Circulating Tumor Cells, Metastasis, and Dissemination Biology 1

• 1061 Tumor-informed circulating tumor DNA identifies high-grade serous ovarian cancer patients at highest risk for recurrence despite optimal first-line treatment with primary macroscopic complete resection Magdalena Postl, Christina Victoria Tauber, Valentina Glueck, Mira Maria Gliga, Nuria Segui, Karen Howarth, Miguel Alcaide, Lucia Oton, Gerda Hofstetter, Isabelle Maurer, Alexander Burges, Sven Mahner, Mirjana Kessler, Melina Danisch, Stephan Polterauer, Nicole Concin, Christoph Grimm, Fabian Trillsch
• 1062 Longitudinal monitoring of circulating tumor cells (CTC) reveals dynamic CTC behaviors associated with disease progression and survival in ALK-positive NSCLC Yuru Chen, Shamileh Fouladdel, Leah Kidder, Yuehang Tang, Harrison Ball, Habib Serhan, Zhaoping Qin, Albert Liu, Xu Cheng, Liwei Bao, Varun Kathawate, Larua Goo, Mary Horn, Stacy Fry, Aaron N. Hata, Justin Gainor, Jessica J. Lin, Stuart Hinton, Chao H. Huang, Nathan Merrill, Aaron M. Udager, Peter J. Ulintz, Angel Qin, Sofia Merajver, Sunitha Nagrath
• 1063 Serum neuron-specific enolase (NSE) as a biomarker of central nervous system (CNS) metastases: Updated results from the BrainStorm program (Oncodistinct 006) Soraia Lobo-Martins, Diogo Martins-Branco, Luca Arecco, Guilherme Nader-Marta, Andrea Gombos, Anthony Gonçalves, Eleonora Stephane de Maio D’Esposito, Philippe Barthelemy, Vincent Vanhaudenarde, Florian Clatot, Stéphane Holbrechts, Francois P. Duhoux, Edith Borcoman, Elisabeth Pop, Damien Parlier, Claire Cheymol, Joseph Gligorov, Hannelore Denys, Paul Clement, Caroline Duhem, Lore Decoster, Jean-Luc Canon, Nadège Kindt, Françoise Rothé, Ahmad H. Awada, Nuria Kotecki
• 1064 · PDF Novel approach of single-cell RNAseq analysis to assess cancer cells in prostate core biopsy specimens Dai Takamatsu, Kelly K. Chong, Gianna Jimenez, David Krasne, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon
• 1065 · PDF Mitosis in circulating tumor cells correlates with highly aggressive disease in metastatic breast cancer Alexis B. Duffy, Massimo Cristofanilli, Carolina Reduzzi, Wlliam V. Williams, Giuseppe Del Priore, Saranya Chumsri, Cha-Mei Tang, Toshiaki Iwase, Naoto Ueno, Daniel L. Adams
• 1066 · PDF Early detection of prostate carcinoma using trajectories of circulating epithelial tumor cell (CETCs/CTCs) numbers Dorothea Schott, Monika Pizon, Joachim Fluhrer, Ulrich Pachmann, Katharina Pachmann, Peter Eng
• 1067 Whole genome sequencing of multiple myeloma genomes with a novel clinical assay enables identification of genetic alterations underlying immunotherapy resistance Bruno Paiva, Peter Voorhees, Patricia T. Greipp, Danielle Sookiasian, Julian Hess, Marisa DeMeo, Vicki Pounder, Sarah Calkins, Reid Meyer, Linda B. Baughn, Christine-Ivy Liacos, Meletios-Athanasios Dimopoulos, Alexandra Papadimou, Taouxi Konstantina, Efstathios Kastritis, Jesus Berdeja, Daniel Auclair, Valentina Nardi, Thomas Mullen, Francois Aguet, Shaji Kunnathu Kumar
• 1068 Combining circulating tumor cells and cancer associated macrophage-like cells enhances risk stratification models in pan-cancer metastatic disease Daniel L. Adams, Steven H. Lin, Massimo Cristofanilli, Carolina Reduzzi, Saranya Chumsri, Martin J. Edelman, Susan Tsai, Raymond C. Bergan, Mohammed Aldakkak, Thai H. Ho, Cha-Mei Tang
• 1069 Clinical significance of viable circulating tumor cells (v-CTCs) and PD-L1 expression in pancreatic cancer patients using a novel oncolytic virus system Masahiro Tanemura, Hisataka Ogawa, Yoshiaki Ohmura, Tadafumi Asaoka, Yasuo Urata, Daisaku Yamada, Hirofumi Akita, Hidetoshi Eguchi
• 1070 · PDF Molecular profiling of diffuse gliomas via liquid biopsy: Insights from circulating tumor cells and ctDNA analysis Josef Srovnal, Pavel Stejskal, Ondrej Kalita, Marek Slachta, Lumir Hrabalek, Alona Rehulkova, Monika Vidlarova, Marian Hajduch
• 1071 Delta-like ligand 3 (DLL3)-based enrichment enables sensitive and specific detection of circulating tumor cells during immunotherapy in small-cell lung cancer Hyung-Joo Oh, Hyun-Ju Cho, Seung-Hee Song, Yoo-Duk Choi, Woo-Jae Son, Jin-Han Bae, In-Jae Oh, Young-Chul Kim, Hae Ung Lee, Cheol-Kyu Park
• 1072 · PDF Parallel microfluidic platform enables efficient label-free capture of p16+ circulating tumor cells in oropharyngeal cancer Chameera E. Weeramange, Jian Zhou, Sreedevi Damodaran, Chiara F. Ghera, Lizbeth Kenny, Brett Hughes, Sarju Vasani, Omar Breik, Rahul Ladwa, Ian Papautsky, Chamindie Punyadeera
• 1073 · PDF Monitoring androgen receptor and neuroendocrine marker expression dynamics in CTCs in patients with mCRPC Nobuaki Matsubara, Kentaro Shirai, Hiroyuki Obinata, Hiromichi Nakajima, Chikako Funasaka, Chihiro Kondoh, Kana Kawasaki, Eri Katsumata, Taiga Ajiri, Maharjan Bishnu, Fumie Kato, Masatoshi Yanagida, Reiko Watanabe, Toru Mukohara
• 1074 Pre-treatment circulating tumor cells are a significant predictor of progression in patients with metastatic breast cancer undergoing abemaciclib therapy Qiang Zhang, Justin Zhang, Andrew A. Davis, Natalie Heater, Diana Jaber, Paolo D’Amico, Jianhua Jiao, Weijun Qin, Pan Du, Shading Jia, Akhil Chawla, Janice Lu, Lisa Flaum, William J. Gradishar
• 1075 · PDF Comparison of tissue and liquid biopsy CGP in advanced solid tumors: Insights from a community cancer center Padmapriya Swaminathan, McKenna Perrin, Crystal Hattum, Stephanie B. Hastings, Shakeel Mir, Zachary Wallen, Lucia Speroni, Michelle F. Green, Emily Teslow, Heidi Ko, Rebecca A. Previs, Kalpesh Patel, Shakti Ramkissoon, David Starks, Benjamin Solomon, William Spanos, Tobias Meissner, Rachel Elsey
• 1076 · PDF Cancer-neuron interaction initiates neural mimicry and brain colonization in EGFR-mutant NSCLC Sam Song, Tomohiro Takehara, Yan Yang, Monique B. Nilsson, Alissa Poteete, Sherise Desiree Ferguson, Xiuning Le, John V. Heymach
• 1077 · PDF Discordance in molecular classification of primary and metastatic endometrial cancer: Implications for precision treatment Mari Kyllesø Halle, Janka Babickova, Hege Fredriksen Berg, Erling Andre Hoivik, Rose M. Gold, Kadri Madissoo, Marta Hjelmeland, Hilde Eide Lien, Jone Trovik, Ingfrid S. Haldorsen, Kathrine Woie, Gema Moreno-Bueno, Rameen Beroukhim, Camilla Krakstad
• 1078 · PDF From protocol to practice: The gap in obtaining progression disease biopsies across 182 oncology trials Anjali Vinocha, Kanwal Pratap Singh Raghav, David S. Hong, Christine Parseghian, Joshua P. Hein, Jyotsna Pera, Funda Meric-Bernstam, Scott Kopetz, Alda L. Tam, Michael J. Overman
• 1079 · PDF Over expressing PD-L1 circulating tumor cells with clusters in prostate cancer patients Jayant Khandare, Bharat Bhosale, Gourishankar Aland, Sreeja Jayant, Amrut Ashturkar, Vikas Jadhav, Ashish Joshi, Sourav Mishra, Pradip Kendre, Aravindan Vasudevan, Vashishth Maniar, Jagdeesh Kulkarni
• 1080 · PDF Development of a murine leptomeningeal disease model for a point-of-care cerebrospinal fluid liquid biopsy assay Eileen Shiuan, Jorge Salcedo-Sifuentes, Leilani Pradis, Trinh Phan, Sonia Su, Martin Shum, Daniel T. Kamei, Won Kim, Robert M. Prins
• 1081 Development and validation of a standardized CELLSEARCH® assay for real-time monitoring of prostate-specific membrane antigen (PSMA) expression on circulating tumor cells Steven M. Jones, Thai Bui, Damodara Gullipalli, Shemeeakah Powell, Margaret LaCava, Zoltan Simandi
• 1082 · PDF Development of a novel CDH17 CTC assay to monitor colorectal patient blood and cerebrospinal fluid Jennifer C. Chow, Casey E. Helmicki, Rachel Ponting, Arturo B. Ramirez, Pashtoon Murtaza Kasi
• 1083 · PDF Kras activity-linked glycolysis and immunosuppression in metastatic pancreatic cancer Shuichi Mitsunaga, Mari Masuda, Kota Kato, Hidetaka Suzuki, Mitsuhito Sasaki, Hiroki Yoshimatsu, Yoichi Kamei, Masafumi Ikeda
• 1084 Serum proteomic profiling reveals metastasis-associated molecular signatures and early systemic remodeling in triple-negative breast cancer Jina Kim, Hyoyoung Kim, Sunao Tanaka, Takeo Fujii, Sungyong You, Hideki Furuya
• 1085 · PDF PHF8 is a major upstream regulator of RIPK2 in prostate cancer cells Jaceline Pires Sanches, Ahmed Elgehama, Lili Guerra, Wei Yang
• 1086 HER2 expression in circulating tumor cells as a minimally invasive biomarker of therapeutic response to trastuzumab deruxutecan in breast cancer Toru Mukohara, Nobuaki Matsubara, Yusuke Takahashi, Kentaro Shirai, Hiromichi Nakajima, Chikako Funasaka, Chihiro Kondoh, Kana Kawasaki, Maharjan Bishnu Devi, Fumie Kato, Hiroyuki Obinata, Taiga Ajiri, Masatoshi Yanagida, Reiko Watanabe
• 1087 Patient-derived breast and melanoma circulating tumor cell (CTC) in vitro models as encouraging new tools for cancer research Paul Lovell, Karlie Wysong, Fafali Deegbe, Fang Tian

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