RNA, Gene and Cell Therapies, and Enabling Assay Technologies

• 459 · PDF CAR T cells engineered via mRNA exhibit enhanced targeting of colorectal cancer Walison Nunes da Silva, Pedro Henrique Dias Moura Prazeres, Marco Tullio Rodrigues Alves, Vivian Vasconcelos Costa, Mauro Martins Teixeira, Pedro Pires Goulart Guimaraes
• 460 · PDF A generic, high throughput unwinding assay for discovery of RNA helicase inhibitors Ha Pham, Robert Lowery
• 461 · PDF Next-generation ERbeta agonists with superior brain uptake suppress glioblastoma and enhance temozolomide response Uday Pratap, Karinel Nieves-Merced, Sridharan Jayamohan, Michael Tidwell, Annabel Maciolek, Khaled Mohamed Nassar, Henriette U. Balinda, Nicholas Clanton, Suryavathi Viswanadhapalli, Gangadhara R. Sareddy, Stanton McHardy, Andrew J. Brenner, Ratna K. Vadlamudi
• 462 Therapy and malignant progression reshape the splicing landscape to generate shared, tumor-wide neoantigens in IDH-mutant gliomas Tim Wu, Darwin Kwok, Joseph Costello, Hideho Okada
• 463 Inflammatory breast cancer patients derived explants: Autologous post-mastectomy wound fluid enhances the expression of adhesome and matrisome genes associated with recurrence and metastasis Mona Mostafa Mohamed, Hossam Taha Mohamed, Alshimaa Tarek, Shrouk Khalaf El-Sayed, Wendy A. Woodward, Jon Mark Hirshon
• 464 Assessment of tumor heterogeneity for Integrin beta-6 expression in non-squamous non-small cell lung cancer specimens using an investigational Integrin beta-6 IHC assay Stefanie Nicole Kapucija, Jim Christian, Dana Sprague, Nicole Medina, Laina Quinones, Maggie Hime, Kiera Borgert, Kevin Brown, Jason Berndt, Pauline Cronin, Emin Oroudjev, Juan Gutierrez, Juan Gutierrez
• 465 Targeted repression of UBTF inhibits growth and metastatic phenotypes of pancreatic cancer via inhibition of ribosome biogenesis Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Rajasekhar Baru, Ayati Marzieh, Jose L. Gonzalez Hernandez, Genaro R. Corea, Dae Joon Kim, Mohammad Moshahid Khan, Subhash C. Chauhan, Bilal Bin Hafeez
• 466 · PDF Combinatorial screening reveals novel gene-drug synergies in breast cancer cells Jifeng Wang, Joshua A. Bauer, Jie Wu, Lili Xu, Regina Courtney, Guochong Damon Jia, Jirong Long, Wei Zheng, Qiuyin Cai
• 467 Profiling the effects of Peroxiredoxin 3 (PRX3) pharmacological inhibition and genetic deletion with the AVITI24™ multi-omic spatial biology platform Victoria Gibson, Seana Lymer, Trevor Wolf, Brian Cunniff
• 468 · PDF Leveraging single-cell multiomics for a generalizable approach to differentiation therapy Scott C. Friedland, Tianli Ding, Gary Schweickart, Alice Mims, Katherine Miller, Adithe Rivaldi, Elizabeth Garfinkle, Sunkel Benjamin, Jaye Navarro, Michelle Wedemeyer, Ann-Kathrin Eisfeld, Elaine R. Mardis
• 469 Quaratusugene ozeplasmid mediated TUSC2 upregulation in EML4-ALK bearing non-small cell lung carcinoma induces apoptosis and is highly effective in preclinical studies Ananya Banerjee, Neeke Busette, Xu Cheng, Kerslee Kohagen, Liwei Bao, Lluis Lopez-Barcons, Mark S. Berger, Matthew B. Soellner, Angel Qin, Sofia Merajver, Nathan Merrill
• 470 JZP898, a conditionally activated interferon alpha, generates efficacy and robust TME engagement in syngeneic mouse models Ankur Karmokar, Emanuele Loro, Zhiling Zhang, Rao Mukavilli, Aparna Gupta, Kevin Trouba, Vian Amber, Robin C. Humphreys
• 471 · PDF DELs in cells: Small-molecule hits for transcription factor identified by intracellular DNA-encoded library screening Leif K. Larsen, Allan B. Christensen, Andrzej Taranta, Charlotte Andersen, Frank A. Sløk, Lars K. Petersen, Ole Kristensen, Rico G. Petersen, Peter Blakskjær, Tobias N. Hansen, Nils J. V. Hansen
• 472 Adapting a TR-FRET platform to decipher G protein-coupled receptor internalization and recycling kinetics Jie Gao, An Ouyang, Spencer Chiang, Yu Sun
• 473 · PDF Accelerating integrated tumor profiling with QIAseq xHYB Pro: A fast, modular approach to CGP and HRD assessment Peter Hahn, Markus Storbeck, Krishna Amin, Jonathan Shaffer, Leif Schauser
• 474 · PDF A comprehensive LinkLight platform for GPCR mechanistic profiling to support cancer drug discovery Yong Wan, Alisha D. Ianni, Haiching Ma, Jianghong Wu
• 475 · PDF A bioluminescent assay for detection of fatty acid oxidation Maggie Bach, Michael P. Valley, Hui Wang, Xavier Aguilar-Enriquez, Wenhui Zhou, Jolanta Vidugiriene
• 476 A practical workflow for adaptive immune receptor profiling and screening of antigen-specific clonotypes with applications in cancer Alex Chenchik, Tianbing Liu, Dongfang Hu, Kitt Paraiso, Lester Kobzik, Khadija Ghias, Paul Diehl
• 477 · PDF Lumit® hKi-67 immunoassay for cell proliferation with optimized performance for screening applications Kevin Kupcho, Jean Osterman, Hui Wang, Chao Gao, Wenhui Zhou, Dan F. Lazar
• 478 · PDF Implementation of single B-cell screening to select antibodies in one day based on affinity and multiple binding properties Marie-Claire Phélipot, Eric Chabrol, Julie Lichière, Alice Aymard, alexandre Baagnolini, Nadjiba Marès, Cécile Lemoigne, Matthieu Tassa, Sophie Mesnard, Caroline Huber, Ester Morgado, Marion Seillier, Jacques Fieschi
• 479 SONNET 5010, a novel proprietary peptide drug conjugate lock and load platform John K. Cini, Susan Dexter, Stephen McAndrew, Arron Hearn, Evert Bokma, Gavin Birch, Grant Harradence, Christopher Sayer, Rosa Gonzalez-Serrano, Joao Nunes
• 480 · PDF An HTS assay for detection of XRN1 exoribonuclease activity with unmodified RNA Mahbbat Ali, Robert Lowery
• 481 · PDF Drug sensitivity profiling of oncology drugs reveals candidate therapeutic targets in uterine leiomyoma subtypes Helmiina Järvi, Simona Bramante, Juuli Raivola, Emilia Piki, Alice Dini, Maija Jäntti, Emma Siili, Ralf Bützow, Oskari Heikinheimo, Annukka Pasanen, Niko Välimäki, Daniela Ungureanu, Kristiina Rajamäki, Lauri A. Aaltonen
• 482 Development of high-affinity human antibodies targeting POR006: A novel target in squamous cell carcinoma identified by spatial transcriptomics MinKyu Kim, Jinyeong Choi, Jae Eun Lee, Hongyoon Choi, Hyung-Jun Im
• 483 Organoids-based high-throughput drug screening identifies selective vulnerability of AR -/lo CRPC to inhibitors of neurotransmission signaling Shan Wu, Ruize Zhao, Xiaozhuo Liu, Wen (Jess) Li, Moyi Wang, Amanda Tracz, Henry Withers, Brian Buckley, Katerina Gurova, Prashant Singh, Eduardo Cortes, Jianmin Wang, Jason S. Kirk, Dean G. Tang
• 484 · PDF Hit finding and assay enablement for VRK1, a paralog synthetic lethal kinase target in VRK2-deficient cancers Katarzyna B. Handing, Kevin M. Cottrell, Mu-Sen Liu, Patrick McCarren, Brett Williams, Kiera M. Vassallo, Alvin Lu, Alice Tsai, Maria Dam Ferdinez, Sirimas Sudsakorn, Brian McMillan, Jannik N. Anderson, William D. Mallender, Wenhai Zhang, John Maxwell, Kimberly J. Briggs

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