Screening and Technology Advances for Probe and Drug Discovery

• 6401 A translational screening platform with AI integration for clinically predictive discovery of safe and effective macropinocytosis-dependent cancer therapeutics Qiuming Chu, Antonio Bonanno, Yanping Kong
• 6402 · PDF Identification of novel CRBN molecular glue ternary binders from a highly diverse CRBN MG library Qingbo Xu, Hailong Yang, Yongqiang Wang, Zhenyu Wu, Hongbo Zhang
• 6403 · PDF High-content morphology profiling identifies autophagy-modulating compounds and their off-target activities Petr Dzubak, Alzbeta Srovnalova, Pavel Polishchuk, Anna Siskova, Martin Mistrik, Matthew Lacey, Marian Hajduch
• 6404 A robust organoid-based platform for high-throughput screening and drug discovery Rene Overmeer, Mariana Martins Costa Silva, Gerben ten Hag, Mayke Doorn, Yasmine Abouleila, Ricardo Korporaal, Francisco Morales Rodriguez, Merel Derksen, Carla Verissimo, Robert G. J. Vries, Sylvia F. Boj
• 6405 Small-molecule screening of HiBiT-tagged PAX3::FOXO1 rhabdomyosarcoma cell lines identifies eltanexor as a potent therapeutic agent against fusion-positive rhabdomyosarcoma Soumili Dey, Yong Y. Kim, Katrina Jia, Mehal Churiwal, Michele Ceribelli, Teresa S. Hawley, Raj Chari, David Milewski, Young K. Song, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Jun S. Wei, Craig Thomas, Robert G. Hawley, Javed Khan
• 6406 · PDF Accelerating selective cancer ligand discovery through an accessible phage display analysis suite Stephen Lees, Monica Shokeen, KIMBERLY KELLY
• 6407 Deep learning-driven image analysis for tracking nucleolar morphology Leif E. Lindberg, Katelyn R. Alley, Sylvia M. Kennerly, Ian Reynolds, Ryan W. Holly, Jongtae Yang, Chris L. Vonnegutt, John C. Rogers, Victoria J. DeRose
• 6408 · PDF Unlocking the unlockable: AS-MS for swift hit identification against challenging targets Renaud Renaud
• 6409 · PDF AI-accelerated discovery of B7-H3 and DLL3-targeted cyclic peptide radioligands: From library design to preclinical validation Tj (Tiejun) Bing
• 6410 mtKO: A dedicated guide RNA library for mitochondria redox biology research Karambir Kaur, Fengchao Lang, Chunzhang Yang
• 6411 · PDF A high content live cell cancer toolbox uniquely enabled by high throughput imaging Matthew Boisvert, Lydia Hernandez
• 6412 · PDF Development of a high-throughput assay platform for the screening of selective integrin inhibitors in cancer Ziwei Zhang, Yu Zhou, Peichuan Zhang, Zhonghua Yan
• 6413 Cellular DNA-Encoded Library (DEL) Screening Coupled with MICRO-TAG Real-Time Cellular Target Engagement Enables Discovery of Novel Therapeutics Ivan Babic, Elmar Nurmemmedov
• 6414 Ultra-sensitive structural biomarker discovery for TNBC and pancreatic cancer using a deep VHH repertoire (IBMET): A translational platform for tissue-agnostic target identification Akihiro Imura, Ryota Maeda, Hiroyuki Yamazaki, Tsuyoshi Inoue, Sadako Aakashi-Tanaka, Hiroko Tsukada
• 6415 Champions: Scalable chem-seq and functional-seq platforms for profiling chemical and genetic perturbations in patient-derived organoids Devin Porter, BanuPriya Sridharan, Gervaise Henry, Kakajan Komurov, Yamini Nallana, Brandon Walling
• 6416 · PDF DEL-chemomics approach for the discovery of targeted protein degraders for cancer therapy Ying Zhang, Anthony D. Keefe, Matthew A. Clark, Marie-Aude Guie, John Guilinger
• 6417 · PDF High-throughput peptide screening for radioligands by DNA encoded libraries Yihui Xie
• 6418 · PDF Adapting the SAR-MAP chemical biology platform to target tumor immune checkpoints Hannah L. Thirman, Stephanie Medina, Jonathan M. Irish
• 6419 · PDF Automated culture and AI-enabled image analysis of compound responses in patient-derived colorectal cancer organoids Oksana Sirenko, Prathyushakrishna Macha, Zhisong Tong, Nikki Carter, Felix Spira
• 6420 · PDF Monitoring S-adenosylmethionine (SAM) and S-Adenosyl homocysteine (SAH) using a homogeneous luminescent assay Said Goueli, Dareen Mikheil, Nathan H. Murray, Kevin Hsiao, Hui Wang, Matt Larsen
• 6421 · PDF Enabling phenotypic high-throughput drug screening with patient-derived organoids Abraham Lin, Maxim Le Compte, Rebecca Stone, Tyler Gilcrest, Edgar Cardenas De La Hoz, Geert Roeyen, Jeroen M. H. Hendriks, Filip Lardon, Christophe Deben
• 6422 · PDF A 3D bioprinted vascularized tumor tissue model of non-small cell lung cancer: A model for drug screening Fahimeh Shahabipour, Yuchi Chen, Yen-Ting Tung, Min Jae Song, Marc Ferrer
• 6423 · PDF DNA-encoded chemical library screening for glue discovery for oncology targets Anthony D. Keefe, Paolo A. Centrella, Zhen Chen, Matthew A. Clark, Paige Dickson, Marie-Aude Guie, John P. Guilinger, Ying Zhang
• 6424 · PDF MICRO-TAG® cell target engagement redefines GPCR drug discovery with functional relevance Ivan Babic, Elmar Nurmemmedov
• 6425 · PDF High throughput screening identifies novel drugs for calreticulin surface translocation in pancreatic ductal adenocarcinoma Yuvasri Golivi, Steven D. Forsythe, Rachael Guenter, Faris Zaibaq, Michele Ceribelli, Craig Thomas, J. Bart Rose
• 6426 · PDF Development and validation of HTS assays for discovery of SMARCAL1 ATPase inhibitors Matthew Blackburn, Robert Lowery
• 6427 · PDF BRETTSA: A BRET-based assay for ultra-sensitive measurement of target engagement through protein denaturation in live cells Cesear Corona, James Vasta, Matthew B. Robers, Michael Beck, Inhong Hwang, Min Zhou, Ani Michaud, Wenhui Zhou, Mei Cong
• 6428 · PDF DiscoveryDirect: Extending direct-to-biology paradigms to accelerate oncology drug discovery Allan Michael Jordan, Daniel Clare, Kam Chohan, Rick Davies, Jonathan Finlayson, Euan Fordyce, Clare Hammond, Philip MacFaul, Christopher Pearce, Raquel Faba Rodriguez, Alexandra Stowell, Denise Swift, Megan Thompson, Graeme Walker, Terence Wu
• 6429 · PDF NMR assessment of ternary complex formation by targeted protein degraders Emily M. Grasso, David Fry, Nabin Panth, Zachary Sparta, Madhavi Latha S. Chalasani, Adam Haidi, Steven Murkli, Nareshkumar Jain

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