Pediatric Cancer Genomics and Epigenomics

• 3486 · PDF Elucidating the role of ecDNA in treatment resistance and immune evasion within pediatric medulloblastoma Meenakshi Singhal, Joy Ku, Kun Wang, Rohit Bhargava
• 3488 · PDF Advancing pediatric tumor subtype classification on the pediatric cancer (PeCan) knowledge base by integrating molecular and morphology data Stephanie Sandor, Delaram Rahbarinia, Yuan Feng, Ramzi Alsallaq, Van L. Nguyen, Daniel K. Putnam, David Finkelstein, Jinman Park, Bo Wang, Jobin Sunny, Jian Wang, Sue Qiu, Michael Edmonson, Robert Greenhalgh, Meghann Kirk, Ira Baranova, Stephen V. Rice, Abbas Shirinifard, Hoaran Chen, Ali F. Pour, Clay McLeod, Lu Wang, Jeffery Klco, Brent Orr, Michael Dyer, Xiang Chen, Xiaotu Ma, Michael Rusch, Jinghui Zhang
• 3489 · PDF EWSR1::WT1 fusion oncoprotein and the androgen receptor shape the biology of desmoplastic small round cell tumors Danh Truong, Emre Arslan, Veena Kochat, Jiaqian Fan, Diana Shamsutdinova, Davis Ingram, Kevin Murgas, Clement Agyemang, Roberto Cardenas-Zuniga, Asmaa G. Ahmed, Justin Magrath, Alexander Lazar, Najat Daw Bitar, Sean B. Lee, Andrea Hayes-Dixon, Kunal Rai, Joseph A. Ludwig
• 3490 · PDF Preservation and clonal behavior of extrachromosomal DNA in patient-derived xenograft models of childhood cancers Rishaan Kenkre, Jon D. Larson, Owen Chapman, Jens Luebeck, Yan Yeun Lo, Paul Megan, Wenshu Zhang, Vineet Bafna, Robert Wechsler-Reya, Lukas Chavez
• 3491 · PDF Epigenetic regulation of the RAB5B GTPase expression in B-cell acute lymphoblastic leukemia Katarina Dovat, Yali Ding, Daniel Bogush, Rabab Husain, Ryan Chingakham, Dhimant Desai, Sinisa Dovat
• 3492 · PDF Targeting ALKBH5 mediated ChREBP signaling impairs cancer stem cell metabolism and tumor growth in medulloblastoma Panneerdoss Subbarayalu, Daisy Medina, Prabhakar Pitta Venkata, Shahad Abdulsahib, Saif Nirzhor, Santosh Timilsina, Deepika Singh, Phat Do, Desiree Denman, Krishna Priya Evani, Dhiya Billa, Meera Nair, Esha Reddy, Yogesh Gupta, Peter Houghton, Yidong Chen, Suryavathi Viswanadhapalli, Gangadhara R. Sareddy, Andrew Brenner, Ratna K. Vadlamudi, Manjeet Rao
• 3493 UltraFast whole genome sequencing enables personalized treatments in childhood cancers Aditi Vedi, Jamie Trotman, Joao Dias, Martina Mijuskovic, Sera Choi, Laura Kingham, Rachel Moore, Sarah M. Leiter, Rowena Guermech, Amanda Semerene, Aviva Grisby, Sophie Wool, Victoria Joslin, Zoya Kingsbury, Mark Ross, David Bentley, Sam Behjati, Sean Humphray, Patrick Tarpey, David Rowitch
• 3494 · PDF Epigenetic landscape and gene regulation in embryonal brain tumors with multilayered rosettes Shanzheng Wang, Sander Lambo, Monika Mauermann, Phylicia Stathi, Robert Autry, Natalie Jäger, Stefan M. Pfister, Marcel Kool
• 3495 · PDF Characterizing the MYC-induced immunopeptidome Jack Faulkner, Anwesha Dasgupta, John R. Prensner
• 3496 · PDF Epigenetic repurposing by CBFA2T3-GLIS2 reveals a druggable DNA methylation axis in high-risk pediatric AML vulnerability in pediatric AML Samrat Roy Choudhury, Arundhati Chavan, Rhonda E. Ries, Giselle Almeida Gonzalez, Soheil Meshinchi, Jason E. Farrar
• 3497 · PDF Comprehensive analysis of genomic landscape of ultra-rare pediatric malignant rhabdoid tumors Elizabeth Rasmussen, Elena Mironova, Dias Kurmashev, Kendra Maaß, Stefanie Volz, Zhao Lai, Stefan M. Pfister, Yidong Chen, Raushan Kurmasheva
• 3498 · PDF Improving the utility of the single-cell pediatric cancer atlas through updated cell type annotations, CNV inference, and visualization tools Allegra G. Hawkins, Joshua A. Shapiro, Stephanie J. Spielman, David S. Mejia, Deepashree Venkatesh Prasad, Nozomi Ichihara, Arkadii Yakovets, Avrohom M. Gottlieb, Kurt G. Wheeler, Chanté J. Bethell, Steven M. Foltz, Jennifer O'Malley, Casey S. Greene, Jaclyn N. Taroni
• 3499 · PDF BRD9 functions as a negative regulator of GBAF in synovial sarcoma Jinxiu Li, Mary Nelson, Li Li, Xiaobo Xia, Christine Stephan, Katarzyna Modzelewska, Gary Yu, Iain Mulford, Honnappa Srinivas, Xinyi Ge, Sarah McCollum, Ewin R Jones, Yixuan Guo, Xi Chen, Thomas Zoller, Gregory Hollingworth, Ensar Halilovic, Tinya J. Abrams, Edmund Harrington, Sofia Gkountela, Giorgio Galli, Hans Voshol, Nathalie Carte, Jason Thomas, Xiaoyang Zhang, David Lum, Martin Hirst, Jeffery Yap, William Forrester, Bradley R. Cairns, Kevin Bruce Jones
• 3500 · PDF Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit Annika Gustafson, Stephanie Nance, Berkley Gryder, Noha A. Shendy, Lars Wick, Grace McKay-Corkum, K. Elaine Ritter, Stephen Connor Purdy, Arthur R. Wolin, Sheera R. Rosenbaum, Sabateeshan Mathavarajah, Nickerson A. Demelfi, Yueyang Wang, Yang Zhang, Mark W. W. Zimmerman, Anoop M. Kavirayani, John Hardin, Alexander LaVeck, Xiang Wang, Neekesh V. Dharia, Andrew Hong, Guillaume Kugener, Jesse S. Boehm, Jennifer Roth, Javed Khan, Francisca Vasquez, Kristin B. Artinger, Rui Zhao, David M. Langenau, Jun Qi, Kimberly Stegmaier, Heide L. Ford, Adam D. Durbin, Brian J. Abraham
• 3501 · PDF A critical dependency in Ewing sarcoma: PAX7 attenuates EWS::FLI1 activity at de novo microsatellite enhancers to maintain oncogenesis Caroline Fraser, Alex Belt, Andrew McFadden, Ian Davis
• 3502 · PDF Loss of histone 3 lysine 9 trimethylation drives recurrence in high-risk pediatric medulloblastoma John DeSisto, Andrew M. Donson, Bethany Veo, Rajeev Vibhakar
• 3503 · PDF Somatic changes in Y chromosome copy number are associated with clinical and molecular features in neuroblastoma Teodoro Rivera-Wills, Preshita Dave, Esther Rheinbay
• 3504 · PDF Mithramycin analogues trap the EWS-FLI1 transcriptional complex, evict ETV6, and disable oncogenic condensate function in Ewing sarcoma Srijan Acharya, Rajesh Yetirajam, Yasuda Kazuto, Suhas Bhosale, Jurgen Rohr, Markos Leggas
• 3505 · PDF DNA methylation signatures of diet quality and treatment-related cardiotoxicity in childhood cancer survivors Yoonji Kim, Xiaoxi Meng, Kwangyeon Oh, Tuo Lan, Tiffany Eulalio, Heather L. Mulder, John B. Easton, Jinghui Zhang, Emily Walker, Geoffrey A. Neale, Deo Kumar Srivastava, Min Ni, I-Chan Huang, Stephanie B. Dixon, Gregory T. Armstrong, Melissa M. Hudson, Kirsten K. Ness, Yikyung Park, Zhaoming Wang

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