Spatial Niches and Functional Boundaries within the Tumor Microenvironment 2

• 6187 Elevating bulk sequencing with high-resolution spatial transcriptomics: A paired-data analysis of clinically-relevant spatial niches in CRC and NSCLC Yajas Shah, Tianyou Luo, Christine M. Hoeman, Luca Lonini, Stanislaw Szydlo, Eduardo Diaz, Rossin Erbe, Matthew B. Maxwell, Michelle M. Stein, Andrew J. Sedgewick, Nicholas Rachell, Zachary Chelsky, Sonal Khare, Ryan D. Jones, Kate Sasser, Richard A. Klinghoffer, Justin Guinney, Chi-Sing Ho
• 6188 · PDF Decoding the archetypes and ecotypes of triple-negative breast cancer in responses to chemotherapy Yun Yan, Yiyun Lin, Tapsi Kumar, Shanshan Bai, Aatish Thennavan, Jianzhuo Li, Tuan Tran, Min Hu, Mitchell Rao, Anna Casasent, Elizabeth Ravenberg, Gaiane Margishvili Rauch, Alyson Clayborn, Debu Tripathy, Alastair Thompson, Bora Lim, Lei Huo, Lei Huo, Stacy Moulder, Clinton Yam, Nicholas E. Navin
• 6189 ERBB2 expression and the immune landscape shape the tumor microenvironment and influence prognosis in esophageal adenocarcinoma brain metastases Nora M. Lawson, Inés Martín-Barrio, Lingqun Ye, Bo Zhao, Thomas Mitchell, Mesut Unal, Chae Yun Cho, Andrew Futreal, Kadir C. Akdemir
• 6190 Spatial architecture analysis reveals disrupted lymphotoxin signaling gradients associate with recurrence in high-grade serous ovarian cancer Zhewei Zhang, Tat San Lau, Chi Chiu Wang
• 6191 Decoding the interactions between cancer cells and monocyte-derived macrophages in a co-culture model using flow cytometry and bead-based multiplexing immunoassay panels Amy Zhao, Anugraha Gandhirajan, Michael Hunegnaw, Anil Kumar Jaiswal, Jessie Ni
• 6192 · PDF Multi-omics reveals the diversity of CAF in ESCC lymph node metastasis Licheng Tan, Beilei Liu, Shuang Zhang, Jiayi Huang, Bowen Yao, Xin-Yuan Guan
• 6193 · PDF Spatial remodeling of immune and stromal microenvironments in sentinel lymph nodes during melanoma progression Shankar Suman, Wendy K. Nevala, Noah A. Stueven, Raymond M. Moore, Chathu L. Atherton, Jeffrey E. Johnson, Ray Guo, James W. Jakub, Svetomir N. Markovic
• 6194 · PDF Spatial architecture of immunochemotherapy response in pleural mesothelioma Harim Chun, Yeoun Eun Sung, Sook Hee Hong, Sangjeong Ahn, Sung Hak Lee
• 6195 Spatial transcriptomics analysis reveals tumor cell plasticity and diverse tumor microenvironments in Ewing sarcoma Heng Luo, Clémence Henon, Gleb Rukhovich, Stefanie Kutschmann, Nina Wilhelm, Wolfgang Hartmann, Uta Dirksen, Duncan T. Odom, Thomas G. Grünewald, Moritz Gerstung
• 6196 · PDF Neutrophil extracellular traps is involved in ovarian cancer-associated venous thrombosis Gaku Yamamoto, Mahiru Kawano, Mina Sakata, Michiko Bun, Aasa Shimizu, Erika Nakatsuka, Yasuto Kinose, Kenjiro Sawada, Michiko Kodama
• 6197 Spatial transcriptomics reveal distinct tumor microenvironment associated with clinical response in thymic epithelial tumors after neoadjuvant therapy Hyunsu Kim, Jinyong Kim, Hyun-Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Yeong Jeong Jeon, Junghee Lee, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Seong Yong Park, Woong-Yang Park, Yoon-La Choi, Sehhoon Park
• 6198 Single cell spatial multi-omic characterization of the tumor microenvironment in transformed follicular lymphoma Shaocheng Wu, Eric Lee, Anne-Sophie Fratzscher, Andrew Lytle, Spencer D. Martin, David G. Huntsman, David W. Scott, Christian Steidl, Andrew Roth
• 6199 · PDF Spatially revealed malignant and microenvironment ecosystems in PanIN- and IPMN-derived PDAC Tengyu Zhang, Assya Legrini, Mari-Claire McGuigan, Stephan B. Dreyer, Ghazal Latifi, Claire Kennedy Dietrich, Hannah Morgan, Eva Verkolf, Virginia Padoan, Yoana Doncheva, Joao Da Silva Filho, Michail Doukas, Bas Groot Koerkamp, Joanne Edwards, Nigel Jamieson
• 6200 · PDF Single-cell spatial CRISPR screen for tumor microenvironment Boyoung Jeong, Xuejiao Zhao, David Kilburn, Kang Jin Jeong, Soon Young Park, Hongli Ma, Gordon B. Mills
• 6201 PaintScape TM enables multiomic in-situ direct visualization of spatial 3D genome architecture of single cells in intact fresh frozen Glioblastoma tissue in native tumor microenvironments Matija Snuderl, Yuxiu Wang, Neha Dhasmana, Pamela Flatley, Stacy Elliott, Douglas Werner, Jude Dunne, Huy Nguyen, Shyamtanu Chattoraj
• 6202 Integrated multiomic atlas of pancreatic solid pseudopapillary neoplasms suggests acinar cells as a potential cell-of-origin Biren Reddy, Maria Korah, James P. Agolia, Rosyli Reveron-Thornton, Maggie Lam, Deshka Foster, Michael T. Longaker, Daniel Delitto
• 6203 Spatial transcriptome mapping identifies endothelial anergy and CD4⁺ T cell stress as key drivers of immune escape in colorectal cancer liver metastasis Peter Kok-Ting Wan, Ranchu Cheng, Len Seymour, Kerry Fisher, Alex Gordon-Weeks
• 6204 Spatial transcriptomic dissection of TSC-associated angiomyolipoma reveals microenvironmental programs driven by mTORC1 dysregulation Ryuta Watanabe, Kensuke Shishido, Shota Nobumori, Naoya Sugihara, Keigo Nishida, Haruna Arai, Takatora Sawada, Shunsuke Haga, Osuke Arai, Tomoya Onishi, Kenichi Nishimura, Tstsuya Fukumoto, Noriyoshi Miura, Mie Kurara, Riko Kitazawa, Yuki Miyauchi, Tadahiko Kikugawa, Takashi Saika
• 6205 Establishing reproducibility standards for Xenium spatial transcriptomics through multi-replicate validation and cross-sectional analysis Tommy Tran, JingHao Tian, Elim Cheung, Rikita Gakhar, Vidyodhaya Sundaram
• 6206 Spatially resolved cell-cell architecture in WHO grade 4 IDH- wildtype glioblastoma revealed by CosMx 6K discovery panel Dexter Wing Lun Lee, Kaiyan Xu, Parker Li, Joshua Jing Xi Li, Wei Dai, Karrie Kiang, Gilberto Ka-Kit Leung, Aya El Helali
• 6207 Spatial organisation of tumor-infiltrating B cells in Claudin 18.2-expressing advanced gastric cancer predicts response to immune checkpoint inhibition Joseph J. Zhao, Choong-Kun Lee, Allison Si-Yu Chan, Wenyi Luo, Li Chang, Woo Sun Kwon, Sejung Park, Minkyu Jung, Joe P. Yeong, Anand Devaprasath Jeyasekharan, María Rodríguez Martínez, Sun Young Rha, Raghav Sundar
• 6208 Subcellular imaging of murine models of metastatic colorectal cancer using a whole transcriptome spatial molecular imaging panel Liang Zhang, Isabel Lee, Shanshan He, Martin Shelton, Owen J. Sansom, Joseph M. Beechem
• 6209 Gynecologic carcinosarcomas beyond epithelial-mesenchymal transition: Morpho-transcriptomic evidence of an immune gradient in the tumor microenvironment Amel Kime, Julie Berthet, Juliette Renard, Antoine Gaudet Chardonnet, Pierre Laurent-Puig, Jerome Alexandre, Bruno Borghese, Guillaume Beinse
• 6210 Spatial compartmentalization of tumor and immune cellular architecture defines opposing prognostic roles in prostate cancer Ahmed Elsehemy, Xinpei Ci, Magnus Lam, Matthew Ramotar, Alejandro Berlin, Theodorus van der Kwast, Housheng Hansen He
• 6211 AI-guided spatial multi-omics integration reveals immune and stromal heterogeneity underlying population disparities in prostate cancer. Samuel Mwakisha Mwamburi, Jevon Layne, Niki Talebian, Ezra G. Baraban, Ashley Kiemen, Clayton C. Yates
• 6212 · PDF Spatial immune and vascular remodeling defines recurrence in oligodendroglioma Julia Louw, Kenan Zhang, Anna Corcoran, Elizabeth Owens, Jodie Jepson, Jose R. Conejo-Garcia, David M. Ashley, Kanish Mirchia, David R. Raleigh, Mustafa Khasraw
• 6213 Single cell imaging uncovers a coordinated tumor-immune-stroma spectrum with genomic associations in pancreatic ductal adenocarcinoma Ferris Nowlan, Noor Shakfa, Sibyl Drissler, Tan Tiak Ju, Elizabeth Sunnucks, Edward LY Chen, Cassandra J. Wong, Brendon Seale, Zhen Yuan Lin, Michelle Chan-Seng-Yue, Amy Zhang, Sabiq Chaudhary, Chengxin Yu, Golnaz Abazari, Michael Geuenich, Matthew Watson, Jiaxi Peng, Somaieh Afiuni-Zadeh, Ayelet Borgida, Ricardo Gonzalez, Sheng-Ben Liang, Klaudia Nowak, Miralem Mrkonjic, Anna Dodd, Julie M. Wilson, Kieran Campbell, Jenn Gorman, Barbara Grünwald, Robert C. Grant, Jennifer J. Knox, Anne-Claude Gringas, Faiyaz Notta, Steven Gallinger, Grainne O'Kane, Hartland Jackson
• 6214 Mapping the tumor landscape: spatial multiomics reveals immune and stromal heterogeneity across early and late-stage NSCLC Gaurav N. Joshi, Nicholas Sciascia, Michael Yang, Brenna Fearey, Junya Yoshioka, Fumiki Yanagawa
• 6215 Spatial biology tools identify distinct spatially localized fibroblasts in adenomacarcinoma lung cancer predictive of survival Calum MacAulay, Paul Gallagher, Martial Daniel Guillaud
• 6216 Novel whole transcriptome spatial transcriptomics technology reveals CAF/TAM-mediated basement membrane remodeling at the invasive front Amanda Janesick, McKenzi Toh, Syrus Mohabbat, Stephanie Kravitz, 10X Genomics Development Team

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