TCR and Autologous T Cell Therapies

• 5609 · PDF Mechano-dynamic-principle-driven rational design of next-generation TCRs with high specificity and sensitivity Yushen Du, Wei Hu, Luying Liu, Suqiong Wang, Wei Chen
• 5610 · PDF Characterization of cancer-reactive T cells and neoantigen-specific T cell receptors Wei Sun, Si Liu, Bo Yu, Zhehao Zhang, Philip Bradley, Marie Bleakley
• 5611 · PDF Adoptive T cell transfer suppresses endogenous tumor-specific CD8⁺ T cell recovery following lymphodepletion Rohan B. Chaudhari, Megan L. Burger
• 5612 · PDF Antigen-specific T cells engineered with nanoparticle photothermal therapy demonstrate antitumor efficacy in an immunocompetent murine model of ovarian cancer Abigail V. Lee, Erin Grundy, Jose Colina, Elizabeth Sweeney, Rohan Fernandes, Nethaji Muniraj, Russell Y. Cruz, Katherine B. Chiappinelli
• 5613 · PDF RenTCR-derived MAGEA1-specific TCRs demonstrated superior peptide sensitivity and potent antitumor activity in vitro and in vivo Yi Yang, Yabo Zhang, Jiawei Yao
• 5614 · PDF RenTCR-derived natural MAGE-A4-specific TCRs outperformed affinity-enhanced TCRs in antitumor efficacy Yi Yang, Yong Wang, Yabo Zhang, Jiawei Yao
• 5615 · PDF ALK-specific TCR-T cells showed potent and specific activity in ALK-positive anaplastic large cell lymphoma Simone Piane, Carmen Mecca, Nirmala Tilija Pun, Ana Azambuja, Luca Alessandri, Phuc Bao Chi Nguyen, Elisa Bergaggio, Gabriele Saccu, Alessandro Gasparetto, Haley Ohlson, Claudia Voena, Marcos Simoes-Costa, Roberto Chiarle
• 5616 · PDF Tumor necrosis factor-alpha armed TCR-T and CAR-T cells for solid tumors provide superior anticancer activity in the absence of toxicity Cole W. Peters, Miriam Valenzuela Cardenas, Moe Kawakami, Jaden Nguyen, Allison Flores, Andrew Dinh, Stephen Ma, Daniel G. Chen, Valerie Rezek, Scott Kitchen, Katie M. Campbell, Melissa Lechner, Theodore Scott Nowicki
• 5617 · PDF Humanized antibody Fab-TCR T cells targeting GPC2 effectively regress neuroblastoma via enhanced TCR signaling and sustained cytotoxicity Mingyu Huo, Alex Quan, Dan Li, Laura E. Hutchins, Constanza Rodriguez, Jangsuk Oh, Hsi-En Tsao, Madeline Spetz, Elijah Edmondson, Dana Ashworth, Rui Zheng, Jing Zhou, Jinyun Chen, Jingbao Liu, Guangyan Xiong, Hongbing Zhang, Cheng Liu, Rosa Nguyen, Nan Li, Mitchell Ho
• 5618 · PDF KRASG12V- and CTAG1B-targeted TCR-T cells from phage TCR library suppress colorectal and esophageal tumors Obed Boadi Amissah, Wenfang Chen, Zhiyuan Li, Gloria Bora Kim
• 5619 · PDF First-in-class anaplastic lymphoma kinase (ALK)-specific TCR-T cells induce potent and selective antitumor immunity across ALK-driven human cancers Carmen Mecca, Simone Piane, Nirmala Tilija Pun, Ana Azambuja, Luca Alessandrí, Rafael Blasco, Chi Nguyen Puc Bao, Elisa Bergaggio, Gabriele Saccu, Alessandro Gasparetto, Haley Ohlson, David A. Barbie, Ellis L. Reinherz, Marcos Simoes-Costa, Roberto Chiarle
• 5620 · PDF Development of T cell receptor (TCR) based cellular therapy for fibrolamellar HCC uncovers role of TCR in CD4 T cell differentiation Kayla J. Bendinelli, Allison M. Kirk, Marina Baretti, Abigail M. Gottschall, Heng-Chung Kung, Jeric Peter Hernandez, Waqar Arif, Julie Nauroth, Jennifer Durham, Christopher Thoburn, Amanda Huff, Neeha Zaidi, Alexei Hernandez, Hassan Jamaleddine, Timothy N. West, Justin McCallen, George Coukos, Alexandre Harari, Challice L. Bonifant, Elizabeth Jaffee, Won Jin Ho, Grégoire Altan-Bonnet, Paul G. Thomas, Mark Yarchoan
• 5621 The GPC3-targeting hYP7 antibody-based gamma/delta TCR-T cell therapy for overcoming antigen mutation and heterogeneity in liver cancer Dan Li, Tianyuzhou Liang, Hsi-En Tsao, Zhijian Duan, Laura E. Hutchins, Madilyn Gaydos, Iris Yang, Elijah Edmondson, Xiaoshan Wang, Rui Zheng, Jing Zhou, Chin-Hsien (Emily) Tai, Jing Bian, Maggie Cam, Hongbing Zhang, Cheng Liu, Mitchell Ho
• 5622 · PDF Development of allogeneic TCR-mimic activating gdT (TAG-T) cells targeting KRAS G12D /HLA-A*11 pMHC for undruggable KRAS-mutated cancers Chia-Chun Chao, Hsin-Yu Chang, Wei-Ze Hong, Jhen-Yu Chen, Yi-Wen Jiang, K.S. Clifford Chao, Kevin Chih-Yang Huang
• 5623 · PDF Novel mechanism for eliminating tumor collagens to boost efficacy by attIL12-TIL therapy in PDX sarcoma models Jiemiao Hu, Harjeet Singh, Yining Jin, Wendong Zhang, Jian Wang, Xueqing Xia, Neeta Somaiah, Richard Gorlick, Shulin Li
• 5624 Clinical strategies to enhance the efficacy of tumor-infiltrating lymphocyte (TIL) therapy using preclinical models Asraa Ahmed, Jonathan F. Khan, Sadna Budhu, Jedd D. Wolchok, Taha Merghoub
• 5625 · PDF Epigenetic reprogramming of T cell exhaustion Tsunghan Hsieh, Ruomin Xin, Enchong Zhao, Xiao Tian
• 5626 · PDF Combination epigenetic therapy unmasks non-canonical neoantigens to improve adoptive T cell therapy in ovarian cancer Jose A. Colina, Katherine B. Chiappinelli, Erin E. Grundy, Conrad Russell Y. Cruz
• 5627 · PDF Intermittent cyclophosphamide and vinorelbine combined with anti-PD-1 induce transferable T-cell-mediated antitumor immunity and long-term memory in TNBC mouse models Stefania Orecchioni, D'Ambrosio Lorenzo, Davide Lombardi, Anna Vaccari, Paola Nistico', Francesco Bertolini, Paolo Falvo

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