Immune Response to Therapies

• 7741 · PDF AI-designed personalized neoantigen vaccine, EVX-01, induces durable de novo T-cell responses in advanced melanoma patients Mads Lausen, Michail Angelos Pavlidis, Ohrt Andersen Rasmus, Thuesen Nikolas, Nadia Viborg, Georgina V. Long, Adnan Khattak, Paolo A Ascierto, Carolina Cimminiello, Thomas Trolle, Christian Garde, Michael J. Chisamore, Benjamin Wolthers, Stine Friis Thorsen, Birgitte Rønø, Daniela Kleine-Kohlbrecher
• 7742 · PDF Intratumoral effector T-cells and macrophages underlie prolonged survival after PD-1 axis blockade in metastatic non-small cell lung cancer (mNSCLC) Daniel Boiarsky, Thazin Nwe Aung, Anna Wurtz, Jianlei Gu, Benjamin Y. Lu, David L. Rimm, Arutha Kulasinghe, Katerina A. Politi, Scott Gettinger, Kurt Alex Schalper
• 7743 · PDF Pre-existing T cells drive durable anti-tumor immunity after oncolytic virus therapy in glioblastoma Maxime Meylan, Ye Tian, Lijian Wu, Alexander L. Ling, Daniel Kovarsky, Graham L. Barlow, Linh D. Nguyen, Jason Pyrdol, Lucas Westphal, Michel Julius, Nicolas L. Gonzalez Castro, Sydney D. Dumont, Andres Santos, Itay Tirosh, Mario L. Suva, E Antonio Chiocca, Kai W. Wucherpfennig
• 7744 · PDF Single-cell and spatial profiling reveal tumor-immune features underlying pathologic complete response to neoadjuvant anti-PD-L1 and chemoradiotherapy in NSCLC Jii Bum (Joy) Lee, Sang Hoon Lee, Haangik Park, Seul Lee, Dong Kwon Kim, Jae-Hwan Kim, Ju-Hyeon Lee, Jaeho Cho, Chang Geol Lee, Chang Young Lee, Jin Gu Lee, Dae Joon Kim, Hyo Sup Shim, Sun Min Lim, Hye Ryun Kim, Byoung Chul Cho
• 7745 · PDF EGFR-TKI enhances anti-CD47 antibody-mediated macrophage phagocytosis in EGFR-mutant non-small cell lung cancer Myungja Ro, Seung Min Yang, Youngtaek Kim, Min-Hak Lee, Eun Ji Lee, JuHyeon Lee, Mi Ran Yun, Ji-Eun Park, Jiyea Choi, Hyesun Lee, Sung Ho Kim, Heung Tae Kim, Byoung Chul Cho
• 7746 · PDF CEACAM5/6+ cancer cell and IL1B+ macrophage-mediated resistance in anti-PD-1 treated gastric cancer Liudeng Zhang, Jian Chen, Yikai Luo, Lie Wang, Han Liang
• 7747 · PDF Comparison of T-cell activation status in patients treated with retifanlimab in combination with anti-LAG3/Anti-TIM3 vs retifanlimab alone Robert I. Haddad, Denis Soulières, Prakash Neupane, Amaury Daste, Zhiwan Dong, Jin Lu, Michelle Kinder, Jeff Jackson, Richard Schaub, Nawel Bourayou, John Janik, Christophe Le Tourneau
• 7748 · PDF Immune-related RNA-seq biomarker-based clustering reveals heterogeneous immunotherapy responses and guides subtype-specific strategies in metastatic NSCLC Jiyon Lyu, Sebastià Franch-Expósito, Sanghwa Kim, Liam Il-Young Chung, Ronald Min, Sung Hwan Lee, Shinkyo Yoon, Michelle M. Stein, JACOB MERCER, Paul Fields, Bella Kim, Young Kwang Chae
• 7749 · PDF Increased immune activity in patients with high-grade serious ovarian cancer after combination PARPi + ATRi therapy Elias Pavlatos, Benjamin Tate, Austin Nguyen, Ian S. Heller, Dimitrios Nasioudis, Janos L. Tanyi, Drew A. Torigian, Diego Rodriguez, Susan M. Domchek, Ronny I. Drapkin, Eric J. Brown, Gordon B. Mills, Fiona Simpkins
• 7750 · PDF Integration of spatial single cell proteomics and spatial metabolomics reveals tumor microenvironment predictive of immunotherapy response in mucosal melanoma Jun Wang, Priyadharsini Nagarajan, Sungnam Cho, Yunhe Liu, Erin H. Seeley, Yibo Dai, Yang Liu, Jared K. Burks, Jennifer L. McQuade, Adi Diab, Linghua Wang, Suhendan Ekmekcioglu
• 7751 · PDF Integrative multi-omics and spatial transcriptomics reveal novel immunotherapy targets in hepatocellular carcinoma Zihui Zhao, Xiaohang Long, Siyuan HUANG, Yan Liu, Alfred S. l. Cheng
• 7752 · PDF Targeting SOAT1 to Boost NK Cell Mediated Cytotoxicity in High Grade Serous Ovarian Cancer Luqi Chen, Michelle K.y. Siu, Ruiqian Zhang, Ling Shan Hung, Mengyi Gu, Dickson Ngan, Xin He, Haonan Lu, Hextan Y.s. Ngan, Kui Liu, Annie Ny Cheung, Karen K.l. Chan
• 7753 · PDF Circulating thymidine kinase activity (TKa) as a predictive and dynamic biomarker in the metastatic non-small cell lung cancer (NSCLC): Immunoblood study Maristella Giammaruco, Lorenza Landi, Mattias Bergqvist, Gabriele Minuti, Silvia Carpano, Francesca Fusco, Martina Brandi, Fabiana Letizia Cecere, Vincenzo Pio Di Noia, Livia Tosetto, Andrea Torchia, Corrado Orciuolo, Daniele Marinelli, Grisel Maver Militello, Diana Giannarelli, Federico Cappuzzo
• 7754 · PDF Peripheral immune signatures associated with peptide receptor radionuclide therapy in neuroendocrine tumors Eriko Katsuta, Takuto Nobuhiro, Masaru Takeuchi, Satoshi Matsui, Asano Daisuke, Ishikawa Yoshiya, Hiroki Ueda, Keiichi Akahoshi, Noritoshi Kobayashi, Yasushi Ichikawa, Daisuke Ban
• 7755 · PDF Precision immune therapies for cancer developed through understanding the role of myeloid checkpoints as key mediators of adaptive resistance in T-cell checkpoint inhibitor resistant patients Rónán O'Hagan, Magali Perderzoli-Ribeil
• 7756 · PDF A tumor-targeting IL-12 immunocytokine therapy increases peripheral natural killer (NK) cells with phenotypes associated with increased tumor cell lysis in patients with advanced solid tumors Stephanie C. Pitts, Nicole J. Toney, Jennifer L. Marte, James L. Gulley, Jeffrey Schlom, Renee N. Donahue
• 7757 · PDF Investigating the mechanisms underlying regulatory T cell dysfunction in ICI-induced colitis Emily Schahrer, Paul Ngai, Mehdi Benjelloun Zahar, Christopher R. Weber, David Zemmour
• 7758 · PDF Prediction of pharmacokinetics and pharmacodynamics profile for a fixed dosing and body weight-based dosing of GI-102 based on cell-level pharmacodynamics-mediated drug disposition model in patients with advanced or metastatic solid tumors Suemin Park, Seung Chan Choi, Kwang-Soo Shin, Nari Yun, Myoung Ho Jang, Hyeong-Seok Lim
• 7759 · PDF Construction of a novel immune gene signature to distinguish immunotherapy responders and non-responders Moonyoung Lee, Yona Kim, Sangjeong Ahn, Sung Hak Lee
• 7761 · PDF Tertiary lymphoid structure (TLS) representative cells elicit response to anti-PD-1 + therapy in a cold tumor Satish Sankaran, Priyanka Chevour, Kowshik Jaganathan, Biswajit Das, Moumita Nath, Abdul Haseeb, Jobin K Paul, Vasanthakumar A, Oliyarasi M, Rajashekar M, Jayaprakash C, Venkatesh T, MS Ganesh, Amritha Prabha, Prakash BV, Upendra K, Méhul Kapur, Ritu Malhotra, Govindaraj K, Pavithira ., Mohit Malhotra
• 7762 · PDF PD-L1-dependent 4-1BB costimulation enhances anti-tumor efficacy and T cell persistence as monotherapy or in combination with tarlatamab Felipe Vences Catalan, Willy Tsai, Wendy Chen, Anja Henn, Kevin Cook, Maryam Yousefi, Tanya Vagner, Andrew Jimena, Khushboo Sharma, Deepali Sawant, Jason DeVoss, Matthias Friedrich, Mithun Khattar, Julie Bailis, Andrew Rankin, Sungeun Kim
• 7763 · PDF FOXA1 in ovarian cancer: Therapeutic target and immunotherapy enhancer Taewan Kim, Baek MooJun, HyoWook Gil, Eunjung Yang, Kwangseock Kim, jaesung Ryu, Kong Hyejeong, Beamjun Park, Seob Jeon
• 7764 · PDF Modeling CRS in humanized immune system mice Audrey Wetzel, Anaïs Meynet-Cordonnier, Clothilde Philouze, Charline Boulot, Emilie Bayon, Sebastien Tabruyn, Dan Georgess
• 7766 · PDF Single-dose neoadjuvant atezolizumab in resectable stage IA-IIIA non-N2 NSCLC: Tumor infiltrate analysis from the PRINCEPS trial Antonio Nuccio, Lydie Cassard, Nathalie Cozic, Malek Ben Salah, Vesna Lukic, Julien Adam, Wael Salem Zrafi, David Planchard, Jordi Remon, Pernelle Lavaud, Anas Gazzah, Vincent Thomas de Montpreville, Maria Rosa Ghigna, Patrick Dumont, Elie Fadel, Fabrice Barlesi, Caroline Caramella, Filippo Gustavo Dall’Olio, Olaf Mercier, Paul-Henry Cournède, Nathalie Chaput, Benjamin Besse
• 7767 · PDF Spatial profiling of the tumor immune microenvironment following oncolytic herpes simplex virus treatment in glioblastoma Sophia A. Paxton, Corinne H. Strawser, Lakshmi Prakruthi Rao Venkata, Elizabeth A. R. Garfinkle, James M. Markert, Katherine E. Miller, Kevin A. Cassady, Elaine R. Mardis
• 7768 · PDF Biological pathways of response to neoadjuvant chemo-immunotherapy in triple-negative breast cancer (TNBC) Nickolas Stabellini, Prerana B. Parthasarathy, Iluja Gautam, Patricia A. Rayman, Monaben Patel, Paul G. Pavicic Jr, Adam Moen, Brian Race, Eden Mundell, Amanda Trevino, Jennifer Powers, Tyler Joseph Alban, Jennifer Ko, Bahar Moftakhar, Takae Mizukami, Cynthia Owusu, Timothy A. Chan, Alberto J. Montero, C. Marcela Diaz-Montero
• 7769 · PDF IL-12/anti-PD-1 armored oncolytic HSV-1 reprograms CNS immunity: Integrated longitudinal immune, genomic, and metabolic CSF profiling in the MVR-C5252 PuMP Trial Elizabeth Owens, Kelly Hotchkiss, Stevie Threatt, Justin T. Low, Monika Anand, Julia Louw, Melody Goldston, Margaret O. Johnson, Claire Bradbury, James E. Herndon, Gerry A. Grant, David M. Ashley, Anoop P. Patel, Annik Desjardins, Michael C. Brown, Mustafa Khasraw

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