Spatial Proteomics and Transcriptomics 3

• 6659 · PDF Spatial proteo-transcriptomic profiling of pancreatic adenocarcinoma unveils distinct malignant subtype-associated immune and stromal functional states Beatrice Wendler Awasthi, Nicole A. Lester, Deniz Guney Olgun, Yi Cui, Gabriel Francisco Pozo Mattos Pereira, Nicholas Caldwell, Mari Mino-Kenudson, Maria Ganci, Manisha Madhavan, Sierra Mckinzie, Jung Woo Bae, Xunqin Yin, Shanshan He, PRAJAN DIVAKAR, Martin Hemberg, Joe Beechem, William L. Hwang
• 6660 · PDF CellScape Quality Control (CSQC): A tissue- and protein-agnostic platform for spatial proteomics quality assessment Daniel Jimenez-Sanchez, Brian J. Lane, Matthew H. Ingalls, Charles Eldon Jackson, Steven T. Lott, Adam Northcutt, Arne Christians, Anke Brix, Jennifer Brooks, Oliver Braubach
• 6661 · PDF High quality whole transcriptome RNA-sequencing from challenging clinical samples Pieter Mestdagh, Lisa Van Den Bossche, Thomas Van Wunsel, Hilke Spooren, Emmanuel Rivière, Jan Van de Velde, Ana Carolina Elisa Fierro Gutierrez, Nathalie Bernard, Lien Heyrman, Dirk Goossens, Jurgen Del Favero
• 6662 · PDF Spatial genomics reveals microenvironmental programs associated with organ-specific metastatic propensity in prostate cancer Maryam Ranjpour, Mohamed Omar
• 6663 · PDF Integrated spatial transcriptomic and proteomic profiling reveals tumor-immune niches driving heterogeneity and resistance in clear cell renal cell carcinoma Qanber Raza, Nick Zabinyakov, Lauren Tracey, Liang Lim, Christina Loh
• 6664 · PDF Single-cell spatial proteomics of 1200+ protein targets in tumor microenvironments from diverse cancers using GeoMx Discovery Proteome Atlas Terence C. Theisen, Alexa E. Lasley, Giang Ong, Megan Vandenberg, Brian Filanoski, Lori Hamanishi, Erin Piazza, Sayani Bhattacharjee, Courtney Anderson, Mirko Corselli, Prajan Divakar, Margaret L. Hoang, Joseph M. Beechem
• 6665 · PDF Validation of two melanoma biomarkers and two novel ready-to-use multiplex immunofluorescence panels for spatial profiling of the stromal and vascular compartments in the tumor microenviroment Paula Juricic, Francois Rivest, Clara Sinthon, Jade Nguyen, Isabelle Blanc, Bastian Nicolai, Alexandre Kehren, Saska Brajkovic
• 6666 Deriving high-fidelity, low-plex clinical signatures from ultra-high-plex spatial data for immunotherapy response prediction Raymond Yan, Brian Falkenstein, A. Burak Tosun, Filippo Pullara, S. Chakra Chennubhotla
• 6667 · PDF Integrated spatial transcriptomics and proteomics workflows for high-resolution multiomics analysis Cindy Pamela Ulloa Guerrero, Michele Bortolomeazzi, Pooja Sant, Laura Schütze, Laura Giese, Denise Keitel, Julia Boehl, Robin Reschke, Jan-Philipp Mallm
• 6668 · PDF Spatial and transcriptomic remodeling of the tumor microenvironment following neoadjuvant atezolizumab in urothelial carcinoma: Insights from the ABACUS Study Robbin Nameki, Jennifer Kinong, Chao-Hui Huang, Michelle Saul, Aakash Sur, Mehmet Tekman, Alexander Trageser, Wenjing Yang, Daniel Chawla, Greg Szeto, Arne Schmidt, Alberto Megina Gonzalo, Srishti Munjal Mehta, Nina Kozar-Gillan, Rosemarie Krupar, Sophie Laturnus, Cornelius Bohm, Marija Pezer, Gloria H.Y. Lin, Diane Fernandez, Keith Ching, Jadwiga R. Bienkowska, Thomas Powles, Craig B. Davis
• 6669 · PDF Spatially resolved multiplex immunofluorescence profiling of antibody-drug conjugate targets in bladder cancer using an AI-powered end-to-end workflow Christoph Kuppe, Markus Eckstein, Samaneh Samiei, Katharina Dornblut, Niklas Klümper, Fabian Schneider, Moritz Widmaier, Florian Leiss
• 6670 · PDF Automated co-detection of small RNAs, RNAs and proteins in tumor tissues with Roche DISCOVERY™ULTRA Renzo S. Adilardi, Rose Delvillar, Manvir Sambhi, Emerald Doolittle, Sonali Deshpande, Anushka Dikshit, Debia Wakhloo, Henry Lamparski
• 6671 · PDF Actionable resistance mechanisms in osteosarcoma uncovered by the elucidate spatial biomarker platform Gulpreet Kaur, Jason Weirather, James Perna, Sizun Jiang, Will Singleterry
• 6672 · PDF Expanding the boundaries of spatial proteomics with a universal antibody labeling strategy and EpicIF™ multiplexing chemistry Thore Boettke, Jannik Boog, Charles Eldon Jackson, Matthew H. Ingalls, Arne Christians, Oliver Braubach
• 6673 · PDF MERFISH 2.0 enables high-sensitivity, customizable spatial transcriptomics for resolving immune and tumor programs in human cancers Renchao Chen, Bin Wang, Bing Yang, Manisha Ray, Justin He, Timothy Wiggin, Lizi Maziashvili, Alexander Genshaft, Peter Reinhold, Angela Vasaturo, Jiang He
• 6674 · PDF Metabolic reprogramming in advanced renal tumors contributes to a dysfunctional immune response and immune exhaustion within the tumor microenvironment Lakshmi Chandramohan, Kirsteen Maclean, Sergio Hernandez, Brigitte Lovell, Courtney Todorov, Harry Nunns, Jiong Fei, Judy Kuo, Erinn A. Parnell, Qingyan Au
• 6675 · PDF An end-to-end quality control pipeline for spatially resolved molecular imaging data in the multi-omic SpaceIQ™ platform Brian Falkenstein, A. Burak Tosun, Raymond Yan, S. Chakra Chennubhotla, Filippo Pullara
• 6676 · PDF Spatial proteomics and AI-driven analysis uncover therapeutic landscapes within the glioblastoma microenvironment Nadine Nelson, Hoyin Lai, Sophie Struble, Richard A. Heil-Chapdelaine, Natasha F. Diaz Granados, Arindam Bose
• 6677 · PDF Multiplexed imaging and AI-guided analysis reveal immune landscape diversity across multiple cancer types Lynne Turnbull, Michael J. Smith, Sophie Struble, Vasundhara Agrawal, Debayon Paul, Richard A. Heil-Chapdelaine, Natasha F. Diaz Granados, Arindam Bose
• 6678 · PDF Ultra-high-plex immunofluorescence analysis of the tumor-immune microenvironment with EpicIF technology on the CellScape platform Arne Christians, Thore Boettke, Jannik Boog, Charles Eldon Jackson, Matt Ingalls, Brian J. Lane, Daniel Jimenez Sanchez, Christoph Rocken, Niclas Christian Blessin, Oliver Braubach
• 6679 · PDF Decoding immune and tumor niches through high-plex spatial multi-omics in human cancer tissues Bin Wang, Kevin Hwang, Yijia Sun, Cassandra Kysilovsky, Angela Vasaturo, Jiang He
• 6680 · PDF Decoding the tumor microenvironment with triple-omics: Automated spatial analysis of protein-protein interactions, RNA, and protein markers on the same section Alice Comberlato, Arec Manoukian, Pino Bordignon, Ge-Ah Kim, Sonali Deshpande, Florent Jeanpetit, Alix Failletaz, Li-chong Wang, Alexandre Kehren, Saska Brajkovic
• 6681 · PDF Innovative 10x Genomics technologies enable clinical-scale cancer research and AI-driven biomarker discovery Hiroshi M. Sasaki, Seayar H. Mohabbet, Ian T. Fiddes, Francesca Meschi, 10x Genomics Development Team
• 6682 · PDF Chimeric antibodies in oncology research: Properties and application in low-multiplexing assays Tom Bright, Nadine Nelson, Antonella Galli, Will Howat, Silvia Sbacchi
• 6683 · PDF Streamlined high-plex imaging with InSituPlex®and ZEISS Axioscan 7 for spatial phenotyping Kevin Hwang, Mike Woerdemann, Lars Loetgering, Moritz Widmaier, Cassandra Kysilovsky, Sherry Derakhshani, Jiang He, Angela Vasaturo
• 6684 · PDF Spatial multi-omics profiling of clear cell renal cell carcinoma (ccRCC) pre-and post-immunotherapy identifies new druggable targets Navneet Kaur, Wadih Issa, Ze Yu, Hua Zhong, Aleksandra Weronika Nielsen, Jay Jasti, Shahed Abdullah, Libin Yan, Damla Gunenc, Qinhan Zhou, Andrew DeVilbiss, Satwik Rajaram, Payal Kapur, Chao Xing, Liwei Jia, Andrew Z. Wang, Tian Zhang
• 6685 · PDF Integrated high-throughput multimodal spatial profiling of RNA, protein, and morphology in FFPE sections with the G4X™ Spatial Sequencer Michael Lawson, Kenneth Gouin, Sabrina Shore, Yuji Ishitsuka, Richard Que, Eli Glezer, Daan Witters
• 6686 · PDF Direct-Seq™ enables spatially resolved in situ sequencing of IgH and TCRbeta transcripts in FFPE tissue at subcellular resolution Michael Lawson, Tung T. Le, Ryan Shultzaberger, Ashley Tsue, Zane Hiatt, Nathan Ing, Kenneth Gouin, Eli Glezer, Daan Witters

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