Spatial Proteomics and Transcriptomics 1

• 1200 · PDF Spatially resolved tumor-cell MHC class II shapes adaptive immunity and therapeutic response in triple-negative breast cancer Yi Liu, Sachin Kumar Deshmukh, Thiti Susiriwatananont, Panuch Eiamprapaporn, Bogang Wu, Heikki Joensuu, Roberto A. Leon-Ferre, David Zahrieh, Judy C. Boughey, James Newell Ingle, Fergus J. Couch, Sharon Wu, Shipra Gandhi, Maryam Lustberg, George W. Sledge, Matthew P. Goetz, Keith L. Knutson, E Aubrey Thompson, Jodi Carter, Saranya Chumsri
• 1201 · PDF Spatial 3D and multi-omics mapping of diffuse gastric cancer evolution from preinvasive to invasive lesions in CDH1 mutation carriers Yunhe Liu, Idania Carolina Lubo Julio, Wei Lu, Alejandra G. Serrano, Jean R. Clemenceau, Amber Famiglietti, Karen Colbert, Yibo Dai, Yang Liu, Jun Wang, Jeremy L. Davis, Mingyao Li, Paul F. Mansfield, Tae Hyun Hwang, Luisa M. Solis-Soto, Linghua Wang
• 1202 · PDF Spatially-resolved transcriptome analysis of renal tumors with sarcomatoid/rhabdoid dedifferentiation uncovers underlying biology and new biomarkers relevant to these tumors Minjun Kim, Mustafa Soytas, Burge Ulukan, Tamiko Nishimura, Senthilkumar Kailasam, Ariel Madrigal, Zohreh Mehrjoo, Kate Glennon, Eleonora Scarlata, Madeleine Arseneault, Morag Park, Hamed Najafabadi, Fadi Brimo, Ozgur Sahin, Simon Tanguay, Yasser Riazalhosseini
• 1203 · PDF Spatial archetypes of conserved and cancer-specific immune-stromal niches Tian Chu, Jimin Min, Yunhe Liu, Yang Liu, Yibo Dai, Kyung Serk Cho, Xueshuai Han, Kai Yu, Fuduan Peng, Anirban Maitra, Humam Kadara, Linghua Wang
• 1204 · PDF Spatial multiomic characterization of spontaneous lung tumors in aged mice Adam Thiesen, Sema Akkurt, Javad Noorbakhsh, Te-Chia Wu, Andrew Salner, Peter Yu, Susan Airhart, Olga Anczukow, Ron Korstanje, Karolina Palucka, Jeffrey H. Chuang
• 1205 Trajectory-aware spatial transcriptomics deconvolution via image representation of RNA-seq data Junyan Liu, Md Tauhidul Islam, Lei Xing
• 1207 · PDF Multimodal profiling of STIC lesions identifies precursor states with genomic features of high grade serous ovarian cancer Duaa Hassan Al-Rawi, Nataly Naser Al Deen, Cristina Sotomayor-Vivas, Kerstin Thol, Herman Chui, Aveline Filliol, Areej Alsaafin, Hunter Green, Danguole Norkunaite, Mercedes Duran, Nicholas Ceglia, Kara Long-Roche, Britta Weigelt, Andrew McPherson, Scott W. Lowe, Sohrab Shah
• 1208 · PDF The MONSTAR-SCREEN-3 Spatial Atlas: Pan-cancer TME archetypes and clinically relevant tumor-immune ecosystems Mitsuho Imai, Eun Seop Seo, Jiyeon Hyeon, Shingo Sakashita, Yuka Nakamura, Tadayoshi Hashimoto, Shin Kobayashi, Jun Yuda, Riu Yamashita, Taro Shibuki, Takao Fujisawa, Masataka Amisaki, Kensuke Matsuda, Shun-ichiro Kageyama, Michiko Nagamine, Takeshi Kuwata, Hideaki Bando, Woong-Yang Park, Takayuki Yoshino
• 1209 · PDF FGFR2 translocated sinonasal adenocarcinoma: A biphasic seromucinous adenocarcinoma with a distinctive and targetable molecular phenotype Diana Bell, Randal S. Weber, Miao Zhang, Michelle Afkhami, Raja R. Seethala
• 1210 · PDF Integrated spatial and single-cell profiling uncovers a pre-existing, treatment-resistant subclone that drives early local relapse in luminal breast cancer Kazutaka Otsuji, Tomo Osako, Yoko Takahashi, Chikako Shibata, Sumito Saeki, Asumi Iesato, Tetsuo Noda, Kengo Takeuchi, Takayuki Ueno, Reo Maruyama
• 1211 · PDF Spatial transcriptomics uncovers pharmacokinetic barriers and tumor-intrinsic determinants of resistance to trastuzumab deruxtecan in breast cancer Changhee Park, Minki Choi, Jiwon Koh, Sungwoo Bae, Hongyoon Choi, Kwon Joong Na, Dae-Won Lee, Kyung-Hun Lee, Han Suk Ryu, Seock-Ah Im
• 1212 · PDF Spatial transcriptomics reveals distinct SPP1-CD44 signaling networks in neoadjuvant osimertinib treated EGFR mutant non-small cell lung cancer Whitney Tamaki, Daniel L. Kerr, Wei Wu, Grant Eilers, Anatoly Urisman, Yu-Ting Chou, Philippe Gui, Shigeki Nanjo, Johannes Ruediger Kratz, David Jablons, Trever G. Bivona, Collin M. Blakely
• 1213 Mitochondrial transcriptome profiles associated with clinical responses to CAR-T therapy in aggressive lymphoma Jacqueline Turner, Panwen Wang, Patrizia Mondello, Melinda Tan, Christoph Schaefers, Chen Wu, Andre de Menezes Silva Corraes, Kevin Regan, Zuoyi Shao, Ma Audrey, Arushi Khurana, Nora N. Benanni, Yucai Wang, Paul Hampel, Saad J. Kenderian, Jonas Paludo, Urshila Durani, Patrick B. Johnston, Jose Caetano Villasboas, Stephen M. Ansell, Haidong Dong, Ying Li, Zeng Hu, Yi Lin
• 1214 · PDF SPACE: Spatially resolved multiomic analysis for high-throughput CRISPR screening in 3D models Mengwei Hu, Yi Cui, Qianhui Huang, Khoi Chu, Sierra McKinzie, Michael Patrick, Sharanya Iyengar, Maerjianghan Abuduli, Marianne Spatz, Nandita Joshi, Brendan Miller, Shams Vellarikkal, Timothy Riordan, Danny Bitton, Jan Lubojacky, Iya Khalil, Federica Piccioni, Michael Rhodes, Alex Tamburino, Shanshan He, Joseph Beechem, Vanessa Peterson
• 1215 · PDF Spatial transcriptomic analysis of primary melanomas with extreme clinical outcomes Prachi Bhave, Marie Trussart, Anthony T. Papenfuss, Grant A. McArthur
• 1216 · PDF Profiling colon cancer architecture with spatial transcriptomics identifies clinically relevant stromal ecotypes Antoine Cazelles, Camilla Pilati, Delphine Le Corre, Gadea Cabrejas, Marine Sroussi, Claire Mulot, Claire Gallois, Gilles Manceau, Mehdi Karoui, Isaias Hernández-Verdin, Antoine Bougoüin, Wolf-Herman Fridman, Aurélien de Reyniès, Côme Lepage, Thierry Andre, Jean-François Emile, Théo Z. Hirsch, Julien Taieb, Pierre Laurent-Puig, Sophie Mouillet-Richard
• 1217 · PDF Multi-omics integration of bulk, single-cell, and spatial transcriptomics identifies robust prognostic biomarkers in head and neck salivary adenoid cystic carcinoma Gopikrishnan Bijukumar, Kathryn J. Brayer, David Lee, Scott A. Ness, Jeremy S. Edwards, Viswanathan Palanisamy
• 1218 · PDF Development of a proximity ligation-imaging mass cytometry platform for spatially resolved immune checkpoint analysis Ghazal Lessan Toussi, Lars Muhl, Anna Gorbunova, Austin James Rayford, Amanda Lindberg, Neda Hekmati, Viktoria Thurfjell, Aglaia Schiza, Agata Zieba Wicher, Patrick Micke, Carina Strell
• 1219 · PDF Spatial multi-omic profiling to capture functional signatures in HER2-heterogeneous FFPE breast cancer tissue Dongyoon Shin, Sumin Lee, Young June Jeon, Jeongwoo Hong, Sohyun Yang, Amos Chungwon Lee, Han Suk Ryu, Youngsoo Kim, Sungwoo Cho, Song-A Park, Sihun Cho, Sungho Ko, Junho Park
• 1220 · PDF Spatial transcriptomics revealed potential resistance and response factors of sacituzumab govitecan in metastatic breast cancer Mengni He, Charles J. Robbins, Julia Benanto, Thazin Nwe Aung, Yalai Bai, Ian E. Krop, David L. Rimm
• 1221 · PDF Imaging mass cytometry of pelareorep treated early breast cancer samples reveals developing tertiary lymphoid structures Julian P. Olea, Homa Dadrastoussi, Kaijin Wu, Harley Wu, Paniz Zarand, Claudia Villa Celi, Jennifer S. Carew, Steffan T. Nawrocki, Xuelian Chen, Richard Trauger, Thomas C. Heineman, Kevin R. Kelly
• 1222 · PDF Spatial transcriptomics of trastuzumab deruxtecan-treated metastatic breast cancer identifies candidate response and resistance factors Charles J. Robbins, Mengni He, Julia Benanto, Thazin Nwe Aung, Yalai Bai, Ian E. Krop, David L. Rimm
• 1223 · PDF Spatial transcriptomics identifies a suppressive T-cell excluded tumour microenvironment in extramedullary multiple myeloma Nicholas E. Bingham, Julie R. Boiko, Daniel C. Jones, Daniel Wong, Tiffany Khong, Sridurga Mithraprabhu, Kathleen S. Ensbey, Anna E. Elz, Evan W. Newell, Andrew Spencer, Geoffrey R. Hill
• 1224 · PDF Antibody-drug conjugate immuno-oncology panel for comprehensive characterization of the tumor and associated microenvironment Sandra F. Lam, Kevin Gallagher, Maryam Rohafza, Courtney Todorov, Harry Nunns, Marianne Thio, Flora Sahafi, Kathy Pham, Victoria Gomez, Erinn A. Parnell, Qingyan Au
• 1225 · PDF 3D spatial multiomics characterization of ovarian cancer tissue samples Lena Nolte, Diogo Bessa-Neto, Salpy Baghdo, Bernadett Szabó, Fabio El Yassouri, Emily Neil, Robert Pinard, Werner Müller, Dominik Eckardt, Christoph Herbel, Andreas Bosio

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