Targeting DNA Repair, Cell Cycle, and Tumor Metabolism

• 1256 · PDF A novel therapeutic approach to overcome metabolic reprogramming in lung cancer Nicholas Blazanin, Xiaobing Liang, Yonathan Lissanu
• 1257 · PDF Synergistic inhibition of PARP and ATM leads to unresolved DNA damage and cohesin-mediated collapse in pediatric osteosarcoma Janeala Morsby, Sona Kocinsky, Estevez Prado Daniel, John Harper, Charlie Wright, Monika Weirdl, Caroline Wechsler, Gabriela Alexe, Kimberly Stegmaier, Paul Geeleher, Lillian Guenther
• 1258 Harnessing combinatorial nanomedicine for simultaneous BRD4 degradation and stromal disruption against pancreatic ductal adenocarcinoma Drishti Rathod, Ketankumar Patel
• 1260 LIPA inhibition enhances the therapeutic efficacy of DNA-damaging agents in ovarian cancer through induction of ER stress and enhancing DNA damage Durga Meenakshi Panneerdoss, Tae-Kyung Lee, Khaled Mohamed Nassar, Gaurav Sharma, Scott Terry Elmore, Henry Neal, William Cole Arnold, Edward Kost, Suryavathi Viswanadhapalli, Jung-Mo Ahn, Ganesh V. Raj, Ratna K. Vadlamudi
• 1261 · PDF Mutation-dependent sensitivity to the dual TTK/PLK1 inhibitor BAL0891 in patient-derived gastric cancer organoids Chan Hee Park, Jinsoo Jang, Woo Sun Kwon, Tae Soo Kim, Seunghyun Ma, Minkyung Kang, Sun Young Rha
• 1262 · PDF Depletion of dominant-negative mutant p53 improves the efficacy of mutant p53 reactivators Allison St. John, Mrinalini Bhosale, Alejandro Parrales, Atul Ranjan, Tomoo Iwakuma
• 1263 · PDF Development of a novel selective CDK4 inhibitor for HR+/HER2- breast cancer Apeng Liang #, *, Meihua Li #, *, Kai Wang, Yi Long, Hui Xu, Haoyun Li, Jian Zhu, Guangbin Liu, Ling Fang, Xi Wang, Yiming Cai, Xiang Zhang, Shengli Dong, Yu Yu, Xinlong Yang, Chao Zhou, Teng Zhou, Wei Wu, Chengshan Niu, Shaoqing Chen, Jun Li*, Yusheng Wu
• 1264 Limited apoptotic response in RBM10 wild type/deficient EGFR-mutant lung cancer patient-derived models overcome by combined EGFR and BCL-2/BCL-xL inhibition Jonathan Wesley Riess, Hongyong Zhang, Jasmine Diaz Sezati, Peyton Apruzzese, Dongguang Wei, Tiffany Le, Luis G. Carvajal-Carmona
• 1265 · PDF PRKDC regulates CDK2 expression and pancreatic neuroendocrine cancer sensitivity to chemotherapy Subin Kim, Mahnaz Norouzi, Courtney M. Townsend, B. Mark Evers, Piotr Rychahou
• 1268 · PDF Targeting PRMT5 enhances ferroptosis in B-cell lymphomas Yunxia Liu, Ruoyu Chen, Xiaoyue Gao, Fen Zhu, Qinyu Ni, Zhuoyan Zai, Paul D Bates, Victoria Ann Obernberger, Christian Capitini, Lixin Rui
• 1269 · PDF Silencing of ACACA sensitizes acute myeloid leukemia cells to venetoclax Akansha Jalota, Anna Skwarska, Yen Bao Huynh, Fumiaki Sato, Christina Glytsou, Iannis Aifantis, Yoko Tabe, Stefano Tiziani, Marina Konopleva
• 1270 · PDF Immunotoxin GB13 Targets GBM and H3.3K27M DIPG with the activation of Golgi-to-ER retrograde transport pathways Nanyun Tang, Yue Hao, Valerie DeLuca, Charles Caleb Shaffer, Randy Schrecengost, Michael E. Berens
• 1272 · PDF Targeting autophagy sensitizes cancer cells to proteasome inhibitors Jing Li, Yi Bao, Ava Cardenas, Ariba Saoda, Fengyu Su, Yuanyuan Qiao, Xuhong Cao, Arul M. Chinnaiyan
• 1273 · PDF Antitumor activity of PARPi and POLQi combination therapy in a BRCA-mutated PDAC model Chani Stossel, Dikla Atias, Yulia Glick-Gorman, Josep Forment, Lee Mulderrig, Gali Altman, Hanita Ovadia, Liora Chouchan, Elina Haimov-Talmoud, Tamar Beller, Talia Golan
• 1274 · PDF Integrated multiomics analysis identifies defective CoQ10 interactome in human kidney cancers Gregory M. Miller, Nischal Mahaveer Chaud, Catarina M. Quinzi, Brian Berman, Vivek K. Vishnudas, Vijay Modur, Vlatcheslav Akmaev, Niven R. Narain, Stephane Gesta, Michael A. Kiebish
• 1275 · PDF Phospholipase D1 overexpression drives metabolic survival and stress resistance in cervical cancer Sung Wan Kang, Dong Woo Kang, Yu-na Noh, Young-Jae Lee, Min-Seo Lee, Yong-Man Kim, Shin-Wha Lee
• 1276 Dual epigenetic-kinase targeting to overcome resistance and immune evasion in hepatocellular carcinoma Kyounghyun Kim, HongDuck Yun, Gabin Kwon
• 1277 Overcoming glioblastoma resistance by targeting its heterogeneity with a synergistic approach: TTFields stimulation and tmCLIC1 impairment Francesca Cianci, Elisa Meraviglia, Guido Rey, Stefania Castiglione, Antonio M. Polito, Sara Torabi, CHIARA MERCURIO, Dietmar Krex, Tatiana Vorobyov, Kerem Wainer-Katsir, Martin Gabay, YAARA PORAT, Roni Blatt, Ori Braten, Tullio Florio, Itai Tzchori, Michele Mazzanti
• 1279 · PDF Exploiting Wnt-induced DNA damage repair vulnerability with PARP inhibitors to overcome chemoresistance in multiple myeloma Kaushlendra Tripathi, Gabriella Santos, Camila Pacocha, Shadika Panta, Emma Younger, Trevor Stepanyan, Lauren Fowler, Brandon Smith, Ryan O'Hare, Xavier Noel Pin Harry, Daniel Ross, Bidyut Mohanty, David Eagerton
• 1280 · PDF Pathway-based radiosensitivity and therapeutic targeting in triple-negative breast cancer subtypes Jaitri Joshi, Jenna Jacoby, Shan Xu, Noëlle François, Tiziana DeAngelis, Anuradha Shastri, Adeseye Adekeye, Nicole L. Simone

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