Genetic Epidemiology 1: GxE, GWAS, Polygenic Risk Scores, and Post-GWAS

• 3583 · PDF Distinct breast cancer gene signatures by estrogen receptor status associated with psychological distress Shipra Gandhi, Sayeeda Yasmeen, Spencer Rosario, Wiam Bshara, Thaer Khoury, Hans Minderman, Orla Maguire, Zhihong Gong, Ayana T. Ruffin, Megan Meek Wyatt, Mahmoud Abdelbary, Chrystal Mary Paulos, Elizabeth Repasky, Pawel Kalinski, Christine Ambrosone, Song Yao, Chi-Chen Hong
• 3584 Characterizing polygenic risk scores for cancer in prospective cohorts: Considering PRS method construction, age of diagnosis, genetic ancestry, and sample overlap Julie-Alexia Dias, Gillian King, David Bogumil, Brian Huang, Fei Chen, David V. Conti
• 3585 A body mass index polygenic risk score (PRS BMI ) and obesity-related cancer risk among women in the Hispanic Community Health Study/Study of Latinos Humberto Parada, Tamar Sofer, Margaret Pichardo, Krista M. Perreira, Laura Zhou, Frank J. Penedo, Amber Pirzada, Martha Daviglus, Gregory A. Talavera, Linda C. Gallo
• 3586 · PDF Validation and population projection of multi-cancer risk incorporating polygenic risk scores and non-genetic factors Emily L. Norton, Thomas Ahearn, Srijon Mukhopadhyay, Jeya Balasubramanian, Elle Kim, Sara Li, Parichoy Pal Choudhury, Montserrat García-Closas, Nilanjan Chatterjee
• 3587 Independent validation of polygenic risk scores for overall and triple-negative breast cancer among high-risk African American women Yijia Sun, Timothy Simmons, James L. Li, Armaan Jamal, Achille V.C. Manirakiza, Dmitry Pruss, Sarah Ratzel, Olufunmilayo I. Olopade, Alexander Gutin, Elisha Hughes, Dezheng Huo
• 3589 Ancestry-driven transcriptional regulation of breast cancer genes through cis- and trans-eQTLs in colombian populations Laura Rey-Vargas, Lina María Bejarano, Patricia López, Diego Felipe Ballen-Lozano, Silvia Juliana Serrano-Gomez
• 3590 · PDF Genetic and immune signaling divergence underlies the inverse associationbetween asthma and cancer Kinsey Garofalo, Yinqiao Wang, Peyton Cook, Yujuan Guo, Yong Zhu
• 3591 Incorporation of polygenic risk scores with PSA testing for prostate cancer risk stratification in men undergoing prostate biopsy Daniel Sabater Minarim, Roshan Karunamuni, Kylie M. Morgan, Tyler Nelson, Craig Teerlink, Julie Lynch, Isla P. Garraway, Anna M. Dornisch, Tyler M. Seibert, Jason L. Vassy, Brent S. Rose
• 3592 · PDF Mitochondrial DNA breaks and copy number and the risk of lung cancer in never-smoking women Batel Blechter, Xiao-Ou Shu, Wei Hu, Elizabeth Francies, Wei Zheng, Yu-Tang Gao, Qiuyin Cai, Hui Cai, Gong Yang, H. Dean Hosgood, Richard Cawthon, Qing Lan
• 3593 Associations of BRCA1/2 mutations and polygenic risk score with prostate cancer risk and mortality in a founder population Ilir Agalliu, Mykhaylo Usyk, Michael D`Angelo, Victor Kamensky, Robert Burk
• 3594 Adrenal-permissive HSD3B1 genotype and prostate cancer-specific mortality among patients: Insights from the multiethnic cohort Study Wei Xiong, Xin Sheng, Peggy Wan, Lynne R. Wilkens, Loïc Le Marchand, David V. Conti, Christopher A. Haiman, Fei Chen
• 3596 Characterizing BRCA1 and BRCA2 mutations in Cameroonian breast cancer patients: Efforts towards bridging the genomic gap in Africa Kenn Chi Ndi, Berthe Sabine Esson Mapoko, Vanessa Mouaye, Carmen Vanvolkenburgh, Bonaventure Dzekem, Paul Ndom, Dezheng Huo, Olufunmilayo I. Olopade
• 3597 · PDF Defining cancer risk germline variants in shelterin complex genes - a genome-first analysis Hasset Nurelegne, Akanksha Nagarkar, Jung Kim, Douglas Stewart, Sharon Savage, Kelvin C. De Andrade
• 3598 · PDF Investigating divergent ER + and ER - breast cancer subtype risks by using oppositely associated genetic variants Phillip Schofield, Meghana Pagadala, Timothy Sears, Hannah K. Carter
• 3599 MYC exon 3 DNA methylation in peripheral blood and the risk of aggressive prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial Patricia A. Erickson, Lauren M. Hurwitz, Søren M. Bentzen, Stella Koutros, Liying Yan, Matthew L. Poulin, Ann Meyer, Allen Burke, Arif Hussain, Sonja I. Berndt, Kathryn Hughes Barry
• 3600 Pan-cancer genome-wide study reveals shared genetic architecture and novel pleiotropic variants across seven solid cancers Xunxuan Chen, Gamaliel T. Taengwa, Brandon J. Coombes, Stacey J. Winham
• 3601 Multi-population GWAS meta-analysis identifies novel bladder cancer susceptibility loci and highlights the genetic regulation of smoking-related risk Ludmila Prokunina-Olsson, Oscar Florez-Vargas, Michael G. Levin, Diptavo Dutta, Charles Breeze, Lauren M. Hurwitz, Wusheng Yan, Philippe Lamy, Brenen Papenberg, Kevin Wang, Chia-Han Lee, Roger L. Milne, Jian Gu, Caroline Y. Um, Vijai Joseph, Helena Furberg, Florence Le Calvez-Kelm, Chikashi Terao, Koichi Matsuda, Francisco X. Real, Lambertus A. Kiemeney, Stephen J. Chanock, Núria Malats, Debra T. Silverman, Lars Dyrskjøt, Nathaniel Rothman, Scott M. Damrauer, Stella Koutros, Jeffrey S. Damrauer
• 3602 Genome-wide association study of mantle cell lymphoma identifies novel loci suggesting a critical role for B-cell chromatin readers and DNA repair mechanisms Charles E. Breeze, Alyssa Clay-Gilmour, Hanla A. Park, Ólafur B. Davíðsson, Angelica Macauda, Brenda M. Birmann, Elizabeth E. Brown, Murat Güler, Michelle A. T. Hildebrandt, Alexandra Nieters, Krystle Ong, Jojo Biel-Nielsen Dietz, Karin E. Smedby, Karl Smith-Byrne, Rosalie Griffin, Sophia S. Wang, Susan Slager, James R. Cerhan, Jonathan N. Hofmann, Qing Lan, Nathaniel Rothman, Ingrid Glimelius, Henrik Hjalgrim, James Mckay, Sonja I. Berndt
• 3603 · PDF Implications of multiple myeloma polygenic risk scores (PRS) for MGUS Alyssa Ione Clay-Gilmour, Angelica Macauda, Cristine Allmer, Danelle Moonen, Aaron D. Norman, Nicholas Boddicker, Janet E. Olson, Elizabeth E. Brown, Vincent S. Rajkumar, Esteban Braggio, David Murray, Susan Slager, Shaji Kunnathu Kumar, Celine Vachon
• 3604 Prostate cancer risk variants regulate oncogenes by activating enhancers and forming multi-connected enhancer-promoter hubs at different stages of prostate cancer Zexun Wu, Andrew Vu, Matthew Salcedo, Suhn K. Rhie
• 3605 · PDF Genetic insights into metabolic traits and prostate cancer susceptibility: A two sample Mendelian Randomization study HWA SUN KIM, Chung-woo Lee
• 3606 · PDF Identification of survival-associated germline variants in hepatocellular carcinoma Younghun Han, Jinyoung Byun, Lewis R. Roberts, Katherine A. McGlynn, Manal M. Hassan, Christopher I. Amos
• 3607 Tissue-based proteome-wide association study identifies novel risk proteins and candidate drug targets for colorectal cancer Qing Li, Timothy Su, Chao Li, Quanhu Sheng, Shuai Xu, Wanqing Wen, Qi Dai, Martha J. Shrubsole, Jirong Long, Qiuyin Cai, Bing Zhang, Xioa-Ou Shu, Bhuminder Singh, Ken S. Lau, You Chen, Yuankai Huo, Zhijun Yin, Stephen B. Gruber, Riki (Ulrike) Peters, Victor R. Moreno, Wei Zheng, Xingyi Guo
• 3608 Multi-ancestry methylation-wide association analyses identifies putative risk methylation markers for breast cancer Shuai Xu, Jiajun Shi, Y-Thanh Lu, Guochong Damon Jia, Fei Ye, Qiuyin Cai, Jirong Long
• 3609 · PDF Identification of miRNA-related SNPs associated with kidney cancer in the Korean population Jung-Hee Lee, Minsun Jung, Sun Ha Jee
• 3610 · PDF Estrogen receptor-mediated pharmacogenomic eQTLs as predictors of endocrine therapy response in breast cancer Martin Meng, Huanyao Gao, August John, Arnab Ghosh, Shreya Indulkar, Liewei Wang
• 3611 · PDF Cell-type aware transcriptome-wide association study of mammographic density phenotypes Joseph H. Rothstein, Adriana Sistig, Sinan Zhu, Tejomay Gadgil, Li Shen, Stacey E. Alexeeff, Ninah Achacoso, Lori C. Sakoda, Vignesh A. Arasu, Laurie R. Margolies, Robert J. Klein, Laurel A. Habel, Xiaoyu Song, Pei Wang, Weiva Sieh

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