Tumor Microenvironment Modulators

• 7926 · PDF Efficacy, in vivo safety, and PK/PD studies for novel, oral, highly selective PTPN2/1 inhibitor (ZE00-0388) Alexei Pushechnikov, Ruben Karapetian, Stepan Mochalov, Sanja Baumann Tomovska, Nikolay Savchuk, Iain Dukes, Ruben Abagyan
• 7927 · PDF Exosomes, regulated by SPRED2, reshape tumor microenvironment via activating IL6/ STAT3 signaling Tong Gao, Akihiro Matsukawa
• 7928 · PDF Immune microenvironmental patterns in rapidly progressive young-onset tongue cancer: A case series analysis Alisa Kimura, Takahiro Tsujikawa, Shota Sugaya, Yuna van der Aar, Koichi Yoshizawa, Sumiyo Saburi, Shigeyuki Mukudai, Hikaru Nagao, Aki Tamura, Nana Sakurai, Aya Miyagawa-Hayashino, Hiroshi Ogi, Saya Shibata, Eiichi Konishi, Kyoko Itoh, Shigeru Hirano
• 7929 · PDF DDR2-CAR macrophages reprogram the tumor microenvironment and normalize vasculature to potentiate antitumor immunity Dandan WANG
• 7930 · PDF Interaction of visceral adiposity and age in shaping the human breast tumor microenvironment Anlan Cao, Sophia Fuller, Jorge Gómez Tejeda Zañudo, Wendy Y. Chen, Deborah A. Dillon, Sandra S. McAllister, Rinath M. Jeselsohn, Bette J. Caan, Adrienne L. Castillo, Elizabeth M. C. Feliciano
• 7931 · PDF Distinct microbiota composition in anorectal mucosal melanoma is associated with resistance to immune checkpoint inhibition Pritika Parmar, Morgan MacBeth, Mallory Karr, Nichole Nusbacher, Stacey M. Bagby, Phaedra Whitty, Kylie Michel, Richard P. Tobin, Martin McCarter, Theresa Medina, Catherine Lozupone, William A. Robinson, Kasey Couts
• 7932 · PDF FL115, a novel IL-15 superagonist rationally designed to minimize safety risks for cancer immunotherapy Quanxiao Li, Yaping Cheng, Dong Wei, Qiang Gao, Yanling Wu, Tianlei Ying
• 7933 · PDF Extracellular vesicle-mediated transfer of cortisol-induced miR-143-3p from macrophages promotes angiogenesis Amod Sharma, Sarabjeet Kour Sudan, Ajay P. Singh, Seema Singh
• 7934 · PDF IL-24 engineered mesenchymal stem cells as a novel therapeutic strategy to remodel the tumor microenvironment in non-small cell lung cancer Yuting Zhang, Yuxuan Zhang, Sai Fung Yeung, Chi-Hang Wong, Tsz Tung Kwong, Connie Wun Chun Hui, Stephen Kwok-Wing Tsui, Tony S. Mok, Desheng Liang, Molly Siu Ching Li
• 7935 · PDF Multimodal immunotherapy remodels the tumor microenvironment in hepatocellular carcinoma: Integrative spatial and transcriptomic profiling from a Phase II trial Lionel Aurelien Kankeu Fonkoua, Christopher L. Hallemeier, Basim Salem, Arina Tkachuk, Kaitlynn McCay, Panwen Wang, Ying Li, Thomas D. Atwell, Krishan R. Jethwa, Caitlin Conboy, Nguyen H. Tran, Leslie A. Washburn, Melody Wu, Chen Wu, Andre De Menezes Silva Corraes, Rondell P. Graham, Jose Caetano Villasboas, Kevin Regan, Zuoyi Shao, Rayaan Kamal, Nathan R. Foster, Haidong Dong, Sean Park, Yi Lin, Lewis R. Roberts
• 7936 · PDF Epigenetic reprogramming of stromal-epithelial crosstalk to improve immunotherapy response in pancreatic ductal adenocarcinoma Celia Martín-Otal, Daire Hanna, Kairbaan Hodivala-Dilke, Angus J. M. Cameron, Oliver Pearce, David Propper
• 7937 · PDF Advancing the best-in-class cross-specific LILRB1/LILRB2 antibody IOMX-0675 into clinical development for solid tumors Ana Ogrinc Wagner, Kristina Heinig, Christina Hartl, Marisa Stebegg-Wagner, Michail Maraslis, Carmen Ginzel, Thomas Jaquin, Bettina Langer, Alina Huth, Tiantom Jarutat, Alexander N. Marziale, Stefan Bissinger
• 7938 · PDF Identification of a novel lncRNA in pancreatic cancer: Contribution to malignancy through Wnt pathway regulation Isshin Narumoto, Keiko Shinjo, Yutaka Kondo, Shu Hirako
• 7939 · PDF Stress-induced anoikis-resistance triggers malignant-like phenotypes in uterine leiomyoma cells Roseli da Silva Soares, Edmund C. Baracat, Katia C. Carvalho
• 7940 · PDF Pharmacokinetics of TNX-1700 in non-human primates and human FcRn/serum albumin transgenic mice Mayanka Awasthi, Jennifer Cho, Nelson Martinez, Bernd Meibohm, Seth Lederman, Christopher Cooper, Sina Bavari, Bruce L. Daugherty
• 7941 · PDF The Sphk1-B cell axis as a targetable immunoregulatory pathway in cancer Mona Singh, Prachi Gupta, Arezou Rahimi, Sunila Pradeep
• 7942 · PDF TAE226 reprograms immune-cold head and neck tumors to immune-hot, augmenting immunotherapy efficacy Atish Ranjan Mohanty, Dana Do, Sharad S. Singhal, Haiqing Li, Sravani Ramisetty, Raju Pillai, Sultatna Shoukath, Prakash Kulkarni, Ellie G. Maghami, Ravi Salgia, Erminia Massarelli
• 7943 · PDF TP53 mutation reshapes the immune microenvironment in endometrial cancer Konrad Snioch, Mahima Rasquinha, Dmitriy Zamarin
• 7944 · PDF Tumor immune micro-environment (TME) dynamics in longitudinal diffuse large B-cell lymphoma (DLBCL) cases from diagnosis to RCHOP relapse Raoul Santiago, Raquel Aloyz, Stéphanie Bianco, Svetlana Dmitrienko, Nathalie Johnson, Andreas I. Papadakis, Naciba Benlimame, Cynthia Guilbert, Alan Spatz, François E. Mercier, Madelyne Abraham, Laura Hilton, David W. Scott, Koren K. Mann, Sarit Assouline
• 7945 · PDF Whole-genome doubling induces chromosomal instability to shape the tumor-immune microenvironment and impair the response to immune checkpoint inhibitors in non-small cell lung cancer Cheolyong Joe, Jinyong Kim, Hyemin Kim, Junsu Choe, Miran Jang, Eunjoo Oh, Naeun Lee, Subin Kim, Sehhoon Park, Hyun Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Joo Kyung Park, Se-Hoon Lee
• 7946 · PDF Identification of a highly selective ITK inhibitor which promotes Th1 differentiation and alleviates T cell exhaustion in vitro and in vivo Lei Jiang, Zhiyong Yu, Xin Cheng, Baoying Cheng, Yuyao Zhang, Wenwen Zhao, Youxi Chen, Feng Zhou
• 7947 · PDF miR-150 orchestrates immune activation and lymphocyte trafficking in breast cancer Masanori Oshi, Rongrong Wu, Colin J. Rog, Li Yan, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe
• 7948 · PDF Targeting the UFMylation pathway to promote immunotherapy response of breast cancers Ciara J. Miller, Jackson P. Riffee, Danielle R. Cook, Timothy D. Martin
• 7949 · PDF Pharmacologic wtIDH1 inhibition remodels the PDAC immune landscape and improves checkpoint blockade efficacy Priyashree Sunita, Shakti Pattanayak, Mehdad Zarei, Omid Hajihassani, Goutam dey, Hallie Graor, Sami Abul-Khoudoud, Faith Nakazzi, Jordan M Winter
• 7950 · PDF Targeting the OSM-OSMR signaling axis to reprogram the tumor microenvironment and overcome immune suppression in pancreatic cancer Yuan Sui, Tony Hunter
• 7951 · PDF Ovarian tumor FAK inhibition releases omega-3 fatty acids stimulating GATA6 peritoneal macrophage CXCL13 production augmenting TIGIT immunotherapy Xiao Lei Chen, Kevin M. Tharp, Marjaana Ojalill, Duygu Ozmadenci, Antonia Boyer, Terrance J. Hannen, Christine Lawson, Hyojae J. Lee, Marvin Xia, Elise Tahon, Yichi Zhang, Cray Minor, Safir U. Khan, Colin C. Anderson, Travis Nemkov, Michael Rose, Monica V. Estrada, Alfredo A. Molinolo, Elias Warren, Patrick Penalosa, Ramez N. Eskander, Michael T. McHale, Shizhen E. Wang, Denise C. Connolly, Kathleen M. Fisch, Dwayne G. Stupack, David D. Schlaepfer
• 7952 · PDF Integrated tissue and secretome profiling identifies an IL-6/IL-8-dominant immune phenotype in peritoneal carcinomatosis Christopher Sherry, Neda Dadgar, Zuqiang Liu, Yong Fan, Hyun Young Park, Ali Zaidi, Paige Mirsky, Oleksii Kucherenko, Albert Donnenberg, David L. Bartlett, Vera S. Donnenberg, Patrick Wagner
• 7953 · PDF Engineered IL7/IL15 secreting iPSC-derived mesenchymal stromal cells convert the immunosuppressive into immune-activated tumor microenvironments (TME) and potentiate antitumor immunity Michael Andreeff, Sandeep Singh, Andrea Bedoy, Muharrem Muftuoglu, Li Li, Vivek Anand, Dipmoy Nath, Lauren Ostermann, Ivo Vletic, Christopher D. Pacheco, Mahesh Basyal, Taeyun Kim, Kyle M. Garland, Matthew Angel, Sanjeev Luther, Robert Pierce, Christopher B. Rohde

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