Novel Experimental Platforms and Causal Inference

• 4913 · PDF Single-cell intercellular CRISPR screen reveals stromal regulators of colorectal cancer plasticity Corinne Molyneux, Rhianna O'Sullivan, Alistair Wilkinson, Nick Li, Shauna Crampsie, Petra Vlckova, Aurelie Dobric, Chris Tape
• 4914 · PDF Defining the immunoregulatory molecular drivers of dendritic cells using CRISPR screens in ex-vivo modelsvivo models Mukta Asnani, Jiekun Yang
• 4915 Using functional CRISPR screening to investigate metabolic genes in lung squamous cell carcinoma adoptive T cell therapy Verra Ngwa, Jin Chen
• 4916 · PDF StromaBlast™: A novel CRISPR-based functional genomics platform to identify therapeutic targets within the tumor microenvironment Abdullah Al Emran, Lu Gong, Nick Patsoukis, Yi Yang, Ruth Fekade, Fen Ma, Jahnavi Tatineni, Renhong Tang, Amin Al-Shami, Pankaj Seth, Tamas Oravecz
• 4917 · PDF Establishment of patient-derived lung epithelial progenitor lines as a foundation for autologous immune and tumor modeling Sanaz Keshavarz Shahbaz, Florentina Marches, Te-Chia Wu, Mohammed Toufiq, Andrew Salner, Peter Yu, Adolfo Garcia-Sastre, Karolina Palucka
• 4918 · PDF Bioprinted multicellular microenvironments to accelerate immunotherapy discovery in pancreatic cancer Aji Istadi, Ali McCorkindale, Silvia Lombardi, Inna Navarro, Diego Chacon Fajardo, Henry Barraclough-Franks, David Hermann, Sean Porazinski, Marco J. Herold, Paul Timpson, Greg Neely, Marina Pajic
• 4919 Decoding the tumor microenvironment of NF1 tumors using spatial and cell-type specific analyses of patient-derived organoids Alberto Mendoza-Valderrey, Michael J. Lippincott, Huyen Thi Lam Nguyen, Jenna Tomkinson, Cameron Mattson, Dave Bunten, Summer Norris, Jeremy Jacobson, Jackson Chin, Paul Piehowski, Le Day, Chelsea Hutchinson Bunch, Christopher Anderton, Brittney Gorman, Sara Gosline, Gregory P. Way, Alice Soragni
• 4920 · PDF Decoding phenotypic and functional states of in vivo -mimetic 3D human pancreatic CAF/ECM units through sequential high-plex IF Mariia Dmitrieva, Edna Cukierman, Janusz Franco-Barraza
• 4921 · PDF An advanced 3D vascularized tumor immune microenvironment on a chip for predictive efficacy and toxicity testing of IO therapeutics Junfeng Wang, Byungjun Lee, Delaney Donnelly, Sabrina Figueroa Buezo, Bushra Rajput, Jihye Baek, Hyeon-geun Park, Eunjeong Kim, Joseph Harris, Aneesh Sathe, Tsung-Li Liu, Branka Mitrovic, Kyusuk Baek, Sanghee Yoo
• 4922 · PDF Development of vascularized 3D tumoroid models using microphysiological systems Geetika Sahni, Hooi Linn Loo, Colin D. Paul, Matthew R. Dallas, Sei Hien Lim, Kuan Chee Mun
• 4923 · PDF A micro-vascularized pancreatic ductal adenocarcinoma-on-chip model recapitulates immune exclusion and altered T cell polarization Thomas Sommermann, Amélie Paillereau, Alina Deipenbrock, Nicole Teusch, Martin Raasch, Knut Rennert
• 4924 · PDF Decellularized lung biomatrix models to investigate microenvironmental regulation of organ-selective tropism in metastatic breast cancer Kasra Goodarzi, Yi Yin, Maureen Aliru, Andrew Z. Wang
• 4925 · PDF Unlocking the extracellular matrix as a source of novel targets: A matrisome-based platform to characterize the tumor microenvironment Edward Long, Cecilia Pennica, Lisa Sassi, Seyed Mahfouzi, Filippo Prestinoni, Luca Frenguelli, Gareth Muirhead, Kovilen Sawmynaden, Athiva Shankar, Tu Vinh, Matthew J. Edwards, Chris Stevenson, Emma Huang, Sam Cooper, Giuseppe Mazza
• 4926 · PDF Modeling the metaplastic triple negative breast cancer matrix Elizabeth Martin, Katherine Hebert, Mackenzie Hawes, Thomas Cheng, Delia Carlino, Matthew E. Burow, Bridgette M. Collins-Burow, Jorge Belgodere
• 4927 · PDF Expression profiles of TCF-4 variants across digestive system cancers quantified by a novel PNA-directed qPCR assay Hironori Koga, Yasuko Imamura, Tomoya Sudo
• 4928 Immune signaling reporter cell lines enable quantitative monitoring of crosstalk among cancer, innate, and adaptive immune cells in tumor microenvironment model Hyeyoun Chang, John G. Foulke, Luping Chen, Meghan Sikes, Catherine McManus, Fang Tian
• 4929 · PDF CAR-Tmigration andcytotoxicity in atumor-vasculature-on-chipmodel Luuk de Haan, Aleksandra Olczyk, Thomas Olivier, Joris Wesselius, Will Allen, Johnny Suiker, Todd Burton, Lenie van den Broek, Karla Queiroz
• 4930 Cell Avidity: The Next-Gen cell binding assay to understand therapeutic mechanism of action through quantifying cell-cell and cell-protein interaction strength Keith Bailey, Riley Pihl, Michael SAVAGE, Trey Simpson
• 4931 · PDF Development of a CyTOF panel for macrophage polarization and functional assessment under treatment conditions Poornima Gourabathini, Rachel Weil, Kimberly Q. McKinney, Jeffrey S. Huo, Kenzie Wells, Kaitlyn Smith, David M. Loeb, Javier Oesterheld
• 4932 · PDF Establishment and characterisation of PDTOs and CAFs for the development of a co-culture system in pancreatic periampullary adenocarcinoma Panagiotis Sarametidis, Jojanneke Stoof, Laura Ivers, Jean Murphy, Niall Swan, Luca Benigno, Fiona Hand, Kevin C. Conlon, Paul B. Mullan, Maeve Lowery, Naomi P. Walsh
• 4934 Identifying molecular regulators of ovarian tumor cell attachment to peritoneal mesothelial cells under shear stress using an ex-vivo microfluidic model Jillian A. Martin, Breanna Baker, Vasilios Morikis, Alessandra DiMauro, Gregory D. Longmore, Whitney R. Grither
• 4935 · PDF Cell cycle regulation by PAX3-FOXO1 via WEE1 kinase in fusion-positive rhabdomyosarcoma Chandra Kaladhar Vemula, JinSeok Park
• 4936 · PDF Dissecting tumor microenvironment and cellular adaptation in ovarian cancer models using Bio-Rad ddSEQ Single-Cell 3' RNA-Seq technology Errile Pusod, Madison Uyemura, Patricia Schnepp, Aqila Ahmed, Angelica P. Olcott, Adnan Chowdhury, Michelle Racey, Elizabeth Dreskin, Zhen Ni Zhou, Analisa DiFeo
• 4937 · PDF Enabling transcriptome-wide single cell RNA sequencing from FFPE tissues with Evercode WT combinatorial barcoding Aisling Sinclair, Ajay Sapre, Alec Salvino, Guillermo Gallareta-Olivares, Vuong Tran, Joey Pangallo, Gokhan Demirkan, Sam You, Charles Roco, Alexander Rosenberg
• 4938 Elucidation and pharmacologic targeting of master regulator proteins representing mechanistic determinants of macrophage state and immunoevasive potential Gaetano Viscido, Mikko Turunen, Zhouzerui Liu, Justyn Chang, Meghna S. Raman, Leo B. Dupire, Hanrui Zhang, Tim Olsen, Jeremy Worley, Aleksandar Obradovic, Andrea Califano
• 4939 Quantifying tumor immune escape through immunogenic tension mapping June-Young Koh, Ludmil B. Alexandrov
• 4940 · PDF A hybrid mathematical model: Emergent CAF structures and their impact on cancer progression Junho Lee, Eunjung Kim

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