Adaptive Immunity in Cancer

• 4233 · PDF Transcription factor c-Maf drives Th17-dependent activation of CD8⁺ T cells to sustain anti-tumor immunity Ching Tung Wu, Shi-Chuen Miaw
• 4234 · PDF Glycan-based site specific ADC achieves sustained tumor control through Improved payload delivery and immune activation Liu Chih-Chun, Tsai Yi-Chien, Huang Jing-Rong, Lo Fei-Yun, Pei Yu, Hsu Ren-Yu, Tu Tzu-Hsuan, Chen Ya-Chi
• 4235 · PDF Cell-level spatial transcriptomics detection of microenvironmental STAT1-expressing plasma cells in colorectal cancer recurrence by G4X I-Chuang Liao, Minh-Khang Le, Vivek Pujara, Haley Jun, Devanshi Pratiher, Jane C. Figueiredo, Nathalie Nguyen, Chintda Santiskulvong, Angie Laguna, Yi Zhang, Keluo Yao, Joshua Jay Levy
• 4236 · PDF The metabotropic Glutamate receptor-1 is a glutamatergic checkpoint that integrates with TCR to augment anti-tumor CD8⁺ T cell activation, metabolism and effector function Salvador Gonzalez Ochoa, Maria Teresa P. de Aquino, Thomas W. Hodo, Thanigaivelan Kanagasabai, Muna A. Mohammed, Jane Tonello, Alla Ivanova, Anil Shanker
• 4237 · PDF Immunofluorescence-based adaptive immune subtypes in an association with long-term disease-free interval in the Carolina Breast Cancer Study Phase III Qichen Wang, Timothy Patrick Sheahan, Alyssa Joy Cozzo, Sarah Christine Van Alsten, Eboneé Nicole Butler, James Stephen Marron, Katherine A. Hoadley, Melissa A. Troester
• 4238 Cytokine expression within the different categories of tumor-infiltrating lymphocytes in primary cutaneous melanoma: an immunohistochemical study Thato Ntuli, Benny Mosoane, Tebogo Marutha, Rahaba Marima, Zodwa Dlamini, Meshack Bida
• 4239 · PDF Aging turns B cells into drivers of CD8⁺ cells that weaken tumor defenses MONICA BODOGAI, Bongsoo Park, Fatima-Zohra Braikia, Kumaraswami Konda, Arya Biragyn
• 4240 · PDF Differential impact of short and long-term hypoxia on effector T cell dysfunction María Villalba-Esparza, Ana Lledó-Delgado, Shruti S. Desai, Adam Aguirre-Ducler, Daniel Boiarsky, Boyu Huang, Samuel M. DeFina, Javier Ramos-Paradas, Kurt A. Schalper
• 4241 · PDF Anti-tumor antigen CD8 T cells infiltrating M3 uveal melanoma metastases are detectable in the blood Sol Y. Nunez, Rachele Sintini, Camille Jamet, Setareh Aflaki, Abdoulaye Soumare, Pascale Mariani, Manuel Rodrigues, Marc-Henri Stern, Olivier Lantz, Ana I. Lalanne
• 4242 · PDF IRF8 regulates T cell differentiation and anti-tumor effector function Zainab Tiamiyu, Dakota Poschel, Aaron Behdadnia, Kendra Fick, Patrick Czabala, Yang Zhao, Dafeng Yang, Sergie BOMBIN, Kebin LIU
• 4243 · PDF Mutational-signature adjusted models reveal HLA-mediated depletion of antigenic mutations in non-small cell lung cancer (NSCLC) Amy Lauren Cummings, Andy Han, Seung J. Park, Sai S. Kollapaneni, Daniel Li, Arjan Gower, Maria Antonia Velez Velez, Aaron Lisberg, Jonathan W. Goldman, Edward B. Garon
• 4244 · PDF Investigating the spatial immune tumor microenvironment of dermatofibrosarcoma protuberans Maryam Al-Ghezi, Malia Rettig, Christopher P. Loo, Rashi Yadav, Wesley Yu, Joshua M. Moreau
• 4245 The Immune strategies to convert cold to hot tumors and overcome resistances Yang-Xin Fu
• 4248 · PDF Characterization of T-cells in ER + breast tumors and their matching adjacent tissue reveals that classical exhaustion markers are not indicative of T-cell function Diana Savage, Edward Buchel, Afshin Raouf
• 4249 · PDF High-throughput discovery of MART1-specific TCR-peptide interactions using a Jurkat NFAT Reporter-K562 antigen-presenting cell system and single-cell adaptive immune receptor profiling Alex Chenchik, Debbie Deng, Kitt Paraiso, Guido Stadler, Ben Yellen
• 4250 Sirt2 dictates TCR activation thresholds through post-translational control of LCK conformational state Imene Hamaidi, Pingyan Cheng, Soo Young Jun, Min-Hsuan Wang, Min Zhang, Odesha Taylor, Luis Lopez-bailon, Ismail Can, Bin Fang, Anders Berglund, Bradford Perez, Ben Creelan, Andriy Marusyk, Virginia Shapiro, Haitao Ji, Jose R. Conejo-Garcia, Sungjune Kim
• 4251 · PDF Th7R cells: CD4⁺ T-cell partners that drive Tpex-mediated antitumor immunity in the tumor microenvironment Shota Takei, Ou Yamaguchi, Satoshi Yamasaki, Atsuhito Mouri, Ayako Shiono, Yu Miura, Kosuke Hashimoto, Hisao Imai, Kyoichi Kaira, Ichiki Yoshinobu, Hiroyuki Nitanda, Tomoyuki Hishida, Katsuhisa Horimoto, Hiroshi Kagamu
• 4252 · PDF Tumor extracellular vesicles prime B cells which promote tumor control and epitope spreading to T cell neoantigens Georgia Lattanzi, Zihan Guo, Kendrick Nguyen, Ferdinando Pucci, Daniel Hollern
• 4253 · PDF Integrating neoantigen immunogenicity and tumor clonality for predicting immunotherapy response Ko-Han Lee, Timothy Sears, Maurizio Zanetti, Hannah K. Carter
• 4254 · PDF Tapasin inhibits MHC I-presentation of a low affinity peptidome which elicits a unique population of highly effective CD8 T cells, in multiple mouse cancers Purva Pundeer, Joseph Dempsey, Adam T. Hagymasi, Jeremy Balsbaugh, Tatiana Scheglova, Ion Mandoiu, Pramod K. Srivastava
• 4256 · PDF Long-read RNA sequencing and immunopeptidomics reveal transcriptomic aberrationneoantigens as targets for T cell immunotherapy in diffuse glioma Kenan Zhang, Megan Benz, Kelly M. Hotchkiss, Lin Lin, Sarah Quackenbush, Aroa Elortza Payros, Mark Pieterse, Wigard Kloosterman, Jeroen Kneppers, Mustafa Khasraw
• 4257 · PDF F5446 epigenetically reprograms T cells to boost CEA CAR T cell immunotherapy efficacy in human colorectal cancer metastasis Kendra Fick, Patrick Czabala, Zainab Tiamiyu, Dafeng Yang, Kebin Liu
• 4258 · PDF In vivo genome-scale enhancer screen decodes T cell fate decisions in the tumor Keely Y. Ji, Alex Chang-Yu Chen, Laura Hinojosa, Bolutito Babatunde, Daniela Martinez, Thomas J. LaSalle, Maria Zschummel, Marc A. Schwartz, Ferhat Ay, Debattama Sen
• 4259 · PDF Peripheral T cell methylome reveals accelerated systemic immune aging in early lung cancer Yu-Ching Wang, Shu-Yung Lin, Yi-Jhen Huang, Sheng-Yao Su, Yi-Chieh Wu, Jin-Shing Chen, Shuenn-Wen Kuo, Mong-Wei Lin, Chong-Jen Yu, Hsing-Chen Tsai
• 4260 · PDF Deciphering the dysfunctional immunological synapse in acute myeloid leukemia through microfluidic Sofia Titah, Clara Lewuillon, Faruk Azam Shaik, Aurelie Guillemette, Eva Gez, Nathalie Jouy, Laure Goursaud, Celine Berthon, Salomon Manier, Carine Brinster, William Langue, Tzung Hsuen Khoo, Alexandre Poulain, Sophie Dabo, Dominique Collard, Bruno Quesnel, Loic Lemonnier, Mehmet Cagatay Tarhan, Yasmine Touil
• 4261 · PDF High-sensitivity HLA-I immunopeptidome profiling from limited clinical PBMC samples Anamarija Pfeiffer, Lucy Yang, Arthur Viodé, Daniel Redfern, Yuehan Feng, Daniel Green, Cheryl McAlpine

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