Epigenetics, Cytogenetics, and Clinical Molecular Genetics

• 5281 · PDF A novel viral-derived epigenetic gene therapy delivered via mRNA-lipid nanoparticles to inhibit HPV-associated malignancies Fan Yang, Yan-Ning Yu, Liliana Echavarria, Leo Holguin, Sarah Schroeder, Shasha Li, Michelle Afkhami, Diana Bell, Krupal Patel, Tristan A. Scott
• 5282 Splicing disruption using a CLK inhibitor shows activity in malignant rhabdoid tumor pre-clinical models Clemence Basse, Pawel Sobczuk, Andrea Gazzo, Tom Zhang, Marissa Mattar, Inna Khodos, Elisa De Stanchina, Romel Somwar, Neerav N. Shukla, Marc Ladanyi
• 5283 Cloud-based computational framework for individualized genomic analysis in pediatric acute lymphoblastic leukemia: A nationwide multi-center real-world clinical study Han Wang, Jiaoyang Cai, Jie Yu, Shaoyan Hu, Yongjun Fang, Ju Gao, Jian Li, Hua Jiang, Xiuli Ju, Sixi Liu, Wenyong Kuang, Runming Jin, Liangchun Yang, Xuedong Wu, Xiaowen Zhai, Qun Hu, Hui Jiang, Ningling Wang, Chi Kong Li, Lirong Sun, Jiao Jin, Chun Li, Changda Liang, Yan Dai, Kaili Pan, Hao Xiong, Ching-Hon Pui, Shuhong Shen, Yu Liu
• 5284 · PDF Epigenetic clusters identified in Hispanic/LatinX colorectal cancers reveal novel molecular subtypes Seeta Rajpara, Vicky Yamamoto, Carmen Chavez, John D. Carpten, David W. Craig, Heinz-Josef Lenz, Bodour Salhia
• 5285 · PDF Toward a functional characterization of polygenic modifiers of BRCA2 associated prostate cancer risk Kenneth Offit, Sanchari Bhattacharyya, Matthew Buas, Brett Carver, Jonathan Fainberg, Yelena Kemel, Catherine Fanjoy, Viaji Joseph, Kathryn Graz, Xu Zhang, Shiv Prakash Verma, Ninghui Mao, Kyrie Pappas, Mitul Waghmare
• 5286 · PDF Molecular and immune landscape of HER2-amplified colorectal cancer Sunyoung Lee, Michelle Weitz, Adam Dugan, Saif Nirzhor, Kayla Layng, Scott Kopetz, James Yu, Asif Rashid, Funda Meric-Bernstam, Mohamed Nuh, Monica Hsiang, Kanwal Pratap Singh Raghav
• 5287 Parent-of-Origin-Aware genomic analysis in hereditary cancer: identifying the side of the family at risk using only the proband's blood sample Lilian Cordova, Vahid Akbari, Tiffany Leung, Kieran O’Neill, Katherine Dixon, Alexandra Roston, Eugene Cheung, Chuyi Zheng, Millicent Sharman, Alshanee Sharma, Steve Bilobram, Yaoqing Shen, Janine Senz, Yanni Wang, Daniel Chan, Alexandra Fok, Jennifer Nuk, Quang Hong, Robin Coope, Eric Chuah, Simon Chan, Hyun-Wu Lee, Yongjun Zhao, Miruna Bala, Karen Mungall, Andrew Mungall, Richard Moore, Nur Diana Binte Ishak, Siao Ting Chong, Ee Ling Chew, Ashley McDonald, Anna Martinez, Gregory Kelly, Rosella Delgado, Caitlin Orr, Joanne Yuen Yie Ngeow, Kara N. Maxwell, Stephen B. Gruber, Dean Regier, Alice Virani, Louis Lefebvre, Fabio Feldman, Marco Marra, Sophie Sun, Stephen Yip, Peter Lansdorp, Steven John Jones, Kasmintan Schrader
• 5288 · PDF HMA-induced oncogene reactivation as a driver of disease progression in MDS Junsu Kwon, Yanjing Liu, Mahmoud A. Bassal, Julie A.I. Thoms, Emiliano Fabiani, John Pimanda, Maria T. Voso, Daniel G. Tenen, Li Chai
• 5289 · PDF Native domain-interaction rewiring collapses the AR neo-enhanceosome in prostate cancer Jie Luo, Jianzhang Yang, Yuanyuan Qiao, Jean Ching-Yi Tien, Eleanor Young, sumit Das, Jocelyn Cai, Kenneth Gu, Shaomeng Wang, Arul M. Chinnaiyan
• 5290 · PDF Investigating the intrinsic epigenetic dependencies of estrogen receptor positive and ESR1 mutant breast cancer Andrej Coleski, Eleanor Young, Sumit Das, Xuhong Cao, Shannon VanAken, Fengyun Su, Yizhi Cao, Rui Wang, James M. Rae, Abhijit Parolia, Yuanyuan Qiao, Lanbo Xiao, Arul M. Chinnaiyan
• 5292 Epigenetic modulators romidepsin and mithramycin A reactivate tumor-suppressive programs and suppress c-MYC under hyperthermic conditions in colorectal peritoneal metastasis Yazid Ghanem, Gena Topper, Sahil Jethi, Jessica Collier, Marlena Buonasorte, Yong Ki Hong, Weam Othman Elbezanti
• 5293 · PDF Targeting the oncogenic RNA m6A reader YTHDF2 inhibits oral squamous cell carcinoma by preventing p53 degradation Anitha Pandi, Vijayashree Priyadharsini Jayaseelan, Paramasivam Arumugam
• 5294 · PDF Epigenetic modulation by DNMT-1 inhibitor induces cell death in SK-N-AS neuroblastoma cells Shyam Sundar Jaganathan, Umamaheswari Natarajan, Appu Rathinavelu
• 5295 Integrative identification and functional interrogation of DNA methylation-mediated epigenetic gene alterations in pancreatic cancer Sanghee Nam, Galam Leem, Seungmin Bang
• 5296 · PDF Epigenetic and transcriptional drivers of mucinous breast carcinoma Lorenzo Ferrando, Higinio Dopeso, Laxmi Gusain, Edaise M da Silva, Thais Basili de Oliveira, Lounes Djerroudi, Hannah Y. Wen, Hong Zhang, Edi Brogi, Richard P. Koche, Pierre-Jacques Hamard, Larry Norton, Jorge S. Reis-Filho, Britta Weigelt, Fresia Pareja
• 5297 · PDF Distinct genomic and pathway-level alterations in early-onset colorectal cancer: A large-scale Korean cohort analysis Ah Reum Lim, Boyeon Kim, Minsoo Kim, Soohyeon Lee
• 5298 Impact of genomic and clinical factors on therapeutic response to arly‑phase epigenetic therapies: An international cohort from two major phase I units Manuel Pedregal, Harold Nathan Tan, Mercedes Avedillo, Ignacio Mahillo, Ester Garcia, Bernard Gaston Doger de Spéville, Miriam Dorta, Jordi Rodon Ahnert, Victor Moreno Garcia
• 5299 · PDF Epigenetic modulation by MDM2 and DNMT inhibitor promotes cell cycle arrest and programmed cell death in neuroblastoma cells Sruthika Talanki, Helen Le, Aashi Chhabra, Rhea Hede, Jose Nazario, Pragya Srivastava, Greeshma Davu, Shyam Jaganathan, Umamaheswari Natarajan, Appu Rathinavelu
• 5300 · PDF Clinical utility of whole genome sequencing for upfront risk stratification in AML and MDS patients Kerry D. Fitzgerald, Dennis D. Krutkin, Jenny Brouckaert, Traci Pawlowski, Pratheesh Sathyan, James Han, Tong Liu, Yuanyu Cao, Xiaojun Guan, Jake Humphrey, Grant Hogg, John Howitt, Amanda Williamson, Shakti Ramkissoon, Marcia Eisenberg, Brian Caveney, Eric A. Severson, Eyad Almasri, Jonathan Williams, Taylor J. Jensen
• 5301 · PDF Evaluating the molecular landscape of genetic mutations among Black patients with acute myeloid leukemia Eno-obong B. Udoh, Xiaoying (Nicole) Chen, Sarah J. Philip, Yazeed Sawalha, Yazan F. Madanat, Ameera Rose, Teodora Kuzmanovic, John C. Molina, Moaath K. Mustafa Ali, Akriti G. Jain, Abhay Singh, Sophia Balderman, Babal Kant Jha, Ronald Sobecks, Betty K. Hamilton, Sudipto Mukherjee, Aaron Gerds, Hetty Carraway, Jaroslaw P. Maciejewski, Mikkael Sekeres, Anjali Advani
• 5302 · PDF Defining the landscape of TP53 mutations in acute myeloid leukemia Joseph Stenberg, Jordan Redemann, Jessica Lewis-Gonzalez, Rama Gullapalli, Charles Foucar

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