Spatial Niches and Functional Boundaries within the Tumor Microenvironment 1

• 4944 Chromogenic triplex characterization of breast and gastrointestinal cancers for biomarker discovery and spatial image analysis Andrew Fuller, Stacey Margerrison, Scott J. Anderson, Anne Hellebust
• 4945 · PDF Distinct colorectal cancer tumor cell subtypes revealed by single-cell and spatial transcriptomics Ji Hye Choi, Yeong Hak Bang, Kyung Yeon Han, Woong-Yang Park
• 4946 · PDF Osteopontin spatially rewires tumor-immune niches to promote colon cancer liver metastasis Patrick Czabala, Yang Zhao, John Klement, Dafeng Yang, Dakota Poschel, Kendra Fick, Zainab Tiamiyu, Martina Zoccheddu, Kristen Carver, Priscilla Redd, Patricia Schoenlein, Jennifer Waller, Huidong Shi, Kebin Liu
• 4947 Spatially organized transcriptional programs and tumor-stroma interfaces shape immunotherapy response in microsatellite instability-high gastrointestinal cancers Xueshuai Han, Kohei Yamashita, Melissa Pool Pizzi, Kyung Serk Cho, Enyu Dai, Kai Yu, Yunhe Liu, Yibo Dai, Tian Chu, Matheus Sewastjanow-Silva, Hiro Yoshimura, Yibo Fan, Rebecca Waters, Qiong Gan, Feng Yin, Shilpa S. Dhar, Isadora Martins, Jason Willis, Mariela B. Murphy, Jenny Li, Brian D. Badgwell, Van K. Morris, Michael J. Overman, Linghua Wang, Jaffer A. Ajani
• 4948 · PDF Spatial architectures of colorectal cancer microenvironment underlying immune checkpoint inhibitor response Chuyan Liu, Hang Yin, Joon Sang Lee, Julien Tessier, Junbum Kim, Donald Jackson, Angela Hadjipanayis, Olivier Elemento
• 4949 High resolution spatial transcriptomics reveals dynamic remodeling of the tumor microenvironment during prostate cancer progression Jiayi Zhou, Gabriel Cruz, Somnath Mahapatra, Radha Paturu, Hanbyul Cho, Xuhong Cao, Fengyun Su, Rui Wang, Dan Robinson, Yi-Mi Wu, Rohit Mehra, Kayla Muschong, Christine Caldwell Smith, Chelsea Decker, Chandan Kumar-Sinha, Saravana Mohan Dhanasekaran, Rahul Mannan, Yuping Zhang, Arul Chinnaiyan
• 4950 Spatially resolved multiomic profiling of cancer tissue with DISS enables variant mapping across tissue landscape Vivian Tran Dien, Tyler Lopez, Connor Thompson, Ben Krajacich, Adeline Mah, Andrew Altomare, Mariam Dawood, Neam Dawood, Keerthana Elango, Daniel Honigfort, Ryan Kelley, Michael Kim, Jean Kwon, Seana Lymer, Kyle Metcalfe, Jacob Moreno, Duuluu Naranbat, Evan O'Brien, Tristin Rammel, Carlos Ruiz Perez, Ramreddy Tippana, David White, Kelly Wiseman, Jennifer Wong, Jane Yao, Grace Yeo, Matthew Kellinger, Sinan Arslan, Michael Previte
• 4951 Unraveling the role of APOE/APOC1/SPP1/TREM2‑positive lipid‑Associated macrophages in destructive venous invasion and metastasis of colorectal cancer Sanha Hwang
• 4952 Spatial Transcriptomics reveals core resistance niches distinguishing non-MPR from MPR in NSCLC after neoadjuvant chemoimmunotherapy Seo Hye Park, Jeongbin Park, Hongyoon Choi, Jaemoon Koh, Taeyoung Yun, Jihyeon Park, Bubse Na, Samina Park, In Kyu Park, Chang Hyun Kang, Young Tae Kim, Kwon Joong Na
• 4953 · PDF Spatial tissue architecture as a unifying principle of tumor and microenvironmental states in adult gliomas Anna Mathioudaki, Zaira Seferbekova, Samuel P. Rutz, Michael Ritter, Domenico Calafato, Gleb Rukhovich, Felix Hinz, Philipp Mahlknecht, Franziska M. Ippen, Ekaterina Popova, Sophia Schinkewitsch, Nela Runa Koeberer, Nina Wilhelm, Pooja Sant, Jan-Philipp Malm, Sascha Dietrich, Christel Herold-Mende, Nima Etminan, Antje Wick, Sandro Krieg, Michael Platten, Andreas von Deimling, Felix Sahm, Abigail Suwala, Moritz Gerstung
• 4954 Integrated scRNAseq andspatial RNAseq analysis of aggressive prostatic adenocarcinoma identifies TIGIT-NECTIN 2/3 and TIGIT/PVR immunosuppressive interactions Jerry A. Ombor, Anurendra Kumar, Jatin Gandhi, Rakesh Shiradkar, Tilak Pathak, Cynthia L. Winham, Ismaheel O. Lawal, Olayinka A. Abiodun-Ojo, Lara Harik, Saurabh Sinha, Martin G. Sanda, David M. Schuster, Adeboye O. Osunkoya, Carlos S. Moreno
• 4955 · PDF Basescope™ duplex assay enables same-slide detection of short RNA targets including isoforms Sonali A. Deshpande, Alvin J. Y. Ling, Julia Yu, Anushka Dikhshit, Li-Chong Wang
• 4956 Spatial and vascular microenvironmental features predict tumor-infiltrating lymphocyte expansion in glioblastoma Jodie Jepson, Kenan Zhang, Anna Corcoran, Elizabeth Owens, Kelly M. Hotchkiss, Beth H. Shaz, Kyra Van Batavia, Jose R. Conejo-Garcia, John Hickey, Mustafa Khasraw
• 4957 Spatially resolved profiling of the tumor microenvironment and therapeutic response in SMARCB1-deficient epithelioid sarcoma Jiayi Fan, Jeffrey Quinn, Wesley Tansey
• 4958 · PDF Spatial transcriptomic profiling reveals heterogeneity in desmoplastic small round cell tumor Elana Sverdlik, Jeffrey Quinn, Jiayi Fan, Christopher Tosh, Tamar Feinberg, Melania Franchini, Jovana Pavisic, Shanita Li, Andoyo Ndengu, Glorymar Ibanez Sanchez, Emily Stockfisch, Filemon Dela Cruz, Andrew L. Kung, Joshua Honeyman, Emily Slotkin, Wesley Tansey
• 4959 Trekker enables high-sensitivity, single-cell spatial profiling of the FFPE lung SCC tumor microenvironment without segmentation or deconvolution Cedric R. Uytingco, Alec Barret, Julie Wilhelmy, Bryant Ngo, Chenglong Xia, Jonathan Sakkos, Diksha Kool, Wanxin Wang, Christina Chang, Christina Fan, Andrew Farmer
• 4960 Cross-platform comparison of spatial transcriptomics technologies in an FFPE lung squamous cell carcinoma sample Bryan Bell, Cedric Uytingco, Alec Barrett, Bryant Ngo, Jonathan Sakkos, Diksha Kool, Wanxin Wang, Melissa del Rosario, Christina Chang, Christina Fan, Andrew Farmer
• 4961 Cell type-specific adipokine signaling networks in the breast tumor microenvironment uncovered by high-plex spatial imaging Samarth Singhal, Amber Rockson, Hanina Hibshoosh, Parin Shah, Fatemeh Derakhshan, Diane Chen, Alireza Salem, Benjamin Izar, Kevin L. Gardner, Coral O. Omene, Daniel Fernandez, Adrienne L. Castillo, Emma Armstrong, Ijeamaka Anyene Fumagalli, Elizabeth M. Cespedes Feliciano, Sandeep K. Singhal, Adana A. M. Llanos
• 4962 Spatial transcriptomics reveals distinct ASCL1 and ASCL2 gene expression patterns in advanced prostate cancer Fan Wei, Joy C. Yang, Kenneth Iczkowski, Marc A. Dall'Era, Chengfei Liu
• 4963 Cross platform validation of spatial domain identification reveals concordant tumor microenvironment architecture in NSCLC using integrated spatial transcriptomics and multiplex immunofluorescence Zeinab Mokhtari, Mint Htun, Debayan Mukherjee, Nima Vakili, Deon Hildebrand, Crysthiane Ishiy, Anna Pasto, Sue Griffin, Paul Barber, Tony NG
• 4964 Spatial interaction between Gli1 high tumor cells and M2 macrophages predicts survival and recurrence in gastric cancer Dae Yeong Kim, Dae-Hee Lee, Sang Cheul Oh
• 4965 Sarcomatoid transformation rewires the immune spatial landscape and checkpoint regulation in chromophobe renal cell carcinoma Wafaa Bzeih, Yan Tang, Tiegang Han, Andrew J. Sedgewick, Nathan D. Maulding, Carmen Priolo, Katrina Collins, Hadi Mansour, Joelle Chami, Michelle M. Stein, Justin Guinney, Michel Alchoueiry, Jessica F. Williams, Michelle S. Hirsch, Pavlos Msaouel, Elizabeth P. Henske
• 4966 · PDF A single-cell spatial proteomic analysis of the TNBC microenvironment defines genotype-specific features Dana Pueschl, Danielle Bragen, Jia-Ren Lin, Anupma Nayak, Derek A. Oldridge, Kate Bennett, Victoria Fang, kConFab Investigators, Kenneth Offit, Andrew K. Godwin, Paul A. James, Phuong L. Mai, Soo Hwang Teo, Antonis Antoniou, Georgia Chenevix-Trench, E. John Wherry, Susan M. Domchek, Katherine L. Nathanson
• 4967 · PDF Spatial divergence across glioblastoma multi-regional biopsies and corresponding neurosphere cultures Roberto Salatino, Jacob Geisberg, Arantxa Romero Toledo, Benjamin Oakes, Dobeen Hwang, Cristina Vincentelli, Oszkar Szentirmai, Thomas O. McDonald, Franziska Michor, Michalina Janiszewska
• 4968 Comprehensive multi-omic profiling of the tumor-immune microenvironment using Xenium transcriptomics and Hyperion XTi Imaging Mass Cytometry Wendell Smith, Elim Cheung, JingHao Tian, Qanber Raza, Toby Astill, Daniel Zangrando, Nina Lane, Tommy Tran, Rikita Gakhar, Vidyodhaya Sundaram
• 4969 Automated multiomics assay with over 100 biomarkers for in-depth spatial profiling of the tumor microenvironment in multiple cancer types Marion Bonnet, Cansaran Saygili-Demir, Kim Handel, Pedro Machado, Alix Failletaz, Debia Wakhloo, Anushka Dikshit, Maria Giuseppina Procopio, Saska Brajkovic
• 4970 · PDF Transcriptomic analysis reveals myoepithelial cell reprogramming in invasive breast cancer Mohamed M. Haq, Curtis Benson, Meik Kunz, Elim Cheung
• 4972 KIT exon 9 versus exon 11 mutations imprint distinct spatial and phenotypic immune microenvironments in gastrointestinal stromal tumors Jean-Philippe Guegan, Jean-Michel Coindre, Carine Ngo, Antoine Bougoüin, Christophe Rey, Catherine SAUTÈS-FRIDMAN, Wolf Herve Fridman, Armelle Dufresne, Alban Bessede, Antoine Italiano

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