RTK-ERBB-PI3K and New Targets in Therapeutic Resistance

• 3294 · PDF Cell-Autonomous EPHB2 signaling sustains neuroendocrine prostate cancer Xinyao Pang, Mingchen Shi, Dong Lin, Adam Classen, Hui Xue, Xin Dong, Rebecca Wu, Zoe Maylin, Ning Kang, Yen-Yi Lin, Yu Wang, Wei Dong, Martin E. Gleave, Colin Collins, Christopher J. Ong, Yuzhuo Wang
• 3295 · PDF Pi3k autoinhibition dictates rras2 dependency across HER2-amplified and PI3K-mutant cancers Miranda R. Cabanski-Dunning, Matthew J. Sale, Lucy C. Young, Maria Tarazona-Guzman, Dylan Aguinaldo, Madeleine Sitton, Rony Andre Francois, Frank McCormick
• 3296 The receptor-like protein tyrosine phosphatase PTPRH modulates dephosphorylation of the tyrosine kinases EPHA2 and EGFR, alters cell morphology and adhesion, and behaves as a tumor-suppressor in non-small cell lung cancer cell Mylena Ortiz, Deeya Patel, Jesus Garcia-Lerena, Andrew C. Nelson, Matthew Swiatnicki, Eran Andrechek
• 3297 · PDF HER2 overexpression confers osimertinib resistance in EGFR-mutant lung cancer Gaku Yamamoto, Yu Tanaka, Miku Tsukuda, Sato Sayaka, Saori Matsui, Tetsuya Sakai, Hiroki Izumi, Eri Sugiyama, Yoshitaka Zenke, Shigeki Umemura, Kiyotaka Yoh, Koichi Goto, Hibiki Udagawa
• 3298 Preclinical development of TJ106, a potent biparatopic dual payload ADC targeting HER2 for the treatment of Enhertu-resistant tumors Siyi Hu, Mao Huang, Xiaobo Cai, Shugaku Takeda, Li Qi, Yangxin Zhang, Haiyan Wu, Yan Zhang, Yanli Mao, Zhaoyuan Chen
• 3299 · PDF Autocrine lymphotoxin signalling promotes ovarian tumor growth through CD74 Tat San Lau, Yi Shun Wong, Maciej Jakub Trybull, Kit Ying Loucia Chan, Ho Sze Jacqueline Lee, Chi Chiu Wang, Joseph Kwong
• 3300 · PDF Targeting OSMR signaling networks for precision oncology Pradeep Chaluvally-Raghavan
• 3301 TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma Anh Tuan Vuong, Aniket S. Joshi, Anirban Roy, Kavya Mathukumalli, Phuong T. Ho, Raksha Bhat, Meiricris Tomaz da Silva, Tagari Samanta, Meghana Trivedi, Bin Guo, Benny A. Kaipparettu, Ashok Kumar
• 3302 · PDF Phosphorylation of StarD10 regulates ErbB2-mediated alcohol-induced breast cancer progression Manisha Dagar, Youngyi Lim, Swati Chandla, Monica Justo, Nirmala Mavela, Komal Ramani, Maria Lauda Tomasi
• 3303 · PDF Investigating the impact of HER4 mutations on HER2 signaling Denis M. Collins, Marta Valenti, Johanna Gaubatz, Debbie O'Reilly, Birgit Bossenmaier, Bryan Hennessy, John Paul Crown
• 3304 · PDF beta , beta -dimethylacrylalkannin inhibits colorectal cancer growth in vitro and in vivo by targeted FGFR1 Ran Zhao, Fanxiang Yin, Kangdong Liu, MeeHyun Lee, Zigang Dong
• 3305 Biochemical and cellular evaluation of HUNK inhibition by an FDA approved drug as potential therapeutic strategy for HER2+ breast cancer Safnas Farwin AbdulSalam, Mia M. Eason, Shuguang Liang, Alison Goupil, Anthony Acinapura, Maia Dominguez, Peter Gallagher, Yuan Wang, Jianghong Wu, Haiching Ma
• 3306 · PDF The role of DDR1 ectodomain shedding in glioblastoma radiation resistance Sophia Dunlap, Caitlin A. Harvey, Christopher D. Willey, Ahn Erin
• 3307 · PDF CD99 homophilic signaling between tumor-associated macrophages and glioblastoma cells regulates response to immunotherapy Tongchao Jiang, Zilu Huang, Nan Li, Haishuang Sun, Tongcui Jiang
• 3308 · PDF NRG1/HER3 axis drives therapy resistance in head and neck squamous cell carcinoma: Evidence from patient-derived xenografts Anna Francia, Cinzia Girone, Boobash-Raj Selvadurai, Daria Maria Filippini, Giulia Querzoli, Matteo Fermi, Achille Tarsitano, Federica Pagano, Davide Zilio, Paola Cecchi, Andrea Ardizzoni, Yosef Yarden, Mattia Lauriola, Donatella Romaniello
• 3309 · PDF Daple-FLT3 gene fusion activates and localizes through a distinct mechanism from FLT3-ITD Darren Kao, Michael Acquazzino, Arnel Ibarra, Elena Valenzuela, Haley Mai, Kimberly Aguilar, Elliot Stieglitz, Jason Ear
• 3310 · PDF UCHL1 deubiquitinates CIP2A to promote tumor progression in gastric cancer Lee Ga-ye, In-ho Jeong, Peter CW Lee
• 3311 · PDF Autologous colorectal cancer-mesothelial co-culture model identifies stromal FGFR3 dependency driving peritoneal dissemination Hiroaki Kasashima, Yasuhiro Fukui, Iguru Omori, Zizhou Wang, Nobuhiro Naito, Yukina Kusunoki, Kenji Kuroda, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Masakazu Yashiro, Yuki Nakanishi, Naoko Ohtani, Kiyoshi Maeda
• 3312 · PDF FLT4-mediated ferroptosis resistance in renal cell carcinoma Djazia Haferssas, Nathalie Henley, Jonatan Barrera Chimal, Casimiro Gerarduzzi
• 3313 · PDF BAP1 stabilizes BIRC5 to promote chemoresistance in gastric cancer Park Yu-Jin, In-ho Jeong, Peter CW Lee
• 3314 · PDF RIPK2 promotes metastatic behavior in inflammatory breast cancer and is an attractive therapeutic target Innocent Ojobile, Alaa Zare, John M. Githaka, Einav Renert, Lynne-Marie Postovit
• 3315 · PDF CYLD regulates thrombin-induced p38-p65 signaling to inhibit breast cancer progression Julio Macias Pimentel, Naa-Oye Bosompra, JoAnn Trejo
• 3316 · PDF The mystery behind mSin1 phosphorylation Samira Mahmoudi, Bing Cheng, Yan Luo, Lei Liu, Shile Huang
• 3317 · PDF ICA-1S and Selinexor decreases atypical teratoid rhabdoid tumor (ATRT) survival and proliferation Nuzhat Nowshin Oishee, Abigail Oluwafisayo Olatunji, Abiral Hasib Shourav, Grazielly Teodoro, Anna Kharitonova, Mildred Acevedo-Duncan
• 3318 · PDF The regulation of IL-6/gp130 signaling by PTPRF in colon cancer Haley Stanczyk, Carolina Galeano-Naranjo, Tianyan Gao
• 3319 · PDF IL-1 beta/ IL-6 co-stimulation synergistically mediates DUOX2/DUOXA2 complex up-regulation via JAK/STAT and p38 signaling events Jennifer L. Meitzler, Becky A. Diebold, David J. Mallick, Yongzhong Wu, Smitha Antony, Mariam M. Konaté, Krishnendu Roy, James H. Doroshow
• 3321 · PDF Validating upstream kinase predictions by linking activity to drug target proximity Dóra Schuller, Gitanjali Dharmadhikari, Monique Mommersteeg, Liesbeth Houkes, Simar Pal Singh, Rik de Wijn
• 3322 Next-Generation FemtoQuest™ system enables dual-analyte ultrasensitive quantitation of active and total HGF in melanoma plasma samples Joseph B. Hwang, Raad Gitan, Matthew Lippold, Brooke Gilliam, Rick Wiese

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