Mechanistic Insights for Targeted Therapies in Pediatric Cancer

• 1149 · PDF Multimodal liquid biopsy of Ewing sarcoma reveals high sensitivity prior to radiotherapy Roman O. Kowalchuk, Lilli J. Greiner, Yohan Kim, Rubia Noori, Jeffrey Szymanski, William S. Harmsen, Pradeep S. Chauhan, Adam C. Amundson, Andrea M. McMahon, Peter J. Schoettler, Wendy A. Allen-Rhoades, Stephanie F. Polites, Peter S. Rose, Kelly M. Bailey, Linda M. McAllister-Lucas, Anita Mahajan, Fabrice Lucien-Matteoni, Nadia N. Laack, Aadel A. Chaudhuri
• 1150 · PDF Combining CDK4/6 inhibitor with TMZ and radiation alters cell states for synergistic responses in orthotopic DIPG models Zilu Huang, Tongchao Jiang, Milagros M. Suarez Palacios, Tommy Ouyang, Aalaa Abdallah, Long Niu, Jinnan Chen, Xin Zhai, Emily Ciolak, Wenan Qiang, Runxin Wu, Nitin Wadhwani, Alicia Lenzen, Michael DeCuypere, Sandi Lam, Shi-Yuan Cheng, Ching Man Wai, Brian Wray, Matthew John Schipma, Xinkun Wang, Wan-Yee Teo, Daniel J. Brat, Yuchen Du, Yunfei Xia, Xiao-Nan Li, John Kalapurakal
• 1151 · PDF Targeting high risk osteosarcoma: MYC modulation alters metastasis Emily Seiden, Scott Sauer, Emma Hiscock, Nha Nhu Le, Ainsley Hellens, Monica Inda, Andrew Fuller, Sridhar M. Veluvolu, Rachael Hinshaw, Zachary P. Tolstyka, Elissa Levine, Rashmi Chugh, Theodore W. Laetsch, Nouri Neamati, Heather Wilson-Robles, Chand Khanna, David Warshawsky, Patrick J. Grohar
• 1152 · PDF Targeting Yap1 -B7-H3 signaling stimulates CD8⁺ anti-tumor response preferentially in male SHH medulloblastoma Nourhan Abdelfattah*, Maryam Faisal*, Han Nhat Tran, Thomas Wong, Freddys Rodriguez, Carston R. Wagner, Kyuson Yun
• 1153 · PDF Genome-driven molecular stratification and clinical impact in pediatric solid tumors: Results from the STREAM program Ji Won Lee, June-Young Koh, Chang Yeon Kim, Joo Whan Kim, Jung Yoon Choi, Seung Ah Choi, Seung-Ki Kim, Se Hoon Kim, Ji Hoon Phi, STREAM Consortium
• 1154 Multi-omic profiling of cellular heterogeneity and microenvironmental remodeling underlying treatment resistance in neuroblastoma Eun Seop Seo, JI WON LEE, In Woo Hwang, Woong-Yang Park, Jun Sun Kim, Ki Woong Sung
• 1155 · PDF High-throughput screening identifies synergistic drug interactions between CDK8/19 and DHFR inhibitors in rhabdomyosarcoma Ukhyun Jo, Ying Wu, Lisa M Jenkins, Tapan Kumar Maity, Seth P Zimmerman, Chris M. Counter, Assil Fahs, Corinne Linardic, Craig J. Thomas, John F. Shern
• 1157 Preclinical evaluation of PEG-[SN22]₄ (PEEL-224), a multivalent polymeric camptothecin prodrug, in pediatric solid tumor patient-derived xenograft models Filemon S. Dela Cruz, Kristina C. Guillan, Samantha Brosius, Armaan H. Siddiquee, Glorife Ibanez Sanchez, Daoqi You, Kristen Victor, Paul Calder, Trent Fowler, Joshua D. Schiffman, Andrew L. Kung
• 1158 · PDF Hypermutation patterns shape tumorigenesis and immunotherapy response in mismatch repair deficient glioma Nicholas R. Fernandez, Yuan Chang, Nuno M. Nunes, Jose R. Dimayacyac, Adrian Levine, Amit Ringel, Logine Negm, Ayse B. Ercan, Julian Hess, Olfat Ahmad, Caitlin Lee, Lucie Stengs, Vanessa Bianchi, Melissa Edwards, Sheradan Doherty, Jiil Chung, Liana Nobre, Julie Bennett, Andrew J. Dodgshun, David TW Jones, Stefan M. Pfister, Anita Villani, David Malkin, Vijay Ramaswamy, Annie Huang, Eric Bouffet, Melyssa Aronson, Peter B. Dirks, Adam Shlien, Gad Getz, Yosef E. Maruvka, Birgit Ertl-Wagner, Cynthia Hawkins, Anirban Das, Uri Tabori
• 1159 Trans-species analysis of replication repair deficient medulloblastoma and response to immune checkpoint inhibition: An IRRDC report Nicholas R. Fernandez, Anirban Das, Adrian Levine, Kyle Smith, Evan Wang, Melissa Galati, Zoya Aamir, Jiil Chung, Logine Negm, Hope Friedman, Katharine O'Flaherty, Owen Crump, Quang M. Trinh, Nuno M. Nunes, Vanessa Bianchi, Lucie Stengs, Melissa Edwards, Lincoln Stein, Eric Bouffet, Michael D. Taylor, Paul Northcott, Vijay Ramaswamy, Cynthia Hawkins, Uri Tabori
• 1160 · PDF Characterizing neddylation as a potential vulnerability in MYC-amplified medulloblastoma Qiyun (Rachel) Shao, Vijay Ramaswamy
• 1161 · PDF Comprehensive pediatric biobanking and model development in the Beat Childhood Cancer Research Consortium Divya Gandra, Katherine McClain, Meenakshi Shukla, Laura Vazquez, Mohammad Haque, Jonathan Lerch, Muhammad Younis, Thussenthan Walter Angelo, Jeremy Hengst, Giselle Saulnier Sholler
• 1162 · PDF Revealing the transformative role of METTL13 in human hematopoietic stem cells and progression of pediatric leukemia Sabina Enlund, Chae-Eun Lim, Isabella Hoang, Sonali Joshi, Amanda Ramilo Amor, Cecilia Thomsson, Maria Rivera, Adena Pepich, Indranil Sinha, Shahrzad S. Fard, Anna Nilsson, Ola Hermanson, Qingfei Jiang, Frida Holm
• 1163 · PDF Combined AKT and XPO1 inhibition to target chimeric transcription factor-driven pediatric sarcoma pathogenesis Cameron Bumbleburg, Suprina Neupane, Henry Schrecker, Megan VanGarven, Janaia Jackson, Allison Reno, Emma Saunders, Jacob Lenski, Reid Barker, Hannah Gulbronson, Jamie Silverman, Kajol Patel, Elizabeth Maahs, C. A. Colvert, Abasi-ama Udeme, Moriah Heifetz, Jenna Schwesig, Margaret Taquey, Abbigayle Szcinski, Abigail Miller, Benjamin Caiello, Joshua Monts, B. J. Kendrick, Evan Bagley, Casey G. Langdon
• 1164 Pacritinib mitigates doxorubicin resistance in osteosarcoma by inhibiting WNT/beta-catenin, efflux proteins and receptor tyrosine kinase network Marina Curcic, Sanjay Kumar Srivastava
• 1165 · PDF Vps34 inhibition enhances immunogenicity and immune-mediated killing in MYCN-amplified neuroblastoma Elisabetta Bartolini, Teresa L. Ramos, Ruize Gao, Bassam Janji
• 1166 Genetic and pharmacologic suppression of pink1 prolongs survival in sonic hedgehog driven medulloblastoma and related mouse model Bahauddeen M. Alrfaei, Amani Almuaysib, Ahmed Aloraidi, Ali Assiri
• 1167 The pan-CLK DYRK inhibitor SM09419 prolongs animal survival times in a subset of pediatric medulloblastoma patient-derived orthotopic xenograft mouse models Xin (Alice) Zhai, Zilu Huang, Milagros Suarez Palacios, Tongchao Jiang, Aalaa Abdallah, Jinnan Chen, Yiming Mei, Emily Ciolak, Nitin Wadhwani, Alicia Lenzen, Yuchen Du, Xiao-Nan Li
• 1168 · PDF Development of RT-dPCR-based functional release assays for the RPS19 gene therapy for Diamond-Blackfan anemia Neshat Masud, Sabina Ranjit, Nana Liu, Madhuri Kalathur, Senthil Bhoopalan, Catherine Willis
• 1169 Global proteomic analysis of pediatric T-cell acute lymphoblastic leukemia patient samples reveals distinct protein upregulation signature Irina Pushel, Thomas Gremminger, Lisa Lansdon, Michaella Rekowski, Midhat S. Farooqi, Michael Washburn, Keith August
• 1170 · PDF Proton-induced exosomal signatures reveal radiation response pathways in pediatric diffuse midline glioma Ann Morcos, Yeonkyu Jung, Nathan R. Wall
• 1171 Copy number variation in Sonic hedgehog-medulloblastoma with unique p53 mutations: Inhibition of PI3K/AKT/mTOR pathways with HDAC inhibitors can serve as therapeutic options Austin Carpenter, Mohan Das, Raphael Salles S Medeiros, Sidnei Epelman, Epelman, Nelci Zanon, Chirag D. Gandhi, Meena Jhanwar-Uniyal
• 1172 · PDF Inhibition of GSK3B signaling in pediatric brain tumors Mohammad Haque, Elizabeth Wert, Jeremey Hengst, Muhammad Younis, Katherine McClain, Tarlan Arjmandi, Meenakshi Shukla, Jonathan Lerch, Thussenthan Walter Angelo, Giselle L. Saulnier Sholler
• 1173 Trans-species analysis of mismatch repair deficient IDH1 mutant gliomas reveals a unique genomic and immune landscape resulting in favorable response to combination immune and targeted therapy Vienna Mazzoli, Nicholas R. Fernandez, Zoya Aamir, Olha Kos, Emma Gattoni, Owen Crump, Lucie Stengs, Nuno M. Nunes, Katharine O'Flaherty, Hope Friedman, Olfat Ahmad, Abigail Suwala, Kevin Bielamowicz, Gadi Abebe-Campino, Shani Caspi, Per Nyman, Richard Graham, John Y. H. Kim, Mari Wilhelmsson, Mette Jorgensen, Orli Michaeli, Maria Baro, Alyssa Reddy, Nicolas Jose Llosa, Amanda Li, Adrian Levine, Logine Negm, Melissa Edwards, Vanessa Bianchi, Birgit Ertl-Wagner, Julie Bennett, Stefan M. Pfister, Peter B. Dirks, Eric Bouffet, Cynthia E. Hawkins, Anirban Das, Uri Y. Tabori

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