Strategies to Enhance the Therapeutic Index of Radiotherapy

• 3329 · PDF Targeting DNA Damage Response Dependencies for Radiosensitization in Li-Fraumeni Syndrome Madeleine Driscoll, Paula R. Quaglietta, David Malkin
• 4624 Investigation of the efficacy of reduced coenzyme Q10 (CoQ10) for alleviating acute intestinal toxicity associated with pelvic radiotherapy: A randomized, placebo-controlled, double-blind comparative study Satoshi Seno, Akifumi Kajiwara, Yasuyuki Shimizu, Kazuma Iwashita, Kana Kobayashi, Qin Qin, Qu Zhang, Hatamei Takabayashi, Kanako Suda, Hiroki Kawaguchi, Takeaki Ishihara, Daisuke Miyawaki, Sae Murakami, Yoshito Terai, Ryohei Sasaki
• 4625 · PDF Mechanistic insights into the radioprotective action of GM-0111 via CCL5 inhibition and endothelial-immune modulation Kholod A. Elhasany, Shukran Alizada, Sushanto Kumar Saha, Thomas A. Zangle, Abigail Pulsipher, Hamid Ghandehari
• 4626 · PDF Radioprotective fullerene derivative as a potential systemic therapeutic to alleviate radiation-induced cardiovascular disease Khadijeh Koushki, Prapannajeet Biswal, Joseph B K Kim, Ngoc Tuyet Tra, Prudhvi C. Mallepaddi, Naren Gundapaneni, Sai Kumar Samala, Lydia WT Cheung, Geraldine Vijay, Sivareddy Kotla, Yuri Mackeyev, Sunil Krishnan
• 4627 · PDF Receptor-targeted gold nanospheres strengthen radiation efficacy and reprogram tumor immunity Bhoomika Muruvekere Lakshmisha, Prudhvi Chand Mallepaddi, Prapannajeet Biswal, Ngoc Tuyet Tra, Aria Sabbagh, Ayobami Fidelix, Sai Kumar Samala, Gabrielle Krouse, P M Quan Mai, Khadijeh Koushki, Lydia WT Cheung, Geraldine V Vijay, Yuri Mackeyev, Sunil Krishnan
• 4628 Mitochondrial serine/threonine phosphatase, phosphoglycerate mutase 5 (PGAM5) is a novel target to promote abdominal radiotherapy Shujah Hamid Rehman, Rishi Man Chugh, Payel Bhanja, Stacey Krepel, Subhrajit Saha
• 4629 · PDF Modeling pharmacokinetics and efficacy of the ATM inhibitor WSD0628 in GBM and melanoma metastasis PDX models Ann Catherine Mladek, Juhee Oh, Sneha Rathi, Lily Liu, Danielle M. Burgenske, Brett L. Carlson, Katrina K. Bakken, Lauren L. Ott, Zeng Hu, Wei Zhong, William F. Elmquist, Jann N. Sarkaria
• 4630 CD46-targeted dual-modality alpha-particle and cytotoxic payload-loaded antibody for enhanced treatment of metastatic castration-resistant prostate cancer Anil Bidkar, Scott Bidlingmaier, Anju Wadhwa, Kondapa Naidu Bobba, Shubhankar Naik, Cheng Xue, Athira Raveendran, Megha Basak, Jonathan Chou, Rahul Aggarwal, Henry VanBrocklin, Youngho Seo, Bin Liu, Robert Flavell
• 4631 · PDF Utilizing a dual action agent for targeted neuroendocrine tumor therapy Tyler M. Bateman, Sukhen C. Ghosh, Solmaz AghaAmiri, Majid Momeny, Servando Hernandez Vargas, Jack T. Adams, Vahid Khalaj, Ali Azhdarinia
• 4632 · PDF LSD1 inhibition enhances radiotherapy efficacy in OSCC by attenuating SUMOylation and activating NK cells Chumki Choudhury, Amit Kumar Chakraborty, Rajnikant Raut, Marilia Takada, Bikash Sahay, Minh-Tam Truong, Daniel L. Gustafson, Jenna Burton, Manish V. Bais
• 4633 Theranostic evaluation of 68 Ga-PMSA, 177 Lu PSMA therapy, and biomarker guided immunotherapy and DDR inhibitor combinations in LNCaP prostate cancer xenografts Juliana Maynard, Anita Liu, Benedetta Arno, Tracy Hall, William Drewe, Kerry Shea, Andrzej Rutkowski, Grace Haydon, Tiffany-Jane Allen, Fiona Yau, Liviu Lucaciu, Mikaela Griffiths, Gayle Marshall
• 4634 · PDF Pretreatment with pan-integrin inhibitor GLPG-0187 sensitizes GBM cells to radiation Maryam Ghandali, lanlan Zhou, Wafik S. El-Deiry
• 4635 · PDF Mapping PSMA-617 sensitivity in prostate cancer PDX models to enable combination therapy and resistance studies Rocio Matesanz Sanchez, Karg Margarete, Nikoline Nielsen, Marina Simón Martin, Kira Røpke Jørgensen, Mette Munk Wessek, Rasmussen Patricia, Anne Hessellund Langhave, Louise Juul Nielsen, Jacobsen Helle Jane, Neal D. Shore, Sebastian Gnosa, Michael Wick, Carsten Haagen Nielsen
• 4636 Deciphering radiation sensitivity identifies MDM2 as a targetable driver of synergistic radiosensitization in TP53 wild-type lung adenocarcinoma Chan Hoon Maeng, Jieon Hwang, Joong Bae Ahn, Sang Joon Shin
• 4637 Alpha-particle radiotherapy combined with anti-CTLA-4 synergistically overcomes radioresistance and induces local and systemic antitumor immunity in PDAC Marco Reis, Poliana C. Marinello, Walison Augusto da Silva Brito, Scott Bright, Mark Wasley, Alexandre Rubinstein, Ronen Sega, Vered Bachar, Gabriel O. Sawakuchi
• 4638 Oncolytic herpes simplex virus, M002, increases the antitumor radiation response by decreasing the G2/M arrest in murine rhabdomyosarcoma orthotopic allograft cells Maryam G. Shaikh, Nazia Nazam, Morgan L. Brown, Pranava Nande, Ali M. Eakes, Shamza Manzoor, Joel C. Opara, James M. Markert, Jamie M. Aye, Elizabeth A. Beierle
• 4639 · PDF Redox modulation by gold nanorods enhances radiosensitivity in MOLT 4 cells Paras Jawaid, Mati Ur Rehman, Azhar Hussain Rajabali, Ather Enam
• 4640 · PDF Benefit of combining DLL3 targeted alpha therapy with standard of care in preclinical small cell lung cancer models Hanan Babeker, Emma Cummins, Alex Mandel, Lily Li, Etienne Melese, Rachael Brake, Iva Kulić
• 4641 Highly soluble prodrug boronophenylalanine (L-BPA) dipeptide, exhibits notable tumor suppression whilst inducing cancer vaccine effect post neutron irradiation treatment Samkeliso Dlamini, Michael Torgov, Arthur Raitano, Jason Quintana, Tioga Martin, Chunying Zhang, Maria Christina Malinao, Maki Ikeura, Linnette Capo, Karen Morrison, Robert Dorn, Kotaro Matsumoto, Aoi Komatsu, Yuya Higashi, Takushi Takata, Yoshinori Sakurai, Minoru Suzuki, Fuyuhiko Tamanoi, Kendall Morrison
• 4642 · PDF Defining radiosensitivity indicators to predict prognosis using patient-derived organoids in oral cancer Sumin Kang, Mi Rim Lee, Jonghyun Lee, Dongkwan Shin, Jong-Ho Lee, Ikjae Kwon, Jiyoung Lee, Yu-Sun Lee, Sun-il Choi, Hye Won Shon, Gyeongmin Kang, Sung Woen Choi, Yun-Hee Kim
• 4643 Microsatellite instability as a determinant of chemoradiotherapy sensitivity in colorectal cancer: Integrated clinical, radiomic, and 3D organoid-based analyses Hyowon Hong, Shin Kim, Sang Jun Byun, Seong Kyu Baek, hyewon lee, sung wook bae
• 4644 · PDF Protein kinase D1 modulates LET- and dose-dependent radiosensitivity in prostate cancer cells Joseph McGrath, Sanjeev Shukla, Mohammad Saki, Hardev Grewal, Jiyeon Park, Mark Artz, K.C. Balaji
• 4645 · PDF Integrative transcriptomic and CRISPRi screening identifies determinants of intrinsic radiosensitivity in breast cancer Breanna Nicole McBean, Priyanka S. Rana, Reine Abou Zeidane, Alexander Davis, Vesna Mercer, Benjamin Hauk, Anna Michmerhuizen, Samuel Lichtman-Mikol, Camila Diedrich, Kari Wilder-Romans, Mingfang Tao, Alan P. Boyle, Corey Speers
• 4646 Validation of a panel of fibroblast activation protein expressing cell line derived xenograft models as a platform for the development of targeted radioligand therapeutics Michael Batey, James Suchy, Taylor Hotz, Michael Milhollen, Kayla Duval, Jackson Chan, Karen Gelinas, Michael Bruce, Michelle Petrozzi, William Maccuaig, Neil Rollins, Jennifer Tavares, Erin Snay, Kyeara Mack-Henry, Soumya Ullas
• 4647 Development and validation of a panel of cell line derived xenograft models representing multiple tumor indications for the evaluation of targeted radioligand therapeutics Michael Batey, James Suchy, Taylor Hotz, Michael Bruce, Jennifer Tavares, Erin Snay, Neil Rollins, Jackson Chan, Karen Gelinas, Kayla Duval, William Maccuaig, Michael Milhollen, Michelle Petrozzi, Kyeara Mack-Henry, Soumya Ullas
• 4648 · PDF Targeting alternative end-joining overcomes miR-21-5p -mediated radioresistance in oral squamous cell carcinoma Lin Ma, Nilupaier Tayier, Weitao Hu, Junyang Chen, Yanhe Li, Lu Wen, Yonghui Luo, Xinghan Li, Qi Liu

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