Application of Bioinformatics to Cancer Biology 5

• 5434 Immune cell infiltration analysis of lung cancer based on proteomics Ruoxian Zhang, Liangcheng Lyu
• 5436 · PDF Spatial identification of hypoxic and normoxic dormancy hotspots predicting in her2-positive and metastatic breast cancer Tzu-Hung Hsiao, Fan Jhen Liu, Yu-Ting Kang, Kuo Yen Huang, Yidong Chen
• 5437 Sensitive detection of rare cfDNA variants utilizing molecular technologies and a novel informatics platform: A combined genomic and proteomic MRD application Emma Kaitlyn Longshore, Ethan Barnett, Ingrid T. Erazo, Leisa Jackson, Helen Halpin, Reis Pestano, Patricia Schnepp, Adam Corner, Howard I. Scher, Gary A. Pestano
• 5438 · PDF Transcript isoform diversity in esophageal squamous cell carcinoma: Insights into tumor heterogeneity and therapeutic targets in Africa Sikhumbuzo Z. Mbatha, Mohammed Alaouna, Botle Precious Damane, Tebogo Marutha, Rodney Hulll, Jonathan Featherston, Aristotelis Chatziioannou, Zodwa Dlamini
• 5439 · PDF Shared and divergent transcriptional signatures of ductal cells in distal human cholangiocarcinoma at a single cell resolution Meng Ting Chen, Jon M. Harrison, David R. Ruddy, Michelle Piquette, Jon Chang, Viviana Cremasco, Andrew L. Warshaw, Carlos Fernandez-Del Castillo, Andrew S. Liss, Divyansh Agarwal
• 5441 · PDF Structural and kinetic effects of R361H SMAD4 mutation on TGF-ß signaling in colorectal cancer Evan Boczko, Isaac Silverman, Yisrael Wiener, Sanjay Goel, Radhashree Maitra
• 5442 · PDF Identifying cell-cell interactions across spatial scales in spatial transcriptomics Alex C. Soupir, Mitchell T. Hayes, Brandon J. Manley, Lauren Cole Peres, Julia Wrobel, BROOKE FRIDLEY
• 5443 · PDF Copy number loss and somatic loss of heterozygosity calling in liquid- and tissue-based genomic profiling Hao Wang, Andrew Gross, Adrian Bubie, Lauren Lawrence, Reagan Barnett, Bernard Herman, Matthew Ellis, Tingting Jiang
• 5444 · PDF Analytical validation of HLA class I allele typing in a liquid biopsy platform Adrian Bubie, Sante Gnerre, Marisa Juntilla, Reagan Barnett, Matthew Ellis, Tingting Jiang
• 5445 Macrophage metabolic rewiring underpins the distinct immunological architecture of invasive mucinous adenocarcinoma revealed through layered molecular profiling ShinYoung Park, KyungA Kim, Chung Lee, Byungjin Hwang, Hyo Sup Shim
• 5446 · PDF BRCA1, RNA-binding proteins, and miR-18a, a molecular tri(umph) in breast carcinoma Raiyan Satti, Anjana Saxena, Shaneen M. Singh
• 5447 · PDF In silico analysis of GSK3alpha to identify novel potential ligands for cancer therapy Neha Sylvia Walter, Sanchit Dora, Jasmeet Kaur
• 5448 · PDF A serotonin transcriptional axis shapes immune phenotypes and clinical outcomes in lung cancer Ecem Kalemoglu, Salih Akgun, Ayse Caner
• 5449 · PDF The effects of survivorship patterns and survival parameters on cancer risk across vertebrates Olivia K. Corrao, Walker Mellon, Zachary Taylor Compton, Harley Richker, Gissel Marquez Alcaraz, Stefania Kapsetaki, Joel Brown, Orsolya Vincze, Mathieu Giraudeau, Michael Lynch, Carlo C. Maley
• 5450 · PDF Decoding ADC payload dynamics with a spatial transcriptomics-integrated tumor microenvironment PK model Sungwoo Bae, Jeongbin Park, Jin Yeong Choi, Daeseung Lee, Hyung-Jun Im, Hongyoon Choi
• 5451 · PDF Omicology: A comprehensive AI/LLM/NLP-based web resource for the ontology, phylogeny, and practical navigation of omics literature James M. Melott, John N. Weinstein
• 5452 · PDF Deep learning enables matched-normal free estimation of tumor mutational burden from whole exome reads in colorectal cancer Amrita Chattopadhyay, Liang-Yu Lin, Ching-Tai Chen, Eric Y. Chuang
• 5453 Machine learning accelerates discovery of synergistic- PI3K-mTOR combinations for robust tumor growth inhibition in KRAS G12 mutant patient-derived xenografts Emily Eastwood, Yuan-Hung Chien, Jose Lopez-Ramos, Paris Offor, Warren Andrews, Long Hoang Do, Raffaella Pippa
• 5454 Identification of microRNA clusters as predictors of chemotherapy response in acute myeloid leukemia Ziang Chen, Jennifer Rangel Ambriz, Yu-Hsuan Fu, David Eugene Frankhouser, Denis O'Meally, Lianjun Zhang, Ying-Chieh Chen, Sergio Branciamore, Jihyun Irizarry, Bin Zhang, Guido Marcucci, Russell Rockne, Ya-Huei Kuo
• 5455 · PDF RNA-seq profiling identifies FOX genes as potential CRC biomarkers Yakshi Nicole Ortiz-Maldonado, Hilmaris Centeno-Girona, Camille Zenon-Melendez, Sheila Natalie Lopez-Acevedo, Elba V. Caraballo
• 5456 · PDF Multiplatform bioinformatic profiling identifies TTK and NEK2 as survival-associated drivers in triple-negative breast cancer Alexandra N. Aquino-Acevedo, Esther M. Irizarry-Quintana, Ángel D. Colón-Burgos, Marileana Rodríguez-Ruiz, Joel A. Orengo-Orengo, Elliott Rodriguez-Lopez, Melanie E. Cruz-Robles, Harold I. Saavedra
• 5457 · PDF From tumor to model: Transcriptomic and therapeutic insights from patient-derived colorectal cancer organoids Matthew Graziano, Ajeet Singh, Stephen Friend, Ruby E. Thamert, Utsav Sharma, Abhay Andar, Jonathan Jacobs, Carolina Lucchesi
• 5458 · PDF Single-cell metabolic flux analysis defines distinct metabolic programs across tumor-infiltrating immune cells Yue Fang, Changlin Wan, Haiqi Zhu, Zheng An, Pengtao Dang, Chi Zhang, Sha Cao
• 5460 · PDF Elucidation of breakage-fusion-bridge (BFB)-mediated EGFR amplification in lenvatinib-resistant hepatocellular carcinoma JungHyun (Jenny) Kim, Ji Young Kim, Hyeonu Yang, Sang Yun Ha, Han-Na Kim, Hoon Kim, Yeup Yoon, Wonseok Kang
• 5461 Molecular genetic profiling of a de novo neuroendocrine prostate cancer in a patient-derived xenograft (PDX) and organoid model from an African ancestry patient Tej Sharma, Surendra Gulla, Sasikumar Ponnusamy, Abbas Jawadwala, Ephraim Gardner, Roberto Pili, Maddie Aust, John Bodkin, John Tomaszewski, Remi-adelaya Ogala
• 6853 · PDF A segmentation-free method for modeling high-resolution spatial transcriptomics at the molecule level Xiao Wang, Nan Zhang, Chi Zhang, Sha Cao

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