Oncogenic Transcription Factors and Cancer Programs

• 4751 · PDF SOX4 upregulation contributes to ovarian cancer initiation through a stress-adaptation program Jayaprakash Mandal, Brielle Hayward Piatkovskyi, Md Masud Rana, Tu-Yung Chang, Tian-Li Wang, Ie-Ming Shih
• 4752 · PDF HMGA1: An epigenetic driver of colon carcinogenesis by inducing FGF19 signals which can be targeted with FGFR4 receptor blockade Yuze Du, Li Luo, Jung-Hyun Kim, Bailey West, Tatianna Larman, Leslie Cope, Eric R. Fearon, Cynthia Sears, Linda Resar
• 4753 · PDF The SOX2-RUNX2/TEAD4 signaling axis drives ESCC progression and exposes therapeutic vulnerabilities via Hippo/MAPK pathways Shangwei Sun, Yixiao Li, Yating Xu, Jin Zhou, Adam Bass, ZHONG WU
• 4754 · PDF ADT-induced stress elevates CDKN2AIP to promote neuroendocrine prostate cancer Benjamin Chen, Pranabananda Dutta, Jerry Salinas, Ali Andalibi, Kamrul Hasan
• 4755 · PDF Novel SOX2-targeting bioPROTACs as multi-faceted anti-tumor agents overcoming resistance to standard therapies in lung cancers Yeryoung Yong, Saeyi Lim, Hyerin Song, Yuna Jeon, Kiyoung Choi, Seunghyun Lee, Jaehyun Choi
• 4756 · PDF Evaluation of strategies to target the Myc oncogene Maria Ahn, Aimee Blair, Juan Bueren-Calabuig, Barbara Farkas, Charlotte Hodson, John Lyons, Stanislava Panova, Mark Wade, George Ward, Alison Woolford
• 4757 CREBBP drives tumorigenicity via aberrant IL-1alpha signaling in EP300 altered bladder cancer James August Rodrigues, Hikmat A. Al-Ahmadie, Sizhi P. Gao, Jiaqian Luo, Jacob Tallman, Fengshen Kuo, Merve Basar, Cansu Yol, Jordan Eichholz, Alejandra Lopez Rojas, Ecenur Turkay, Jonathan E. Rosenberg, Gopa Iyer, Eugene J. Pietzak, Dan Li, Dana Schoeps, Shipra Shukla, Zoe Jacobs, Chen Khuan Wong, Woo Hyun Cho, Ping Chi, David B. Solit, Yu Chen
• 4759 · PDF NELFE and SMARCB1 cooperate to regulate chromatin accessibility and allow MYC-driven gene activation in hepatocellular carcinoma Alvaro Lucci, Anna E. Barry, Laura M. Reynolds, Brittany N. Ruiz, Trish Nguyen, Pongsakorn Choochuen, Kai Zhang, Hien T. Dang
• 4760 · PDF Uncovering a highly transforming, Myc-stabilizing isoform of dipeptidase-1 in colorectal cancer Elizabeth Grace Fisher, Sarah E. Glass, Chelsie K. Sievers, Zheng Cao, Matthew E. Bechard, Samuel T. Ellis, Radhika Aramnadla, Ping Zhao, Ryan T. Smith, Yu Wang, James N. Higginbotham, Frank Revetta, M. Kay Washington, Martha J. Shrubsole, Qi Liu, Ken S. Lau, Bruce Aronow, Robert J. Coffey
• 4761 · PDF Investigation of the role of N-MYC in lung neuroendocrine carcinoma Hiroki Yamamoto, Takashi Sato, Yuri Yagami, Ryosuke Inoue, Hiromi Matsuo, Hideo Watanabe, Naoki Katsuhiko
• 4762 · PDF KIF11 regulates EWS-FLI1 and EWS-ATF1 target gene expression in Ewing and clear cell sarcomas Hannah Louise Walker-Mimms, Nicole Londono, Neelkamal Chaudhary, David Bean, Yi Liao, Lancia N.F. Darville, Jose Serrano-Velez, Yalin Liao, Jiqiang Yao, Andrew Smith, Fumi Kinose, Xueli Li, Joseph O. Johnson, Smitha R. Pillai, Eric B. Haura, Mingxiang Teng, Uwe Rix, Derek R. Duckett
• 4763 · PDF Alternative splicing of ABI1 by enzalutamide treatment drives tumor plasticity in prostate cancer Kevin M. Lin, Anna Seidl, Tanner Waldman, Xiang Li, Eva Corey, Adam G. Sowalsky, Leszek Kotula
• 4764 · PDF Exploring the anti-proliferative impact of PBX1 perturbation in enzalutamide-resistant CRPC Ephraim J. Gardner, Surendra Gulla, Sasikumar Ponnusamy, Abbas Jawadwala, Madison Aust, Remi M. Adelaiye-Ogala
• 4765 · PDF Induction of epidermal like differentiation irreversibly limits the invasive and metastatic potential of basal like breast cancer cells Justin Hui, Andrea E. Doak, Nicole Rhoads, Ruijin Yang, Jimin Park, Cory L. Simpson, Manu Setty, Kevin J. Cheung
• 4767 · PDF Targeted antagonism of the activator protein 1 transcription factor complex results in potent anti-tumor activity in HNSCC models Karen Mendelson, Zachary F. Mattes, Siok Leong, Ricardo Ramirez, Mark Koester, Claudio Scuoppo, Julia Diehl, Erin Gallagher, Binh Lee, Franco Abbate, Lila Ghamsari, Gene Merutka, Barry J. Kappel, Abi Vainstein-Haras, Jim A. Rotolo
• 4768 · PDF From peptide screens to biological insights, FOXO4 and the PBAF complex Dieu An Hoang Nguyen, Andrea Cochran, Shalini Gupta, E Megan Flynn
• 4769 Unravelling the transcriptome in mantle cell lymphoma Chioniso Patience Masamha, Mahesh Gupta, Demiah Lockett, Caiden Lukan, Lael Pasipamire, Jie Li
• 4770 Molecular features of patient-derived triple-negative breast cancer models based on super-enhancer-associated transcriptional regulators and biomarkers Kuniko Horie, Kazuhiro Ikeda, Satoshi Inoue
• 4771 · PDF DEL data-driven discovery of Brachyury (TBXT) ligands toward chordoma therapeutics Zhen Chen, Rebecca Swett, Miklos Feher, AJ Baghaie, Jeffrey Santandrea, Philippe McGee, Massaba Keita, Jenny Liu, Ying Zhang, Jithender Vakiti, Natalia Sannikova, Julien Pomarole, Timothy Morgan, Jean-Christophe Grenier-Petel, Aurélien Coelho, Ryan Walsh, Dylan Hale, Faraz Hussain, Arnaud Clerc
• 4772 · PDF snoRNA-guided ribosome heterogeneity in a model of NSCLC collective invasion Sarah F. Webster, Yi-Ru Li, Virginie Marchand, Tala O. Khatib, Ryan M. Nottingham, Lutfur Rahman, Janna K. Mouw, Alan M. Lambowitz, Blerta Xhemalçe, Yuri Motorin, Adam I. Marcus, Homa Ghalei
• 4773 · PDF MYC associated transcriptional heterogeneity at the single cell level Saravana Gowtham Baskaran, Min-Zhi Jiang, Ada Tam, Hongkai Ji, Chi Van Dang
• 4775 · PDF Reflux-induced NEK2 activates cap-dependent mRNA translation program in esophageal adenocarcinoma Lei Chen, Chloe Xiao, Tianling Hu, Oliver Gene McDonald, Steven Xi Chen, Heng Lu, Zheng Chen, Alexander Zaika, Wael El-Rifai, Dunfa Peng
• 4776 · PDF Lurbinectedin alters EWS::FLI1 binding to chromatin to poison transcription Zachary P. Tolstyka, Raphael D. Lopez, Sridhar M. Veluvolu, Emma Hiscock, Andrew Fuller, Mia Lollo, Emily Seiden, Rachael Hinshaw, Lauren Gaetano, Elizabeth Wilson, Gretchen Lam, Rebecca Kaufman, Elissa Boguslawski, Michelle Paulsen, Ishwarya Narayanan, Jenna Gedminas, Mats Ljungman, Patrick J. Grohar
• 4777 · PDF Core tension and control: Fxr1 mediates mechanoregulation via ahnak in head and neck cancer Anitha Vijayakumar, Samuel John, Tae-Hyung Kim, Breege V. Howley, Viswanathan Palanisamy
• 4778 · PDF FOXR2 reverses MDM2-mediated but not MDM4-mediated p53 repression Wei-Hsiung Yang, Anmol P. Patel, William H. Yang
• 4779 IL-6/STAT3 signaling mediates MYB dysregulation in prostate cancer: Implications for aggressive disease progression and racial disparities Vinayaraj Ellu Valappil, Shashi Anand, Kunwar Somesh Vikramdeo, Ranjana Mitra, Seema Singh, Ajay P. Singh

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