Proteomics: Biomarker Discovery and Signaling Networks

• 7677 High-throughput plasma proteomics enables sarcopenia stratification and identifies the IGFBP axis as a key mediator of muscle impairment in cancer patients Filippo Gustavo Dall'Olio, Wael Salem Zrafi, Xinran Song, Littisha Lawrance, Fei Chen, Pierre Busson, Catherine Brenner, Rebecca Ibrahim, Marie Guinhut, Caroline Even, Nathalie Lassau, Diana Cardenas-Braz, Fabrice Barlesi, Yohann Loriot, Fabrice Andre, Mariam Jamal-Hanjani, Antoine Italiano, Yegor Vassetzky, Benjamin Besse
• 7678 · PDF Ultra-low-abundance cancer biomarker discovery: Multiplexed protein profiling with attomolar sensitivity Malcolm MacKenzie, Ilya Alexandrov, Matthew Preimesberger
• 7679 · PDF Advanced proteomic profiling of patient-derived tumor models reveals high cross-model concordance and improved translational fidelity Jia Xue, Hengyuan Liu, Xiaobo Chen, Sheng Guo
• 7680 · PDF Pre-diagnostic plasma proteomic signatures associated with early-onset colorectal cancer in two large prospective cohorts Mengyao Shi, Xiaoyu Zong, Ruiyi Tian, Daniel Hong, Xinyuan (Cindy) Zhang, Yichen Sun, A. Heather Eliassen, Edward L. Giovannucci, Gong Yang, Andrew T. Chan, Wei Zheng, Yin Cao
• 7681 Chemical proteomics identifies a transcription-related network of proteins that interact with the next-generation poly(ADP-ribose) polymerase inhibitor saruparib Rachael H. Martin, Lindsey Nguy, Thales Da Costa Nepomuceno, Ou Deng, John M. Koomen, Uwe Rix, Alvaro N. Monteiro
• 7682 · PDF Integrative Blood Proteomics Reveals the HuBP Atlas of over 10,000 Proteins Informing Human Physiology and Disease. Zhenyu Sun, Tung-Shing M. Lih, Yuanyu Huang, Yingwei Hu, Yuefan Wang, Hui Zhang
• 7683 A proteomic analysis of differential protein expression between platinum-sensitive and platinum-resistant high grade serous ovarian cancer Nujsaubnusi Cassandra Vue, Kyla Frenia, Xi Peng, Eirwen Miller, John Nakayama, Sharon Liang, Sarah Crafton, Alyssa Wield, Christopher Morse, Thomas Krivak, Qiangmin Zheng, Kunhong Xiao
• 7684 Absolute quantification of 400 plasma proteins using a novel NGS-based immunoassay: Analytical validation and biomarker discovery in breast cancer David Aaron Routenberg, Evan A. Gizzie, Annamaria Szabolics, Lucie Hebert, Somnath Paul, Anthony Williams, Richard J. Cote, Jacob N. Wohlstadter
• 7685 · PDF Absolute quantification of aqueous humor proteins for prognostic stratification in uveal melanoma Donny Liang, Elaine Huang, Yilin Chen, Chen-Ching (Patrick) Peng, Jesse Berry, Liya Xu
• 7686 · PDF Identification of a first-in-class therapeutic target using machine learning enabled translational-optimized proteomics system (TPS) Catherine Wong, Ning Li, Shuaixin Gao, Nan Zhang, Jiming Yin, Yonghong Zhang
• 7688 Blood-based proteomic profiling reveals novel biomarkers of neuroendocrine prostate cancer Tatiana Erazo, Ethan S. Barnett, Amanda Weaver, A. Zara Herskovits, Alisa Valentino, Howard I. Scher, Gary A. Pestano
• 7689 Absolute quantification by targeted proteomics identifies BRCA1 hypomorphs and other PARP inhibitor resistance mechanisms in patient-derived xenografts Beom-Jun Kim, Alba Llop-Guevara, Steve M. Sweet, Camille Lombard-Banek, Robert Hanson, Chris Richardson, Violeta Serra, Elizabeth A. Harrington, Josep Forment, Yeoun Jin Kim
• 7690 · PDF Extracellular kinome network reveals secretory kinase FAM20C as a key driver of recurrence in oral squamous cell carcinoma Mi Rim Lee, Yu-Sun Lee, Sumin Kang, Jiyoung Lee, Hye Won Shon, Sun Il Choi, Gyeongmin Kang, Kyung-Hee Kim, Jong-Ho Lee, Ik-Jae Kwon, Sung Woen Choi, Yun-Hee Kim
• 7691 · PDF A magnetic bead-based workflow for streamlined and quantitative mass spectrometry sample preparation in cancer proteomics Mike Rosenblatt, Zhiyang Zeng, Atul Deshpande, Marjeta Urh, Wenhui Zhou
• 7692 Proteomic analysis of immune synapses by high-precision microscopy-guided photo-biotinylation Jung-Chi Liao, Chantal Hoi Yin Cheung, Weng-Man Chong, Harry Huang, Hsiao-Jen Chang, Chia-Wen Chung
• 7693 Unlocking the surfaceome: Nanoscale spatial proteomics for biomarker and target discovery using Synlight-Rich and Synlight-Pure Jung-Chi Liao, Po-Chao Chan, Weng-Man Chong, Hsiao-Jen Chang, Michelli Faria de Oliveira, Elate Huang, Daniel Dlugolenski
• 7694 Proteomic analysis of BRAF-V600E mutant metastatic colorectal cancer FFPE tissues reveals potential involvement of WEE1 expression in therapeutic resistance Shotaro Yamaguchi, Satoshi Muraoka, Yosui Nojima, Toshiharu Hirose, Hidekazu Hirano, Natsuko Okita, Atsuo Takashima, Jun Adachi, Hirokazu Shoji, Ken Kato
• 7695 · PDF Blood-based proteomics analysis for uveal melanoma prognosis Abarajithan Chandrasekaran, Nikhil Nayee, Jerome Lacombe, Timothy Karr, Frederic Zenhausern, Justin Moser
• 7696 · PDF Quantitative plasma proteomics on stellar MS enables discovery of clinically relevant cancer biomarkers Stephanie Samra, Qingling Li, Cristina Jacob, Philip Remes, Jared Deyarmin
• 7697 · PDF Machine learning-based plasma proteomic signatures for diagnosis and prognosis of cholangiocarcinoma Chongming Zheng, Yi Wang, Gang Chen
• 7698 Advancing plasma proteomics: A next-generation nanoparticle enrichment workflow for deep and quantitative biomarker discovery in colorectal cancer Cameron Ellis, Katharina Limm, Sandra Schär, Roland Bruderer, Nils Kulak
• 7699 · PDF Quantitative TMT-based proteomic profiling reveals stage-specific protein dysregulation in colorectal cancer Camille N. Zenón Meléndez, Gabriel Borges Vélez, Josue Perez-Santiago, Yakshi Ortiz Maldonado, Liliana Castro Jimenez, Hilmaris Centeno Girona, Sheila N. Lopez Acevedo, Elba V. Caraballo
• 7700 · PDF Secretomic profiling of triple-negative breast cancer media using Mag-Net™ HP Antolize Deetlefs, Charne Scully, Hafiza Parkar, Andrea Ellero, Amy van Graan, Melissa Vorster, Justin Jordaan, Previn Naicker
• 7701 · PDF Potential clinical utility of small extracellular vesicles derived from head and neck tumors Abolfazl Jangholi, B. W. M. Thilini Basnayake, Omar Breik, Liz Kenny, Sarju Vasani, Riccardo Dolcetti, Chamindie Puyadeera
• 7702 · PDF Integrin alphavbeta3-driven secretome remodeling uncovers THBS1 as a potential prognostic mediator in cutaneous T-cell lymphoma María Mercedes Debernardi, Lucero Alvarado, Ingrid Souza, Alejandro Cagnoni, Karina Formoso, Graciela Cremaschi, Alejandro Correa Dominguez, Florencia Cayrol
• 7703 · PDF Proteomic profiling of Neem (Azadirachta indica) leaves Abigail Kahsay, Basir Syed, Dorna Davani, Aftab Ahmed
• 7704 Proteome-wide high throughput perturbation screening of microglial response to oncologic compounds reveals distinct immunomodulation and toxicity profiles Alyssa Rosenbloom, Kiran Edwardson, Nathaniel Robichaud, Narges Rashidi, Milad Dagher
• 7705 Simultaneous quantitation and discovery of cancer-related proteins in plasma using a fast, high-resolution accurate mass spectrometry-based assay provides insight into precision oncology and drug discovery Dominique Figueroa, Qingling Li, Jared Deyarmin, Sophia Steigerwald, Matthew R. Dallas, Stephanie Samra
• 7706 · PDF Phase-separated RTK fusion condensates orchestrate oncogenic signaling through extensive protein recruitment and RTK crosstalk Wei Yang, Thomas C. Whisenant, Daniel J. Donoghue

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