Biomarkers Predictive of Therapeutic Benefit 2

• 1033 · PDF Leronlimab induces PD-L1 expression and is associated with long‑term survival with an ICI in PD-L1 low metastatic TNBC Richard G. Pestell, Ritika Harish, Zhiping Li, Danni Li, Xuanmao Jiao, Hallgeir Rui, Massimo Cristofanilli, Daniel L. Adams, Neil E. Buss, Jonah B. Sacha, Jacob P. Lalezari
• 1034 · PDF Transcriptomic and genomic signatures associated with response or resistance to immunotherapy(IO) in locally advanced/metastatic (LA/M) head and neck squamous cell carcinoma (HNSCC) patients Elodie Girard, Sonia Canjura-Rodriguez, Bastien Cabarrou, Constance Lamy, Anne Schnitzler, Frédérique Penault-Llorca, Emmanuel Bouilhol, Roger Sun, Eric Deutsch, François Legrand, Séverine Tabone-Eglinger, Valery Attignon, Caroline Even, Christophe Le Tourneau, Ellen Van Obberghen-Schilling, Marta Jimenez, Nicolas Servant, Thomas Filleron, Edith Borcoman, Pierre Saintigny, Ivan Bièche
• 1035 · PDF Ultrasensitive cfDNA fragmentomics assay for early treatment response assessment in solid tumors Atul Bharde, Kiran Kirdat, Amol Chaudhari, Ajay Pandita, Gowhar Shafi, Mohan Uttarwar, Sudhir K. Sinha, Hiromi Brown, Bill Haack
• 1036 An integrated clinicopathologic and genomic analysis of PPP2R1A alterations reveals distinct patterns in uterine and ovarian cancers Kai Wang, Bo Yang, Chengyi Wang, Yannan Zhu, Jinmei Wang, Kunxu Xu, Zanmei Xu
• 1037 Single cell and spatially resolved determinants of the clinical outcome of patients (pts) treated with locally advanced/metastatic head and neck squamous cell carcinoma (LA/M SCCHN) treated with immunotherapy (IO) Mehdi Lamkhioued, Thimothee Casini, Elodie Girard, Karène Mahtouk, Sonia Canjura-Rodriguez, Valery Attignon, Bastien Cabarrou, Constance Lamy, Anne Schnitzler, Frederique Penault-Llorca, Caroline Even, Christophe Le Tourneau, Ellen Van Obberghen-Schilling, Nicolas Servant, Fayette Jerome, Nathalie Bendriss-Vermare, Ivan Bièche, Pierre Saintigny
• 1038 · PDF Integrating genomics and real-world data to predict fam-trastuzumab deruxtecan response in metastatic breast cancer across HER2 subtypes Abraham Apfel, Alka A. Potdar, Yuanqing Ye, Viswanath Devanarayan, Evvie Jagoda, Shelley MacNeil, Yan Zhang, Pallavi Sachdev
• 1040 · PDF Blinded clinical validation of LiquidTME, a cell-free DNA assay for predicting response to immunotherapy by noninvasively profiling the tumor microenvironment Aadel A. Chaudhuri, David Y. Chen, Tucker Hansen, Mirna Jarosz, Vincent A. Miller, Aaron M. Newman
• 1041 · PDF Extracellular vesicle-associated noncanonical ORFs as biomarkers of surgical outcome and chemoresistance in ovarian cancer Tatiana V. Karpinets, Xiaogang Wu, Sara Corvigno, Amma Asare, Joseph Celestino, Jeffry J. Cutrera, Pamela T. Soliman, Shannon N. Westin, Amir A. Jazaeri, P. Andrew Futreal, Anil K. Sood, Sanghoon Lee
• 1042 · PDF Clinical and immune correlates of response to neoadjuvant chemoimmunotherapy in dMMR/MSI-H gastric cancer Pengfei Yu, Xingmao Huang, Xiangliu Chen, Hang Chen, Song Wang, Di Wang, Junrong Yan, Jiahui Chen, Qing Wei, Zequan Wu, Shengxin Fang, Han Chen, Hongtao Wang, Chengkang Zhu, Ling Huang, Yian Du, Hua Bao, Haimeng Tang, Xue Wu, Xiangdong Cheng
• 1043 · PDF MUC5AC expression defines an immune-inflamed but functionally restrained tumor microenvironment in pancreatic ductal adenocarcinoma Ashish Manne, Wancai Yang, Yongchen Guo, Vaibhav Sahai, Prachi Bajpai, Yonghua Bao, M Khalid Khan Niazi, Alejandro Leyva, Upender Manne
• 1044 · PDF Class II HLA supertype diversity predicts poor outcomes with immune checkpoint inhibitors in a pan-cancer cohort Luke Xiyu Zhao, Franshisca Hayek, Howard Liu Li, Mark Yarchoan, Mari Nakazawa
• 1045 · PDF A novel epithelial tumor signature predicts survival and response to PD-1 blockade in non-small cell lung cancer Muaath Alsufi, Jehad Yasin, Muthafar Alsufi, Osama Younis, Amro Assayed, Fawzi Abu Rous
• 1046 · PDF Leveraging transcriptomic profiles and deep learning to detect homologous recombination deficiency in breast cancer with softHRD Yashwin Madakamutil, Leo Joseph, Daniyal Rahman, Ammal Abbasi, Ludmil Alexandrov
• 1047 · PDF MORPHEUS-lung: Biomarkers and clinical response to atezolizumab + bevacizumab + stereotactic body radiotherapy in patients with metastatic non-small cell lung cancer Byoung Chul Cho, Sun Min Lim, Sang Hoon Lee, Dong Kwon Kim, Nuria Pardo, Hen Prizant, Yaacov R. Lawrence, Nedal Al-Sakaff, Hans-Joachim Helms, Gayevskiy Velimir, Barzin Nabet, Jan Pintoffl, Francois Ghiringhelli
• 1048 · PDF Smad deficiency impacts chemotherapeutic responses through alterations in immuno-stromal microenvironment of pancreatic adenocarcinoma Chih Chieh Yen, Ying Jui Chao, Ping Jui Su, Ting Kai Liao, Wei Hsun Lu, Zhe Wei Hsu, Chien Jui Huang, I Ting Liu, Wen Yen Huang, Yan Shen Shan, Chia Jui Yen
• 1049 · PDF DNA repair phenotypes inform carboplatin and PARP inhibitor response Ionut-Gabriel Funingana, John Ambrose, Luca Porcu, Philip Smith, Bradley Thomas, Ines Prata Machado, Patrick Tarpey, Mireia Crispin-Ortuzar, Marc Tischkowitz, Florian M. Markowetz, Alona Sosinsky, James D. Brenton
• 1050 · PDF Assessment of spectral overlap and crosstalk in multiplex digital PCR for effective monitoring of next-generation CAR T-cells in cancer clinical trials Sarah Johnson, Yogita Raj, Nathan Riccitelli
• 1051 · PDF CXCR4/LITAF as predictive biomarkers for nimotuzumab plus AG therapy in pancreatic cancer with liver metastasis: Integrative single-cell and spatial analysis Linze Xu, Yang Liu, Linlin Fu, Dandan Wu, Jin Zhang, Hao Wang, Huikai Li, Jihui Hao
• 1052 · PDF Real-world treatment patterns and outcomes reveal distinct clinical trajectories of patients with Cyclin E1-positive ovarian cancer Jinkil Jeong, Mona Abed, Catherine Lee, Heekyung Chung, Alexandra Levy, Nandini Molden, Divya Rajendran, Joyce F. Liu, Leslie M. Randall, Fiona Simpkins, Funda Meric-Bernstam, Danielle D. Jandial, Doris Kim, Olivier Harismendy
• 1053 · PDF Single-cell immune profiling reveals biomarkers of pembrolizumab response in early triple-negative breast cancer Inaki Comino-Mendez, Maria Rosario Chica-Parrado, María Elena Quirós-Ortega, Ana Godoy-Ortiz, Maria Emilia Dominguez-Recio, Esperanza López-López, María Victori Ortega-Jiménez, Martina Alvarez, Javier Pascual, Enrique de Alava, Emilio Alba
• 1054 · PDF Plasma metabolomic profiling predicts response to neoadjuvant immunochemotherapy in locally advanced NSCLC Yan Wang, Hui Yang Shi, Haonan Gu, Wenxin Jiang, Linyan Tian, Fang Wei, Danru Zheng, Haiyan Xu, Ting Xiao
• 1055 · PDF Assessing biomarker reproducibility for glioblastoma patient response stratification Christopher M. Jannotta, C. Zoe Linke, Charles A. Whittaker, Vikas Patil, Accelerating GBM Therapies TeamLab, Farshad Nassiri, Gelareh Zadeh, E. Antonio Chiocca, Alexander L. Ling
• 1056 · PDF Integrative multi-omics characterization and AI-driven biomarker discovery for NSCLC stage III outcomes Katherina C. Chua, Yun-Ching Chen, Ariel Chen, Stewart Bates, Mehdi Pirooznia, Assieh Saadatpour

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