Immunomodulatory Agents and Interventions

• 7773 · PDF Continuation of immune checkpoint inhibitor therapy after progression in head and neck squamous cell carcinoma: A multicenter study Hyun Ae Jung, Young Kim, Ross Merkin, Thomas Roberts, Manisha Patel, Boram Park, Jinyong Kim, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Lori J. Wirth, Jong Chul Park
• 7774 · PDF Blockade of cell-ECM interaction with an oncolytic virus suppresses tumoral STING activation while inducing antitumor immunity Upasana Sahu, Matthew Mullarkey, Kimberly Rivera Caraballo, Sergie Bombin, Adam Chadli, Ravindra Kolhe, James M. Markert, Bangxing Hong, Balveen Kaur
• 7775 · PDF Pharmacodynamic biomarkers of TGFbetaR2xPD-1 bispecific antibody INCA33890 in patients with MSS metastatic colorectal cancer (mCRC) Michelle Kinder, Rui Hong, Chifei Sun, Yunlan Fang, Michael Smith, Cynthia Timmers, Chiara Greggio, Jordi Rodon Ahnert
• 7776 · PDF An exopolysaccharide-containing yogurt preserves CCR6 + CD4 + T Cells: Th7R, and may enhance immunotherapy responses in lung cancer patients Hiroshi Kagamu, Ayako Shiono, Hisao Imai, Atsuto Mouri, Ou Yamaguchi, Kosuke Hashimoto, Shota Takei, Hirotaka Kawanabe-Matsuda, Kyoichi Kaira
• 7777 · PDF Direct in vivo activation and functional reprogramming of human TILs using a multifunctional nanoengager in humanized renal carcinoma Man Wang, Lifu Ruan, Xin Wen, Tian Zhang, Andrew Z. Wang
• 7778 · PDF GS24-B047, a potential best-in-class DLL3-targeting T-cell engager with integrated costimulatory signal, for the treatment of small cell lung cancer Zeng Qi, Fu Li, Zhiyu Cui, Hongmei Xie, Sijia Liu, Dechen Cao, Liang Xu, Yihui Lin, Lishan Kang, Siqin Wang, Lei Jin, John L. Xu
• 7779 · PDF A tunable interleukin-18 (IL-18) platform engineered for complete escape from the decoy receptor IL-18 binding protein (IL-18BP) Haiming Huang, Wencong Peng, Ruohan Zhu, Quanxiao Li, Liwen Ji, Yao Lu, Dong Wei, Yanling Wu, Tianlei Ying
• 7781 · PDF Patient derived tumor-immune organoids capture the functional and mechanistic interface in predicting response to standard therapeutics and immunotherapeutics in colorectal cancer patients Suman Dutta, Debarpan Mitra, Manoranjan Jha, Rimi Mukherjee, Juluri Srinivas, Kadambari Dixit, Krishanu Dey, Aswin Pandit, Sindu Pilli, Chandra C. Ghosh, Amjad Hussain, Gnaneswar Atturu, Ram Shankar Upadhayaya, Pradip K Majumder, Biswanath Majumder
• 7782 · PDF Cbl-b-Notch1 axis blockers rewire immunosuppressive tumors to drive cytotoxic and anti-angiogenic immune responses Zhi Huang, Mairah Khan, Laura Naldi, Brionna King, Luis Del Valle, Silvana Leit, Beth Browning, Christine Loh, Lucio Miele, Giulia Monticone
• 7783 · PDF Collagen-binding IL-12 remodels immunosuppresive microenvironment and improves survival in recurrent glioblastoma Opeyemi Iwaloye, Jun Takei, Lewis Barr, Ken Furudate, Koichi Sasaki, Haruka Ichie, Shunsuke Tsuzuki, Jun Ishihara, Satoru Osuka
• 7784 · PDF Targeting PRMT7 elicits anti-AML immunity by promoting MHC-I expression Shuaishuai Ge, Kaixiu Luo, Lei Zhang, Meng Liu, Xin He, Guohua Wu, Yang Li, Yadav P. Umesh, Haojie Dong, Shengli Xue, Jian Jin, Ling Li
• 7785 · PDF Spatial profiling reveals epigenetic and immunotherapy-driven remodeling of the tumor and lymph node microenvironment in HPV-associated HNSCC Takeshi Ito, Alexander Ladenheim, Hans Zhao, Ernest Hidalgo Cedeno, Benjamin Judson, Saral Mehra, Ansley Roche, Zafar Sayed, Avanti Verma, Natalia Isaeva, Wendell Yarbrough, Aarti Bhatia, Barbara Burtness, Michael Chiorazzi
• 7786 Targeted, conditionally active interferons, interleukins and CD8 T cell engagers for novel cancer immunotherapies Lennart Zabeau, Anje Cauwels, Leander Huyghe, Silvie Taveirne, Joris Wauman, Alexander Van Parys, Jared E. Lopes, Erik Depla, Niko Kley
• 7787 · PDF Phenotype-tailored prophylactic immunomodulation enables safe immune checkpoint inhibitor rechallenge after severe irAEs in high-risk patients Lucrezia Mencarelli, Pierre Van Mol, Douglas Daoudlarian, Sofiya Latifyan, Nuria Alfonso Mederos, Hasna Bouchaab, Matteo Torsello, Antonia Stamatiou, Nicolas Etienne, Karim Abdelhamid, Nabila Ferahta, Athina Stravodimou, Keyvan Shabafrouz, Solange Peters, Michel Obeid
• 7788 · PDF Daiad-2/15: A conditionally active, targeted, hyperpotent IL-2/IL-15 immune agonist is safe and effective in vivo Anu Jayabalu, Mark E. Branum, Jonathan G. Drachman, Alexander Astrakhan
• 7790 · PDF Peptide-delivered low dose IL-2 reprograms pancreatic cancer immunity to improve survival In Hwan Park, Shawn Abeynaike, Ashley Martinez, Jonathan Cho, Daisuke Nishizaki, Gregory P. Botta
• 7791 · PDF PAI-1 inhibition attenuates the inflammatory response in a murine model of sclerodermatous chronic graft-versus-host disease Sahra Gabure, Yogamaya Divakar Prabhu, Vasantharaja Raguraman, Shanid Mohiyuddin, Yan Ji, William Fay, Senthilnathan Palaniyandi, Gerhard Hildebrandt
• 7792 PIK3CA activating mutation reshapes the tumor microenvironment to promote immune evasion in squamous cell carcinoma Sydney Fisher, Benjamin Nicholson, Weijie Guo, Yuxuan Phoenix Miao
• 7793 · PDF Bioelectromagnetic reprogramming of tumor-immune metabolism to selectively destroy NSCLC Sunny Huang, Jennifer Petssche, Danielle Foster, Charles Searby, Val Sheffield, Douglas R. Spitz, Calvin Carter
• 7794 When stress spreads: Transmissible ER stress as a driver of immune remodeling in PDAC Naveen Chintala Ramulu, Shreya Pokharel, Nishanthini Pirashanna, Basel Abuaita, Joseph Francis

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