Aging and Host Determinants of Tumor Progression: The Macroenvironmental Axis

• 2071 Aging impairs NK-cell surveillance to promote metastatic outgrowth in breast cancer Pulkit Datt, Jhon Pasamonte, Kelly Coutant, Anastasiia Burtseva, Mitchell Fane
• 2072 Role of the aging on the ᵧdelta T-cells in metastatic cutaneous melanoma progression Kelly Coutant, Christopher Price, Jhon Pasamonte, Pulkit Datt, Mitchell Fane
• 2073 · PDF In vivo single-cell CRISPR screens identify targets to restore T cell function in aged tumors Alex C. Y. Chen, Keely Ji, Cansu Yerinde, Daniela Martinez, Thomas J. LaSalle, Kazuhiro Taguchi, Marc A. Schwartz, Maria Zschummel, Thorsten R. Mempel, Nir Hacohen, Debattama R. Sen
• 2074 Adenosine-driven inflammatory reprogramming of aged cancer-associated fibroblasts promotes immune suppression in pancreatic ductal adenocarcinoma Shuncang Zhu, Jinpeng Lu, Ziyi Tu, Hongyi Lin, Yinhao Chen, Yiting Chen, Haoxiang Zhang, Zuwei Wang, Shi Chen
• 2075 Lactate-driven cholesterol reprogramming induces fibroblast senescence and immune suppression in aged pancreatic cancer Ziyi Tu, Jinpeng Lu, Shuncang Zhu, Hong-yi Lin, Yi-ting Chen, Yinhao Chen, Haoxiang Zhang, Zu-Wei Wang, Shi Chen
• 2076 · PDF FGFR1 drives progression of ER+ breast cancer brain metastases in young and aged hosts Morgan S. Fox, Jenny A. Jaramillo-Gómez, R. Alejandro Marquez-Ortiz, Karen L. F. Alvarez-Eraso, Maria J. Contreras-Zárate, Trinh C. Pham, Elaina N. Barela, Stella Koliavas, Peter Kabos, Carol A. Sartorius, Elizabeth A. Wellberg, Diana M. Cittelly
• 2077 · PDF Remodeling the aged bone marrow niche: LRG1-mediated immunosuppression promotes prostate cancer metastasis Lele Xu, Yuanhao Song, Wenlin Zhao, Peter Ka Fung Chiu, Anthony Chi-Fai Ng, Dinglan Wu
• 2078 Aging promotes liver and lung melanoma metastasis via tissue-infiltrating Tregs Anastasiia Burtseva, Kelly Coutant, Jhon Pasamonte, Christopher Price, Mitchell Fane
• 2079 · PDF Aging attenuates brain metastasis in lung cancer through the MT1G/NF-κB/SPARC signaling Abhishek Tyagi, Shih-Ying Wu, Jee Won Kim, Kerui Wu, Ravindra Deshpande, Kounosuke Watabe
• 2080 Aged-induced increases in IL-11 leads to immune escape and PD-1 resistance in melanoma through myeloid cell polarization Michael F. Emmons, Chao Zhang, ethan vallebuona, Richard L. Bennett, Manali Phadke, Jonathan D. Licht, Keiran Smalley
• 2081 Age of host impact on epigenetics in tumors derived from early or late onset Hispanic colorectal cancer patients Lesly Torres-Gonzalez, Shivani Soni, Zeyi Yang, Ben Y. Tew, Jae H. Lo, Pooja Mittal, Unnati H. Shah, Michela Bartolini, Steve Soto Trujillo, Yitzher Goretsky, Sandra Algaze, Wu Zhang, David W. Craig, John D. Carpten, Salhia Bodour, Heinz-Josef Lenz
• 2082 Multiplex immunofluorescence reveals compartment-specific immune cell correlations associated with age and immunotherapy response in ovarian carcinoma Kathy Kwock, Okan Gültekin, Hanim I. Ozkizilkaya, Lynda D. Roman, William Dean Wallace, Tirzah Petta, Joseph W. Carlson
• 2083 · PDF Spatial profiling reveals distinct immune microenvironments in early vs late onset colorectal cancer Niti Jani, Michael Martinez, Christopher Flynn, Hatano Yuichiro, Zhongqiu Zhang, Daniel W. Rosenberg
• 2084 Angiotensin-II-induced chronic hypertension reprograms the antitumor-immune-response in pancreatic ductal adenocarcinoma Benjamin Wolf, Heena Kumra, Ryo Morisue, Karim El-marouk, Igor L. Gomes-Santos, Rieke Schleinhege, Tsion H. Tale, Marc Charabati, Sonu Subudhi, Dai Fukumura, Rakesh K. Jain
• 2085 · PDF Novel obesity-associated adipokine modulates the malignant phenotype of endometrial cancer cells Chi Lam Au Yeung, Gaayathri Binoj, Qian Zhang, Yadira Pacheco, Samuel Mok
• 2087 · PDF Intermittent fasting remodels gut ecosystem to influence initiation and therapy responses in pancreatic cancer Le Li, Vidhi Chandra, Fuduan Peng, Luca S. Santovito, Olivereen Le Roux, Rian M. Howell, Thais Bartelli, Virginia Tahan, Erika Y. Faraoni, Seyda Baydogan, Haiyan D. Miller, Kejing Song, Vasanta Putluri, Badrajee Piyarathna, Abu Hena Kamal, Nagireddy Putluri, Joseph Petrosino, Arun Sreekumar, Jay Kolls, James R. White, Zheng Sun, Lora V. Hooper, Linghua Wang, Faraz Bishehsari, Florencia McAllister
• 2088 · PDF Prostaglandin E 2 signaling promotes adverse survival outcome in B-cell acute lymphoblastic leukemia Michael Cohen, Nayaonika Vasishtha, Byourak Shabane, Jia Tan, Tyler Kuk, Neha Chandra, In Sook Ahn, Xia Yang, Etan Orgel, Steven D. Mittelman
• 2089 · PDF Sex-specific IgA secretion in muscle-invasive bladder cancer: A preliminary study Yasmine Ilkhani, Sirine Bouabda-Barc, Rachel Chevalier, Orlando Yuan, Jose Joao Mansure, Madhuri Koti, Wassim Kassouf, Éva Michaud
• 2090 · PDF Modifiable lifestyle factors and immune gene expression in breast tumor and normal-adjacent tissue Kristen D. Brantley, Cheng Peng, Clara Bodelon, Deborah A. Tadesse, Peter Kraft, Rulla M. Tamimi
• 2091 Progesterone promotes immunosuppression in murine mammary tumors by modulating CD4 T cell viability and helper functions, promoting T cell apoptosis and a shift from inflammatory to anti-inflammatory cytokine profiles Amanda Glen Heard
• 2092 Single-cell RNA sequencing reveals ancestry-associated molecular and cellular immunosuppressive features in non-small cell lung cancer Liang Liu, Pengbo Zhang, Enzo Palma, Ashley Ballard, Lance Miller, Gregory Hawkins, Cristina M. Furdui, Edward Levine, Alberto de Hoyos, Wencheng Li, Fang-Chi Hsu, Ralph D'Agostino, David Foureau, Wei Zhang
• 2093 Elucidating the mechanistic connection between the elevated occurrence of EGFR mutation in Hispanic/Latinx lung adenocarcinoma patients Jonathan Castillo, William D. Wallace, Leonidas Arvanitis, Dan Raz, Crystal N. Marconett
• 2094 Investigating the influence of genetic background on TNBC-T cell interactions in TNBC organoids and co-cultures Batoul Farran, Moses Kamita, Shuk Mei Wong, Sylvester Antwi, Valerie Ofori Aboah, Harriet Larrious-Lartey, Jessica Jessica Bensenhaver, Ali Haythem, Walker Eleonor, Foster Amponsah, Josephine Nsafu., Rose Dampson, Patrick Kafui Akapko, Evelyn Jiage
• 2095 · PDF Smoking is associated with reduced tumor-infiltrating lymphocyte density in breast cancer Annelie Marika Augustinsson, Karolin Isaksson, Anikó Kovács, Helena Jernström
• 2096 · PDF Investigating the effect of SGLT2 inhibitor dapagliflozin on acute lymphoblastic leukemia in obese mice Jia Tan, Thomas Tran, Tyler Kuk, Houfu Leng, Michael Cohen, Etan Orgel, Steven D. Mittelman
• 2097 · PDF Fibroblast galectin-3 remodels the obese breast tumor microenvironment to promote cancer progression Ellen E. Bamberg, Kiran Vinod-Paul, Amy L. Pyo, Kirk C. Hansen, Carol A. Sartorius, Paul S. MacLean, Peter Kabos, Heather Brechbuhl
• 2098 · PDF CNTF governs exercise-induced myofibroblast reversion in prostate cancer Pengju Gong, Yuan Liu, Leng Han, Liuqing Yang, Chunru Lin
• 2099 · PDF Iron supplementation rescues anemia of chronic disease in pancreatic ductal adenocarcinoma Yichi (Tony) Zhang, Cindy Pyo, Anna Barbeau, Davey Feng, Amit Roopan, Matthew Vander Heiden, Kendra Libby, Alison Epstein Ringel

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