In Vivo Models 1: Mouse, Zebrafish, and Alternative Species

• 2150 · PDF Drosophila -based screening identifies ferroptosis induction via NAD-GPx4 axis inhibition as a therapeutic strategy for PDAC Masahiro Sonoshita
• 2151 · PDF Understanding the mechanisms by which environmental arsenic elevates the risk of urothelial bladder cancer Yuyang Huang, Britton C. Goodale, Jordan E. Magurk, Xiaoying Liu, Yang Zheng, Stephen A. Watts, Steven D. Leach
• 2153 · PDF The Miniature Oncopig ® cancer model as an innovative large animal platform for preclinical pharmaceutical evaluation Taeyoung Shin, Jennifer J. Meudt, C. Dustin Rubinstein, Brent Lehman, Lobna Elkhadragy, Matthew M. Niemeyer, Jamie Reichert, Kathryn M. Nelson, Jennifer Frank, Ashley Nelson, Paige Munns, Devon Klipsic, Eric Schmuck, Mahmoud Khalafalla, Navin Viswakarma, Jessicca Rege, Ali Pirasteh, Lawrence B. Schook, Tanja Dominko, Dhanansayan Shanmuganayagam, Kyle M. Schachtschneider
• 2154 · PDF Modeling olaparib resistance in prostate cancer PDXs to elucidate PARP inhibitor escape mechanisms Nadège BIDAN, Claire BERAUD, Emilie INDERSIE, Marie TAVERNIER, Clementine KRUCKER, Eric POTIRON, Philippe LLUEL, Olivier DÉAS
• 2156 · PDF Syngeneic mouse models of prostate cancer driver mutations Jean C. Tien, Yunhui Cheng, Fan Yang, Christina E. Wheeler, Abigail J. Todd, Somnath Mahapartra, Shuqin Li, Jie Luo, Rahul Mannan, Arul M. Chinnaiyan
• 2157 · PDF Feasibility and challenges of developing PDX models of neuroendocrine cancers Caleb A. Morgan, Alexandria A. Peterson, Carlos H.F. Chan, Andrew M. Bellizzi, James R. Howe, Po H. Ear
• 2159 · PDF Establishment of new preclinical tumor models for pancreatic neuroendocrine carcinoma Takuto Yasuda, Ryota Tanaka, Daisuke Inoue, Koichi Nakanishi, Kosuke Hatta, Shigeaki Kurihara, Jun Tauchi, Sadaaki Nishimura, Masahiko Kinoshita, Kohei Nishio, Hiroji Shinkawa, Ken Kageyama, Akira Yamamoto, Takeaki Ishizawa
• 2161 · PDF Paired PDX-PDXO models serve an integrated preclinical platform for high-throughput payload screening and ADC drug development Jinxi Wang, Leilei Chen, Qingzhi Liu, Jiawen Gao, Jun Zhou, Wubin Qian, Likun Zhang, Ludovic Bourre, Jessie Jingjing Wang
• 2162 · PDF GliomaPDOX - A direct brain-to-brain glioma xenograft library for drug discovery and development Elizabeth G. Fernandez, Christopher Tse, Jennifer Salinas, Nicholas Bayley, Lisa H. Ta, Laura Gosa, Henan Zhu, Michael Vigman, Francesco Sanvito, Benjamin M. Ellingson, Linda M. Liau, Timothy Cloughsey, Thomas G. Graeber, Nathanson David
• 2163 Triple-negative breast cancer PDX models with acquired resistance to Enhertu ® : A preclinical platform to uncover mechanisms of escape Emilie INDERSIE, Benjamin GUERRIN, Eugenie DELHORBE, Eva CYPRIEN, Elena DARBINEAN, Delphine NICOLLE, Marie TAVERNIER, Olivier DÉAS
• 2164 Breast cancer PDX models with acquired resistance to olaparib: A preclinical platform to uncover mechanisms of PARP inhibitor escape Emilie INDERSIE, Benjamin GUERRIN, Eugenie DELHORBE, Eva CYPRIEN, Elena DARBINEAN, Delphine NICOLLE, Marie TAVERNIER, Olivier DÉAS
• 2165 · PDF An integrated preclinical platform for comprehensive evaluation of T-Cell engagers Hongyan Sun, Xinjie Lian, Shiying Guo, Yujing Zhang, Huixin Yang, Xiang Gao
• 2166 · PDF Robust in vivo CAR-T efficacy evaluation in a PBMC-reconstituted NCG-MHC-dKO model with delayed GVHD Hongyan Sun, Xiaoliu Yang, Shiying Guo, Yujing Zhang, Huixin Yang, Xiang Gao
• 2167 · PDF A novel humanized mouse model for preclinical assessment of anti-CD47 and anti-SIRPΑtherapeutics Hongyan Sun, Shaotong Ma, Yujing Zhang, Huixin Yang, Xiang Gao
• 2168 · PDF Human IgG1-expressing mouse models for tolerance induction and reliable assessment of IgG1-based therapeutic antibodies Angela Pappalardo, Gaëlle H. Martin, Patricia Isnard-Petit, Fabiane Sonego, Kader Thiam
• 2170 Patient-derived orthotopic xenograft models predict chemotherapeutic response in pancreatic ductal adenocarcinoma: an emerging platform for translational research Xin Zhang, Nathan Bolton, Alicia Ray, Grace Maresh, Rachel Graham, Li Li
• 2171 · PDF Maintaining blood-brain barrier integrity in translational brain tumor models T. Liz Bailey, Melissa Tran, Cheryl Davis, Ben Hoerner, Victoria Caruso, Kathleen Hutchinson, Helen Ketteringham, Corrine Silvio, Shannan Paul, Chris Holding, Aliccia Koznecki, Dawn Lusk, Shorena Nadaraia-Hoke
• 2172 · PDF Differential expression of the Kv3.4 channel in in vitro and in vivo models of cervical cancer: Potential clinical implications Ana Alejandra Ramirez, Andrea Jazmín Chiliquinga, Ingrid Ogonaga-Borja, Brenda Acosta, Patricio Gariglio, Rodolfo Ocádiz-Delgado, Jaime de la Garza, Elisabeth Hernández-Gallegos, María de Guadalupe Chávez-López, J. Martha Noyola, Javier Camacho
• 2173 Development of novel syngeneic mouse models of mHSPC and mCRPC for evaluation of radiopharmaceuticals on the immune tumor microenvironment (TME) Brian Ragaishis, Andrei Molotkov, Shruti Bansal, Krishan Saini, Maierdan Palihati, Chelsea Rahiman, Courtney Buress, Jasleen Kaur Virk, Mikhail Doubrovin, Catherine Spina
• 2174 A comprehensive CRISPR/Cas9-based RAS knock-in cell line platform (50+ models) for assessing efficacy of KRAS-targeted inhibitors in RAS-mutant malignancies. Lin Zhou, Guoqian Wang, Tingduo Lv, Zidan Su, Yue Huang, Jinying Ning, Feng Hao
• 2175 · PDF Towards ethical and robust drug development: comprehensive validation of an animal-free matrix for in vivo tumor models Julia B. Schueler, Kanstantsin Lashuk, Philipp Meyer, Alejandra Ferrer Diaz, Eva Oswald, Kalhara Menikdiwela, JOHN HUANG
• 2177 Characterization of a panel of PDX models derived from PARP inhibitors pretreated breast and ovarian cancer patients for therapeutic evaluation Qingzhi Liu, Jinxi Wang, Leilei Chen, Wubin Qian, Likun Zhang, Ludovic Bourre, Jessie Jingjing Wang
• 2178 · PDF Integrating patient-derived tumor models into translational oncology and drug discovery Umar Khalid, Thomas Quinn, Cong Fu, Lucia Arabit Loosbrock, Anand Panigrahy, Aniket Shetty, Keith Ligon, Sonam Bhatia
• 2876 · PDF Influence of transgenic MUC13 expression on gut microbiota and chemokine profile Swati Dhasmana, Anupam Dhasmana, Shweta Singh, Iris A. Perez, Shabnam Malik, Bilal B. Hafeez, Sheema Khan, Murali M. Yallapu, Subhash C. Chauhan

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