Signaling Pathways, Metabolism, and Emerging Therapeutic Targets

• 5007 · PDF ELAVL3 post-transcriptionally regulation of the NOTCH2 signaling pathway shapes the plasticity of small cell lung cancer Shuangsi Liao, Zichong Peng, Kai Kang, Shanghai Liu, Hui Wang, Yufeng Zhang, Ren Luo, Linglu Yi, Feifei Na, Guo Lin, Yue Zheng, Jianxin Xue, You Lu, Zhuoran Yao
• 5008 · PDF Combination therapy with AKT and MEK inhibitors is effective in patient-derived models of adrenocortical carcinoma Suresh Kumar, Yoo Sun Kim, Nai-Yun Sun, George Karadimov, Yasuhiro Arakawa, Briana N. Cortez, Diana Varghese, Arnulfo Mendoza, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Jonathan M. Hernandez, Chuong D. Hoang, Noemi Kedei, Xiaoling Luo, Stephen Hewitt, Yves Pommier, Craig Thomas, Jaydira Del Rivero, Nitin Roper
• 5009 · PDF A tumor-derived PTHrP-calcium axis drives cardiac dysfunction to connect cancer cachexia with mortality Tuba Mansoor Thakir, Sam Oscar Kleeman, Miriam Ferrer González, Tobias Janowitz
• 5010 · PDF Loss of SHP phosphorylation reprograms lipid metabolism to promote colorectal tumorigenesis Ting Fu
• 5011 · PDF Targeting DUSP1 overcomes resistance to ¹⁷⁷Lu-DOTATATE in neuroendocrine tumors Majid Momeny, Solmaz AghaAmiri, Servando Hernandez Vargas, Sukhen C. Ghosh, Tyler M. Bateman, Jack T. Adams, Nafiseh Ghazanfari, Vahid Khalaj, Ali Azhdarinia
• 5012 Multiomic profiling reveals ligand and cell specific regulatory programs of LXR selective modulation in myeloid immune cells Yifan Fei, Rajendra K C, Mark Flory, Natalia Julianna Krawczynska, Yu Wang, Kevin T. VanBortle, Hisham Mohammed, Erik R. Nelson
• 5013 Comprehensive characterization of DICER1 mutations and two hit tumorigenesis mechanisms in follicular thyroid carcinoma using multi-omics analysis Dakyung Lee, Young Ah Lee, Yeonju Kyoung, Seong-Keun Yoo, Sun-Wha Im, Jaeyong Choi, Yoo Hyung Kim, Dohyun Han, Young Joo Park, Jong-Il Kim
• 5014 · PDF CDC73 loss does not augment cyclin D1-driven parathyroid tumorigenesis in transgenic mice Jen-Yuan C. Kao, Callie Burke, Justin Bellizzi, Andrew Arnold, Jessica Costa-Guda
• 5015 · PDF Targeting insulin to improve endometrial cancer Alexander Emmanuelli, Ezequiel Dantas, Marcus DaSilva Goncalves
• 5016 · PDF Oncogenic PIK3CA mutation enhances cyclin D1-driven parathyroid tumorigenesis in transgenic mice Maia Jakubowski, Callie Burke, Justin Bellizzi, Andrew Arnold, Jessica Costa-Guda
• 5017 · PDF Targeting human melanoma growth with non-calcemic vitamin d3 hydroxyderivative: A synergistic approach with vemurafenib Senthilkumar Ravichandran, Ewa Podgorska, Zorica Janjetovic, Tae-Kang Kim, Gitali Ganguli Indra, Arup K. Indra, Andrzej T. Slominski
• 5019 Preclinical mechanistic PK/PD/Efficacy modeling for AZD4241, a novel oral estrogen receptor (ER) degrader (PROTAC), to support dose selection during early clinical development Ana Quiroga, Pablo Morentin Gutierrez, Lynet Nyoni, Natalie Cureton, Mandy Lawson, Aaron Smith, Thomas Hayhow, Neil Gibson
• 5020 · PDF Oxysterol sulfotransferase in prostate cancer inhibition: Cell-intrinsic and -extrinsic roles Bobae Park, Zhao Zhang, Chiou-Miin Wang, Mohin Patel, Yaguang Liu, Chia-Nung Hung, Bandana Chatterjee
• 5021 · PDF Role of ZFX variants in parathyroid tumorigenesis Sara Halili, Lucas Iommazzo, Callie Burke, Justin Bellizzi, Jessica Costa-Guda, Andrew Arnold
• 5022 · PDF Hormonal alterations distinguishing high-risk women from breast cancer patients across the menopause transition Jiaqing Hao, Reilly T. Enos, Sam Rosin, Jinyu Wang, Shanshan Liu, Melissa A. Curry, Sonia L. Sugg, Marinella Temprosa, E. Angela Murphy, Bing Li
• 5024 · PDF USP8, a survival gatekeeper turned oncogenic trigger via hyperactivation of the integrated stress response Debjani Mandal, Santosh Kumar, Dhruval Bhatt, Yan Li, Kory Johnson, Maric Dragan, Prashant Chittiboina

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