RAS/MAPK Signaling, KRAS Targeting, and Adaptive Resistance

• 5976 Spatiotemporal control of RAS-RAF signaling at the single-molecule level Rodrigo E. Cáceres-Gutiérrez, Rebika Shreshta, Jean Castillo-Badillo, Vanessa Wall, Scott Eury, Katie Powell, William Burgan, Min Hong, Peter Frank, Dwight V. Nissley, Frank McCormick, Thomas Turbyville
• 5977 mTOR inhibition activates the EGFR-MAPK network by a novel AKT-initiated feedback loop promoting adaptive resistance Keiichi Koshizuka, Hiroki Izumi, Tomohiko Ishikawa, Kuniaki Sato, Jean-Philippe Coppe, J. Silvio Gutkind
• 5978 SPR2015, a highly potent and selective KRAS G12D (on) inhibitor, exhibits favorable pharmacokinetic behavior and significant anti-tumor efficacy against colorectal cancer as monotherapy in preclinical models Yi Qian, Zirong Zhang, Zhifei Fu, Kai Zhou, Meibi Dai, Shuqin Liu, Yang Zhang, Tao Hu
• 5979 · PDF RASurgence: ARF6 boosts RAS oncoprotein synthesis and accelerates tumor progression. Gwen Kramer, Deja M. Brooks, Joshua Tay, Prachi Gupta, Sheri L. Holmen, Thomas Jacob, Allie H. Grossmann
• 5980 AUBE00: A novel cyclic peptide pan-KRAS inhibitor targeting KRAS-activated cancers including KRAS-mutant cancers and wild-type colorectal cancer Kana Takei, Mayuki Ueda, Toshiaki Tsunenari, Ai Shinoda, Munehiro Yuki, Hitoshi Sase, Saki Michisaka, Yukako Tachibana, Masami Hasegawa, Toshihiko Fujii, Shino Kuramoto, Miho Nagayasu, Mengxuan Gao, Kazuhiro Ohara, Keisuke Oki, Mikito Owa, Seiya Hirai, Haon Futamata, Takuya Torizawa, Hatsuo Kawada, Mirai Kage, Mikimasa Tanada, Takuya Shiraishi, Hitoshi Iikura, Takehisa Kitazawa, Hiroshi Tanaka
• 5981 · PDF Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma Niti Kumari, Xu Chen, Amber M. Baldwin, Kristin I. Clemons, Mohammad Alharakeh, Lilian Calisto, Balawant Kumar, Qiaoqiao Zhang, Jiang Min, Bin Xiao, Amar B. Singh, Bin Wang, Brian J. North
• 5982 · PDF Eradicating metastatic cancers by targeting a major tumor vulnerability of the K-RAS pathway: Seven in absentia homolog (SIAH) Jonathan M. Baker, Emanuel Frank Petricoin, Julia Wulfkhule, Andrew Howell, Ashleigh Hannah, Amy H. Tang
• 5983 · PDF Functional characterization of the RAS processing enzyme Rce1 David Van Dongen
• 5984 · PDF Small molecule induced KRAS activation triggers ferroptosis in mutant KRAS expressing PDAC Haiyuxin Zhu, Kartini Iskandar, Nur Syafiqah B. Suleiman, Benedict J. Leong, Hanqing Pang, Alessandro Carrer, Anne-Sophie ARMAND, Franck Oury, Shazib Pervaiz
• 5985 · PDF GNAS R201C enhances peritoneal carcinomatosis in K RAS G12D -driven gastrointestinal cancer models Ichiaki Ito, Saikat Chowdhury, John Paul Shen
• 5986 Deletion of AKT1 inhibits PTEN-loss induced intrahepatic cholangiocarcinoma but not hepatocellular carcinoma development in mice Ielyzaveta Slarve, Yining Ding, Yushan Wang, Zifei Xu, Lina He, Bangyan L. Stiles
• 5987 · PDF Dual targeting of Pyk2/FAK and MEK/ERK pathways enhances growth suppression in glioblastoma Emely Morales-Colon, Kevin A. Rosa- Gonzalez, Lilia Kucheryavykh
• 5988 · PDF MEK1/2 degraders uncover kinase-independent role of MEK1/2 in CRAF stabilization and maturation Jason S. Wasserman, Alison M. Kurimchak, Carlos Herrera-Montávez, Glenn A. Doyle, Brandon D. Fox, Ishadi K. M. Kodikara, Jian Jin, James S. Duncan
• 5989 · PDF Targeting SHOC2 and GAB2 in acral melanomas driven by RAS-GTP Rony Andre Francois, Nick Lertwiriyapiti, Lucy C. Young, Matthew J. Sale, Frank McCormick
• 5990 · PDF UBE3A and SV2A modulate GBM progression through MAPK pathway regulation. Lee Eunju, MIN-JEE KIM, Peter CW Lee
• 5991 · PDF p53-induced FBXL20 suppresses the PP2A regulatory subunit PR55alpha Alison L. Camero, Michel Ouellette, Keith Johnson, Ying Yan
• 5992 · PDF A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ipek S. Gokulu, Lila Taylor, Ruchita Rathod, Sophia Abrahamson, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, Anum Glasgow, Neil Vasan
• 5993 · PDF The Rho-GEF ECT2 links Rho GTPases to MEK/ERK pathway activation in pancreatic ductal adenocarcinoma Dania Al-Qasrawi, Nayya N. Murray, Ryan A. Argo, Alicia K. Fleming Martinez, Prita Pandya, Anaya Y. Clarke, Kayla C. Winter, Murli Krishna, Peter Storz, Nicole R. Murray, Verline Justilien
• 5994 · PDF Mechanism of oncogenicity induced by overexpression of the PRL phosphatases Jingmei Yu, Frederick Nguele Meke, Yunpeng Bai, Meaghan Maureen Broman, Haoran Zhang, Abhinanda Kar, Zhong-Yin Zhang
• 5995 · PDF Pterostilbene enhances dabrafenib activity in BRAF mutant melanoma through synergistic MAPK suppression and apoptotic induction Joshua Steven Fraser, Jordan Bury, Colt Summers, Jennifer Meyer, Gennie Lynne Parkman
• 5996 · PDF Evaluating the effects of the Pan-KRas inhibitor RMC-6236 in KRas-mutant colorectal cancer cells Seema nadir, Sumaiya Binte Hamid, Mati Ur Rehman, Azhar Hussain Rajabali, Kulsoom K. Ghias, Arooj Shafiq
• 5997 Network based mapping reveals mechanistic drivers and targetable hubs contributing to Sotorasib resistance in KRAS G12C lung cancer Atish Ranjan Mohanty, Baiyi Quan, Dana Do, Ting-Yu Wang, Tsui-Fen Chou, Prakash Kulkarni, Ravi Salgia

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