Precision Oncology and Real World Data

• 5333 · PDF Profiling membrane antigen expression of select antibody-drug conjugate (ADC) targets in EGFR -altered non-small cell lung cancer treated with osimertinib Kevin Lu, Tali Azenkot, Ellen B. Jaeger, Unnati Jariwala, Stamatina Fragkogianni, Jacob Mercer, Jyoti D. Patel, Sandip P. Patel
• 5334 Genomic profiling of lung cancer in Guizhou province and comparative performance of DNA-NGS versus DNA+RNA-NGS for fusion detection Weiwei Ouyang, Yichao Geng, Chuang Tian
• 5335 · PDF Integrated machine learning and large language models reveal molecular determinants of survival and treatment response in KRAS-mutant lung cancer Qingtian Li, Albert Lee, Wei Wu, Trever G. Bivona
• 5336 · PDF Distinct KRAS mutation codons differentially associate with microsatellite instability in colorectal carcinoma Mark Evans, Vishal Chandan, Kenna Shaw, Scott Kopetz, Anirban Maitra, Julian Bryan
• 5337 · PDF MSI colon adenocarcinoma transcriptomic subtypes are biomarkers of response to immunotherapy Matthew B. Maxwell, Akul Singhania, Michelle Stein, Radia Johnson, Van K. Morris, Andrew J. Sedgewick, Scott Kopetz, Justin Guinney
• 5338 · PDF Clinicogenomic predictors of first-line immune checkpoint inhibitor outcomes in non-small cell lung cancer: A nationwide C-CAT cohort from Japan Mika Iwasaki, Takahiro Ando, Koki Fujii, Kousuke Watanabe, Katsutoshi Oda, Hidenori Kage
• 5339 · PDF Prevalence and distinct biological programs of small cell lung cancer molecular subtypes revealed by real-world clinico-genomics database Yige Luo, Lujia Wang, Nadine Jahchan, Peter Ansell, Xi Zhao, Weilong Zhao
• 5340 · PDF Landscape of ALK fusion breakpoints and subtypes: A comparative analysis of DNA-NGS versus RNA-NGSs Yanwei Li, Yanli Chen, Yameng Cui
• 5341 · PDF Real-world landscape of BRAF fusions in chinese patients with lung and colorectal cancers: Insights from 26,248 DNA-NGS and RNA-NGS tests Li Wang, Wanpu Wang, Xinyan Pan, Ming Tang, Juanjuan Zhang
• 5342 · PDF Analysis of RNA expression of 47 cell surface proteins in real-world small cell lung cancer patients Sana Parveen, Emma T. Corcoran, Sebastià Franch-Expósito, Prerna Jain, Jacob Mercer, Abdul R. Naqash, Christine M. Lovly, Paul Fields, Hui-Zi Chen
• 5344 · PDF Variant allele frequency machine learning model identifies unique TP53-mutant phenotypes with worse post-operative survival in pancreatic cancer Imaad Said, Eugene Chen, Megan Zeller, Mohammed Aldakkak, Matthew Sochor, Bhabishya Neupane, Kshitij Gaur, Mandana Kamgar, Alexandria Phan, Janice Zhao, Samih Thalji, Beth Erickson, Christina Small-Tom, Callisia Clarke, Kathleen K. Christians, Nikki K. Lytle, Thomas McFall, William A. Hall, Anai N. Kothari, Douglas B. Evans, Yongwoo David Seo
• 5345 · PDF Large-scale genomic analysis of pancreatic cancer in a real-world patient population Avinash Ramu, Vasily Aushev, J. Bryce Ortiz, Alyssa Antonopoulos, Maria Diab, Philip A. Philip, David Kwon, Soma Subramaniam, Adham Jurdi, Gregory P. Botta
• 5346 · PDF Prognostic impact and clinical characteristics of KRAS mutations and CDKN2A loss in IDH1 -mutant intrahepatic cholangiocarcinoma Eiichiro So, Chigusa Morizane, Kouya Shiraishi, Nobuyoshi Hiraoka, Miyuki Sone, Takafumi Koyama, Rui Kitadai, Yusuke Okuma, Takashi Kohno, Tetsuro Shiraishi, Yuno Goto, Shiho Hakui, Kiyoaki Ochi, Keita Fujisaki, Kazunori Onuma, Yasuhiro Komori, Daiki Yamashige, Mao Okada, Shota Harai, Yuta Maruki, Yasuyuki Kawamoto, Yoshikuni Nagashio, Susumu Hijioka, Hideki Ueno, Kenro Hirata, Takanori Kanai, Takuji Okusaka
• 5347 Real-world clinicogenomic comparison of early- and average- onset gastric cancer Hannah McDonald, Lilia Turcios, Neelima Hosamani, Abu Saleh Mosa Faisal, Chi Wang, Joseph Kim, Mautin Barry-Hundeyin
• 5348 · PDF Tumor remodeling pathways are enriched in the tumor microenvironment of obesity-associated colorectal cancer Yu Fujiwara, Sarbajit Mukherjee, Yali Zhang, Jianmin Wang, Emily Baiyee Toegel, Tiago Biachi De Castria, Bodour Salhia, Anne M. Noonan, Michael J. Cavnar, Dae Won Kim, Muneeb Rehman, Patrick B. Boland, Melissa L. Fishel, Carlos H.F. Chan, Michele M. Gage, Hassan Hatoum, Julia White, Robert J. Rounbehler, Michelle Churchman, Deepak Vadehra
• 5349 · PDF Refining tumor mutational burden as a predictive biomarker for pembrolizumab: A real-world analysis of 1,899 Japanese patients Tomoyo Yasuda, Mio Yumura, Azusa Hamasaki, Tongyi Fei, Takashi Kubo, Hitoshi Ichikawa, Takashi Kohno, Kuniko Sunami
• 5350 · PDF Evaluating prognostic biomarkers in advanced epithelial ovarian carcinoma using machine learning on real-world data Carlos Ronchi, Coryandar Coulomb, Frances Peterson, Danielle Bloch, Kathleen Burke
• 5351 · PDF Epidemiology of folate receptor alpha expression in ovarian cancer by age, race/ethnicity, and histotype in a real-world, US-based clinicogenomic database Rebecca C. Arend, Kent F. Hoskins, Jenny S. Guadamuz, Gregory S. Calip, Megan A. Clarke, Yookyung Christy Choi, Qu Zhang, Ricardo R. Lastra, Amanda L. Strickland, Sarah K. Lynam
• 5352 · PDF Genomic and ancestry-associated determinants of survival in gynecologic cancers Laura Chambers, Avinash Ramu, Vasily N. Aushev, Susan Rojahn, Alyssa Antonopoulos, Carly B. Scalise, Faraz Salmasi, Minetta C. Liu, Adam C. ElNaggar, Rebecca C. Arend
• 5354 · PDF Extrachromosomal DNA shapes aggressive transcriptional states in multiple myeloma Hi Eun Jung, Saeam Shin, Yu Ri Kim, Ja Min Byun, Youngil Koh, Junshik Hong, Dong-Yeop Shin, Inho Kim, Hoon Kim, Hyunsoo Cho
• 5356 · PDF Leveraging a real-world clinicogenomic database for post-sequencing quality assessment in solid tumor comprehensive genomic profiling (CGP) Erin N. Newburn, Rebecca A. Previs, Michelle F. Green, Kyle C. Strickland, Heidi Ko, Taylor Jensen, Eric Severson, Hardik Parikh, Maria-Fernanda Senosain, Jie An, Erik Van Roey, Daniel Metzger, R.J. Seager, Mark Sausen, Jennifer Jackson, Kenneth Valkenburg, Brian Caveney, Marcia Eisenberg, Shakti Ramkissoon
• 5357 · PDF Molecular tumor registries - A learning system for real world data (RWD) Erik Larsen, Chenbo Sun, Michele Cosi, Rudy Salcido, Sarah Roberts, Nirav Merchant, Justin Starren, Ritu Pandey
• 5358 · PDF Disparities between genomic alterations and clinical trial representation in precision oncology Jingyao Zhang, Raoul Santiago, Kamila Bakirhan, Tenzin Tamdin
• 5359 · PDF Precision oncology in practice: Comprehensive genomic profiling identifies actionable alterations and guides therapeutic selection in 756 clinical solid tumors Sarabjot Pabla, Sushant Khadgi, Anjana N. Bhattacharya, Asia Chang, Mark Gardner

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