Therapeutic Modulation of the Tumor Microenvironment: New Targets and Approaches 1

• 3508 Glioblastoma treatment with multifunctional nanodrug inhibiting laminin-411 activates local immune response, increases survival of mice and reveals AI-selected immune molecular pathways Alexander V. Ljubimov, Rameshwar Patil, Vladimir A. Ljubimov, Hui Ding, Yizhou Wang, Sarah Song, Andrei A. Kramerov, Oksana Chepurna, Vanessa Borges, Jessica Dos Santos, Eggehard Holler, Julia Y. Ljubimova, Keith L. Black
• 3509 · PDF Targeting Spns2 induces immunogenic cell death and systemic anti-tumor immunity to suppress metastasis Han Gyul Lee, Wyatt Wofford, Alhaji H. Janneh, Paramita Chakarborty, Natalia Oleinik, Mohamed Faisal Kassir, Odai Darawshi, Neil Parikh, Stefano Berto, Kevin R. Lynch, Webster L. Santos, Özgür Şahin, Shikhar Mehrotra, Besim Ogretmen
• 3510 High-dose FcRH5xCD3 T-cell-engaging bispecific antibody (TCB) overcomes Treg-mediated suppression in-vitro in multiple myeloma Kai Lu, Darya Khantakova, Rin Nakamura, Kerstin Trunzer, Hyun Yong Jin, Elizabeth Punnoose, Elizabeth Germino, Katerina Hatzi
• 3511 Reprogramming the tumor microenviroment to halt metastasis: Akos targets metastatic cancer-associated fibroblast in solid tumors Valentina Cerda I, Benjamin Prieto, Muriel Nuñez, Daniela Barrera, Alexis Salas, Patricia Garcia, Enrique Brandan, Javier Cerda-Infante
• 3512 High-precision carbon ion radiotherapy elicits effective in-situ tumor vaccination and durable antitumor immunity Sarah Meister, Matilde Recusani, Maximilian Knoll, Ralph Sinn, Aoife Gahlawat, Jennifer Furkel, Michael Breckwoldt, Dirk Jäger, Jürgen Debus, Amir Abdollahi
• 3513 The novel lncRNA SEAL1 - key regulator of the pan-cancer myCAF cell state dictating prognosis ans immunotherapy response - is a promising new therapeutic target for solid cancers Emely Möller, Baroj Abdulkarim, Venkatesh Kancherla, Soumitra Ghosh, Sanne Schrevens, René Dreos, Kristen Gentry, Claire Roberts, Marco Mina, Rudi Micheletti, G. Paolo Dotto, Daniel Blessing, Samir Ounzain
• 3514 Histone deacetylase 9 (HDAC9) mediates therapy resistance by regulating tumor-neutrophil interaction in advanced hepatocellular carcinoma Yunong Xie, Minghe Zhang, Linglin Liu, Yimiao He, Jiahuan Cai, Clive Yik-Sham Chung, Leung Hoi Wing, Terence Kin-Wah Lee, Stephanie Ma, Ka-Fai To, Jingying Zhou, Carol Man Carol Tong
• 3515 Modulating pancreatic juice ENPP1-STING crosstalk to reprogram the tumor immune landscape in pancreatic cancer Sadaaki Nishimura, Jun Tauchi, Ryota Tanaka, Shigeaki Kurihara, Masahiko Kinoshita, Kohei Nishio, HIroji Shinkawa, Takeaki Ishizawa
• 3518 · PDF Role of sialic acid-siglec axis in pancreatic cancer immune evasion Barnita Haldar, Karin Hardiman, Susan Bellis
• 3519 · PDF PD-L2-RGMb interaction modulates anti-cancer immunity through swinging the shift of Th1/Th2 cell balance Siyi He, Xiaoyi Chong, Fangli Jiang, Xinru Hua, Chenlin Cao, Cheng Zhang, Xiaotian Zhang, Lin Shen
• 3520 · PDF New role for CDK6 activation in tumor-induced monocyte and platelet reprogramming in breast cancer Karen Norek, Jacob Kennard, Kenneth Fu, Robert Shepherd, Kristina Rinker, Olesya Kharenko
• 3521 Studying the mechanism of action and bystander effect of the GSK5764227 antibody-drug conjugate in patient-derived cancer organoids Maria Fankhaenel, Priya Narayanan, Halh Al-Serori, Veronika Yankova, Mint Htun, Elias Sulaiman, Barbara Seller, Irina Piven, Lena Wedeken, Anna Pasto, Tony NG
• 3522 Vitamin D (calcitriol) potentiates CB2-mediated anti-tumor responses in prostate cancer cell lines: Molecular mechanisms and therapeutic potential William B. Speed, Cimona Vaughn Hinton, Nakea Pennant
• 3523 Immunological roles of antigen-presenting cancer-associated fibroblasts and mesothelial cells in colorectal cancer Yasuhiro Fukui, Hiroaki Kasashima, Yukina Kusunoki, Nobuhiro Naito, Zizhou Wang, Iguru Omori, Yuki Seki, Kenji Kuroda, Yuichirou Miki, Mami Yoshii, Tatsurou Tamura, Masatsune Shibutani, Takahiro Toyokawa, Masakazu Yashiro, Yuki Nakanishi, Naoko Ohtani, Kiyoshi Maeda
• 3524 Exploring both targeted and untargeted (bystander) effects of GSK5764227 antibody‑drug conjugate in patient‑derived tumor explants (PDEs) Debayan Mukherjee, Jenny Wade, Morgan Heycock, Mint Htun, Benjamin Miller, Zeinab Mokhtari, Diana Munera, Anna Pasto, Paul Barber, Tony NG, Sue Griffin

在完整检索应用中浏览本分会场 →