Integration of Clinical and Research Data

• 2708 · PDF Revealing fibroblast-mediated impacts to therapy response through spatially resolved drug response prediction in lung cancer Robert F. Gruener, Weijie Zhang, Lilin Wang, Adam M. Lee, R. Stephanie Huang
• 2709 · PDF PRECISE: A prognostic thyroid follicular cell-derived gene signature for papillary thyroid carcinoma Sophie Li, Chia C. Wu, Vicente R. Marczyk, Matthew A. Loberg, Aatish Thennavan, Maxime Tarabichi, Li Xu, Ying C. Henderson, Tuan M. Tran, Quanhu Sheng, George J. Xu, Eric C. Huang, Marie-Claude Hofmann, Xiao Zhao, Stephen Y. Lai, Michelle D. Williams, Wenyi Wang, Sarah Hamidi, Mark E. Zafereo, Maria E. Cabanillas, Nicholas E. Navin, Vivian L. Weiss, Jennifer R. Wang
• 2710 · PDF Single-nuclei multiomic profiling reveals conserved adaptive states in EGFR- and ALK-mutant lung adenocarcinoma Naomi Kaste Mfonfu, Floriane Brayé, Galina Boldina, Matteo Cesaroni, Luc Friboulet, Sergey Nikolaev, Andrey Yurchenko
• 2711 · PDF Large-scale integration of single-nuclei and spatial transcriptomics from the ETOP BEAT-meso trial reveals clinically relevant heterogeneity in malignant pleural mesothelioma Daria Buszta, Jonathan Bac, Maxim Norkin, Arsh Shaikh, Bernd Illing, Adriano Martinelli, Isinsu Katircioglu, Melissa Ensmenger, Sylvie Andre, Marina Alexandre-Gaveta, Sanjay Popat, Anthony Pope, Riyaz Shah, Toby Talbot, Julia Giner, Janthur Wold-Dieter, Ernst Nadal, Annamaria Catino, David Gilligan, Amy Roy, Georgia Dimopoulou, Rosita Kammler, Stephen P. Finn, Zoi Tsourti, Enriqueta Felip, Patrick Vagenknecht, Solange Peters, Rolf A. Stahel, Marianna Rapsomaniki, Raphael Gottardo, Krisztian Homicsko
• 2712 · PDF MPACT-DPD: An interpretable machine learning classifier for predicting the functional impact of DPYD missense variants Lulu Jiang, Ryan Jonathan Swartz, Lauryn Allyn Hahn, Brianna Bembenek, Hannah Marie Krause, Kelly Bouchonville, Steven M. Offer
• 2713 · PDF Ensemble machine learning using unmatched pre-treated multi-omic data can classify response to immune checkpoint inhibition in non-small cell lung cancer Alexander Azizi, Arvind Ravi, Natalie Vokes, Stephen-John Sammut, Petar Stojanov, Justin Gainor, Gad Getz
• 2714 · PDF Development of a novel Ikaros/Aiolos transcriptional signature and correlation with patient response in multiple myeloma patients treated with CELMoDs Saleh Tamim, Nicholas Stong, Yan Kai, Diana Jankeel, Bonny Gaffney, Antonina Kurtova, Alberto R. Perez, Celia Fontanillo, Tracy T. Chow, Patrick R. Hagner, Danny Jeyaraju, Chad C. Bjorklund, Michael Amatangelo, Kai Wang, Anita Gandhi, Maria Ortiz-Estevez
• 2715 · PDF A comprehensive single-cell atlas of head and neck squamous cell carcinoma defines malignant cell states and enables deconvolution of legacy bulk transcriptomic cohorts Yuanyuan Shen, Tingyi Li, Roger Li, Xuefeng Wang, Xiaoqing Yu
• 2716 · PDF Machine learning-based screening tool for multiple myeloma detection in chronic kidney disease patients with limited laboratory testing Wen-Chi Wu, Muh-Hwa Yang, Chih-Yu Yang
• 2717 · PDF Prostate cancer risk stratification by polygenic score in diabetic and non-diabetic men Gukjin Lee, Sang-Hyuk Jung, Jonghyun Lee, Ki Won Moon, Jae-Seung Yun, Dokyoon Kim
• 2718 · PDF Liquid biopsy cfDNA methylation predicts lung tumor size and metastatic potential in a single assay Kade P. Pettie, Shiva Farashahi, Jackson Killian, Andrew Wong, Yifan Wu, Dorna Kashef, Franziska Michor, Jocelyn Charlton, Kieran Chacko
• 2719 · PDF Molecularly-informed prediction of treatment efficacy in GDSC cell line data using computational reasoning Robert Doczi, Akos Takacs, Anna Dirner, Dora Lakatos, Barbara Vodicska, Dora Gorog-Tihanyi, Reka Szalkai-Denes, Eniko Kispeter, Andras Makkos, Aniko Gorbe, Peter Ferdinandy, William T. Beck, Christophe Le Tourneau, Petak Istvan
• 2720 · PDF A comprehensive LLM-enabled pharmacodynamic biomarker resource to accelerate cancer drug development Yuntao Yang, Li Zhao, Seyedmehdi Orouji, Ying Zhu, Rebecca Johnson, David Maxwell, Kaitlyn Brickey, Bissan Al-Lazikani
• 2721 Phenome-wide association study of pre-cancer diagnosis electronic health records identifies risk and protective factors in the All of Us Research Program Charles C. D. Rich, Alyssa B. Bair, Britton E. Richardson, Katelyn C. Forbes, Blaine A. Bates, Mary F. Davis, Matthew H. Bailey
• 2722 · PDF Integrated analysis identifies ELF3-CREB1 co-activation as a prognostic driver of high-risk pancreatic cancer Poorva Poorva, Rimpi Khurana, Varunkumar Krishnamoorthy, Sudhakar Jinka, Yan Guo, Vineet Kumar Gupta, Nagaraj Nagathihalli
• 2723 · PDF Genomic drivers and an immune-cold microenvironment are associated with relapse in Chinese pediatric B-ALL Dan Yu, Yanni Hu, Xue Tang, Junlin Wang, Junwen Wang, Jianwen Xiao
• 2724 · PDF A machine learning approach to classify breast cancer receptor subtype using genomic features Sandro Satta, Philip Miller, Samuel Rivero-Hinojosa, Ekaterina Kalashnikova, Angel Rodriguez, Minetta C. Liu
• 2725 · PDF Grade-dependent survival and co-mutation landscapes in TP53-mutant gliomas: Biological insights and therapeutic implications Harpreet Kaur, Kevin Camphausen, Uma Shankavaram
• 2726 · PDF Clinicopathological and molecular significance of MUC13 in HCC Anupam Dhasmana, Swati Dhasmana, Rajasekhar Baru, Abigail Gomez, Iris A. Perez, Sheema S. Khan, Murali M. Yallapu, Subhash C. Chauhan
• 2727 · PDF A designed live bacterial therapeutic restores responder-like microbiome profiles and improves immune checkpoint inhibitor (ICI) response in a predictive model Glen J. Weiss, Sonia Timberlake, Kinga Zielinska, Marina Santiago, Johannes Woehrstein, Christopher Weidenmaier
• 2728 · PDF The Cancer Complexity Knowledge Portal: A FAIR-aligned tool for resource discovery Orion Banks, Ashley Clayton, Aditi Gopalan, Amber Nelson, Verena Chung, Amy Heiser, Jay Hodgson, Aditya Nath, Adam Hindman, Milen Nikolov, Adam Taylor, Angie Bowen, Susheel Varma, Jineta Banerjee
• 2729 · PDF The selective landscape of somatic mutations encodes histopathological information in breast cancer Gift Asefon, Nic Fisk
• 2731 · PDF Sylvester Data Portal: Population-level characterization of a diverse clinicogenomic cohort Oliver Mazariegos, Jeronimo Pissinis, Pearl Seo, Marcin Pilarczyk, Lukas Rupprecht, Caty Chung, Franklin Sotolongo, Marcin Blicharz, Piotr Smol, Michal Pyrkosz, Mateusz Jura, Vasileios Stathias, Stephan Schürer
• 2732 · PDF Florida Cancer Research (FL CARES) network and the Platform for Accelerating Collaborative Computational Cancer Research (PAC3R) Jeronimo Pissinis, Michael S. Sinclair, Marcin Pilarczyk, Caty Chung, Dusica Vidovic, Lukas Rupprecht, Franklin Sotolongo, Oliver Mazariegos, Kathleen M. Jagodnik, Carlos Obregon, Tingyi Li, Ling Cen, Jiang Bian, Ji-Hyun Lee, Qianqian Song, Bikhyat Adhikari, Till Krenz, Ritik Bhandari, Umamaheswari Natarajan, Gogce C. Crynen, Appu Rathinavelu, Stuart Chalk, Mondal M. Ananda, Xuefeng Wang, Vasileios Stathias, Stephan Schürer
• 2733 · PDF An interactive web platform for integrative analysis of drug responses in polyploid giant cancer cells Li-Ju Wang, Hsiao-Chun Chen, Chien-Hung Shih, Yuan Zhang, Huikang Ye, Ying-Ju Lai, Yushu Ma, Tiffany Habib, Hsi-Chun Wang, Yu-Chih Chen, Yu-Chiao Chiu

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