Epigenetic Changes as Molecular Markers of Cancer

• 3191 · PDF Loss of SMYD5 downregulates proliferative signaling pathways in B cell acute lymphoblasticleukemia Brunna Letícia Oliveira Santana, Mariana Braccialli de Loyola, Brenno Vinicius Martins Henrique, Ana Cristina Moura Gualberto, Fabio Pittella-Silva
• 3192 Genome-wide DNA methylation profiling reveals distinct epigenetic landscapes and novel biomarkers in estrogen receptor-positive and -negative breast cancers Dalma Müller, Balazs Gyorffy
• 3193 · PDF Secreted BRAF V600E drives ADAR1-dependent RNA editing and defines a therapeutic vulnerability in colorectal cancer Toshiaki Takahashi, Kunitoshi Shigeyasu, Kazuya Moriwake, Masashi Kayano, Hibiki Umeda, Kazuhiro Yoshida, Sho Takeda, Yuki Matsumi, Hiroyuki Kishimoto, Tomokazu Fuji, Kazuya Yasui, Hideki Yamamoto, Kosei Takagi, Hiroyuki Michiue, Yoshiko Mori, Fuminori Teraishi, Hiroshi Tazawa, Yuzo Umeda, Ajay Goel, Toshiyoshi Fujiwara
• 3194 · PDF SETD4 regulates cell proliferation and methotrexate response in pediatric acute lymphoblastic leukemia Mariana B. de Loyola, Ana Cristina Moura Gualberto, Brunna Santana, Fabio Pittella-Silva
• 3196 · PDF MPP8 inhibits PRKN signaling through interactions with SIRT1 and ZEB1 to promote bladder cancer proliferation and metastasis Stephany Gonzalez Tineo, Ryan M. Kemper, Surya K. Tripathi, Daniel J. Crona
• 3197 · PDF PROMISE, a clonal promoter methylation signature capturing early epigenetic evolution and prognostic programs across epithelial cancers Francisco Gimeno-Valiente, Constantino De La Vega, Yun-Hsin Liu, Carla Castignani, Ieva Usaite, Martín Arana Jorge, Elrick Hillary, Stephan Beck, Miljana Tanic, Jonas Demeulemeester, Peter Van Loo, Charles Swanton, Mariam Jamal-Hanjani, Nnennaya Kanu
• 3198 · PDF BAP1 loss rewires chromatin and lineage identity in uveal melanoma Daulet Aitymbayev, Emma Hammes, Lucinda Innes, Holy Mary Zaher, Juan Martinez Villalobos, Arnaud Augert, Mathieu Bakhoum
• 3199 · PDF Investigating gene regulatory mechanisms associated with B-cell acute lymphoblastic leukemia incidence in Hispanic/Latino populations Clarissa Garcia, Julian Grandvallet Contreras, Tzu Phang, Matthew T. Witkowski
• 3200 WREm6A Prism: Single-cell sequencing of m6A methylation expression signatures and its clinical translation in esophageal squamous cell carcinoma Yuan Li, Zhuya Xiao, Qian Mo, Qian Wang, Caiyutian Zhang, Tian Tang
• 3201 · PDF Chromatin accessibility differentiates cancer associated fibroblast subtypes in pancreatic cancer Minh Duc Pham, Chang-Il Hwang, Kedi Huang
• 3202 · PDF RNA editing is the potential biomarker for carcinogenesis of Crohn's disease Kazuya Moriwake, Kunitoshi Shigeyasu, Masashi Kayano, Eiki Miyake, Yuhei Kondo, Yuya Sakurai, Shunsuke Nakamura, Masafumi Takahashi, Kaori Nitta, Nobuhiko Kanaya, Yoshitaka Kondo, Hiroshi Tazawa, Toshiyoushi Fujiwara
• 3203 · PDF Deciphering gene regulatory network and spatial heterogeneity underlying cutaneous T cell lymphoma large cell transformation Xiaofei Song, Jennifer M. Garbarino, COLIN NG, Lucia Seminario-Vidal, Carly M. Harro, Jodi A. Balasi, Chaomei Zhang, Nan Sun, Douglas C. Marchion, Sean J. Yoder, Jose R. Conejo-Garcia, Pei-Ling Chen
• 3204 DNA methylation profiling in ethnically diverse prostate tissues to identify novel biomarkers predicting prostate cancer progression Claire A. Stevens, Leonardo Gonzalez-Smith, Colton Stensrud, Divya Ranjith, Jenaye Mack, Sarah Buxbaum, Sara Falzarano, Suhn K. Rhie
• 3205 Single cell DNA methylation of early breast cancer reveals epigenomic response to driver mutations and unique signatures of progression and invasion Ryan Mulqueen, Xiang Li, Mariam Mosaad, Shanshan Bai, Jianzhuo Li, Emi Sei, Savitri Krishnamurthy, Alastair Thompson, Nicholas E. Navin
• 3206 · PDF Unraveling novel epigenetic therapies for the treatment of TP53 WT glioblastoma Laurence Haddadin, Shuo Zhang, Mansi Solanki, Bin Lu, Xueqin (Sherine) Sun
• 3207 · PDF SNP rs4381241 promotes renal cell carcinoma progression via the FAF1-HDAC3-PDGFB axis Haodong Liu, Xinru Yu, Zeyun Mi, Kexin Chen
• 3209 Enzymatic enrichment of unmethylated cell-free DNA improves the sensitivity of fragmentomic analysis for the diagnosis of patients with lung cancer Valentina Miano, Paulina Siejka-Zielińska, Calum Mould, Sean Knight, Seamus Grundy, Robert K. Neely
• 3210 · PDF Epigenomic liquid biopsy molecular lung subtyping and real-world (RW) patient outcomes in advanced NSCLC (aNSCLC) Jayati Saha, Nicole Zhang, Sheila R. Solomon, Shaun Forbes, Matthew Ellis
• 3211 · PDF A novel workflow for ultra short cfDNA fragmentomics and multiomic profiling in liquid biopsies Xiaojing Yang, Madison Valle, Duang Ratanachan, Kaitlyn Lee, Neeti Swarup, Irene Choi, Hanjun Kim, David T. Wong
• 3212 Enhancing the detection of circulating tumor DNA by combining Interlace™ global methylation discovery with next-generation sequencing test Labcorp Plasma Complete™ Kimberly A. Holden, Cynthia Maddox, Calum Mould, Nana Mensah, Luca Tosti, Iwo Pieniak, Paulina Siejka-Zielinska, Stephen Evans, Debora Lucarelli, Robert Neely, Anthony Smith, Kenneth C. Valkenburg, Marcia Eisenberg, Brian Caveney, Eric Severson, Taylor J. Jensen, Shakti Ramkissoon, Jonathan Williams
• 3213 · PDF Utility of TAPS+: a positive-readout methylation sequencing approach for high-fidelity epigenetic profiling Kimberly A. Holden, Kerry D. Fitzgerald, Adib Shafi, Ashraf Shabaneh, Dennis D. Krutkin, Tong Liu, Eyad Almasri, Graham McLennan, Nathan Faulkner, Craig Marshall, Travis Sanders, Thomas Harrison, Eduard Casas, Kristina Giorda, Doug Wendel, Brian Kudlow, Shakti Ramkissoon, Marcia Eisenberg, Brian Caveney, Eric Severson, Taylor J. Jensen, Jonathan Williams
• 3214 · PDF Dysregulation of the RNA modification m6A promotes cancer progression and provides therapeutic opportunities Gudrun Stengel, Zachary Miles, Eric Davis, Byron Purse

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