Application of Bioinformatics to Cancer Biology 4

• 4121 Incorporation of cut-point robustness in the discovery and evaluation of molecular cancer biomarkers using SCRIBE (Survival Cut-point Reporting and Integrative Biomarker Evaluation) Miguel Lopez de Rodas Gregorio, Barani Kumar Rajendran, Javier Ramos Paradas, Carlos E. de Andrea, David L. Rimm, Hongyu Zhao, Kurt Alex Schalper
• 4122 · PDF Identification of molecular signatures in pancreatic ductal adenocarcinoma through multiomics Benjamin Miao, Tung-Shing Mamie Lih, Yingwei Hu, Hui Zhang
• 4123 Dissecting the baseline tumor microenvironment in mNSCLC by transcriptional profiling identifies tumor microenvironmental conditions predictive for immunotherapy response Lilian van Vlerken-Ysla, Arash Nabbi, Zhou Zhu, Ross Stewart
• 4124 · PDF Cancer stem cells and where to find them: Their trajectories and implications in cancer evolution Zixuan Lan, Philip Awadalla
• 4125 Goblet cell appendiceal adenocarcinoma is molecularly distinct from other histologic subtypes: Insights from large-scale genomic, transcriptomic, and organoid modeling Saikat Chowdhury, Ichiaki Ito, Samuel Rivero-Hinojosa, Chia-Mei Young, Eleanor A. Fallon, Beth A. Helmink, Taylor Neilson, Vasily Aushev, Sacha El Khoury, Abdelrahman MG Yousef, Mahmoud Mohamad Gamal Yousef, Shruti Sharma, Robert Lentz, Adham Jurdi, Paul F. Mansfield, Keith Fournier, Yuan-Hung Lo, Michael G. White, John Paul Shen
• 4126 · PDF Quantification of step-specific selection reveals ordered acquisition of driver mutations in colon cancer Kira A. Glasmacher, Jeffrey Peter Townsend
• 4127 · PDF Inferring transcriptomic programs from circulating tumor DNA methylation signatures in small cell lung cancer using RRBS and EM-seq Yuanxin Xi, Allison Stewart, Lixia Diao, Qi Wang, Li Shen, Runsheng Wang, Alberto Duarte, Alexa Halliday, Kavya Ramkumar, Robert Cardnell, Bingnan Zhang, Carl M. Gay, Lauren A. Byers, Jing Wang
• 4128 · PDF Proteomic signatures of tumorigenicity, immune evasion, and multidrug resistance in a murine T-cell lymphoma with CNS/ocular tropism Ori Braitbard, Jacob Hochman
• 4129 · PDF Spatial single-cell transcriptomic profiling reveals distinct immune and stromal landscapes across TIL/PD-L1-defined TNBC subtypes Kyungsoo Kim, Soong June Bae, Yoonjin Cha, Yoonwon Kook, Ah Yoon Kim, Jee Hung Kim, Sung Gwe Ahn, Joon Jeong
• 4130 Single-cell multi-omic characterization of gastric intestinal metaplasia reveals potential genetic, epigenetic and isoform signatures of lesions at high risk for GC progression Dongin Lee, Xiangqi Bai, Sue Grimes, Kyungtae Lee, Yan Wang, Charlotte Wong, Anuja Sathe, Ignacio Wichmann, Youlim Kim, Rithika Meka, Renee Long, Allison Im, Billy Lau, Robert Huang, Hanlee P. Ji
• 4131 · PDF Multi-omics characterization of PRMT5 inhibition identifies vulnerabilities for combination therapy in MTAP-deleted cancers Eliana Destefanis, Blanka Bordas, Jose C. Martinez, Samar Sayedyahossein, Samuel Moffitt, Enakireru M. Erhumuoghene, Daniel Dominguez, Kathleen M. Mulvaney
• 4132 Landscape of allele-specific expression in prostate cancer reveals recurrent, stage-specific events in AR signaling and resistance pathways Margaret Tsui, Kevin Hu, Hanbing Song, Sarah Hsu, Rebecca Chen, Lorraine Nuniz, Julia Pham, Chih-Hao Chang, Keliana Hui, David Quigley, Jingjing Li, Franklin Huang
• 4133 · PDF Single cell multi-omics enables molecular dissection of gastric cancer subtypes Junha Cha, Anuja Sathe, Yan Wang, Susan M. Grimes, Hanlee P. Ji
• 4134 A long-read sequencing and phylogenetic framework for improved detection and timing of overlapping and repetitive somatic structural variations Anton Goretsky, Yuelin Liu, Ayse Keskus, Tanveer Ahmad, Chi-Ping Day, Erin K. Molloy, Mikhail Kolmogorov
• 4135 · PDF Site-specific oral microbiome patterns in Puerto Rican head and neck cancer patients Gabriela N. García Quiñones, Jaleniz Suárez Pérez, Orlando Castro Ortíz, María Sánchez Vázquez, Jonathan Hernández Agosto, Filipa Godoy Vitorino, Magaly Martínez Ferrer
• 4136 · PDF Pan-cancer transcriptomic signatures of immune checkpoint blockade response and machine learning-based prediction across TIGER cohorts Junqing Zhang, Hongru Shen, Yajing Bi, Xiangchun Li
• 4137 The acidic tumor microenvironment facilitates colorectal cancer liver metastasis through LPL lactylation-mediated reprogramming of macrophage cholesterol metabolism Yifan Zheng, Zhengyu Wei, Zhengran Zhou, Peishan Hu
• 4138 Integrative computational and experimental analysis identifies carcinogenic effects of 1,4-Phenylenediamine in hepatocellular carcinoma via PI3K/AKT-MAPK and JAK/STAT signaling pathway Liuxian Ban, Ran Ding, ZhiQing Long
• 4139 · PDF Resource allocation deconvolution for pathway analysis Junhao Wang, Yifei Wang, Tianshu Michael Bao, Yong Li
• 4140 · PDF In silico analysis of Lacunae cornuta phytochemical against high-risk HPV targets Solomon Owumi, Esther M. Pius, Oluwaseun M. Owolabi, Ifeoluwa O. Alabi, Victor O. Eso, Sanusi A. Abdullah, Hikmah A. Abdulganiyu, Jesutosin O. Babalola, Chima Amadi, Chinedum Udekwu, Adegboyega K. Oyelere, E. Oluwabunmi Olapade-Olaopa, Olorunseun O. Ogunwobi
• 4141 Multimodal single-cell analysis of systemic immune remodeling induced by cytoreductive nephrectomy combined with immune checkpoint inhibitors in metastatic renal cell carcinoma Suebin Park, Byungjin Hwang
• 4142 · PDF Metabolic transition analysis from dormancy to awakening in breast cancer Javier Villela Castrejon, Herbert Levine, Jason T. George
• 4143 · PDF Integrative analysis of XPC and VEGFA as risk biomarkers in T-cell lymphoma: A case-control study Faten Awwad, Lama M. Bani Salameh, Laith N. AL-Eitan, Nour Abdo, Sohaib Al-Khatib
• 4144 · PDF Immunotherapy response predictors in colorectal cancer: A multi-omics approach Joaquin Pedro Merlo, Marco Adrian Scheidegger, Ada G. Blidner, Alejandro Cagnoni, Gabriel A. Rabinovich, Karina Mariño
• 4145 · PDF Genome-wide metabolic modeling identifies key modifiers of precancerous LUSC evolution Neel Sanghvi, Thomas Cantore, Chi-Ping Day, Sanna Madan, Nishanth Ulhas Nair, Eytan Ruppin
• 4146 · PDF Melanocytic transcriptional state is an independent marker of survival in metastatic melanoma Ziyin Huang, Kristen E. Rhodin, Rami Al-Rohil, Viviana Geron, Arul M. Chinnaiyan, Margaret H. O'Connor, Christina Vadala Angeles, Smita K. Nair, Georgia M. Beasley, Matthew K. Iyer
• 4147 · PDF CEDAR: A comprehensive database of curated cancer epitopes and receptors Zeynep Kosaloglu-Yalcin, Ibel Carri, Nina Blazeska, Randi Vita, Daniel Marrama, Hannah K. Carter, Morten Nielsen, Alessandro Sette, Bjoern Peters

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