Mathematical Modeling and Statistical Methods

• 6830 · PDF State-transition model of time-series single-cell RNA-seq identifies gene-level origins of disease microstate stability in chronic myeloid leukemia (CML) David Eugene Frankhouser, Anupam Dey, Jennifer Rangel Ambriz, Ziang Chen, Denis O'Meally, Yu-Hsuan Fu, Jihyun Irizarry, Tiffany Kanesa Ybarra, Ryan Sathianathen, Jeffrey Trent, Stephen J. Forman, Kathleen M. Sakamoto, Ya-Huei Kuo, Bin Zhang, Adam L. MacLean, Guido Marcucci, Russell Rockne
• 6831 · PDF Virtual clinical trials of BMP4 differentiation therapy Nicholas Harbour, Lee Curtin, Loizos Michaelides, Matthew E. Hubbard, Pamela Jackson, Vinitha Rani, Rajappa Kenchappa, Virginea Farias, Anna Carrano, Markus Owen, Alfredo Quinones-Hinojosa, Kristin Swanson
• 6832 · PDF Toward personalized rotational multi-agent therapies to overcome treatment resistance in pancreatic cancer: A virtual trial framework in mice Krithik Vishwanath, Hoon Choi, Mamta Gupta, Rong Zhou, Anna G. Sorace, Thomas E. Yankeelov, Ernesto A.B.F. Lima
• 6834 · PDF Modeling the role of homeostatic T-cell reconstitution in durable response to CAR T-cell therapy Philipp Martin Altrock, Álvaro Martinez-Rubio, María Rosa, Arne Traulsen, Michael D. Jain, Frederick L. Locke
• 6835 · PDF Multiomic state-transition framework reveals chemotherapy-induced metabolic reprogramming in acute myeloid leukemia Jennifer Rangel Ambriz, Ziang Chen, Yu-Hsuan Fu, David Eugene Frankhouser, Denis O'Meally, Lianjun Zhang, Ying-Chieh Chen, Sergio Branciamore, Jihyun Irizarry, Bin Zhang, Guido Marcucci, Russell Rockne, Ya-Huei Kuo
• 6836 Mechanistic modeling platform predicts patient response to guide antibody-drug conjugate clinical development NING Wang, Nathan Siemers
• 6837 · PDF Scalable cell type and spatial domain modeling using spatially informed topic inference of cancer niches Jeongbin Park, Tingrui Zhang, Cong Ma
• 6838 · PDF Most severe adverse events in approved combination therapies occur at rates consistent with independent action Kunhee Kim, Rishi Bollapalli, Adam C. Palmer
• 6839 · PDF Structural vulnerabilities of the breast tumor-draining lymph node to radiotherapy-induced fibrosis and lymphedema risk Laia Vancells, Leopold Green, Nan Kong
• 6840 · PDF Developing a data assimilation framework to forecast patient-specific tumor burden in low-grade glioma Sophia Ty, Devika Shankar, Bikash Panthi, Mohamad El-Jammal, Victoria White, Holly Langshaw, Eleni Konstantinopoulou, Hannah Green, Ashi Jain Chakresh, Vishantan Kumar, Thomas E. Yankeelov, Caroline Chung, David A. Hormuth
• 6842 · PDF ctDNA precedes imaging: A predictive model for real-time treatment adaptation in HPV-associated anal squamous cell carcinoma Phebe M.A Havor, Brandon M Huffman, James Cleary, Renee Brady-Nicholls
• 6843 · PDF A joint model for integrating serial methylation-based tumor fraction and ESR1 assessment to forecast overall survival in patients with ER+/HER2- metastatic breast cancer Christopher Pretz, Matthew Ellis, Mitchell J. Elliott, Caroline Weiport, Amar Das, Carin Espenschied, David Cescon
• 6844 · PDF Functional data analysis of spatial protein imaging data using spatial trajectories with application to ovarian cancer Brooke L. Fridley, Alex C. Soupir, Daisy Liao, Chase Sakitis, Joellen Schildkraut, Andrew B. Lawson, Mary K. Townsend, Shelley Tworoger, Kathryn L. Terry, Julia Wrobel, Lauren Cole Peres
• 6845 · PDF Using cell-type-specific nucleosome patterns to improve cell-free DNA fragmentation models in lung cancer Brian Sun Liu, Mengran Zhang, Mohammad Shahrokh Esfahani
• 6846 · PDF Using physiologically-based pharmacokinetics-quantitative systems pharmacology model to optimize peptide-drug conjugates design Yuezhe Li, Cole Zmurchok, Daniel C. Kirouac
• 6848 · PDF HPlot: A novel quantitative framework for spatial profiling of Immune heterogeneity in tumor microenvironments Chao Hui Huang, Jadwiga Renata Bienkowska, Diane Fernandez, Sara Beth Linker, Xinmeng Jasmine Mu, Robbin Nameki, Jennifer Kinong, Michelle Saul, Aakash Sur, Mehmet Tekman, Alexander Trageser, Wenjing Yang, Daniel Chawla, Greg Szeto, Arne Schmidt, Alberto M. Gonzalo, Srishti Munjal Mehta, Rosemarie Krupar, Nina Kozar-Gillan, Sophie Laturnus, Cornelius Böhm, Marija Pezer, Gloria H.Y. Lin, Darlan Conterno Minussi, Keith Ching, Thomas Powles, Craig Davis
• 6849 · PDF Tumor microenvironment gene expression dynamics: Keystone cell types and non-cancer cell driver genes Yongzhong Zhao, Yixiao Cui, Ji Zheng, Cody Stevens, Jenny Bundy, Eranga Wettewa, Christopher Edwards, Victoria Thilker, Donald Carpenter, Zhongqiang Qiu, Zhijiu Zhong, Eric Zhao, Lili Liao, Qiang Xu, Nan Zhang, John Lin
• 6850 Dynamic modeling of invisible tumor growth with simulated residual disease and PDX data Bryan A. Hawickhorst, Daniel J. McWilliams, Jonathan M. Baker, Amy H. Tang
• 6851 · PDF Multi-cell type model for analyzing spatial single-cell protein imaging data with application to ovarian cancer Chase Sakitis, Jose Laborde, Julia Wrobel, Alex C. Soupir, Christelle M. Colin-Leitzinger, Benjamin G. Bitler, Mary K. Townsend, Andrew B. Lawson, Joellen M. Schildkraut, Shelley S. Tworoger, Kathryn L. Terry, Lauren C. Peres, Brooke L. Fridley
• 6852 · PDF Measure of three cell population co-localization for spatial protein imaging data analysis Kirill Sabitov, Alex Soupir, Lauren C. Peres, Brooke L. Fridley

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