Modifiers of Inflammation and the Tumor Microenvironment

• 2891 · PDF Specificity and timing of TREM-1 blockade initiation impact its therapeutic efficacy in cancer Alexander B. Sigalov
• 2892 · PDF Safety and activity of cLRRC15-IFNa, a conditionally active biologic targeting IFNa specifically to LRRC15+ CAFs Justin Killebrew, Linda Liang, Shannon Okada, Aelish Guinn, Alton Etheridge, Brett Robison, David Colby, David Jurchen, Jacqueline Pham, Jamie Nguyen, John Skonier, Kendyl Daniels, Kerri Thomas, Laura Carlucci, Lynn Amon, Megan Sprague, Meri Galindo, Remington Lance, Sam Wrenn, Sandra Notonier, Shannon Fallen, Shea McClain, Wendy Curtis, Zane Kraft, John Mulligan, Diane Hollenbaugh
• 2893 · PDF Selective inhibition of eIF4A targets tumor-associated macrophages to restore lymphoma-specific immunity Haley Lynn Klimaszewski, A. Douglas Kinghorn, Michael R. Grever, Robert A. Baiocchi, John T. Patton
• 2894 · PDF Alphavirus replicon expressing IL-12 reprograms tumor-associated macrophages and neutrophils and induces anti-tumor immunity Forrest Bowling, Momoko Ishikawa, Dhanya Nambiar, Jayalaxmi Sastri, Keiko Ishimoto, Fumiya Tao, Koyo Takahashi, Ivan Stepanek, Hongbin Cao, Davis Leitner, Kenta Matsuda, Fred Baik, John Sunwoo, Quynh Thu Le, Jonathan Smith, Wataru Akahata
• 2895 · PDF JAK inhibition enhances virotherapy in gliomas by modulating interferon-driven resistance Andres R. Lopez-Rivas, Andrew Gregg Gillard, Akhila Parthasarathy, Dong Ho Shin, Angelis Morales-Rivera, Claudia Solbes-Godina, Alejandra Duran, Joy Gumin, Christopher A. Alvarez-Breckenridge, Marta M Alonso, Frederick F. Lang, Juan Fueyo, Candelaria Gomez-Manzano
• 2896 · PDF Therapeutic targeting of TGR5 abrogates bile acid driven myeloid cell immunosuppression in cholangiocarcinoma Enis Hikmet Ozmert, Binbin Li, Jingchun Yang, Hannah Elizabeth Stumpf, Jessica R. Willhite, Danielle Carlson, Jennifer L. Tomlinson, Jon Covel, Raghuveer Ramachandra, Steven Olson, Rory L. Smoot, Sumera Ilyas
• 2897 A patient-derived fragmented tumor assay for detailed evaluation of drug response in the tumor microenvironment (TME) using scRNAseq Daniel C. Rabe, Daniel J. Gorski, Shiyuan Zheng, Mary Flaherty, Tommy Trieu, A'Riane Branch, Terykah Hollis, Lovepreet Singh Chahal, Brian Roberts, Richard A. Klinghoffer, Sonal Khare
• 2898 · PDF Aging-related morphological change in regional lymph nodes promotes an immunosuppressive microenvironment in colorectal cancer Kosuke Kanemitsu, Rin Yamada, Daiki Yoshii, Yukio Fujiwara, Yoshiyuki Tagayasu, Teruki Sako, Kota Arima, Kohei Yamashita, Kazuto Harada, Norihisa Hanada, Yoshihiro Komohara, Masaaki Iwatsuki
• 2899 · PDF Oncolytic virus-chemotherapy combination improves control of PDAC growth and spread Biplov Sapkota, Naveen Chintala Ramulu, Shreya Pokharel, Mohammed T. Hussain, Brent Stanfield, Konstantin Kousoulas, Joseph Francis
• 2900 · PDF Activation of the cGAS-STING signaling pathway as an immunotherapeutic approach to glioblastoma Louise Leparc, Judit Sanchez Gil, Hiroaki Wakimoto
• 2901 · PDF Integrated spatial, single-cell, and in vivo dissection of matrix CAF-driven immune exclusion in colorectal cancer Yuki Nakanishi, Kosuke Iwane, Yu Muta, Kento Yasumura, Mayuki Omatsu, Naoki Aoyama, Munehiro Ikeda, Yoko Masui, Go Yamakawa, Yasuhiro Fukui, Hiroaki Kasashima, Akihisa Fukuda, Hiroshi Seno
• 2902 · PDF Deciphering the function of lipid-associated macrophages in immunotherapy resistance of hepatocellular carcinoma Xiaohang Long, Yaxian Wang, Siyuan HUANG, Joaquim Si Long VONG, Joseph Jao-Yiu Sung, Lam, Stephen CHAN, Alfred Sze-Lok Cheng
• 2903 · PDF Modulating the tumor microenvironment (TME) to enhance anti tumor immunity using metabolic inhibitors Takeshi Ito, Shun Kishimoto, Kazutoshi Yamamoto, Jeffrey Brender, Frank Echtenkamp, Daniel Crooks, Murali Cherukuri Krishna, William Marston Linehan
• 2904 Infectious bursal disease virus (IBDV) as a novel virotherapy for stimulating innate and adaptive immune responses in different cancer models Vicent Tur Planells, Yonina Bykov, Gloria Dawodu, Leticia Perez Rodriguez, Noemi Garcia Romero, Angel Ayuso Sacido, Jordi Cano Ochando, Daniel Lozano Ojalvo, Adolfo Garcia Sastre, Estanislao Nistal Villan, Sara Cuadrado Castano
• 2905 · PDF Pancreatic adenocarcinoma immune tumor microenvironment is shaped by differential miRNA expression Maksymilian Jan Pilecki, Shannon M. Wallet, Robert Maile, Gerik Tushoski- Alemán, Song Han, Steven J. Hughes
• 2906 · PDF The iRGD peptide reprograms the tumor microenvironment and potentiates immunotherapy in an advanced humanized PDAC mouse model. Norio Miyamura, Yukihito Kuroda, Kodai Suzuki, Yuki Kunisada, Hotaka Kawai, Henri Havia, Tero Järvinen, Moriya Tsuji, Kazuki N. Sugahara
• 2907 · PDF Characterization of tumor microenvironment phenotypes as potential biomarkers for immune infiltration Iqra A. Arif, Ruchi Shah, Katherine A. Johnson, Cheri A. Pasch, Dustin Deming
• 2908 SR-A antagonism remodels the myeloid population of tumor immune microenvironment, expands CD8-positive T cells, and enhances antitumor efficacy in vivo Steven R. Post, Fariba Jousheghany, Thomas J. Kelly, Charles M. Quick, Behjatolah M. Karbassi
• 2909 · PDF Targeting USP22 reprograms the tumor microenvironment and sensitizes KRAS-mutant, TP53-Null Lung cancer to immunotherapy Keqiang Zhang, Ching Ouyang, jinhui Wang, Wendong Li, Walter Tsark, Yuanyuan Gao, Mingxiao Yang, Aimin Li, Colt Egelston, Crystal Marconett, Dan Raz
• 2910 · PDF GRN deficiency loosens stromal barriers and enhances MHC-II signaling yet reduces MHC-I driven cytotoxic immunity Feng Guo, Boping Jing, Tadahito Yasuda, Mayu Yasuda, Hudie Li, Fabio N. de Mello, Alan Y. Wang
• 2911 · PDF Versican expression and proteolysis as a biomarker for CD8+ T cell infiltration across cancer types and molecular profiles Ruchi Shah, Elizabeth L. Field, Cheri Pasch, Dustin A. Deming
• 2912 SECN-15: Antisense oligonucleotide-mediated Neuropilin-1 suppression enhances anti-tumor immunity and overcomes checkpoint inhibitor resistance in solid tumors Andre Maaske, Sven Michel, Anne Sadewasser, Julia Festag, Monika Schell, Janani Sekar, Stefanie Raith, Frank Jaschinski, Richard Klar
• 2913 Type I interferon reprograms neutrophil-T cell interactions to enhance antitumor immunity and informs a combinatorial strategy for esophageal cancer Tingxuan Gu, Kun Yu, Zigang Dong
• 2914 · PDF Modulating the tumor microenvironmentwith an engineered oncolytic herpesvirus facilitates potent antitumor response Joseph Najjar, Geetanjali Geetanjali, Chase Kangas, Vk Gadi, Bin He
• 2915 · PDF Tumor-intrinsic METTL5 restricts T cell-induced ferroptosis by impairing ATF4 translation in ovarian cancer Jiakai Hou, Cheng-wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro Gerges, Mason D. Flores, Han Li, Li-Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng
• 2916 Tumor-intrinsic IRE1alpha signaling drives immune evasion and resistance to immune checkpoint inhibitor in lung cancer by upregulating PD-L1 and remodeling the tumor microenvironment Youngjoo Jeon, Hyun Kyung Ahn, Hongsoon Kim, Sung-Yup Cho, Jaemoon Koh, Yoon Kyung Jeon
• 2917 · PDF Novel strategies for targeting B7-H3 to empower precision oncology Di Zhao
• 2918 Agonist activation of RIG-I + tumor associated macrophages enhances anti-tumor immunity and therapeutic response in glioblastoma Han Xu, Sungwoon Lee, Felipe Saceanu Leser, Olga Federova, Peiwen Lu, Eric Song, Anne Eichmann, Akiko Iwasaki, Anna Anna Marie Pyle, Jean-Leon Thomas
• 2919 A little STING spices up tertiary lymphoid structures: Therapeutic induction of mature TLS by STING and lymphotoxin-beta receptor activation confers immune protection against cancer metastasis Yasuhiro Kikuchi, Maxwell Duah, Fumiaki Kanamori, Masanobu Komatsu
• 2920 Metabolic reprogramming of hepatic macrophages restores CD8⁺ T cell immunity in T cell-desert hepatocellular carcinoma Liangliang Ji, Delaney Bessel, Sophia Brosnan, Isha Malik, Zijian Xu, Jiaxin Li, Peng Li, Xian Zhang, Jing Zhang, Ting-Wei Tsu, Shengyu Gao, Amaia Lujambio, Ming Li

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