Immunomodulatory Agents

• 4297 · PDF COX-2/PGE2 driven, photoimmunotherapy-induced edema is reduced by prophylactic NSAIDs in mouse tumor models Christopher M. Amantea, Abram Lozano, Ryosuke Takahashi, Takuya Osada, Shohei Sase, Ryuhei Okada, Amy H. Thorne
• 4298 · PDF High-dose vitamin C induces ROS-dependent calreticulin exposure to drive immunogenic cell death and cancer immune surveillance Alessandro Cavaliere, Federica Maione, Marco Macagno, Vito Amodio, Rosaria Chilà, Marcello Turi, Marc Escobosa, Giovanni Germano, Simona Lamba, Chiara Baretta, Anita Brignacca, Valeria Pessei, Elena Perez, Daniela Grases, Alice Bartolini, Fabio Penna, Eduard Porta, Manel Esteller, Dieter Saur, Roland Rad, Annamaria Gullà, Alberto Bardelli, Teresa Troiani, Salvatore Siena, Andrea Sartore-Bianchi, Federica Di Nicolantonio
• 4299 · PDF STING pathway activation reveals feedback inhibition potentially limiting immunostimulatory response in adenoid cystic carcinoma Annie Li, Samantha E. Flynn, Prinjali Kalyan, Dawn R. Mitchell, Chengzhou Gao, Edwin Zhang, Diane Yang, Ross D. Merkin, William C. Faquin, Daniel L. Faden, Xin Gao, Jong Chul Park, Lori J. Wirth, A. John Iafrate
• 4300 · PDF IND-enabling development of a novel STING agonist, IMGS-203, for the treatment of glioblastoma Christine Gagliardi, Paul Blezinger, Ahmad Salameh, Michael A. Curran, James Barlow, Federica Pericle
• 4301 A systemically administered detoxified TLR4 agonist displays potent antitumor activity across multiple tumor models and favorable preclinical tolerance profile Laury-Anne Leroy, Capucine Phelip, Armando Andres Roca Suarez, Sabine Beaumel, Anais Debesset, Abdelkamel Chettab, Martine Caroff, Audrey Diederichs, Alexey Novikov, Barbara Testoni, Frédérique Brune, Fabien Zoulim, Jérôme Kerzerho, Juliette Humeau, Charles Dumontet
• 4302 · PDF Next-generation STING mRNA therapy with reduced toxicity and dual action against cancer by boosting immunity and inducing tumor cell death Yong Ho Heo, Youngjin Han, Seung-Hyun Shin, Chang Gyu Lim, Ji Hee Lee, Hocheol Shin, Jooyun Byun, Daejin Kim, In Young Choi
• 4303 · PDF Reprogramming tumor immunogenicity by targeting EGFL6 in ovarian cancer Weiche Wu, Zonghao Tang, Sujanitha Umamaheswaran, Zhiqiang An, Ningyan Zhang, Lingegowda S. Mangala, Anil K. Sood
• 4304 · PDF Effects of antisense oligonucleotides targeting PD-1 pre-mRNA identified by DIRAC-dCas13-based screening on PD-1-positive lymphocytes Yuto Tan, Naoko Kumagai-Takei, Shuya Yano, Yurika Shimizu, Akira Yamasaki, Mari Hara-Yamamoto, Shigeru Mitani, Tatsuo Ito
• 4307 · PDF Pregnancy-inspired DNA nanocarriers reproduce a cGAS-driven pro-inflammatory monocyte phenotype Mathew R. Schnorenberg, Elizabeth Ann L. Enninga, Wendy K. Nevala, Noah A. Stueven, Svetomir N. Markovic
• 4308 · PDF Systemic nanoplasmid gene therapy with engineered cancer-activated promoters selectively programs tumor cells to express inflammatory interleukins and drive antitumor immunity Evan Bishop, Priyanka Balasubrahmanyam, Ajda Rojc, Trupti Patil, Moataz Reda, Lingyun Li, Dang Dang, Xiaobin Wu, Robby Chandra, Nikki Kimura, Kim Tran, Blaine McCarthy, Sushil Lathwal, Sathyapriva Rajagopal, Badriprasad Ananthanarayanan, Nadege Morisot, David Brian Rosen, David Suhy
• 4309 · PDF Preclinical antitumor and immunomodulatory activity of ARV-6723, a PROTAC hematopoietic progenitor kinase 1 (HPK1) degrader, versus immune checkpoint inhibitors (ICIs) Anna C. Van Acker, William Corwin, Albert DeBerardinis, Emma Rousseau, Rebecca Conrad, Morena Scopel, Christopher Kuhlberg, Gregory Cadelina, Kim Davenport, Wendy Wu, John Corradi, Jennifer Pizzano, Keith R. Hornberger, Angela Cacace, Ignacio J. Juncadella, Sean Landrette, XiaoZhe (Janet) Wang
• 4310 · PDF CLD-401, an IL-15 superagonist gene medicine via redtail virotherapy, achieves sustained tumor eradication Duong H. Nguyen, Yunyi Kang, Stephanie Songco, Trevor Smith, David Nguyen, Yan Pang, Lina Schulte, Hongli Zhang, Sinje Tigges, Fabian Kortum, Daniela Kleinholz, Susan Tamraz, Ivelina Minev, Evan Cassavaugh, Travis Clifton, Thomas Herrmann, Barbara Härtl, Antonio F. Santidrian
• 4311 · PDF Arenavirus based Non-lytic Viral Immune Drivers with tumor-tropic mutations as new class of amplificators of anti-tumoral T cell responses Philipp A. Lang, Jörg Vollmer, Karl S. Lang
• 4312 · PDF FAP-targeting Small molecule-immunostimulator conjugate bearing a novel TLR7 agonist payload induces tumor eradication and long-lasting antitumor immunity in vivo Matilde Bocci, Matilde Monaci, Marta Mascellani, Dario Neri, Samuele Cazzamalli, Andrea Galbiati
• 4313 · PDF Light-free photochemical internalization-inducing polymer conjugate elicits cancer pyroptosis to coordinate host immune responses Torsha Ghosh, Jae Hyung Park, Sol Shin, Soyoung Son
• 4314 · PDF Bipolar pulsed field ablation triggers local and abscopal tumor control with robust immune activation in a syngeneic PDAC model MacKenzie Demmel, Lincoln Strickland, Khadija Turabi, Alyssa Waller, Urvinder Kaur Sardarni, Nirav C. Thosani, Raju Viswanathan, Jennifer Bailey-Lundberg
• 4315 · PDF Co-activation of Wnt/beta-catenin and c-MET induced inflamed hepatocellular carcinoma responsive to immune checkpoint therapy Araceli Selena Bernal, Subash Khadka, Morgana McLaughlin, Ankur Tiwari, Brittany Barre, Francisco Cigarroa, LuZhe Sun
• 4316 An in vivo MAIT cell activation and rejuvenation systemfor liver cancer therapy Yan-Ruide Li, Haochen Nan, Zhengyao Shao, Xinyuan Shen, Lili Yang
• 4317 · PDF A porphyrin-HDL nanoparticle for low-dose photodynamic therapy-induced antitumor immune activation Yiming Yang, Juan Chen, Gang Zheng
• 4318 Combined Quad Shot regimen and immunotherapy for incurable recurrent or metastatic head and neck cancer Xiao Yang, Zheng Yang, Fei Wang, Lingyi Kong, Chao Wan, Kunyu Yang
• 4319 Exploring oncolytic viral therapy to target osteosarcoma Sumbul Khan, Therasa A. Higgins, Isabella S. Lofano, Payal Agarwal
• 4320 · PDF Rational design of a repeated-dosing schedule for KNP-101 guided by IFN-gamma regulation Jihoon Chang, Byoung Chul Lee
• 4321 · PDF Oncolytic virus exhibits potent antitumor and immunomodulatory effects in triple-negative breast cancer using syngeneic and PDX models Yelin KIM, Jihye B Lee, Yoonjin Cha, Keunhee Oh, Namhee Lee, Seoyoung Lee, Hei Cheul Jeung, Soong June Bae, Sung Gwe Ahn, Joon JEONG, Jee Hung Kim
• 4322 · PDF Tumor treating fields (TTFields) overcome anti-PD-1 resistance in a murine lung adenocarcinoma model Yun Hu, Fatemeh Maspourour, Qi Wang, Ailing Huang, Carola Leuschner, Jing Wang, James W. Welsh
• 4323 · PDF The SPHK2 inhibitor opaganib potentiates tumor-intrinsic STING activation in triple-negative breast cancer in vitro Colette R. Worcester, Amrita Mitra, Harsh B. Pathak, Shane R. Stecklein
• 4324 · PDF Dipeptidyl peptidase 4 restoration facilitates anti-tumor immunity in KRAS-LKB1-mutant lung cancer Hiraku Yanada
• 4326 · PDF Dissecting oncolytic virus anti-virus vs anti-tumor immunity in glioma: Insights from a patient derived organoid model C. Zoe Linke, Ethan Chen, Jennifer Gantchev, Aanchalika Chauhan, Christopher Jannotta, Keith L. Ligon, Andres Santos, Nathalie Agar, E Antonio Chiocca, Alexander L. Ling
• 4327 · PDF Serotonin receptor 5-HT 2A as a potential target for HCC immunotherapy Rong En Tay, Charmaine M. Ho, Nicholas D. Z. Ang, Hui Chien Tay, Daniel Z. Lopez, Qiao Rui Na, Yi Wen Tan, Ser Mei Koh, Kim Peng Tan, Wendy W. L. Lee, Jack Wee Lim, Mai Chan Lau, Han Chong Toh, Olaf Rötzschke, Laurent Rénia

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