Translational Biomarkers and Emerging Molecular Approaches

• 7896 · PDF Induction of targeted-cytoxicity and immunogenic cell death using an anti-CEA antibody linked to IRDye700Dx Simran Mehta, Jitender Jitender, Teresa Hong, Michael Bouvet, John E. Shively, Paul J. Yazaki, Thinzar Min Lwin
• 7897 Novel Rho-GTPase regulatory protein gene family variants are frequent and associate with poor survival in patients (pts) with acute myeloid leukemia (AML) Ethan Hamp, Lorenz Oelschläger, Bailee N. Kain, Deedra Nicolet, Krzysztof Mrozek, Katherine E. Miller, Audrey Bollas, Michael C. Walker, Christopher J. Walker, Jill Buss, Andrea Laganson, Andrew J. Carroll, William G. Blum, Bayard L. Powell, Geoffrey L. Uy, Wendy Stock, Marina Y. Konopleva, Richard M. Stone, John C. Byrd, Martin Carroll, Tanmoy Sarkar, Akmaljon Salimov, Benjamin J. Kelly, Electra D. Paskett, Jesse J. Plascak, Shannon McWeeney, Jeffrey W. Tyner, Jeffery Klco, Nathan Salomonis, H. Leighton Grimes, Elaine R. Mardis, Ann-Kathrin Eisfeld
• 7898 Clinical benefit of the HIF-2alpha inhibitor casdatifan (Cas) across molecular subtypes in clear cell renal cell carcinoma (ccRCC) patients from the ARC-20 Clinical Study Benjamin Weeder, Yinghui Guan, Jaskirat Singh, Brian Rini, Toni K. Choueiri, Angelo Kaplan, Omar Kabbarah, Soonweng Cho
• 7899 BGB-21447, a next generation Bcl-2 inhibitor, shows high potential in Bcl-2 overexpressing B cell non-Hodgkin lymphomas (NHL) cancers in preclinical studies Haitao Wang, Lin Li, Yiwen Wang, Weiwei Song, Shuang Peng, Sijia Zhai, Ziyu Jia, Peng Chi, Teiko Sumiyoshi, Ting Deng, Yang Liu, Wei Jin, Zhirong Shen
• 7900 · PDF Clinical significance of elevated UBQLN4 expression with resistance to cisplatin in intrahepatic cholangiocarcinoma Kodai Abe, Kelly K. Chong, Yuta Abe, Minoru Kitago, Motonori Edanami, Yosuke Uematsu, Yohei Masugi, Akihisa Ueno, Anton Bilchik, Yosef Shiloh, Yuko Kitagawa, Dave Hoon
• 7901 · PDF Renal cancer early diagnosis using a novel B7-H3 targeted ultrasound contrast imaging Arutselvan Natarajan, Jihye Baek, Ramasamy Paulmurugan, Jeremy Dahl
• 7902 Analytical accuracy and clinical performance of the OncoMate MSI Dx Analysis System in a subset of KEYNOTE-775 endometrial carcinoma classified as MSS (not MSI-H) by the companion diagnostic Sam Sibley, Matthew Marton, Amy Wehn, Yiwei Zhang, Kathryn Oostdik, Ryan Mordini, Gary Tarpley
• 7903 · PDF MiR-362-3p enhances platinum response in breast cancer Zhaoji Liu, Shizhong Ke, Xiaohui Li, Catherine Wu, Madison M. Uyemura, Brian R. Sardella, Erica S. Massicott, Lin Wang, Emily K. Aronson, Dimitra Karagkouni, Nikolas Kalavros, Ioannis S. Vlachos, Felipe Batalini, Cristina S. Bogsan, Jit Kong Cheong, Lihan Zhou, He Cheng, Phillip Munson, Erica L. Mayer, Judy E. Garber, Stuart J. Schnitt, Nadine M. Tung, Andrea L. Kasinski, Frank J. Slack, Gerburg M. Wulf, Yujing J. Heng
• 7904 · PDF Galectin-9 as a glycan-modulating adjuvant to enhance Elotuzumab-mediated immunotherapy in multiple myeloma Rajib Kumar Shil, Guenther Koehne, Charles J. Dimitroff
• 7905 Dihydroorotate dehydrogenase (DHODH) inhibition as a promising therapeutic strategy with synergistic targeting of ROR1 in small cell lung cancer Bahareh Nourmohammadi, Ola A. Elgamal, Sandip Vibhute, Christopher C. Coss, Thomas E. Goodwin, Erin Hertlein, Joseph M. Amann, Ju Hwan Cho, Chad E. Bennett, John C. Byrd, David P. Carbone
• 7906 · PDF Integrated multi-omics profiling identifies an immunotherapy vulnerable and prognostic associated subtype in cholangiocarcinoma Lu Chen, Xiangdong Tian
• 7907 Genomic, immune, and clinical characterization of estrogen receptor-positive, HER2-low breast cancer: The NextGIM trial latest updates Barbara Cardinali, Alice Stella, Chiara Molinelli, Marco Bruzzone, Yanina Lizet Castillo, Francesca Pitto, Barbara Massa, Simona Pigozzi, Andrea Sciutto, Giorgia Anselmi, Maria Dono, Virna Maltoni, Benedetta Conte, Giulia Buzzatti, Davide Soldato, Gaia Griguolo, Valentina Guarneri, Mario Giuliano, Caterina Marchiò, Fabio Puglisi, Lorenzo Gerratana, Francesca Poggio, Lucia Del Mastro
• 7908 Distinct molecular and clinical aggressiveness in very early-onset colorectal cancer: Survival and genomic divergence between patients aged 30-39 vs 40-49 years Andrea Pretta, Gaia Rebecchi, Giulia Maddalena, Federica Marmorino, Pina Ziranu, Federica Manoni, Maria Caterina De Grandis, Martina Carullo, Clelia Donisi, Giovanni Randon, Eleonora Perissinotto, Ada Taravella, Vincenzo Nasca, Federica Buggin, Paolo Ciracì, Francesca Bergamo, Chiara Cremolini, Sara Lonardi, Mario Scartozzi, Filippo Pietrantonio
• 7909 · PDF Exploring a LINC00092-associated multiomics signature as a clinically tractable biomarker in colorectal cancer Pankaj Kumar Ahluwalia, Alicia Walker, Sade Logan, Denton Lord, Shamia Jordan, Kimya Jones, Ashis Mondal, Ravindra Kolhe
• 7910 Advanced preclinical cancer models and imaging protocols for translational treatment studies in orthotopic prostate, bladder, liver, pancreatic and brain cancer Celine Christine Jensen, Emilie Garly, Rikke Stagaard, Michala Nordfalk, Sigrid Cold, Mette Munk Wessel, Tea Kirkegaard Nielsen, Margarete Karg, Natalia Łopuszyńska, Marina Simón Martin, Sara Vangsgaard, Sebastian Gnosa, Ingrid Hunter, Emma Papin, Camilla Malec, Anne Hessellund Langhave, Trine Nielsen, Andreas Kjaer, Esben Christensen, Trine Bjoernbo Engel, Lotte Kellemann, Carsten Haagen Nielsen
• 7911 · PDF Multi-cohort transcriptomic profiling identifies pathways driving high-risk biochemical recurrence in prostate cancer Sabrina Yepes-Rodriguez, Rafael Parra-Medina
• 7912 · PDF Performance analysis of a novel PD-L1 CAL10 assay in esophageal cancer Ibrahim Abukhiran, Matthew G. Hanna, Dimitrios Korentzelos, Rajiv Dhir, Aatur D. Singhi, Shubham Dayal, Joseph Chiweshe, Xiaozhi Zhou, Robert Monroe, Michelle Wood-Trageser
• 7913 · PDF OXC-101 (karonudib) in canine lymphoma and hemangiosarcoma: Safety, early efficacy, and translational potential Kumar Sanjiv, Sara Saelström, Martin Scobie, Ulrika warpman Berglung, Thomas Helleday, Henrik Rönnberg
• 7914 · PDF Preclinical modeling of plasmacytoid urothelial carcinoma to study cancer mechanisms and therapeutic response Kanisha Kar, Caroline Dickey, William Kim, Kathryn Gessner
• 7915 · PDF Molecular landscape of colorectal cancer (CRC) with KRAS 13D mutations Masango Samuel, Yuliang Chen, Sarah Castillo, Chenbo Sun, Natalia Ignatenko, Daruka Mahadevan, Ritu Pandey
• 7916 · PDF Galectin-2 expression in the tumor microenvironment: A silent pathway of pancreatic ductal adenocarcinoma progression Moacyr Jesus B. Melo Rêgo, Richard Tomasini, Sophie Vasseur, Maira Pitta, Maria Clara P. D. Sampaio, Amanda P. B. Albuquerque, Pascal Finetti, Cláudio Montenegro, Michelly Cristiny Pereira, Michelle Rosa
• 7917 · PDF RUVBL1 and SPARC as prognostic biomarkers in breast cancer Flavia Rotea Mangone, Fernando A. Soares, Maria Aparecida Nagai
• 7918 · PDF Suppression of MAGED1 increases sensitivity to PARP inhibitor in BRCA-mutated breast cancer cells In Hee Lee, Soo Jung Lee, Byeongju Kang, Jeeyeon Lee, Ho Yong Park, Joon Suk Moon, Ji-Young Park, Yee Soo Chae, Eun Ae Kim, Seol-Hwa Jeong, Jieun Kang
• 7919 Clinical, genomic, and therapeutic outcomes of lung squamous cell carcinoma with high LGR5 expression : A study from the LC-SCRUM-Asia database Yu Tanaka, Shuji Murakami, Kazumi Nishino, Motoko Tachihara, Ichiro Nakachi, Mayu Kawakami, Satoshi Hara, hitomi Aono, Shoichi Kuyama, Gaku Yamamoto, Eri Sugiyama, Tetsuya Sakai, Hiroki Izumi, Shigeki Umemura, HIBIKI UDAGAWA, Yoshitaka Zenke, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
• 7920 · PDF Integrated proteogenomics reveals molecular predictors of recurrence beyond HER2 IHC in HER2-positive breast cancer Eunjoo Lee, Seung Min Park, Kyung-Hee Kim, So-Youn Jung, Gi Yeon Lee, Eun-Gyeong Lee, Min-Chae Kang, Jong Bae Park, Kong Sun-Young
• 7921 · PDF The development of a novel PDGFRA resistance mutation in a recurrent KIT -mutant gastrointestinal stromal tumor (GIST) Rachael S. Lowney, Shruthi R. Perati, Aaron Dinerman, Abraham Hakim, Molly A. Sullivan, Stephanie N. Canady, Diane S. Ahn, Michael C. Heinrich, Homma Khosroyani, Andrew M. Blakely
• 7922 · PDF Effect of plasma activated media, with and without chemotherapeutics, on viability of normal and malignant human breast cells Jakob Doster, Lavanya Sankaran, Chuanling Xu, Nathalie Gonce, Valentyne Thomas, Sofia Melendrez, Komal Vig, Vijay Rangarari, Satyanarayana Pondugula, Amit Morey

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