In Vivo Models 2: Genetically Engineered Mouse Models, PDXs, Syngeneic Models

• 6055 Targeting CEP55 as a universal oncogenic dependency: Integrating spatial multi-omics and targeted therapy across translational preclinical cancer models Behnam Rashidieh, Pirjo Apaja, Quan Nguyen, Nigel McMillan, Kum Kum Khanna
• 6056 The KSHV genome, devoid of the essential immediate early transactivator RTAORF50, induces angiosarcoma in transgenic mice Dirk P. Dittmer, Kyle Shifflett, Eason B. Anthony, Su Huanjuan, Zhigang Zhang, Blossom Damania
• 6057 The IKZF1 N159Y partial tandem duplication mutant drives chromatin remodeling, B-cell developmental defects and leukemia initiation Ruth W. Wang'ondu, Devanand Bondage, Qiong Zhang, Yiming Wu, Baranda Hansen, Chun Shik Park, Prady Baviskar, Emily  Backhaus-Wagner, Ilaria Iacobucci, Surbhi Sona, Huiyun Wu, Qingsong Gao, Wojciech Rosikiewicz, Beisi Xu, Hongjian Jin, Ti-Cheng Chang, Stanley Pounds, Laura Janke, Trevor Cunningham, Kristine R. Crews, Jun J. Yang, Shondra Pruett-Miller, Charles G. Mullighan
• 6058 Tumor suppressor gene inactivation shapes the landscape of EGFR-mutant lung adenocarcinoma progression with therapeutic implications Mariana Do Carmo, Matthew Martin, Michael Rosen, Lily Blair, Anna Tribe, Keita Maemura, Giorgia Foggetti, Francisco Exposito, Zeynep Ugur, Lafia Sebastian, Vy Tran, Ian Lai, Alyna Katti, Ian Winters, Dmitri A. Petrov, Nicolas Floc'h, Monte M. Winslow, Katerina A. Politi
• 6059 Vertical MAPK pathway targeting is required for tumor regression in novel human and mouse models of NF1-inactivated melanoma Olvania-Danyca Hilaire, Alexis M. Jones, Moriah H. Nissan, Sebastien Monette, Jordan Eichholz, Cailian Liu, Xia Yang, Ayana Sawai-Frantz, Elisa de Stanchina, Taha Merghoub, Neal Rosen, David B. Solit, Aphrothiti J. Hanrahan
• 6060 · PDF Patient-derived models of primary breast cancer for preclinical evaluation of neoadjuvant therapies Stefan J. Hutten, Xue Chao, Madelon Badoux, Timo Eijkman, Michael Sheinman, Roebi de Bruijn, Andrea Herencia-Ropero, Alba Llop-Guevara, Catrin Lutz, Jelle Wesseling, Violeta Serra, Jacco Van Rheenen, Colinda LGJ Scheele, Jos Jonkers
• 6061 Development of pancreatic and colon patient-derived xenograft (PDX) tumor microarrays (TMAs) from the NCI patient derived models repository Cindy R. Timme, Lindsay Dutko, Sayak Ghatak, Ting-Chia Chang, Alice P. Chen, Li Chen, Biswajit Das, Tara Grinnage-Pulley, Shahanawaz Jiwani, Kaci Paulus, Chris A. Karlovich, Sergio Alcoser, Yvonne Evrard, Melinda G. Hollinghead, James H. Doroshow
• 6062 · PDF The role of sex hormones and sex chromosomes in urethane-induced lung carcinogenesis Maksat Babayev, Carolyn D. Ekpruke, Omar Borges Sosa, Shikha Sharma, Dustin Rousselle, Chukwudike Igwe, Patricia Silveyra
• 6063 · PDF MICAL2 promotes oncogenic Kras -induced pancreatic cancer initiation by regulating acinar to ductal metaplasia Nirakar Rajbhandari, Evangeline Mose, Mojgan Hosseini, Deepa Sheik Pran Babu, Herve Tiriac, Andrew Lowy
• 6064 · PDF The in vivo impact of UBTF tandem duplications on hematopoiesis and leukemia development Lisett Contreras, Juan Martin Barajas, Tamara Westover, Melvin Thomas III, Emily Xiong, Catherine Callahan, Chandra Rolle, Masayuki Umeda, Michael Walsh, Jing Ma, Laura Janke, Jeffery Klco
• 6065 Decoding KRAS signaling intensity: A key driver of tumor aggressiveness and response to RAS inhibition in pancreatic cancer Mehrnaz Salehi, Sara Raji, Mohammadreza Ranjouri, Fengming Chen, Ashley Fletcher, Peter J. Allen, Zahra Kabiri
• 6066 · PDF A model of spontaneous brain metastasis in small cell lung cancer undergoes epithelial-to-neuronal transition Shreoshi Pal Choudhuri, Thomas Salisbury, Mantre Dehnad, Bratati Mukherjee, Braeden Freitas, Kyle May, Seth Hamilton, Shruti Raghavan, Victor Stastny, Kimberley Avila, Jui Wan Loh, Urooba Nadeem, Luc Girard, Jeon Lee, Michael S. Lawrence, Genevieve Konopka, James Kim, Benjamin J. Drapkin
• 6067 · PDF HPV+ and HPV- head and neck cancer patient-derived models in the NCI Patient-Derived Models Repository Yvonne A. Evrard, Ting-Chia Chang, Jasmine B'Lanton, Gareth Bliss, Alice Chen, Li Chen, Kevin Cooper, Kristin Cox, Natalie Czarra, Isabella Czernia, Biswajit Das, Kelly Dougherty, Aarin Dreyer, Lindsay Dutko, Katie Frey, Marion Gibson, Tara Grinnage-Pulley, Shahanawaz Jiwani, Poorva Juneja, Keegan Kalmbach, Tamikia Lamb, Eva Loewenstein, Candace Mallow, Chelsea McGlynn, Justine Mills, Michael Mullendore, Matthew Murphy, Sandra Navas-Reyes, Michelle Norris, Jessica Park, Kaci Paulus, Kevin Plater, Tia Shearer, Jessica Steed, Luke Stockwin, Howard Stotler, Ruth Thornton, Cindy R. Timme, Shannon Uzelac, Dianne L. Newton, Chris A. Karlovich, Melinda G. Hollingshead, James H. Doroshow
• 6069 · PDF Mutant BRAF and AKT cooperate to induce melanoma formation Camden VanTassell, MiKaela N. Field, Boyd Griffiths, Landen Barnett, Madison Hawkins, Joshua Knight, Katie Culver, Allison Stevens, Sheri L. Holmen, Gennie Lynne Parkman
• 6070 · PDF Clinical and genomic determinants of PDX engraftment across solid tumors Leva Gorji, Kurt W. Evans, Xiaofeng Zheng, Erkan Yuca, Ran Zhang, Hung Le, Gabriela Raso, Argun Akcakanat, Ana Galan Cobo, Timothy P. DiPeri, Milind Javle, Burak Uzunparmak, Funda Meric-Bernstam
• 6072 · PDF Characterization of the immunological responses in a mouse model expressing humanized FcgammaR/FcRn Angela Pappalardo, Julie Donaghey, Danielle Huggins, Patrick Kirby, Fabiane Sonego, Gaëlle H. Martin, Kader Thiam
• 6073 Establishment and characterization of a panel of EGFR-mutant lung XPDX models representing naïve, chemotherapy, and targeted therapy-resistant patient populations Christopher Nelson, Mia Lopez, Amy Fredrickson, Alyssa Simonson, Natalia Baños Herraiz, Shaquille Johnson, Ian Sturgill, Guillermo Sanz Martin, Jim Lund, Jennifer Garcia, Kyriakos P. Papadopoulos, Victor Moreno Garcia, Chris Takimoto, Michael J. Wick
• 6075 · PDF Lentiviral vector induced modeling of low grade glioma in the minipig spinal cord Kecheng Lei, Angeliki Mela, Thais Federici, Muhibullah S. Tora, Marybeth Yonk, Yuliya Lakhina, Brett Henshey, Melissa Danielle Babbitt, Roy Raheb Khelo, Jeffrey N. Bruce, Peter Canoll, Nicholas M. Boulis
• 6076 · PDF Preclinical models of cancer cachexia: Bridging the gap to clinical applications Hongyan Sun, Dan Zhou, Yunlong Jiang, Yujing Zhang, Jianming Xu, Jing Zhao, Xiang Gao
• 6077 A natural antibody response associated with improved survival of SCLC patients can be actively induced in a SCLC mouse model and leads to significantly improved survival Diego Alejandro Velarde, Joseph Valdes, Chunli Yan, Sarah Elmalh, Hannah Lee, Daniel James Mullen, Angie Moreno, Matthew A. Gladstone, JONATHAN CASTILLO, Crystal N. Marconett, Nicky Nie, Ming Li, W. Martin Kast, Ite A. Offringa
• 6078 · PDF Integrating patient-derived systems to model metastatic prostate cancer and decode therapy resistance Agustina Sabater, Pablo Sanchis, Jun Yang, Jiabin Dong, Peter Shepherd, Nicolas Anselmino, Christopher J. Logothetis, Geraldine Gueron, Estefania Labanca
• 6080 · PDF Multi-omics analysis revealed clonal evolution of sarcoma patient-derived xenografts Kentaro Gosho, Shigehiro Yagishita, Kaito Mimura, Takahiro Ebata, Nobuyuki Kakiuchi, Kotoe Katayama, Seiya Imoto, Yoshitaka Narita, Akihiro Yoneda, Mitsuya Ishikawa, Yukihide Kanemitsu, Kan Yonemori, Akira Kawai, Shun-ichi Watanabe, Ayumu Arakawa, Toshikazu Ushijima, Seishi Ogawa, Akinobu Hamada, Kenichi Yoshida
• 6081 Development of a lung cancer orthotopic transplantation model for investigating the TME and evaluating anticancer agents for preclinical studies Chiyoko Nishime, Eiko Nishinaka, Hitomi Satou, Toshio Imai, Masayuki Komatsu, Misa Mochizuki, Taichi Yamamoto, Masami Suzuki
• 6082 IFNalpha polarizes granulocytic MDSCs from neutrophils by inducing protein translation Juanita L. Merchant, Lin Ding
• 6083 Intracarotid injection-based brain metastasis models without disrupting the blood-brain barrier for preclinical drug evaluation Arianna Bandini, Gojko Bijelic, Melanie Heisler, Pia Norz, Philipp Metzger, Cynthia Obodozie, Holger Weber

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