Microbiome, Inflammation, and Response to Immunotherapy in Cancer

• 2861 Comparative genomics of gut commensal Lachnospiraceae and their associations with cancer treatment response with immune checkpoint inhibitors Shiva Jahanbakhshi, Amna Bibi, Rebecca Hoyd, Caroline Dravillas, Nyelia Williams, Shiqi Zhang, Aaditya Pallerla, Shankar Suman, Joseph Amann, Mounika Goruganthu, Tamio Okimoto, Yangyang Liu, Marisa A. Bittoni, Ni Shi, Alvin Anand, Bailey Conrad, Lane Nevers, Kristen Heitman, Maxine Webb, Elizabeth M. Grainger, Madison Grogan, Christian Quiles, Tong Chen, Carolyn J. Presley, Lang Li, Patrick Bradley, Yael Vodovotz, David P. Carbone, Steven K. Clinton, Jiangjiang Zhu, Daniel Spakowicz
• 2862 Dietary animal protein intake and progression-free survival (PFS) of patients (pts) with advanced urothelial cancer (UC) and renal cell carcinoma (RCC) on immune checkpoint blockade (ICB) Timothy B. Winslow, Ritesh Kotecha, Neha Ratna, David Gavrilov, Cihan Duzgol, Mahnoor Akhlaq, Min Yuen Teo, Ashley M. Regazzi, Samuel Funt, David H. Aggen, Scot Niglio, Maria Carlo, Daniel Lage, Neil Shah, Aditi Gupta, Darren F. Feldman, Martin H. Voss, Robert J. Motzer, Jonathan E. Rosenberg, Gopa Iyer, Brendan John Guercio
• 2863 · PDF Investigating the impact of metabolic endotoxemia on breast cancer risk and progression Lauren M. Moulden, Adam S. Wilson, Valerie S. Payne, Marissa M. Howard-McNatt, Katherine L. Cook
• 2864 Prebiotic fiber supplementation mitigates the effects of maternal obesity on offspring's gut microbiome and mammary tumorigenesis Seema Yadav, Fabia Andrade, Melike Ozgul Onal, Sydney Shirk, Sercan Kenanogly, Christopher Staley, Leena Hilakivi-Clarke
• 2865 Colorectal cancer-infiltrating bacteria promote the proliferation of cytotoxic lymphocyte populations endowed with antitumor properties Martina Villa, Julija Djordjevic, Elisa Sorrenti, Pedro Ventura, Davide Bressan, Antonino Cassotta, Caroline Junqueira, Fulvio Chiacchiera, Federica Sallusto, Dimitrios Christoforidis, Giandomenica Iezzi
• 2866 Host-microbe-epigenetic crosstalk: Dissecting the role of microbiome, immune dysregulation, and DNA methylation in squamous cell carcinoma Armando G. Licata, Cristina Gurizzan, Deborah Lenoci, Marta Lucchetta, Carlo Resteghini, Luigi Lorini, Rosalba Miceli, Paolo Bossi, Loris De Cecco
• 2867 Interaction between T-cell inflamed gene expression profile score and tumor-associated microbiome on colorectal cancer mortality in a heterogeneous patient population Claire Elizabeth Thomas, Hang Yin, Jeroen Huyghe, Nicole Catalina Lorona, Scott D. Labrie, Keith R. Curtis, Orsalem Kahsai, Sosun Nayemi, Ningxin Ma, Timothy Randolph, Conghui Qu, Sushma Thomas, Li Hsu, Amanda L. Koehne, Heather Green-Mantrana, Marc Matrana, James J. Tiesinga, William M. Grady, Diana Redwood, Christopher I. Li, Li Li, Riki (Ulrike) Peters, Jane C. Figueiredo, Timothy K. Thomas, Amanda I. Phipps, Meredith A. Hullar
• 2868 MaaT013 pooled fecal microbiotherapy improves gastrointestinal physiology and controls inflammation which delays GvHD in a proof-of-concept humanized mouse study Julie Reygner, Margaux De Seilhac, Cyrielle Gasc, Emmanuel Prestat, Charlotte Petitjean, Sophie Declomesnil, Carole Schwintner, Nathalie Corvaia, Sheri Simmons, Ernst Holler, Robert R. Jenq, Bastien Laperrousaz
• 2869 · PDF Maternal obesity promotes gut dysbiosis, CD4⁺ T-cell reprogramming and increased prostate cancer in offspring Fabia de Oliveira Andrade, Lu Jin, Melike Özgül Önal, Seema Yadav, Sercan Kenanoglu, Christopher Staley, Leena Hilakivi-Clarke
• 2870 Amino acid metabolic reprogramming drives doramectin-enhanced CD8⁺ T cell immunity and tumor control Sedigheh Taghinezhad-S, Amirhossein Mohseni, Vincenzo Casolaro, Zhongwei Lv, Dan Li
• 2873 · PDF Neurotensin suppresses anti-tumor immunity and is associated with poor prognosis in colorectal cancer Haoming Wu, Yang Wang, Dana Napier, Hong Jiang, Dong Li, Jing Li, B. Mark Evers
• 2874 PPARdelta overexpression in villin-positive gastric progenitor cells drive gastric tumorigenesis independent of helicobacter infection in mice Daoyan Wei, Yi Liu, James C. Yao, Imad Shureiqi, Xiangsheng Zuo
• 2875 Toll-like receptor 4 deletion promotes bacterial burden and cutaneous tumorigenesis in mice lacking one Ikkalpha allele in keratinocytes Deep Kumari Yadav, Amit Kumar Singh, Debra Tross, Yinling Hu
• 2877 · PDF The role of oral microbiota in pre-metastatic niche preparation in the brain Rene Nicolas Rico, Sarah B. Johnson, Vivian R. Orellana, Ashish V. Damania, Matthew C. Wong, Bharat B. Singh, Lon W. R. Fong, Brenda Melendez, Nadim J. Ajami, Jennifer A. Wargo, Golnaz Morad
• 2879 Intra-tumoral microbiota and host genotype cooperatively shape neutrophil antitumor activity in colorectal cancer Elisa Sorrenti, Valeria Governa, Davide Bressan, Nicolo' Formaggio, Bianca Calì, Camilla Basso, Martina Villa, Giuseppe Sconocchia, Klaus-Peter Janssen, Milo Frattini, Fulvio Chiacchiera, Jean-Philippe Theurillat, Sara De Dosso, Luigi M. Terracciano, Lubor Borsig, Giulio C. Spagnoli, Dimitrios Christoforidis, Giandomenica Iezzi
• 2880 · PDF Antibiotic driven microbiota disruption impairs HER2 targeted therapy efficacy Romina Elizabeth Araya, Lily Parker, Payal Mitra, Nofar Erlichman, Pavani Chalasani, Rong Li
• 2881 Interleukin-1 upregulates dual oxidase 2 expression and ROS production in human pancreatic cancer cells in a STAT1/STAT3-dependent manner David J. Mallick, Yongzhong Wu, Mariam M. Konaté, Becky A. Diebold, Smitha Antony, Jennifer L. Meitzler, Goujian Jiang, Jiamo Lu, Krishnendu K. Roy, James H. Doroshow
• 2882 · PDF The impact of high fat diet on tumor growth is dependent on fatty acid composition and tumor type Rebecca C. Simpson, Freya E. R. Edge, Jordan W. Conway, Hsin-Yi Tseng, Mirei Okada, Inah Camaya, Laura Smith, Akshaya Ramanathan, Oliver K. Fuller, Stewart W. C. Masson, Jessamy Tiffen, Georgina V. Long, Erin R. Shanahan
• 2883 Divergent gut microbial communities are linked to differences in baseline immune profiles, tumor features and ICI outcomes in melanoma Rebecca C. Simpson, Ines Pires Da Silva, Jayden Beckwith, Irene L. M. Reijers, Judith M. Versluis, Camelia Quek, Alexander M. Menzies, Gonzalez Maria, James S. Wilmott, Christian U. Blank, Richard A. Scolyer, Erin R. Shanahan, Georgina V. Long
• 2884 · PDF Defined bacterial consortium highlights the impact of carcinogenic bacteria on DNA methylation and tumorigenesis Siddhi Chitre, Claudia Mercado-Rodriguez, Anthony Pompetti, Pyounghwa Park, Raad Z. Gharaibeh, Jean-Pierre Issa, Christian Jobin
• 2885 Intron retention marks a myeloid‑skewed immune desert and nominates an ICI nonresponse marker in H. pylori -positive gastric cancer Daisuke Takayanagi, Junya Kitadani, Masahiro Katsuda, Toshiyasu ojima, Keiji Hayata, Manabu Kawai, Sinichi Hashimoto, Kazuhiko Tagawa, Toru Sugino, Satoshi Wada, Hiroki Yamaue, Takuya Tsunoda
• 2886 · PDF Microbiota-driven modulation of tumor growth in Li-Fraumeni Syndrome: Evidence for bile acids as a key mediator Noel W. Y. Ong, Camilla Giovino, Nicholas Fischer, Paula Rosanna Quaglietta, Ashby Kissoondoyal, David Malkin

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