccella, Silvia Bozzarelli, Gianluca Basso, Marco Erreni, Capretti Giovanni, Vincenzo Corbo, Alberto Mantovani, Massimo Locati, Federica Marchesi
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1590 · PDF 肿瘤代谢物D2HG重编程巨噬细胞以驱动IDH1突变型胆管癌中的免疫抑制 The oncometabolite D2HG reprograms macrophages to drive immunosuppression in IDH1-mutant cholangiocarcinoma Sara E. Young, Emma Kartalia, Johnathan DeBetta, James Leatherman, Kayla J. Bendinelli, Tamara Lopez-Vidal, Edwin Y. He, Mark Yarchoan, Daniel J. Zabransky
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1591 · PDF microRNA-25通过Syndecan3抑制固有免疫和体液免疫从而驱动对免疫检查点治疗的初始耐药 microRNA-25 drives initial resistance to immune checkpoint therapy by repressing innate and humoral immunity via Syndecan3 Zhouting Zhu, Wenyan Han, Yufei Deng, Zhaoyang Jia, Lujing Wu, Shweta Jakhmola, Gulshanbir Baidwan, Tongyun Wang, Dhenugen Logeswaran, Amanda Y. Sun, Bill Bray, Na Li, Lingling Wang, Hui Hui, Jiaqian Wu, Sandip Pravin Patel, Tariq M. Rana
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1592 · PDF 年龄驱动的肿瘤相关巨噬细胞变化促成小鼠黑色素瘤和乳腺癌模型中肿瘤生长的减缓 Age-driven changes in tumor-associated macrophages contribute to slower tumor growth in murine melanoma and breast cancer models. Manasa Suresh, Marie Durr, Bryan Weselman, Xintang Li, Francisco Tapia Belmonte, Sonia Sebaoui, Adhithi Rajesh, Katherine Fisher, Megan Winakur, Matias Hepp, Alexis Salas-Burgos, Satish Noonepalle, Alejandro Villagra
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1593 · PDF 线粒体酶A促进结直肠癌中巨噬细胞依赖性的抗肿瘤应答 Mitochondrial enzyme A promotes macrophage-dependent antitumor responses in colorectal cancer Lin Chung, Shi-Chuen Miaw
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1594 · PDF 赛庚啶及其衍生物通过在膀胱癌中引发NK细胞介导的抗肿瘤应答来抑制肿瘤生长 Cyproheptadine and its derivatives inhibit tumor growth by eliciting NK cell-mediated anti-tumor responses in bladder cancer Himani Kumari, Chin Pui Chan, Ciao-Ni Chen, Hsin-An Shih, Tsung-Yu Tseng, Chao-Ling Yao, Steven Lin, Cheng-Huang Shen, Michael W.Y. Chan
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1595 · PDF 联合DNA甲基化抑制与STING激动剂治疗转移性三阴性乳腺癌 Combining DNA methylation inhibition and STING agonist in the treatment of metastatic triple-negative breast cancer Sofiane Berrazouane, Rhea Dumitrescu, Xiaoting You, Jack Su, Margarita Bartish, Marios Langke, Benjamin Lebeau, Young Im, Valérie Sabourin, Sonia del Rincon, Josie Ursini-Siegel, Michael R. Witcher
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1597 · PDF 一种由TNF-alpha过表达驱动的自发性关节炎小鼠模型 A spontaneous arthritis mouse model driven by TNF-alpha overexpression Qingqing Qi, Shuang Li, Xiaolei Qiu, Yi Li, Ruilin Sun
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1598 · PDF 利用人源化多发性骨髓瘤小鼠模型研究双特异性NK细胞衔接器的临床前疗效 Preclinical efficacy of a bispecific NK cell engager studied using a humanized multiple myeloma mouse model Mari I. Suominen, Katja M. Fagerlund, Mervi Ristola, Justyna Zdrojewska, Yumei Diao, Carina Norström, Kristina Witt-Mulder, Ellen Santangelo, Thorstein Boxaspen, Hannah Cuthbertson Husbyn, Kim A. Giang, Caterina Heinz, Silje Z. Krokeide, Fredrik Schjesvold, Per-Åke Nygren, Ebba Sohlberg, Karl-Johan Malmberg, Stefan Svensson Gelius, Jukka P. Rissanen, Jenni H. E. Mäki-Jouppila
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1600 · PDF 在免疫肿瘤学建模中,NSG-SGM3xIl15xDKO(SDKO)小鼠较NSG-MHC I/II DKO小鼠对外周血单个核细胞的人源化更佳 Improved humanization of peripheral blood mononuclear cells in NSG-SGM3xIl15xDKO (SDKO) over that of NSG-MHC I/II DKO mice for immuno-oncology modeling Leandro Salati D'Abronzo, Xiaoqing (Nancy) Zheng, Beau Parry, Guoxiang Yang, Destanie Rose, Li-Chin Yao, James Keck, Jiwon Yang
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1601 · PDF 一种释放IL-18在癌症免疫治疗中潜力的新型临床前工具:genO-hIL-18-hIL-18R小鼠 A novel preclinical tool to unlock the potential of IL-18 in cancer immunotherapy: genO-hIL-18-hIL-18R mice Angela Pappalardo, Gaëlle H. Martin, Patricia Isnard-Petit, Fabiane Sonego, Kader Thiam
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1602 · PDF Quaking调控巨噬细胞MHC II介导的抗原呈递及胶质母细胞瘤中的免疫功能 Quaking regulates macrophage MHC II-mediated antigen presentation and immune function in glioblastoma Spring Yewon Hwang
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1603 · PDF FAK与PYK2对MHC-II抗原呈递的相反调控:对治疗干预的意义 Opposing control of MHC-II antigen presentation by FAK and PYK2: Implications for therapeutic intervention Terrance James Haanen, Xiao Lei Chen, David D. Schlaepfer
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1604 · PDF PTEN-L/CD68轴通过IL-4和AKT通路调控饮食诱导的肥胖、单核细胞向巨噬细胞极化及信号传导 PTEN-L/CD68 axis regulates diet-induced obesity, monocyte-to-macrophage polarization, and signaling via IL-4 and AKT pathways Tiphaine C. Martin, Sait Ozturk, Benjamin Kepecs, Nicolas de Azevedo, Ivan Reyes-Torres, Royce Zhou, Kaitlyn Bosch, Emily Gallagher, Miriam Merad, Ang Cui, Alexander Tsankov, Ramon Parsons
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1605 · PDF 基序新表位在CCL21基因修饰树突状细胞疫苗接种试验(NCT03546361)中显示出免疫原性信号 Motif neoepitopes demonstrate immunogenic signal in CCL21-gene modified dendritic cell vaccination trial (NCT03546361) Amy Lauren Cummings, Andy Han, Michael Oh, Camelia Dumitras, Seung J. Park, Sai S. Kollapaneni, Daniel Li, Arjan Gower, Maria Antonia Velez Velez, Aaron Lisberg, Monica Cappelletti, Steven M. Dubinett, Bin Liu, Edward B. Garon
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1606 · PDF 人NK细胞的转录调控:TAL1作为调节因子 Transcriptional regulation of human NK cells: TAL1 as a modulator Baomou Feng, Dandan Wang, Subramaniam Malarkannan