Metastasis and Organ-Specific Microenvironmental Evolution

• 6110 Systemic inflammation induced by calprotectin (S100A8/S100A9 complex) triggers reactivation of dormant cells in mouse models of breast cancer Ahmet B. Caglayan, Ying Xin, Aysun Caglayan, Shruti Nagaraja, Deeksha Sharma, Cody Hager, Fulya Koksalar-Alkan, Hilmi K. Alkan, Monika Burness, Hasan Korkaya, Max S. Wicha
• 6111 Opposite regulation of brain and lung metastases by endothelial FAK deletion Shoko Noda-Narita, Atsu Aiba
• 6112 · PDF Inflammatory niche remodeling by metastatic breast cancer stem cells Claire Engstrom, Jessica Pham, Wenxue Ma, Emma Klacking, Kendale Wirtjes, Patrick Chang, Inge van der Werf, Catriona H. M. Jamieson
• 6113 ccRCC lung metastases harbor cancer associated fibroblast lymphocyte exclusion sites that form a confined TME as revealed by single cell and spatial multi-omics Yufei Wang, Jae-Won Cho, Yasmin Nabil Laimon, Wenxin Xu, Kun Huang, Aseman Bagheri Sheshdeh, Nithyassree Murugan, Hsien-Chi Yuan, Jon Wee, David Alexander Braun, Toni K. Choueiri, Catherine J. Wu, Sabina Signoretti, Gordon J. Freeman, Martin Hemberg, Wayne A. Marasco
• 6114 Integrated single-cell and spatial atlas of tumor-draining lymph nodes reveals metastasis-associated stromal and immune remodeling Enshuo Zhang, Lu Zhang, Haitang Yang, Feng Yao
• 6115 Deciphering tumor microenvironment dynamics in tumorigenesis and lymph node metastasis of esophageal squamous cell carcinoma using single-cell and spatial transcriptomics Tae Hee Hong, Hansoll Na, Chung Lee, Young Ho Yang, Ha Eun Kim, Byung Jo Park, Min Hee Hong, Hye Ryun Kim, Hyun Ki Kim, Dae Joon Kim
• 6116 · PDF Spatial multi-omics dissection of colorectal cancer micrometastasis Yang Liu, Akshaya S. Jadhav, Yuwen Pan, Jianlong Liao, Isha Khanduri, Yunhe Liu, Riham Katkhuda, Wei Lu, Kyung Serk Cho, Tieling Zhou, Baohua Sun, Mei Jiang, Sharia D. Hernandez, Idania Carolina Lubo Julio, Patrick Brennan, Guangsheng Pei, Kai Yu, Yibo Dai, Tian Chu, Fuduan Peng, Khaja Khan, Saxon Rodriguez, Ling Xia, Youming Guo, Alicia Mejia, Zhiming Tong, Sean W. Barnes, Ou Shi, Shreeya Indulkar, Alaa Mohamed, Natalie Wall Fowlkes, Timothy Newhook, Yun Shin Chun, Van K. Morris, David G. Menter, Dadi Jiang, Jean-Nicolas Vauthey, Ruoyan Li, Humam Kadara, Luisa M. Solis Soto, Scott Kopetz, Linghua Wang, Dipen M. Maru
• 6117 Fibroblast-derived extracellular vesicles promote organ-specific tumor growth and chemoresistance in pancreatic cancer liver metastasis via ptch2 downregulation Mahsa Pahlavanneshan, Weikun Xiao, Eileen Fung, Chae Young Eun, Chang-Il Hwang, Shannon Mumenthaler, Reginald Hill
• 6118 Spatially resolved SEED (stromal-enriched metastatic decider) niches integrate tumor, stromal, and immune ecosystems to enable lymph node dissemination in LUAD Junghan Oh, Hoyeon Jeong, Yoon La Choi, Donggun Lee, Misook Lee
• 6119 · PDF Immune-vascular profiles in primary tumors and paired liver metastases of colorectal cancer Alfonso Martín-Bernabé, Tove Bekkhus, Elisabet Rodríguez-Tomàs, Reetta Peltonen, Pauliina Reijonen, Emerik Osterlund, Caj Haglund, Jaana Hagström, Helena Isoniemi, Bengt Glimelius, Tobias Sjöblom, Arne Östman, Ari Ristimäki, Teijo Pellinen, Pia Osterlund
• 6120 · PDF Histologic growth pattern dictates immune cell spatial topography in liver metastases Artur Mezheyeuski, Gemma Garcia-Vicién, Núria Ruiz, Jose C. Ruffinelli, Kristel Mils, María Bañuls, Natalia Molina, Miguel A. Pardo, Laura Lladó, Patrick Micke, David G. Mollevi
• 6121 · PDF Hippo/YAP1 mediated interplay of tumor-stromal-immune suppressive TME through IL6/gp130/STAT3 axis in advanced gastric cancer Junsong Zhao, Xiaodan Yao, Yibo Fan, Dipti Athavale, Yanting Zhang, Francis Spitz, Generosa Grana, Shilpa S. Dhar, Jaffer A. Ajani, Shumei Song
• 6122 · PDF Organ-specific immune and metabolic programs shape spatial microenvironments in MSS colorectal cancer metastases Jian Ye, Colt A. Egelston, Chongkai Wang, Marwan Fakih
• 6123 TNBC-derived lipocalin-2 potentiates metastasis by inducing immunologic reprogramming of premetastatic and metastatic microenvironments Gabriela Ortiz-Soto, Joshua Gamez, Carolyn Rentz, Raynah Cheng, Francesca Sanchez, Abigail Terry, Peter Gray, Mary Lauren Benton, Jonathan Kelber
• 6124 TIM3 + tumor associated M2 macrophages impair antitumor T cell immunity and promote gastric cancer progression and peritoneal metastasis Xiaodan Yao, Junsong Zhao, Yibo Fan, Yanting Zhang, Dipti Athavale, Curt Balch, Mikel Ghelfi, Anthony Pompetti, Jiankang Jin, Yong Ki Hong, Jamin Morrison, Madeline Torres, Francis Spitz, Generosa Grana, Shilpa S. Dhar, Linghua Wang, Jaffer A. Ajani, Shumei Song
• 6125 · PDF Osteosarcoma exploits macrophage VCAM1-VLA4 signaling axis to facilitate pulmonary metastasis Daniel Kingsley, Sung Hee Choi, Jay Myers, Alex Y. Huang
• 6126 Multiomics integration unveils a shifted balance in the sphingosine-1 phosphate/ceramide rheostat fueled by macrophage immunosuppression in metastatic colorectal cancer Michelle M. Maurin, Siddabasave Gowda B. Gowda, Divyavani Gowda, Heiman Wang, Michael Nebozhyn, Ramani Soundararajan, Mckayla Carr, Punith M Sundaraswamy, Ashley Alden, Carolina Martinez, Robert David Bennett, Allen Chudzinski, Andreas Karachristos, Timothy M. Nywening, Paul M. Cavallaro, Matthew Linley Anderson, Robert J. Coffey, Michael Schell, Jorge Marcet, Richard Jacobson, Andrey Loboda, Ganesh V. Halade, Mingli Yang, Lance Pflieger, Warren Jackson Pledger, Shu-Ping Hui, Timothy J. Yeatman
• 6127 · PDF Hepatic niche driven metabolic-epigenetic reprogramming mediates metastatic colonization through liver progenitor like plasticity Ajit Kumar SHARMA, Nobuyuki Takahashi, Sophie Zhuang, Amira Kazi, Michael Nirula, Abhinav Joshi, Yingying Cao, Rajesh Kumar, Kanak Parmar, Christopher Schultz, Parth Anil Desai, Samantha Nichols, Linda Sciuto, Yue Huang, Chiori Tabe, Yang Zhang, Sanghvi Neel, Nishanth Ulhas Nair, Christopher A Febres Aldana, Nir Friedman, Simone Difilippantonio, Thorkell Andresson, Eytan Ruppin, Stephen M. Hewitt, Anish Thomas
• 6131 BDNF-TrkB.T1 receptor signaling modulate an immunosuppressive tumor microenvironment and epithelial-mesenchymal transition in gliomas Leyre Merino-Galan, Jin-Yih Low, Sergio Ortiz-Espinosa, Hawa L. Jagana, John M. Hemmenway, Ashmitha Rajendran, Mathew R. Hattaway, Taylor S. Jackson, Maryam Shabar, Noemi Reche-Ley, Sonali Arora, David Johnson, Daniel A. Kuppers, Patrick J. Paddision, Siobhan S. Pattwell
• 6132 · PDF Linking metabolic reprogramming to JAK-STAT signaling in triple-negative breast cancer brain metastasis Jayshree Mishra, Narendra Kumar
• 6133 · PDF Horizontal mitochondria transfer stimulates pro-tumorigenic astrocyte reprogramming in glioblastoma Jonathan Mitchell, Brandon Leon, Oriana Teran Pumar, Asmita Pathak, Carolina De La Pena Fernandez, Pedro Assenza Tavares Coroa, Ogechukwu Mbegbu, Yi-An Chen, Floris P. Barthel, Justin Ruiz, Irem Karaman, Anna Lasorella, Antonio Iavarone, Defne Bayik, Dionysios C. Watson
• 6134 · PDF Immunomodulatory PIGR + RORC + dendritic cells (PRDCs) are enriched in malignant ascites Steven M. Blum, Thomas L. Chan, Neal P. Smith, Courtney Ambrose, Katherine H. Xu, Alice Tirard, Nandini Samanta, Sidney Martin, Roya Best, Elizabeth Tuttle, Christopher T. Stueber, Vaishnavi R. Yalala, Haley Barnes, Sean T. Bannon, Yuhui Song, Benjamin Y. Arnold, Mushriq Al-Jazrawe, Joseph J. Zhao, Kamil Slowikowski, Jessica Tantivit, Kasidet Manakongtreecheep, Lukas M. Altenburger, Simon Knott, Matthew R. Strickland, Michael G. Drage, Linda T. Nieman, Jesse S. Boehm, Raghav Sundar, Gary Reynolds, Samuel J. Klempner, Alexandra-Chloé Villani
• 6135 · PDF Amyloid-beta accumulation in glioblastoma is driven by vascular remodeling and APP-processing pathways Felix Y. Narvaez Irizarry, Alondra M. Bermudez Adorno, Lilia Kucheryavykh
• 6136 · PDF Macrophages support the growth of pediatric posterior fossa ependymoma type A Gabrielle L. Persad, Kaitlin Kharas, Andrea Ribeiro, Alexandra Rasnitsyn, Michael D. Taylor, Lincoln David Stein
• 6137 · PDF Multi-omicsinpostoperative lymphatic exudate in HPV-negative head and neck cancer Zachary Costliow, Seka Lazare, Zhuosheng Gu, Adam Harmon, Maciej Pacula, Megan Rivera, Aadel A. Chaudhuri, Jose P. Zevallos, Jessalyn Marie Ubellacker, Wendy Winckler
• 6138 Profiling the unique resident immune cell compartment in acral skin and its implications for acral melanoma tumor immunity Joshua K. H. Tay, Emilio Cortes-Sanchez, Amanda Jiang, Anastasia Prokofyeva, Robert Judson-Torres, Melissa Q. Reeves
• 6139 · PDF Development of a flow cytometry panel for microglia and immune cell populations in a brain tumor model Helen Ketteringham, Cheryl Davis, Mollie McArthur, Corrine Silvio, Shannan Paul, Ben Hoerner, Victoria Caruso, Liz Bailey, Chris Holding, Aliccia Koznecki, Dawn Lusk, Shorena Nadaraia-Hoke

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